Development of a topically active imiquimod formulation

Pharmaceutical Development and Technology

Volumn 4, Issue 1, 1999, Pages 35-43

  Chollet, John L ^a   Jozwiakowski, Michael J ^a   Phares, Kenneth R ^a   Reiter, Michael J ^a   Roddy, Patrick J ^a   Schultz, Helen J ^a   Ta, Quang V ^a   Tomai, Mark A ^a  

^a 3M COMPANY   (United States)

Author keywords

Cytokines; Emulsion; Imiquimod; Isostearic acid; Solubility

Indexed keywords

4 HYDROXYBENZOIC ACID ESTER; ALPHA INTERFERON; BENZYL ALCOHOL; BIOLOGICAL RESPONSE MODIFIER; CYTOKINE; DRUG PRESERVATIVE; EXCIPIENT; IMIQUIMOD; INTERLEUKIN 6; POLYSORBATE 60; SOLVENT; SORBITAN STEARATE; SURFACTANT; TUMOR NECROSIS FACTOR ALPHA; WATER OIL CREAM; XANTHAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONDYLOMA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; LIPID COMPOSITION; MALE; NONHUMAN; NUDE MOUSE; PH; PKA; PRIORITY JOURNAL; TOPICAL DRUG ADMINISTRATION;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, TOPICAL; AMINOQUINOLINES; ANIMALS; CHEMISTRY, PHARMACEUTICAL; CYTOKINES; EMULSIONS; EXCIPIENTS; GELS; HYDROGEN-ION CONCENTRATION; MALE; MICE; MICE, INBRED HRS; MOLECULAR STRUCTURE; OINTMENTS; SKIN; SOLUBILITY; STEARIC ACIDS; SURFACE-ACTIVE AGENTS; SUSPENSIONS; TEMPERATURE;

EID: 0033004584     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-100101337     Document Type: Article

References (14)

1. R. L. Miller, W. Birmachu, J. F. Gerster, J. F. Gibson, L. M. Imbertson, M. J. Reiter, L. R. Scribner, M. A. Tomai, C. E. Weeks, and T. L. Wagner, Cytokine induction by imiquimod, Chemother. J., 4(3), 148-150 (1995).
2. T. Kono, S. Kondo, S. Pastore, G. Shivji, M. A. Tomai, R. C. McKenzie, and D. N. Sauder, Effects of a novel topical immunomodulator, imiquimod, on keratinocyte cytokine gene expression, Lymphokine Cytokine Res., 13(2), 71-75 (1994).
3. C. J. Harrison, L. Jenski, T. Voychehovski, and D. I. Bernstein, Modification of immunological responses and clinical disease during topical R-837 treatment of genital HSV-2 infection, Antiviral Res., 10, 209-224 (1988).
4. M. Chen, B. P. Griffith, H. L. Lucia, and G. D. Hsiung, Efficacy of S-26308 against guinea pig cytomegalovirus infection, Anitmicrob. Agents Chemother., 32(5), 678-683 (1988).
5. B. Idson, Pharmaceutical emulsions, in Pharmaceutical Dosage Forms: Disperse Systems, Vol. 1 (H. A. Lieberman, M. M. Rieger, and G. S. Banker, eds.), Marcel Dekker, Inc., New York, 1988, pp. 199-243.
6. K. H. Beyer Jr., W. F. Bergfeld, W. O. Berndt, R. K. Boutwell, W. W. Carlton, D. K. Hoffman, and A. L. Schroeter, Final report on the safety assessment of isostearic acid, J. Am. Coll. Toxicol., 2(7), 61-74 (1983).
7. D. W. Osborne and A. H. Amann, Topical Drug Delivery Formulations, Marcel Dekker, Inc., New York, 1990.
8. S. M. Wick, H. J. Schultz, G. R. Nelson, A. K. Mitra, and S. M. Berge, Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo[4, 5-C]quinolin-4-amine, U.S. Patent No. 5,238,944, August 24, 1993.
9. H. T. S. Britton and R. A. Robinson, J. Chem. Soc., 458, 1931.
10. M. J. Reiter, T. L. Testerman, R. L. Miller, C. E. Weeks, and M. A. Tomai, Cytokine induction in mice by the immunomodulator imiquimod, J. Leukocyte Biol., 55, 234-240 (1994).
11. T. Higuchi, Rate of release of medicaments from ointment bases containing drugs in suspension, J. Pharm. Sci., 50(10), 874-876 (1961).
12. M. Corbo, T. W. Schultz, G. K. Wong, and G. A. Van-Buskirk, Development and validation of in vitro release testing methods for semisolid formulations, Pharm. Technol., Sept., 112 (1993).
13. J. P. Skelly, V. P. Shah, H. I. Maibach, R. H. Guy, R. C. Wester, G. Flynn, and A. Yacobi, FDA and AAPS report of the workshop on principles and practices of in vitro percutaneous penetration studies: relevance to bioavailability and bioequivalence, Pharm. Res., 4(3), 265-267 (1987).
14. B. M. Elyan, M. B. Sidhom, and F. M. Plakogiannis, Evaluation of the effect of different fatty acids on the percutaneous absorption of metaproterenol sulfate, J. Pharm. Sci., 85(1), 101-105 (1996).