The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding

Genes and Development

Volumn 16, Issue 7, 2002, Pages 836-845

  Vikis, Haris G ^a   Li, Weiquan ^a   Guan, Kun Liang ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

PAK; Plexin B1; Rac; Semaphorin4D

Indexed keywords

P21 ACTIVATED KINASE; PHOSPHOTRANSFERASE; PLEXIN B1; PROTEIN; RAC PROTEIN; SEMAPHORIN 4D; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING COMPETITION; CELL SURFACE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; GROWTH CONE; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD; BIOTINYLATION; CELL LINE; CELL MEMBRANE; COS CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPEPTIDASE K; ENZYME ACTIVATION; GLYCOPROTEINS; HUMANS; KINETICS; LIGANDS; MEMBRANE GLYCOPROTEINS; MODELS, BIOLOGICAL; NERVE TISSUE PROTEINS; PLASMIDS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; RAC GTP-BINDING PROTEINS; RECEPTORS, CELL SURFACE; SEMAPHORIN-3A; SEMAPHORINS; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0036206649     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.966402     Document Type: Article

References (31)

1. Cytoskeletal events in growth cone steering
2. Conformational switch and role of phosphorylation in PAK activation
3. Functions of netrins and semaphorins in axon guidance
4. Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells
5. Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho
6. The organization of F-actin and microtubules in growth cones exposed to a brain-derived collapsing factor
7. The kit ligand: A cell surface molecule altered in steel mutant fibroblasts
8. Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation
9. Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila
10. Plexin b mediates axon guidance in Drosophila by simultaneously inhibiting active rac and enhancing rhoa signaling
11. Racl mediates collapsin-1-induced growth cone collapse
12. The p21Rac/Cdc42-activated kinases (PAKs)
13. Myelin and collapsin- 1 induce motor neuron growth cone collapse through different pathways: Inhibition of collapse by opposing mutants of racl
14. 1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade
15. Regulation of phosphorylation pathways by p21 GTPases. The p21 Rasrelated Rho subfamily and its role in phosphorylation signalling pathways
16. Semaphorin-mediated axonal guidance via Rho-related G proteins
17. Collapsin: A protein in brain that induces the collapse and paralysis of neuronal growth cones
18. Semaphorin III can function as a selective chemorepellent to pattern sensory projections in the spinal cord
19. Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila
20. Accumulation of actin in subsets of pioneer growth cone filopodia in response to neural and epithelial guidance cues in situ
21. The semaphorins: A family of axonal guidance molecules?
22. Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension
23. Plexin/neuropilin complexes mediate repulsion by the axonal guidance signal semaphorin 3A
24. The semaphorin 3A receptor may directly regulate the activity of small GTPases
25. Human p21-activated kinase (Pakl) regulates actin organization in mammalian cells
26. EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin
27. Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors
28. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates
29. The molecular biology of axon guidance
30. The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner
31. Signal transduction in neuronal migration. Roles of gtpase activating proteins and the small gtpase cdc42 in the slitrobo pathway