Leptin concentration in women is influenced by regional distribution of adipose tissue

American Journal of Clinical Nutrition

Volumn 66, Issue 6, 1997, Pages 1340-1344

  Bennett, Franklyn I ^a   McFarlane Anderson, Norma ^b   Wilks, Rainford ^b   Luke, Amy ^b   Cooper, Richard S ^b   Forrester, Terrence E ^b  

^a UNIVERSITY OF THE WEST INDIES   (Jamaica)

^b NONE

Author keywords

Body composition; Hip circumference; Leptin; Obesity; Sex

Indexed keywords

LEPTIN;

ADIPOSE TISSUE; ADULT; ANTHROPOMETRY; ARTICLE; BODY COMPOSITION; DIABETES MELLITUS; FEMALE; HIP; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; OBESITY; SEX DIFFERENCE;

EID: 0030784421     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/66.6.1340     Document Type: Article

References (24)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-32.
2. Masuzaki H, Ogawa Y, Isse N, et al. Human obese gene expression. Adipocyte specific expression and regional differences in the adipose tissue. Diabetes 1995;44:855-8.
3. Lonnqvist F, Arner P, Nordfors L, Schalling M. Over expression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med 1995;1:950-3.
4. Pelleymounter MA, Cullen MJ, Baker MB, et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995;269:540-3.
5. Halaas J, Gajiwala KS, Maffei M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995;269:543-6.
6. Lynn RB, Cao GU, Considine RV, Hyde TM, Caro JF. Autoradiographic localization of leptin binding in the choroid plexus of ob/ob and db/db mice. Biochem Biophys Res Commun 1996;219:884-9.
7. Malik KF, Young WS. Localization of binding sites in the central nervous system for leptin (OB protein) in normal, obese (ob/ob), and diabetic (db/db) C57BL/6J mice. Endocrinology 1996;137:1497-500.
8. Bennett WI. Beyond overeating. N Engl J Med 1995;332:673-4.
9. Rohner-Jeanrenaud F, Jeanrenaud B. Obesity, leptin, and the brain. N Engl J Med 1996;334:324-5.
10. Hamilton BS, Paglia D, Kwan AYM, Deitel M. Increased obese mRNA expression in omental fat cells from massively obese humans. Nat Med 1995;1:953-6.
11. Maffei M, Halaas J, Ravussin E, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1995;1:1155-61.
12. Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996;334:292-5.
13. Caro JF, Kolaczynski JW, Nyce MR, et al. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 1996;348:159-61.
14. Trayhurn P, Thomas MEA, Duncan JS, Rayner DV. Effects of fasting and refeeding on ob gene expression in white adipose tissue of lean and obese (ob/ob) mice. FEBS Lett 1995;368:485-90.
15. Lukaski HC, Bolonchuk WW, Hall CB, Siders WA. Validation of tetrapolar bioelectrical impedance method to assess human body composition. J Appl Physiol 1986;60:1327-32.
16. Reaven GM, Olefsky JM. Relationship between heterogeneity of insulin responses and insulin resistance in normal subjects and patients with chemical diabetes. Diabetologia 1977;13:201-6.
17. Forrester T, Wilks R, Bennett F, et al. Obesity in the Caribbean. In: Chadwick DJ, Cardew G. The origins and consequences of obesity. Chichester, United Kingdom: Wiley, 1996:17-31.
18. Pace N, Rathbun EN. Studies on body composition. III. The body water and chemically combined nitrogen content in relation to fat content. J Biol Chem 1945;158:685-91.
19. Havel PJ, Kasim-Karakas S, Dubuc GR, Mueller W, Phinney SD. Gender differences in plasma leptin concentrations. Nat Med 1996;2:949-50.
20. Rosenbaum M, Nicolson M, Hirsch J, et al. Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab 1996;81:3424-7.
21. Havel PJ, Kasim-Karakas S, Mueller W, Johnson PR, Gingerich RL, Stern JS. Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss. J Clin Endocrinol Metab 1996;81:4406-13.
22. Wei M, Haffner SM, Stern MP. High leptin/BMI ratio associated with obesity - does leptin resistance play a role in human obesity? Obes Res 1996;4:44S (abstr).
23. Krotkiewski M, Bjorntorp P, Sjostrom L, Smith U. Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution. J Clin Invest 1983;72:1150-62.
24. Bouchard C, Despres JP, Mauriege P. Genetic and nongenetic determinants of regional fat distribution. Endocrinol Rev 1993;14: 72-93.