-
1
-
-
0041342015
-
Drug-induced hepatotoxicity
-
Lee W.M. Drug-induced hepatotoxicity. N Engl J Med. 349:2003;474-485
-
(2003)
N Engl J Med
, vol.349
, pp. 474-485
-
-
Lee, W.M.1
-
2
-
-
0037418609
-
Redox control of hepatic cell death
-
Hentze H., Latta M., Kunstle G., Lucas R., Wendel A. Redox control of hepatic cell death. Toxicol Lett. 139:2003;111-118
-
(2003)
Toxicol Lett
, vol.139
, pp. 111-118
-
-
Hentze, H.1
Latta, M.2
Kunstle, G.3
Lucas, R.4
Wendel, A.5
-
3
-
-
0033067354
-
Regulation of hepatic glutathione synthesis: Current concepts and controversies
-
Lu S.C. Regulation of hepatic glutathione synthesis: current concepts and controversies. FASEB J. 13:1999;1169-1183
-
(1999)
FASEB J
, vol.13
, pp. 1169-1183
-
-
Lu, S.C.1
-
4
-
-
0037103764
-
Multiple isoforms of mitochondrial glutathione S-transferases and their differential induction under oxidative stress
-
Raza H., Robin M.A., Fang J.K., Avadhani N.G. Multiple isoforms of mitochondrial glutathione S-transferases and their differential induction under oxidative stress. Biochem J. 366:2002;45-55
-
(2002)
Biochem J
, vol.366
, pp. 45-55
-
-
Raza, H.1
Robin, M.A.2
Fang, J.K.3
Avadhani, N.G.4
-
5
-
-
0021345926
-
N-acetyl-p-benzoquinone imine: A cytochrome P-450-mediated oxidation product of acetaminophen
-
Dahlin D.C., Miwa G.T., Lu A.Y., Nelson S.D. N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen. Proc Natl Acad Sci USA. 81:1984;1327-1331
-
(1984)
Proc Natl Acad Sci USA
, vol.81
, pp. 1327-1331
-
-
Dahlin, D.C.1
Miwa, G.T.2
Lu, A.Y.3
Nelson, S.D.4
-
7
-
-
0015733053
-
Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione
-
Mitchell J.R., Jollow D.J., Potter W.Z., Gillette J.R., Brodie B.B. Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. J Pharmacol Exp Ther. 187:1973;211-217
-
(1973)
J Pharmacol Exp Ther
, vol.187
, pp. 211-217
-
-
Mitchell, J.R.1
Jollow, D.J.2
Potter, W.Z.3
Gillette, J.R.4
Brodie, B.B.5
-
8
-
-
0000889408
-
Biotransformation of xenobiotics
-
Klaassen CD, editor, New York: McGraw-Hill;
-
Parkinson A. Biotransformation of xenobiotics. In: Klaassen CD, editor, Casarett and Doull's toxicology, New York: McGraw-Hill; 2001. pp. 133-224.
-
(2001)
Casarett and Doull's Toxicology
, pp. 133-224
-
-
Parkinson, A.1
-
9
-
-
0036783335
-
Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes
-
Rushmore T.H., Kong A.N. Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes. Curr Drug Metab. 3:2002;481-490
-
(2002)
Curr Drug Metab
, vol.3
, pp. 481-490
-
-
Rushmore, T.H.1
Kong, A.N.2
-
10
-
-
0031601462
-
Regulatory DNA elements of phenobarbital-responsive cytochrome P450 CYP2B genes
-
Honkakoski P., Negishi M. Regulatory DNA elements of phenobarbital- responsive cytochrome P450 CYP2B genes. J Biochem Mol Toxicol. 12:1998;3-9
-
(1998)
J Biochem Mol Toxicol
, vol.12
, pp. 3-9
-
-
Honkakoski, P.1
Negishi, M.2
-
11
-
-
0030888748
-
Aryl hydrocarbon receptor-mediated signal transduction
-
Rowlands J.C., Gustafsson J.A. Aryl hydrocarbon receptor-mediated signal transduction. Crit Rev Toxicol. 27:1997;109-134
-
(1997)
Crit Rev Toxicol
, vol.27
, pp. 109-134
-
-
Rowlands, J.C.1
Gustafsson, J.A.2
-
12
-
-
0034685897
-
Transcriptional regulation of the antioxidant response element. Activation by Nrf2 and repression by MafK
-
Nguyen T., Huang H.C., Pickett C.B. Transcriptional regulation of the antioxidant response element. Activation by Nrf2 and repression by MafK. J Biol Chem. 275:2000;15466-15473
-
(2000)
J Biol Chem
, vol.275
, pp. 15466-15473
-
-
Nguyen, T.1
Huang, H.C.2
Pickett, C.B.3
-
13
-
-
0031577292
-
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
-
Itoh K., Chiba T., Takahashi S., Ishii T., Igarashi K., Katoh Y., et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun. 236:1997;313-322
-
(1997)
Biochem Biophys Res Commun
, vol.236
, pp. 313-322
-
-
Itoh, K.1
Chiba, T.2
Takahashi, S.3
Ishii, T.4
Igarashi, K.5
Katoh, Y.6
-
14
-
-
0035870298
-
The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes
-
McMahon M., Itoh K., Yamamoto M., Chanas S.A., Henderson C.J., McLellan L.I., et al. The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. Cancer Res. 61:2001;3299-3307
-
(2001)
Cancer Res
, vol.61
, pp. 3299-3307
-
-
McMahon, M.1
Itoh, K.2
Yamamoto, M.3
Chanas, S.A.4
Henderson, C.J.5
McLellan, L.I.6
-
15
-
-
0035963293
-
Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene
-
Dhakshinamoorthy S., Jaiswal A.K. Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene. Oncogene. 20:2001;3906-3917
-
(2001)
Oncogene
, vol.20
, pp. 3906-3917
-
-
Dhakshinamoorthy, S.1
Jaiswal, A.K.2
-
16
-
-
0024997241
-
Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants
-
Rushmore T.H., Pickett C.B. Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants. J Biol Chem. 265:1990;14648-14653
-
(1990)
J Biol Chem
, vol.265
, pp. 14648-14653
-
-
Rushmore, T.H.1
Pickett, C.B.2
-
17
-
-
0033543566
-
Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene
-
Alam J., Stewart D., Touchard C., Boinapally S., Choi A.M., Cook J.L. Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene. J Biol Chem. 274:1999;26071-26078
-
(1999)
J Biol Chem
, vol.274
, pp. 26071-26078
-
-
Alam, J.1
Stewart, D.2
Touchard, C.3
Boinapally, S.4
Choi, A.M.5
Cook, J.L.6
-
18
-
-
0033546686
-
Up-regulation of the human gamma-glutamylcysteine synthetase regulatory subunit gene involves binding of Nrf2 to an electrophile responsive element
-
Moinova H.R., Mulcahy R.T. Up-regulation of the human gamma-glutamylcysteine synthetase regulatory subunit gene involves binding of Nrf2 to an electrophile responsive element. Biochem Biophys Res Commun. 261:1999;661-668
-
(1999)
Biochem Biophys Res Commun
, vol.261
, pp. 661-668
-
-
Moinova, H.R.1
Mulcahy, R.T.2
-
19
-
-
0018666729
-
Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine)
-
Griffith O.W., Meister A. Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). J Biol Chem. 254:1979;7558-7560
-
(1979)
J Biol Chem
, vol.254
, pp. 7558-7560
-
-
Griffith, O.W.1
Meister, A.2
-
20
-
-
1642472658
-
A novel model of continuous depletion of glutathione in mice treated with L-buthionine (S, R)-sulfoximine
-
Watanabe T., Sagisaka H., Arakawa S., Shibaya Y., Watanabe M., Igarashi I., et al. A novel model of continuous depletion of glutathione in mice treated with L-buthionine (S, R)-sulfoximine. J Toxicol Sci. 28:2003;455-469
-
(2003)
J Toxicol Sci
, vol.28
, pp. 455-469
-
-
Watanabe, T.1
Sagisaka, H.2
Arakawa, S.3
Shibaya, Y.4
Watanabe, M.5
Igarashi, I.6
-
21
-
-
0033956744
-
The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin
-
Hayes J.D., Chanas S.A., Henderson C.J., McMahon M., Sun C., Moffat G.J., et al. The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin. Biochem Soc Trans. 28:2000;33-41
-
(2000)
Biochem Soc Trans
, vol.28
, pp. 33-41
-
-
Hayes, J.D.1
Chanas, S.A.2
Henderson, C.J.3
McMahon, M.4
Sun, C.5
Moffat, G.J.6
-
22
-
-
0035841226
-
A statistical method for flagging weak spots improves normalization and ratio estimates in microarrays
-
Yang M.C., Ruan Q.G., Yang J.J., Eckenrode S., Wu S., McIndoe R.A., et al. A statistical method for flagging weak spots improves normalization and ratio estimates in microarrays. Physiol Genomics. 7:2001;45-53
-
(2001)
Physiol Genomics
, vol.7
, pp. 45-53
-
-
Yang, M.C.1
Ruan, Q.G.2
Yang, J.J.3
Eckenrode, S.4
Wu, S.5
McIndoe, R.A.6
-
23
-
-
0037075063
-
Mining the National Cancer Institute's tumor-screening database: Identification of compounds with similar cellular activities
-
Rabow A.A., Shoemaker R.H., Sausville E.A., Covell D.G. Mining the National Cancer Institute's tumor-screening database: identification of compounds with similar cellular activities. J Med Chem. 45:2002;818-840
-
(2002)
J Med Chem
, vol.45
, pp. 818-840
-
-
Rabow, A.A.1
Shoemaker, R.H.2
Sausville, E.A.3
Covell, D.G.4
-
24
-
-
0037339466
-
An information theoretic approach for analyzing temporal patterns of gene expression
-
Kasturi J., Acharya R., Ramanathan M. An information theoretic approach for analyzing temporal patterns of gene expression. Bioinformatics. 19:2003;449-458
-
(2003)
Bioinformatics
, vol.19
, pp. 449-458
-
-
Kasturi, J.1
Acharya, R.2
Ramanathan, M.3
-
25
-
-
0242607632
-
Parallel analysis of transcript and metabolic profiles: A new approach in systems biology
-
Urbanczyk-Wochniak E., Luedemann A., Kopka J., Selbig J., Roessner-Tunali U., Willmitzer L., et al. Parallel analysis of transcript and metabolic profiles: a new approach in systems biology. EMBO Rep. 4:2003;989-993
-
(2003)
EMBO Rep
, vol.4
, pp. 989-993
-
-
Urbanczyk-Wochniak, E.1
Luedemann, A.2
Kopka, J.3
Selbig, J.4
Roessner-Tunali, U.5
Willmitzer, L.6
-
26
-
-
0030801002
-
Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
-
Altschul S.F., Madden T.L., Schaffer A.A., Zhang J., Zhang Z., Miller W., et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25:1997;3389-3402
-
(1997)
Nucleic Acids Res
, vol.25
, pp. 3389-3402
-
-
Altschul, S.F.1
Madden, T.L.2
Schaffer, A.A.3
Zhang, J.4
Zhang, Z.5
Miller, W.6
-
27
-
-
4444304628
-
Cluster analysis
-
Etheridge AM, Gross LJ, Lenhart S, Maini PK, Safer HM, Voit EO, editors. London: CRC Press;
-
Draghici S, Cluster analysis. In: Etheridge AM, Gross LJ, Lenhart S, Maini PK, Safer HM, Voit EO, editors. Data analysis tools for DNA microarrays. London: CRC Press; 2003. pp. 263-307.
-
(2003)
Data Analysis Tools for DNA Microarrays
, pp. 263-307
-
-
Draghici, S.1
-
28
-
-
0025948113
-
The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity
-
Rushmore T.H., Morton M.R., Pickett C.B. The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity. J Biol Chem. 266:1991;11632-11639
-
(1991)
J Biol Chem
, vol.266
, pp. 11632-11639
-
-
Rushmore, T.H.1
Morton, M.R.2
Pickett, C.B.3
-
29
-
-
0038146898
-
Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis
-
Lee J.M., Calkins M.J., Chan K., Kan Y.W., Johnson J.A. Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis. J Biol Chem. 278:2003;12029-12038
-
(2003)
J Biol Chem
, vol.278
, pp. 12029-12038
-
-
Lee, J.M.1
Calkins, M.J.2
Chan, K.3
Kan, Y.W.4
Johnson, J.A.5
-
30
-
-
0037106099
-
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
-
Thimmulappa R.K., Mai K.H., Srisuma S., Kensler T.W., Yamamoto M., Biswal S. Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res. 62:2002;5196-5203
-
(2002)
Cancer Res
, vol.62
, pp. 5196-5203
-
-
Thimmulappa, R.K.1
Mai, K.H.2
Srisuma, S.3
Kensler, T.W.4
Yamamoto, M.5
Biswal, S.6
-
31
-
-
0037333902
-
Toxicogenomics of bromobenzene hepatotoxicity: A combined transcriptomics and proteomics approach
-
Heijne W.H., Stierum R.H., Slijper M., van Bladeren P.J., van Ommen B. Toxicogenomics of bromobenzene hepatotoxicity: a combined transcriptomics and proteomics approach. Biochem Pharmacol. 65:2003;857-875
-
(2003)
Biochem Pharmacol
, vol.65
, pp. 857-875
-
-
Heijne, W.H.1
Stierum, R.H.2
Slijper, M.3
Van Bladeren, P.J.4
Van Ommen, B.5
-
32
-
-
0033795106
-
Peroxisome proliferator-activated receptor alpha-null mice lack resistance to acetaminophen hepatotoxicity following clofibrate exposure
-
Chen C., Hennig G.E., Whiteley H.E., Corton J.C., Manautou J.E. Peroxisome proliferator-activated receptor alpha-null mice lack resistance to acetaminophen hepatotoxicity following clofibrate exposure. Toxicol Sci. 57:2000;338-344
-
(2000)
Toxicol Sci
, vol.57
, pp. 338-344
-
-
Chen, C.1
Hennig, G.E.2
Whiteley, H.E.3
Corton, J.C.4
Manautou, J.E.5
-
33
-
-
0033799773
-
PPAR-alpha: A key to the mechanism of hepatoprotection by clofibrate
-
Mehendale H.M. PPAR-alpha: a key to the mechanism of hepatoprotection by clofibrate. Toxicol Sci. 57:2000;187-190
-
(2000)
Toxicol Sci
, vol.57
, pp. 187-190
-
-
Mehendale, H.M.1
-
34
-
-
0032545018
-
Mechanism of action of the nongenotoxic peroxisome proliferators: Role of the peroxisome proliferator-activator receptor alpha
-
Gonzalez F.J., Peters J.M., Cattley R.C. Mechanism of action of the nongenotoxic peroxisome proliferators: role of the peroxisome proliferator-activator receptor alpha. J Natl Cancer Inst. 90:1998;1702-1709
-
(1998)
J Natl Cancer Inst
, vol.90
, pp. 1702-1709
-
-
Gonzalez, F.J.1
Peters, J.M.2
Cattley, R.C.3
-
35
-
-
0034630204
-
Prolonged phenobarbital pretreatment abolishes the early oxidative stress component induced in the liver by acute lindane intoxication
-
Videla L.A., Arisi A.C., Fuzaro A.P., Koch O.R., Junqueira V.B. Prolonged phenobarbital pretreatment abolishes the early oxidative stress component induced in the liver by acute lindane intoxication. Toxicol Lett. 115:2000;45-51
-
(2000)
Toxicol Lett
, vol.115
, pp. 45-51
-
-
Videla, L.A.1
Arisi, A.C.2
Fuzaro, A.P.3
Koch, O.R.4
Junqueira, V.B.5
-
36
-
-
0142154214
-
Phylogenetic tree facilitates the understanding of gene expression data on drug metabolizing enzymes obtained by microarray analysis
-
Kiyosawa N., Watanabe T., Sakuma K., Kanbori M., Niino N., Ito K., et al. Phylogenetic tree facilitates the understanding of gene expression data on drug metabolizing enzymes obtained by microarray analysis. Toxicol Lett. 145:2003;281-289
-
(2003)
Toxicol Lett
, vol.145
, pp. 281-289
-
-
Kiyosawa, N.1
Watanabe, T.2
Sakuma, K.3
Kanbori, M.4
Niino, N.5
Ito, K.6
-
37
-
-
0036328387
-
Role of constitutive androstane receptor in the in vivo induction of Mrp3 and CYP2B1/2 by phenobarbital
-
Xiong H., Yoshinari K., Brouwer K.L., Negishi M. Role of constitutive androstane receptor in the in vivo induction of Mrp3 and CYP2B1/2 by phenobarbital. Drug Metab Dispos. 30:2002;918-923
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 918-923
-
-
Xiong, H.1
Yoshinari, K.2
Brouwer, K.L.3
Negishi, M.4
-
38
-
-
0031863453
-
Endocrine factors modulate the phenobarbital-mediated induction of cytochromes P450 and phase II enzymes in a similar strain-dependent manner
-
Ganem L.G., Jefcoate C.R. Endocrine factors modulate the phenobarbital-mediated induction of cytochromes P450 and phase II enzymes in a similar strain-dependent manner. Toxicol Appl Pharmacol. 150:1998;68-75
-
(1998)
Toxicol Appl Pharmacol
, vol.150
, pp. 68-75
-
-
Ganem, L.G.1
Jefcoate, C.R.2
-
40
-
-
0021891891
-
Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin
-
Nichol C.A., Smith G.K., Duch D.S. Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin. Annu Rev Biochem. 54:1985;729-764
-
(1985)
Annu Rev Biochem
, vol.54
, pp. 729-764
-
-
Nichol, C.A.1
Smith, G.K.2
Duch, D.S.3
-
41
-
-
0025802125
-
Antioxidation activity of tetrahydrobiopterin in pheochromocytoma PC 12 cells
-
Shen R.S., Zhang Y.X. Antioxidation activity of tetrahydrobiopterin in pheochromocytoma PC 12 cells. Chem Biol Interact. 78:1991;307-319
-
(1991)
Chem Biol Interact
, vol.78
, pp. 307-319
-
-
Shen, R.S.1
Zhang, Y.X.2
-
42
-
-
0035397392
-
Ferritin and the response to oxidative stress
-
Orino K., Lehman L., Tsuji Y., Ayaki H., Torti S.V., Torti F.M. Ferritin and the response to oxidative stress. Biochem J. 357:2001;241-247
-
(2001)
Biochem J
, vol.357
, pp. 241-247
-
-
Orino, K.1
Lehman, L.2
Tsuji, Y.3
Ayaki, H.4
Torti, S.V.5
Torti, F.M.6
-
44
-
-
0033853838
-
Coordinate transcriptional and translational regulation of ferritin in response to oxidative stress
-
Tsuji Y., Ayaki H., Whitman S.P., Morrow C.S., Torti S.V., Torti F.M. Coordinate transcriptional and translational regulation of ferritin in response to oxidative stress. Mol Cell Biol. 20:2000;5818-5827
-
(2000)
Mol Cell Biol
, vol.20
, pp. 5818-5827
-
-
Tsuji, Y.1
Ayaki, H.2
Whitman, S.P.3
Morrow, C.S.4
Torti, S.V.5
Torti, F.M.6
-
45
-
-
0030632095
-
Antioxidant activity of metallothionein compared with reduced glutathione
-
Miura T., Muraoka S., Ogiso T. Antioxidant activity of metallothionein compared with reduced glutathione. Life Sci. 60:1997;301-309
-
(1997)
Life Sci
, vol.60
, pp. 301-309
-
-
Miura, T.1
Muraoka, S.2
Ogiso, T.3
-
46
-
-
0345280793
-
Metallothionein induction attenuates the effects of glutathione depletors in rat hepatocytes
-
Haidara K., Moffatt P., Denizeau F. Metallothionein induction attenuates the effects of glutathione depletors in rat hepatocytes. Toxicol Sci. 49:1999;297-305
-
(1999)
Toxicol Sci
, vol.49
, pp. 297-305
-
-
Haidara, K.1
Moffatt, P.2
Denizeau, F.3
|