-
2
-
-
0029073613
-
Weight-reducing effects of the plasma protein encoded by the obese gene
-
Halaas J.L., Gajiwala K.S., Maffei M., Cohen S.L., Chait B.T., Rabinowitz D., Lallone R.L., Burley S.K., and Friedman J.M. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269 (1995) 543-546
-
(1995)
Science
, vol.269
, pp. 543-546
-
-
Halaas, J.L.1
Gajiwala, K.S.2
Maffei, M.3
Cohen, S.L.4
Chait, B.T.5
Rabinowitz, D.6
Lallone, R.L.7
Burley, S.K.8
Friedman, J.M.9
-
3
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., and Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature 372 (1994) 425-432
-
(1994)
Nature
, vol.372
, pp. 425-432
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
Barone, M.4
Leopold, L.5
Friedman, J.M.6
-
4
-
-
2342439732
-
Leptin signaling in the central nervous system and the periphery
-
Bjorbaek C., and Kahn B.B. Leptin signaling in the central nervous system and the periphery. Recent Prog. Horm. Res. 59 (2004) 305-331
-
(2004)
Recent Prog. Horm. Res.
, vol.59
, pp. 305-331
-
-
Bjorbaek, C.1
Kahn, B.B.2
-
5
-
-
0030784421
-
Leptin concentration in women is influenced by regional distribution of adipose tissue
-
Bennett F.I., McFarlane-Anderson N., Wilks R., Luke A., Cooper R.S., and Forrester T.E. Leptin concentration in women is influenced by regional distribution of adipose tissue. Am. J. Clin. Nutr. 66 (1997) 1340-1344
-
(1997)
Am. J. Clin. Nutr.
, vol.66
, pp. 1340-1344
-
-
Bennett, F.I.1
McFarlane-Anderson, N.2
Wilks, R.3
Luke, A.4
Cooper, R.S.5
Forrester, T.E.6
-
6
-
-
2042480671
-
Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans
-
Fain J.N., Madan A.K., Hiler M.L., Cheema P., and Bahouth S.W. Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology 145 (2004) 2273-2282
-
(2004)
Endocrinology
, vol.145
, pp. 2273-2282
-
-
Fain, J.N.1
Madan, A.K.2
Hiler, M.L.3
Cheema, P.4
Bahouth, S.W.5
-
7
-
-
0034504237
-
Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome
-
Wajchenberg B.L. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr. Rev. 21 (2000) 697-738
-
(2000)
Endocr. Rev.
, vol.21
, pp. 697-738
-
-
Wajchenberg, B.L.1
-
8
-
-
0031054698
-
Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution
-
Montague C.T., Prins J.B., Sanders L., Digby J.E., and O'Rahilly S. Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution. Diabetes 46 (1997) 342-347
-
(1997)
Diabetes
, vol.46
, pp. 342-347
-
-
Montague, C.T.1
Prins, J.B.2
Sanders, L.3
Digby, J.E.4
O'Rahilly, S.5
-
9
-
-
0032474246
-
Not all fat is alike
-
Arner P. Not all fat is alike. Lancet 351 (1998) 1301-1302
-
(1998)
Lancet
, vol.351
, pp. 1301-1302
-
-
Arner, P.1
-
10
-
-
0030942844
-
The leptin receptor
-
Tartaglia L.A. The leptin receptor. J. Biol. Chem. 272 (1997) 6093-6096
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 6093-6096
-
-
Tartaglia, L.A.1
-
11
-
-
0030789977
-
The leptin receptor promoter controls expression of a second distinct protein
-
Bailleul B., Akerblom I., and Strosberg A.D. The leptin receptor promoter controls expression of a second distinct protein. Nucleic Acids Res. 25 (1997) 2752-2758
-
(1997)
Nucleic Acids Res.
, vol.25
, pp. 2752-2758
-
-
Bailleul, B.1
Akerblom, I.2
Strosberg, A.D.3
-
12
-
-
0030007116
-
Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction
-
Cioffi J.A., Shafer A.W., Zupancic T.J., Smith-Gbur J., Mikhail A., Platika D., and Snodgrass H.R. Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction. Nat. Med. 2 (1996) 585-589
-
(1996)
Nat. Med.
, vol.2
, pp. 585-589
-
-
Cioffi, J.A.1
Shafer, A.W.2
Zupancic, T.J.3
Smith-Gbur, J.4
Mikhail, A.5
Platika, D.6
Snodgrass, H.R.7
-
13
-
-
0032558725
-
Leptin and the regulation of body weight in mammals
-
Friedman J.M., and Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 395 (1998) 763-770
-
(1998)
Nature
, vol.395
, pp. 763-770
-
-
Friedman, J.M.1
Halaas, J.L.2
-
14
-
-
30044434035
-
Intracellular signalling pathways activated by leptin
-
Fruhbeck G. Intracellular signalling pathways activated by leptin. Biochem. J. 393 (2006) 7-20
-
(2006)
Biochem. J.
, vol.393
, pp. 7-20
-
-
Fruhbeck, G.1
-
16
-
-
0001421697
-
SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985
-
Bjorbaek C., Lavery H.J., Bates S.H., Olson R.K., Davis S.M., Flier J.S., and Myers Jr. M.G. SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J. Biol. Chem. 275 (2000) 40649-40657
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 40649-40657
-
-
Bjorbaek, C.1
Lavery, H.J.2
Bates, S.H.3
Olson, R.K.4
Davis, S.M.5
Flier, J.S.6
Myers Jr., M.G.7
-
17
-
-
17844401180
-
Molecular and anatomical determinants of central leptin resistance
-
Munzberg H., and Myers Jr. M.G. Molecular and anatomical determinants of central leptin resistance. Nat. Neurosci. 8 (2005) 566-570
-
(2005)
Nat. Neurosci.
, vol.8
, pp. 566-570
-
-
Munzberg, H.1
Myers Jr., M.G.2
-
18
-
-
0242413107
-
Adipocyte-selective reduction of the leptin receptors induced by antisense RNA leads to increased adiposity, dyslipidemia, and insulin resistance
-
Huan J.N., Li J., Han Y., Chen K., Wu N., and Zhao A.Z. Adipocyte-selective reduction of the leptin receptors induced by antisense RNA leads to increased adiposity, dyslipidemia, and insulin resistance. J. Biol. Chem. 278 (2003) 45638-45650
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 45638-45650
-
-
Huan, J.N.1
Li, J.2
Han, Y.3
Chen, K.4
Wu, N.5
Zhao, A.Z.6
-
19
-
-
29144510014
-
Fat storage in adipocytes requires inactivation of leptin's paracrine activity: implications for treatment of human obesity
-
Wang M.Y., Orci L., Ravazzola M., and Unger R.H. Fat storage in adipocytes requires inactivation of leptin's paracrine activity: implications for treatment of human obesity. Proc. Natl. Acad. Sci. USA 102 (2005) 18011-18016
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 18011-18016
-
-
Wang, M.Y.1
Orci, L.2
Ravazzola, M.3
Unger, R.H.4
-
20
-
-
4344698092
-
Suppressor of cytokine signaling 3 expression and insulin resistance in skeletal muscle of obese and type 2 diabetic patients
-
Rieusset J., Bouzakri K., Chevillotte E., Ricard N., Jacquet D., Bastard J.P., Laville M., and Vidal H. Suppressor of cytokine signaling 3 expression and insulin resistance in skeletal muscle of obese and type 2 diabetic patients. Diabetes 53 (2004) 2232-2241
-
(2004)
Diabetes
, vol.53
, pp. 2232-2241
-
-
Rieusset, J.1
Bouzakri, K.2
Chevillotte, E.3
Ricard, N.4
Jacquet, D.5
Bastard, J.P.6
Laville, M.7
Vidal, H.8
-
21
-
-
33747873586
-
-
World Health Organization Obesity. Preventing and managing the global epidemic. Report of a WHO consultation on obesity. WHO/NUT/NCD/981, WHO, Geneva (1998).
-
-
-
-
22
-
-
33747883432
-
-
Expert Panel, Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults-The Evidence Report. Bethesda, MD: National Institute of Health, National Heart, Lung, and Blood Institute, U. S. Department of Health and Human Services, Public Health Service (1998).
-
-
-
-
23
-
-
0242300698
-
-
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus, Follow-up report on the Diagnosis of Diabetes Mellitus, Diabetes Care 26 (2003) 3160-3167.
-
-
-
-
24
-
-
0031691317
-
Comparison of air displacement plethysmography with dual-energy X-ray absorptiometry and 3 field methods for estimating body composition in middle-aged men
-
Sardinha L.B., Lohman T.G., Teixeira P.J., Guedes D.P., and Going S.B. Comparison of air displacement plethysmography with dual-energy X-ray absorptiometry and 3 field methods for estimating body composition in middle-aged men. Am. J. Clin. Nutr. 68 (1998) 786-793
-
(1998)
Am. J. Clin. Nutr.
, vol.68
, pp. 786-793
-
-
Sardinha, L.B.1
Lohman, T.G.2
Teixeira, P.J.3
Guedes, D.P.4
Going, S.B.5
-
25
-
-
0032910464
-
New techniques in nutritional assessment: body composition methods
-
Elia M., and Ward L.C. New techniques in nutritional assessment: body composition methods. Proc. Nutr. Soc. 58 (1999) 33-38
-
(1999)
Proc. Nutr. Soc.
, vol.58
, pp. 33-38
-
-
Elia, M.1
Ward, L.C.2
-
26
-
-
0034909383
-
Precision of measurement and body size in whole-body air-displacement plethysmography
-
Wells J.C., and Fuller N.J. Precision of measurement and body size in whole-body air-displacement plethysmography. Int. J. Obes. Relat. Metab. Disord. 25 (2001) 1161-1167
-
(2001)
Int. J. Obes. Relat. Metab. Disord.
, vol.25
, pp. 1161-1167
-
-
Wells, J.C.1
Fuller, N.J.2
-
28
-
-
27744496203
-
Air displacement plethysmography: validation in overweight and obese subjects
-
Ginde S.R., Geliebter A., Rubiano F., Silva A.M., Wang J., Heshka S., and Heymsfield S.B. Air displacement plethysmography: validation in overweight and obese subjects. Obes. Res. 13 (2005) 1232-1237
-
(2005)
Obes. Res.
, vol.13
, pp. 1232-1237
-
-
Ginde, S.R.1
Geliebter, A.2
Rubiano, F.3
Silva, A.M.4
Wang, J.5
Heshka, S.6
Heymsfield, S.B.7
-
29
-
-
0014478342
-
Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen
-
Trinder P. Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen. J. Clin. Pathol. 22 (1969) 158-161
-
(1969)
J. Clin. Pathol.
, vol.22
, pp. 158-161
-
-
Trinder, P.1
-
30
-
-
0015348189
-
Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
-
Friedewald W.T., Levy R.I., and Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18 (1972) 499-502
-
(1972)
Clin. Chem.
, vol.18
, pp. 499-502
-
-
Friedewald, W.T.1
Levy, R.I.2
Fredrickson, D.S.3
-
31
-
-
0031737373
-
Correct homeostasis model assessment (HOMA) evaluation uses the computer program
-
Levy J.C., Matthews D.R., and Hermans M.P. Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care 21 (1998) 2191-2192
-
(1998)
Diabetes Care
, vol.21
, pp. 2191-2192
-
-
Levy, J.C.1
Matthews, D.R.2
Hermans, M.P.3
-
32
-
-
0029050937
-
Overexpression of the obese (ob) gene in adipose tissue of human obese subjects
-
Lonnqvist F., Arner P., Nordfors L., and Schalling M. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat. Med. 1 (1995) 950-953
-
(1995)
Nat. Med.
, vol.1
, pp. 950-953
-
-
Lonnqvist, F.1
Arner, P.2
Nordfors, L.3
Schalling, M.4
-
33
-
-
13344295079
-
Serum immunoreactive-leptin concentrations in normal-weight and obese humans
-
Considine R.V., Sinha M.K., Heiman M.L., Kriauciunas A., Stephens T.W., Nyce M.R., Ohannesian J.P., Marco C.C., McKee L.J., Bauer T.L., et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 334 (1996) 292-295
-
(1996)
N. Engl. J. Med.
, vol.334
, pp. 292-295
-
-
Considine, R.V.1
Sinha, M.K.2
Heiman, M.L.3
Kriauciunas, A.4
Stephens, T.W.5
Nyce, M.R.6
Ohannesian, J.P.7
Marco, C.C.8
McKee, L.J.9
Bauer, T.L.10
-
34
-
-
32944463503
-
Leptin predicts a worsening of the features of the metabolic syndrome independently of obesity
-
Franks P.W., Brage S., Luan J., Ekelund U., Rahman M., Farooqi I.S., Halsall I., O'Rahilly S., and Wareham N.J. Leptin predicts a worsening of the features of the metabolic syndrome independently of obesity. Obes. Res. 13 (2005) 1476-1484
-
(2005)
Obes. Res.
, vol.13
, pp. 1476-1484
-
-
Franks, P.W.1
Brage, S.2
Luan, J.3
Ekelund, U.4
Rahman, M.5
Farooqi, I.S.6
Halsall, I.7
O'Rahilly, S.8
Wareham, N.J.9
-
35
-
-
0031587582
-
Quantification of the full length leptin receptor (OB-Rb) in human brown and white adipose tissue
-
Kutoh E., Boss O., Levasseur F., and Giacobino J.P. Quantification of the full length leptin receptor (OB-Rb) in human brown and white adipose tissue. Life Sci. 62 (1998) 445-451
-
(1998)
Life Sci.
, vol.62
, pp. 445-451
-
-
Kutoh, E.1
Boss, O.2
Levasseur, F.3
Giacobino, J.P.4
-
36
-
-
0035930605
-
SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice
-
Emanuelli B., Peraldi P., Filloux C., Chavey C., Freidinger K., Hilton D.J., Hotamisligil G.S., and Van Obberghen E. SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice. J. Biol. Chem. 276 (2001) 47944-47949
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 47944-47949
-
-
Emanuelli, B.1
Peraldi, P.2
Filloux, C.3
Chavey, C.4
Freidinger, K.5
Hilton, D.J.6
Hotamisligil, G.S.7
Van Obberghen, E.8
-
37
-
-
0032014178
-
Identification of SOCS-3 as a potential mediator of central leptin resistance
-
Bjorbaek C., Elmquist J.K., Frantz J.D., Shoelson S.E., and Flier J.S. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol. Cell 1 (1998) 619-625
-
(1998)
Mol. Cell
, vol.1
, pp. 619-625
-
-
Bjorbaek, C.1
Elmquist, J.K.2
Frantz, J.D.3
Shoelson, S.E.4
Flier, J.S.5
-
38
-
-
0842347854
-
Differentially expressed genes in visceral or subcutaneous adipose tissue of obese men and women
-
Linder K., Arner P., Flores-Morales A., Tollet-Egnell P., and Norstedt G. Differentially expressed genes in visceral or subcutaneous adipose tissue of obese men and women. J. Lipid Res. 45 (2004) 148-154
-
(2004)
J. Lipid Res.
, vol.45
, pp. 148-154
-
-
Linder, K.1
Arner, P.2
Flores-Morales, A.3
Tollet-Egnell, P.4
Norstedt, G.5
-
39
-
-
0035162054
-
The role of leptin resistance in the lipid abnormalities of aging
-
Wang Z.W., Pan W.T., Lee Y., Kakuma T., Zhou Y.T., and Unger R.H. The role of leptin resistance in the lipid abnormalities of aging. FASEB J. 15 (2001) 108-114
-
(2001)
FASEB J.
, vol.15
, pp. 108-114
-
-
Wang, Z.W.1
Pan, W.T.2
Lee, Y.3
Kakuma, T.4
Zhou, Y.T.5
Unger, R.H.6
-
40
-
-
0033597897
-
Subcellular localization and internalization of the four human leptin receptor isoforms
-
Barr V.A., Lane K., and Taylor S.I. Subcellular localization and internalization of the four human leptin receptor isoforms. J. Biol. Chem. 274 (1999) 21416-21424
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 21416-21424
-
-
Barr, V.A.1
Lane, K.2
Taylor, S.I.3
-
41
-
-
0033008075
-
Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation
-
Uotani S., Bjorbaek C., Tornoe J., and Flier J.S. Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation. Diabetes 48 (1999) 279-286
-
(1999)
Diabetes
, vol.48
, pp. 279-286
-
-
Uotani, S.1
Bjorbaek, C.2
Tornoe, J.3
Flier, J.S.4
-
42
-
-
0031436148
-
Divergent signaling capacities of the long and short isoforms of the leptin receptor
-
Bjorbaek C., Uotani S., da Silva B., and Flier J.S. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J. Biol. Chem. 272 (1997) 32686-32695
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 32686-32695
-
-
Bjorbaek, C.1
Uotani, S.2
da Silva, B.3
Flier, J.S.4
-
43
-
-
0030828823
-
Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways
-
Kellerer M., Koch M., Metzinger E., Mushack J., Capp E., and Haring H.U. Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways. Diabetologia 40 (1997) 1358-1362
-
(1997)
Diabetologia
, vol.40
, pp. 1358-1362
-
-
Kellerer, M.1
Koch, M.2
Metzinger, E.3
Mushack, J.4
Capp, E.5
Haring, H.U.6
-
44
-
-
0034646633
-
Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes
-
Zhao A.Z., Shinohara M.M., Huang D., Shimizu M., Eldar-Finkelman H., Krebs E.G., Beavo J.A., and Bornfeldt K.E. Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes. J. Biol. Chem. 275 (2000) 11348-11354
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 11348-11354
-
-
Zhao, A.Z.1
Shinohara, M.M.2
Huang, D.3
Shimizu, M.4
Eldar-Finkelman, H.5
Krebs, E.G.6
Beavo, J.A.7
Bornfeldt, K.E.8
-
45
-
-
0029739826
-
Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice
-
Vaisse C., Halaas J.L., Horvath C.M., Darnell Jr. J.E., Stoffel M., and Friedman J.M. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat. Genet. 14 (1996) 95-97
-
(1996)
Nat. Genet.
, vol.14
, pp. 95-97
-
-
Vaisse, C.1
Halaas, J.L.2
Horvath, C.M.3
Darnell Jr., J.E.4
Stoffel, M.5
Friedman, J.M.6
-
46
-
-
0030015417
-
Defective STAT signaling by the leptin receptor in diabetic mice
-
Ghilardi N., Ziegler S., Wiestner A., Stoffel R., Heim M.H., and Skoda R.C. Defective STAT signaling by the leptin receptor in diabetic mice. Proc. Natl. Acad. Sci. USA 93 (1996) 6231-6235
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 6231-6235
-
-
Ghilardi, N.1
Ziegler, S.2
Wiestner, A.3
Stoffel, R.4
Heim, M.H.5
Skoda, R.C.6
-
47
-
-
0034538494
-
Serum leptin and leptin receptor isoforms in omental adipose tissue of nondiabetic women undergoing gynecologic surgery for benign disease
-
Huang K.C., Chuang L.M., Chen C.Y., Chow S.N., and Lin R.S. Serum leptin and leptin receptor isoforms in omental adipose tissue of nondiabetic women undergoing gynecologic surgery for benign disease. J. Formos. Med. Assoc. 99 (2000) 839-843
-
(2000)
J. Formos. Med. Assoc.
, vol.99
, pp. 839-843
-
-
Huang, K.C.1
Chuang, L.M.2
Chen, C.Y.3
Chow, S.N.4
Lin, R.S.5
-
48
-
-
0033935884
-
How tight are your genes? Transcriptional and posttranscriptional regulation of the leptin receptor, NPY, and POMC genes
-
Good D.J. How tight are your genes? Transcriptional and posttranscriptional regulation of the leptin receptor, NPY, and POMC genes. Horm. Behav. 37 (2000) 284-298
-
(2000)
Horm. Behav.
, vol.37
, pp. 284-298
-
-
Good, D.J.1
|