The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras

Science

Volumn 305, Issue 5685, 2004, Pages 862-865

  Oinuma, Izumi ^a   Ishikawa, Yukio ^a   Katoh, Hironori ^a   Negishi, Manabu ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CELL CULTURE; GROWTH KINETICS; NEUROLOGY; TISSUE;

CELL GROWTH; CELL SURFACES; GUANOSINE TRIPHOSPHATASE (GTPASE); NEURONS;

PROTEINS;

CELL SURFACE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PLEXIN B1; PROTEIN RND1; RAS PROTEIN; RHO FACTOR; SEMAPHORIN 4D RECEPTOR; UNCLASSIFIED DRUG;

BIOLOGY;

ARTICLE; CELL ADHESION; CELL MIGRATION; ENZYME ACTIVITY; GROWTH CONE; HIPPOCAMPUS; NERVE FIBER GROWTH; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN INTERACTION;

ANIMALS; ANTIGENS, CD; AXONS; CELLS, CULTURED; COS CELLS; DOWN-REGULATION; GTP PHOSPHOHYDROLASES; GTPASE-ACTIVATING PROTEINS; GUANOSINE TRIPHOSPHATE; HIPPOCAMPUS; HUMANS; MEMBRANE GLYCOPROTEINS; NEURITES; NEURONS; PC12 CELLS; PROTEIN STRUCTURE, TERTIARY; RAS PROTEINS; RATS; RECEPTORS, CELL SURFACE; RECOMBINANT FUSION PROTEINS; RHO GTP-BINDING PROTEINS; RHOA GTP-BINDING PROTEIN; RNA, SMALL INTERFERING; SEMAPHORINS; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 3843065433     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1097545     Document Type: Article

References (29)

1. L. Tamagnone et al., Cell 99, 71 (1999).
2. F. Nakamura, R. G. Kalb, S. M. Strittmatter, J. Neurobiol. 44, 219 (2000).
3. J. A. Raper, Curr. Opin. Neurobiol. 10, 88 (2000).
4. L. Trusolino, P. M. Comoglio, Nat. Rev. Cancer 2, 289 (2002).
5. Y. Goshima, T. Ito, Y. Sasaki, F. Nakamura, J. Clin. Invest. 109, 993 (2002).
6. B. Rhom, B. Rahim, B. Kleiber, I. Hovatta, A. W. P̈schel, FEBS Lett. 486, 68 (2000).
7. H. Hu, T. F. Marton, C. S. Goodman, Neuron 32, 39 (2001).
8. K. Scheffzek, M. R. Ahmadlan, A. Wittingohfer, Trends Biochem. Sci. 23, 257 (1998).
9. Z. Zhang, K. Vuori, H. Wang, J. C. Reed, E. Ruoslahti, Cell 85, 61 (1996).
10. P. J. Keely, E. V. Rusyn, A. D. Cox, L. V. Parise, J. Cell Biol. 145, 1077 (1999).
11. J. K. Ivins, P. D. Yurchenco, A. D. Lander, J. Neurosci. 20, 6551 (2000).
12. K. Kinbara, L. E. Goldfinger, M. Hansen, F. L. Chou, M. H. Ginsberg, Nat. Rev. Mol. Cell Biol. 4, 767 (2003).
13. C. D. Nobes et al., J. Cell Biol. 141, 187 (1998).
14. I. Oinuma, H. Katoh, A. Harada, H. Negishi, J. Biol. Chem. 278, 25671 (2003).
15. I. Oinuma, Y. Ishikawa, H. Katoh, M. Negishi, data not shown.
16. M. van Triest, J. de Rooij, J. L. Bos, Methods Enzymol. 333, 343 (2001).
17. V. Perrot, J. Vázquez-Prado, J. S. Gutkind, J. Biol. Chem. 277, 43115 (2002).
18. J. M. Swiercz, R. Kuner, J. Behrens, S. Offermanns, Neuron 35, 51 (2002).
19. M. H. E. Driessens et al., Curr. Boil. 11, 339 (2001).
20. J. Aurandt, H. G. Vikis, J. S. Gutkind, N. Ahn, K.-L. Guan, Proc. Natl. Acad. Sci. U.S.A. 99, 12085 (2002).
21. M. H. E. Driessens, C. Olivo, K. Nagata, M. Inagaki, J. G. Collard, FEBS Lett. 529, 168 (2002).
22. T. Yamamoto et al., J. Biol. Chem. 270, 30557 (1995).
23. Y. Ishikawa, H. Katoh, M. Negishi, J. Neurosci. 23, 11065 (2003).
24. S. M. Zanta, I. Hovatta, B. Rohm, A. W. Püschel, J. Neurosci. 22, 471 (2002).
25. G. Serini et al., Nature 424, 391 (2003).
26. T. Takahashi et al., Cell 99, 59 (1999).
27. D. Barberis et al., FASEB J. 18, 592 (2004).
28. http://rsb.info.nih.gov/nih-image/
29. We thank L. Tamagnone for Plexin-B1 cDNA and H. Kikutani for the soluble forms of Sema4D expression plasmids. This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture of Japan and a grant from Takeda Science Foundation. Molecular interaction data have been deposited in the Biomolecular Interaction Network Database with accession codes 149198, 149199, 149200, 149201, 149204, and 149207.