Tumour therapy with genes encoding apoptin and E4orf4

Anticancer Research

Volumn 25, Issue 2 A, 2005, Pages 1087-1090

  Mitrus, Iwona ^a   Missol Kolka, Ewa ^a   Plucienniczak, Andrzej ^b   Szala, Stanislaw ^a  

^a INSTITUTE OF ONCOLOGY   (Poland)

^b INDUSTRIAL CHEMISTRY RESEARCH INSTITUTE   (Poland)

Author keywords

Apoptin gene; Apoptosis; Cancer gene therapy; E4orf4 gene

Indexed keywords

APOPTIN; GENE PRODUCT; PROTEIN E4ORF4; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTIN GENE; APOPTOSIS; ARTICLE; CANCER GENETICS; CELL TRANSFORMATION; CONTROLLED STUDY; E4ORF4 GENE; ELECTROPORATION; GENE; GENE INDUCTION; GENE SYNTHESIS; GENE THERAPY; GENE TRANSFER; GROWTH INHIBITION; MOUSE; NICK END LABELING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; CAPSID PROTEINS; CARCINOMA, RENAL CELL; CERCOPITHECUS AETHIOPS; COS CELLS; ELECTROPORATION; GENE THERAPY; IN SITU NICK-END LABELING; KIDNEY NEOPLASMS; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NEOPLASMS, EXPERIMENTAL; VIRAL PROTEINS;

EID: 17444407035     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Noteborn MH: Apoptin-induced apoptosis: a review. Apoptosis 4: 317-9, 1999.
2. Noteborn MH: Chicken anemia virus induced apoptosis: underlying molecular mechanisms. Vet Microbiol 98: 89-94, 2004.
3. Kleinberger T: Induction of apoptosis by adenovirus E4orf4 protein. Apoptosis J: 211-5, 2000.
4. Branton PE and Roopchand DE: The role of adenovirus E4orf4 protein in viral replication and cell killing. Oncogene 20: 7855-65, 2001.
5. Danen-Van Oorschot AA, Zhang YH, Leliveld SR, Roan JL, Seelen MC, Bolk MW, Van Zon A, Erkeland SJ, Abrahams JP, Mumberg D and Noteborn MH: Importance of nuclear localization of apoptin for tumor-specific induction of apoptosis. J Biol Chem 278: 27729-36, 2003.
6. Danen-Van Oorschot AA, Fischer DF, Grimbergen JM, Klein B, Zhuang S, Falkenburg JH, Backendorf C, Quax PH, Van der Eb AJ and Noteborn MH: Apoptin induces apoptosis in human transformed and malignant cells but not in normal cells. Proc Natl Acad Sci USA 94: 5843-7, 1997.
7. Muller U, Kleinberger T and Shenk T: Adenovirus E4orf4 protein reduces phosphorylation of c-Fos and E1A proteins while simultaneously reducing the level of AP-1. J Virol 66: 5867-78, 1992.
8. Shtrichman R and Kleinberger T: Adenovirus type 5 E4 open reading frame 4 protein induces apoptosis in transformed cells. J Virol 72: 2975-82, 1998.
9. Shtrichman R, Sharf R, Barr H, Dobner T and Kleinberger T: Induction of apoptosis by adenovirus E4orf4 protein is specific to transformed cells and requires an interaction with protein phosphatase 2A. Proc Natl Acad Sci USA 96: 10080-5, 1999.
10. Horn NA, Meek JA, Budahazi G and Marquet M: Cancer gene therapy using plasmid DNA: purification of DNA for human clinical trials. Hum Gene Ther 5: 565-73, 1995.
11. Abdallah B, Hassan A, Benoist C, Goula D, Behr JP and Demeneix BA: A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine. Hum Gene Ther 7: 1947-54, 1996.
12. Cichon T, Jamrozy L, Glogowska J, Missol-Kolka E and Szala S: Electrotransfer of gene encoding endostatin into normal and neoplastic mouse tissues: inhibition of primary tumor growth and metastatic spread. Cancer Gene Ther 9: 771-7, 2002.
13. Noteborn MH, De Boer GF, Van Roozelaar DJ, Karreman C, Kranenburg O, Vos JG, Jeurissen SH, Hoeben RC, Zantema A, Koch G et al: Characterization of cloned chicken anemia virus DNA that contains all elements for the infectious replication cycle. J Virol 65: 3131-9, 1991.
14. Pietersen AM, van der Eb MM, Rademaker HJ, van den Wollenberg DJ, Rabelink MJ, Kuppen PJ, van Dierendonck JH, van Ormondt H, Masman D, van de Velde CJ, van der Eb AJ, Hoeben RC and Noteborn MH: Specific tumor-cell killing with adenovirus vectors containing the apoptin gene. Gene Ther 6: 882-92, 1999.