Gene interaction network analysis suggests differences between high and low doses of acetaminophen

Toxicology and Applied Pharmacology

Volumn 215, Issue 3, 2006, Pages 306-316

  Toyoshiba, Hiroyoshi ^a,b   Sone, Hideko ^a,b   Yamanaka, Takeharu ^c   Parham, Frederick M ^a   Irwin, Richard D ^a   Boorman, Gary A ^a   Portier, Christopher J ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^c FOUNDATION FOR BIOMEDICAL RESEARCH AND INNOVATION   (Japan)

Author keywords

Apoptosis; Dose dependent toxicity; Oxidative stress; Risk assessment; Systems biology; Toxicogenomics

Indexed keywords

PARACETAMOL;

ALGORITHM; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BAYES THEOREM; CLUSTER ANALYSIS; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG MEGADOSE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE INTERACTION; LOW DRUG DOSE; MALE; MULTIPLE DRUG DOSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; RAT;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; APOPTOSIS; BAYES THEOREM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; LIVER; MALE; MODELS, GENETIC; OXIDATIVE STRESS; RATS; RATS, INBRED F344;

EID: 33748052654     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2006.03.009     Document Type: Article

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