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Volumn 24, Issue 4, 2006, Pages 237-252

Microlitre/millilitre shaken bioreactors in fermentative and biotransformation processes - A review

Author keywords

Mass transfer correlations; Monitoring and control; Predictive models; Small scale bioreactors

Indexed keywords

CHARACTERIZATION; FERMENTATION; FORECASTING; MASS TRANSFER; MATHEMATICAL MODELS;

EID: 33747343757     PISSN: 10242422     EISSN: 10292446     Source Type: Journal    
DOI: 10.1080/10242420600667684     Document Type: Review
Times cited : (42)

References (90)
  • 1
    • 0035811224 scopus 로고    scopus 로고
    • Scale-down model to simulate spatial pH variations in large-scale bioreactors
    • Amanullah, A and McFarlane, CM and Emery, AN and Nienow, AW. (2001) Scale-down model to simulate spatial pH variations in large-scale bioreactors Biotechnol Bioeng, 73, pp. 390-399.
    • (2001) Biotechnol Bioeng , vol.73 , pp. 390-399
    • Amanullah, A.1    McFarlane, C.M.2    Emery, A.N.3    Nienow, A.W.4
  • 2
    • 0035101827 scopus 로고    scopus 로고
    • Device for sterile online measurement of the oxygen transfer rate in shaking flasks
    • Anderlei, T and Büchs, J. (2001) Device for sterile online measurement of the oxygen transfer rate in shaking flasks Biochem Eng J, 7, pp. 157-162.
    • (2001) Biochem Eng J , vol.7 , pp. 157-162
    • Anderlei, T.1    Büchs, J.2
  • 3
    • 1042287173 scopus 로고    scopus 로고
    • Online respiration activity measurement (OTR, CTR, RQ) in shake flasks
    • Anderlei, T and Zang, W and Papaspyrou, M and Büchs, J. (2004) Online respiration activity measurement (OTR, CTR, RQ) in shake flasks Biochem Eng J, 17, pp. 187-194.
    • (2004) Biochem Eng J , vol.17 , pp. 187-194
    • Anderlei, T.1    Zang, W.2    Papaspyrou, M.3    Büchs, J.4
  • 4
    • 0008705267 scopus 로고
    • Aerated and unaerated power and mass transfer characteristics of Prochem agitators
    • In New York: American Institute of Chemical Engineers
    • Balmer, GJ and Moore, IPT and Nienow, CM. (1987) Aerated and unaerated power and mass transfer characteristics of Prochem agitators. In Biotechnology Processes Scale-up and Mixing. (pp. 116-127). New York: American Institute of Chemical Engineers.
    • (1987) Biotechnology Processes Scale-up and Mixing , pp. 116-127
    • Balmer, G.J.1    Moore, I.P.T.2    Nienow, C.M.3
  • 5
    • 0035931413 scopus 로고    scopus 로고
    • Continuous enzymatic regeneration of redox mediators used in biotransformation reactions employing flavoproteins
    • Baminger, U and Ludwig, R and Galhaup, C and Leitner, C and Kulbe, KD and Haltrich, D. (2001) Continuous enzymatic regeneration of redox mediators used in biotransformation reactions employing flavoproteins J Molec Catal B: Enzym, 11, pp. 541-550.
    • (2001) J Molec Catal B: Enzym , vol.11 , pp. 541-550
    • Baminger, U.1    Ludwig, R.2    Galhaup, C.3    Leitner, C.4    Kulbe, K.D.5    Haltrich, D.6
  • 7
    • 0037048809 scopus 로고    scopus 로고
    • High-throughput screening for expression of heterologous proteins in the yeast Pichia pastoris
    • Boettner, M and Prinz, B and Holz, C and Stahl, U and Lang, C. (2002) High-throughput screening for expression of heterologous proteins in the yeast Pichia pastoris J Biotechnol, 99, pp. 51-62.
    • (2002) J Biotechnol , vol.99 , pp. 51-62
    • Boettner, M.1    Prinz, B.2    Holz, C.3    Stahl, U.4    Lang, C.5
  • 8
    • 0035313593 scopus 로고    scopus 로고
    • Improved biocatalysts by directed evolution and rational protein design
    • Bornscheuer, UT and Pohl, M. (2001) Improved biocatalysts by directed evolution and rational protein design Curr Opin Chem Biol, 5, pp. 137-143.
    • (2001) Curr Opin Chem Biol , vol.5 , pp. 137-143
    • Bornscheuer, U.T.1    Pohl, M.2
  • 10
    • 0342265153 scopus 로고    scopus 로고
    • Power consumption in shaking flasks on rotary shaking machines: I. power consumption measurement in unbaffled flasks at low liquid viscosity
    • Büchs, J and Maier, U and Milbradt, C and Zoels, B. (2000a) Power consumption in shaking flasks on rotary shaking machines: I. power consumption measurement in unbaffled flasks at low liquid viscosity Biotechnol Bioeng, 68, pp. 589-593.
    • (2000) Biotechnol Bioeng , vol.68 , pp. 589-593
    • Büchs, J.1    Maier, U.2    Milbradt, C.3    Zoels, B.4
  • 11
    • 0342748564 scopus 로고    scopus 로고
    • Power consumption in shaking flasks on rotary shaking machines, part II: Non-dimensional description of the specific power consumption and flow-regimes in unbaffled flasks at elevated liquid viscosity
    • Büchs, J and Maier, U and Milbradt, C and Zoels, B. (2000b) Power consumption in shaking flasks on rotary shaking machines, part II: non-dimensional description of the specific power consumption and flow-regimes in unbaffled flasks at elevated liquid viscosity Biotechnol Bioeng, 68, pp. 594-601.
    • (2000) Biotechnol Bioeng , vol.68 , pp. 594-601
    • Büchs, J.1    Maier, U.2    Milbradt, C.3    Zoels, B.4
  • 12
    • 0035108591 scopus 로고    scopus 로고
    • Introduction to advantages and problems of shaken cultures
    • Büchs, J. (2001) Introduction to advantages and problems of shaken cultures Biochem Eng J, 7, pp. 91-98.
    • (2001) Biochem Eng J , vol.7 , pp. 91-98
    • Büchs, J.1
  • 13
    • 0035105527 scopus 로고    scopus 로고
    • Out-of-phase operating conditions, a hitherto unknown phenomenon in shaken bioreactors
    • Büchs, J and Lotter, S and Milbradt, C. (2001) Out-of-phase operating conditions, a hitherto unknown phenomenon in shaken bioreactors Biochem Eng J, 7, pp. 135-141.
    • (2001) Biochem Eng J , vol.7 , pp. 135-141
    • Büchs, J.1    Lotter, S.2    Milbradt, C.3
  • 14
    • 0031873720 scopus 로고    scopus 로고
    • Miniaturization technologies in HTS: How fast, how small, how soon?
    • Burbaum, JJ. (1998) Miniaturization technologies in HTS: How fast, how small, how soon? Drug Discovery Today, 3, pp. 313-322.
    • (1998) Drug Discovery Today , vol.3 , pp. 313-322
    • Burbaum, J.J.1
  • 15
    • 3342932515 scopus 로고    scopus 로고
    • Development of a robust microtiter plate-based assay method for assessment of bioactivity
    • Casey, JT and O'Cleirigh, C and Walsh, PK and O'Shea, DG. (2004) Development of a robust microtiter plate-based assay method for assessment of bioactivity J Microbiol Meth, 58, pp. 327-334.
    • (2004) J Microbiol Meth , vol.58 , pp. 327-334
    • Casey, J.T.1    O'Cleirigh, C.2    Walsh, P.K.3    O'Shea, D.G.4
  • 16
    • 0036209122 scopus 로고    scopus 로고
    • Oxygen transfer and mixing in mechanically agitated airlift bioreactors
    • Chisti, Y and Jauregui-Haza, UJ. (2002) Oxygen transfer and mixing in mechanically agitated airlift bioreactors Biochem Eng J, 10, pp. 143-153.
    • (2002) Biochem Eng J , vol.10 , pp. 143-153
    • Chisti, Y.1    Jauregui-Haza, U.J.2
  • 17
    • 1042264083 scopus 로고    scopus 로고
    • Maximizing cell densities in miniprep-scale cultures with H15 medium and improved oxygen transfer
    • Danielson, PB and Büchs, J and Stöckmann, C and Fogleman, JC. (2004) Maximizing cell densities in miniprep-scale cultures with H15 medium and improved oxygen transfer Biochem Eng J, 17, pp. 175-180.
    • (2004) Biochem Eng J , vol.17 , pp. 175-180
    • Danielson, P.B.1    Büchs, J.2    Stöckmann, C.3    Fogleman, J.C.4
  • 18
    • 0037026964 scopus 로고    scopus 로고
    • The use of microscale processing techniques for quantification of biocatalytic Baeyer - Villiger oxidation kinetics
    • Doig, SD and Pickering, SR and Lye, GJ and Woodley, JM. (2002) The use of microscale processing techniques for quantification of biocatalytic Baeyer - Villiger oxidation kinetics Biotechnol Bioeng, 80, pp. 42-49.
    • (2002) Biotechnol Bioeng , vol.80 , pp. 42-49
    • Doig, S.D.1    Pickering, S.R.2    Lye, G.J.3    Woodley, J.M.4
  • 19
    • 13244259396 scopus 로고    scopus 로고
    • Characterisation of a novel miniaturised bubble column bioreactor for high throughput cell cultivation
    • Doig, SD and Diep, A and Baganz, F. (2005a) Characterisation of a novel miniaturised bubble column bioreactor for high throughput cell cultivation Biochem Eng J, 23, pp. 97-105.
    • (2005) Biochem Eng J , vol.23 , pp. 97-105
    • Doig, S.D.1    Diep, A.2    Baganz, F.3
  • 20
    • 15344339338 scopus 로고    scopus 로고
    • Modelling surface aeration rates in shaken microtitre plates using dimensionless groups
    • Doig, SD and Pickering, SCR and Lye, GJ and Baganz, F. (2005b) Modelling surface aeration rates in shaken microtitre plates using dimensionless groups Chem Eng Sci, 60, pp. 2741-2750.
    • (2005) Chem Eng Sci , vol.60 , pp. 2741-2750
    • Doig, S.D.1    Pickering, S.C.R.2    Lye, G.J.3    Baganz, F.4
  • 21
    • 0343673773 scopus 로고    scopus 로고
    • Methods for intense aeration, growth, storage, and replication of bacterial strains in microtiter plates
    • Duetz, WA and Rüedi, L and Hermann, R and O'Connor, K and Büchs, J and Witholt, B. (2000) Methods for intense aeration, growth, storage, and replication of bacterial strains in microtiter plates Appl Environ Microbiol, 66, pp. 2641-2646.
    • (2000) Appl Environ Microbiol , vol.66 , pp. 2641-2646
    • Duetz, W.A.1    Rüedi, L.2    Hermann, R.3    O'Connor, K.4    Büchs, J.5    Witholt, B.6
  • 22
    • 0035101279 scopus 로고    scopus 로고
    • Effectiveness of orbital shaking for the aeration of suspended bacterial cultures in square deepwell microtiter plates
    • Duetz, WA and Witholt, B. (2001) Effectiveness of orbital shaking for the aeration of suspended bacterial cultures in square deepwell microtiter plates Biochem Eng J, 7, pp. 113-115.
    • (2001) Biochem Eng J , vol.7 , pp. 113-115
    • Duetz, W.A.1    Witholt, B.2
  • 23
    • 1042275653 scopus 로고    scopus 로고
    • Oxygen transfer by orbital shaking of square vessels and deepwell microtiter plates of various dimensions
    • Duetz, WA and Witholt, B. (2004) Oxygen transfer by orbital shaking of square vessels and deepwell microtiter plates of various dimensions Biochem Eng J, 17, pp. 181-185.
    • (2004) Biochem Eng J , vol.17 , pp. 181-185
    • Duetz, W.A.1    Witholt, B.2
  • 24
    • 0008693536 scopus 로고
    • Power absorption by new and hybrid mixing systems under gassed and ungassed conditions
    • In New York: American Institute of Chemical Engineers
    • Eliezer, ED. (1987) Power absorption by new and hybrid mixing systems under gassed and ungassed conditions. In Biotechnology Processes Scale-up and Mixing. (pp. 22-30). New York: American Institute of Chemical Engineers.
    • (1987) Biotechnology Processes Scale-up and Mixing , pp. 22-30
    • Eliezer, E.D.1
  • 25
    • 0142026352 scopus 로고    scopus 로고
    • pH control in microwell fermentations of S. erythraea CA340: Influence on biomass growth kinetics and erythromycin biosynthesis
    • Elmahdi, I and Baganz, F and Dixon, K and Harrop, T and Sugden, D and Lye, GJ. (2003) pH control in microwell fermentations of S. erythraea CA340: Influence on biomass growth kinetics and erythromycin biosynthesis Biochem Eng J, 16, pp. 299-310.
    • (2003) Biochem Eng J , vol.16 , pp. 299-310
    • Elmahdi, I.1    Baganz, F.2    Dixon, K.3    Harrop, T.4    Sugden, D.5    Lye, G.J.6
  • 26
    • 1042298884 scopus 로고    scopus 로고
    • Validating shaking flasks as representative screening systems
    • Freyer, SA and König, M and Künkel, A. (2004) Validating shaking flasks as representative screening systems Biochem Eng J, 17, pp. 169-173.
    • (2004) Biochem Eng J , vol.17 , pp. 169-173
    • Freyer, S.A.1    König, M.2    Künkel, A.3
  • 27
    • 0002527815 scopus 로고
    • Improved shaken flask performance
    • Gaden, EL. (1962) Improved shaken flask performance Biotechnol Bioeng, 4, pp. 99-103.
    • (1962) Biotechnol Bioeng , vol.4 , pp. 99-103
    • Gaden, E.L.1
  • 28
    • 0008722826 scopus 로고
    • Characterization of oxygen transfer and power absorption of hydrofoil impellers in viscous mycelial fermentations
    • In New York: American Institute of Chemical Engineers
    • Gbewonyo, K and Dimasi, D and Buckland, BC. (1987) Characterization of oxygen transfer and power absorption of hydrofoil impellers in viscous mycelial fermentations. In Biotechnology Processes Scale-up and Mixing. (pp. 128-134). New York: American Institute of Chemical Engineers.
    • (1987) Biotechnology Processes Scale-up and Mixing , pp. 128-134
    • Gbewonyo, K.1    Dimasi, D.2    Buckland, B.C.3
  • 29
    • 0032143673 scopus 로고    scopus 로고
    • Influence of reactor systems on the morphology of Aspergillus awamori. Application of neural network and cluster analysis for characterization of fungal morphology
    • Gerlach, SR and Siedenberg, D and Gerlach, D and Schügerl, K and Giuseppin, MLF and Hunik, J. (1998) Influence of reactor systems on the morphology of Aspergillus awamori. Application of neural network and cluster analysis for characterization of fungal morphology Process Biochem, 33, pp. 601-615.
    • (1998) Process Biochem , vol.33 , pp. 601-615
    • Gerlach, S.R.1    Siedenberg, D.2    Gerlach, D.3    Schügerl, K.4    Giuseppin, M.L.F.5    Hunik, J.6
  • 30
    • 0035107955 scopus 로고    scopus 로고
    • Small-scale bioreactor system for process development and optimization
    • Girard, P and Jordan, M and Tsao, M and Wurm, FM. (2001) Small-scale bioreactor system for process development and optimization Biochem Eng J, 7, pp. 117-119.
    • (2001) Biochem Eng J , vol.7 , pp. 117-119
    • Girard, P.1    Jordan, M.2    Tsao, M.3    Wurm, F.M.4
  • 31
    • 0141961573 scopus 로고    scopus 로고
    • A study of oxygen transfer in shake flasks using a non-invasive oxygen sensor
    • Gupta, A and Rao, G. (2003) A study of oxygen transfer in shake flasks using a non-invasive oxygen sensor Biotechnol Bioeng, 84, pp. 351-358.
    • (2003) Biotechnol Bioeng , vol.84 , pp. 351-358
    • Gupta, A.1    Rao, G.2
  • 32
    • 0036499268 scopus 로고    scopus 로고
    • A colorimetric assay for the quantitation of free adenine applied to determine the enzymatic activity of ribosome-inactivating proteins
    • Heisler, I and Keller, J and Tauber, R and Sutherland, M and Fuchs, H. (2002) A colorimetric assay for the quantitation of free adenine applied to determine the enzymatic activity of ribosome-inactivating proteins Anal Biochem, 302, pp. 114-122.
    • (2002) Anal Biochem , vol.302 , pp. 114-122
    • Heisler, I.1    Keller, J.2    Tauber, R.3    Sutherland, M.4    Fuchs, H.5
  • 33
    • 0026066542 scopus 로고
    • Suitability of shaking flasks for oxygen supply to microbial cultures
    • Henzler, H-J and Schedel, M. (1991) Suitability of shaking flasks for oxygen supply to microbial cultures Bioprocess Eng, 7, pp. 123-131.
    • (1991) Bioprocess Eng , vol.7 , pp. 123-131
    • Henzler, H.-J.1    Schedel, M.2
  • 34
    • 0035812463 scopus 로고    scopus 로고
    • Optical method for the determination of the oxygen-transfer capacity of small bioreactors based on sulfite oxidation
    • Hermann, R and Walther, N and Maier, U and Büchs, J. (2001) Optical method for the determination of the oxygen-transfer capacity of small bioreactors based on sulfite oxidation Biotechnol Bioeng, 74, pp. 355-363.
    • (2001) Biotechnol Bioeng , vol.74 , pp. 355-363
    • Hermann, R.1    Walther, N.2    Maier, U.3    Büchs, J.4
  • 35
    • 0037454635 scopus 로고    scopus 로고
    • Characterization of gas-liquid mass transfer phenomena in microtiter plates
    • Hermann, R and Lehmann, M and Büchs, J. (2003) Characterization of gas-liquid mass transfer phenomena in microtiter plates Biotechnol Bioeng, 81, pp. 178-186.
    • (2003) Biotechnol Bioeng , vol.81 , pp. 178-186
    • Hermann, R.1    Lehmann, M.2    Büchs, J.3
  • 36
    • 0033863669 scopus 로고    scopus 로고
    • High-throughput screening: New technology for the 21st century
    • Hertzberg, RP and Pope, AJ. (2000) High-throughput screening: New technology for the 21st century Curr Opin Chem Biol, 4, pp. 445-451.
    • (2000) Curr Opin Chem Biol , vol.4 , pp. 445-451
    • Hertzberg, R.P.1    Pope, A.J.2
  • 37
    • 0024053261 scopus 로고
    • Effects of microorganisms on effective oxygen diffusion coefficients and solubilities in fermentation media
    • Ho, CS and Ju, L-K. (1988) Effects of microorganisms on effective oxygen diffusion coefficients and solubilities in fermentation media Biotechnol Bioeng, 32, pp. 313-325.
    • (1988) Biotechnol Bioeng , vol.32 , pp. 313-325
    • Ho, C.S.1    Ju, L.-K.2
  • 38
    • 0037403181 scopus 로고    scopus 로고
    • Growth of the salt-tolerant yeast Zygosaccharomyces rouxii in microtiter plates: Effects of NaCl, pH and temperature on growth and fusel alcohol production from branched-chain amino acids
    • Jansen, M and Veurink, JH and Euverink, G-JW and Dijkhuizen, L. (2003) Growth of the salt-tolerant yeast Zygosaccharomyces rouxii in microtiter plates: Effects of NaCl, pH and temperature on growth and fusel alcohol production from branched-chain amino acids FEMS Yeast Res, 3, pp. 313-318.
    • (2003) FEMS Yeast Res , vol.3 , pp. 313-318
    • Jansen, M.1    Veurink, J.H.2    Euverink, G.-J.W.3    Dijkhuizen, L.4
  • 39
    • 0035916872 scopus 로고    scopus 로고
    • Quantitative screening method for hydrolases in microplates using pH indicators: Determination of kinetic parameters by dynamic pH monitoring
    • John, GT and Heinzle, E. (2001) Quantitative screening method for hydrolases in microplates using pH indicators: Determination of kinetic parameters by dynamic pH monitoring Biotechnol Bioeng, 72, pp. 620-627.
    • (2001) Biotechnol Bioeng , vol.72 , pp. 620-627
    • John, G.T.1    Heinzle, E.2
  • 40
    • 0242501473 scopus 로고    scopus 로고
    • Integrated optical sensing of dissolved oxygen in microtiter plates: A novel tool for microbial cultivation
    • John, GT and Klimant, I and Wittmann, C and Heinzle, E. (2003) Integrated optical sensing of dissolved oxygen in microtiter plates: A novel tool for microbial cultivation Biotechnol Bioeng, 81, pp. 829-836.
    • (2003) Biotechnol Bioeng , vol.81 , pp. 829-836
    • John, G.T.1    Klimant, I.2    Wittmann, C.3    Heinzle, E.4
  • 41
    • 3242789580 scopus 로고    scopus 로고
    • Scale-up methodologies for Escherichia coli and yeast fermentation processes
    • Junker, BH. (2004) Scale-up methodologies for Escherichia coli and yeast fermentation processes J Biosci Bioeng, 97, pp. 347-364.
    • (2004) J Biosci Bioeng , vol.97 , pp. 347-364
    • Junker, B.H.1
  • 42
    • 0031902844 scopus 로고    scopus 로고
    • Development of novel box-shaped shake flask with efficient gas exchange capacity
    • Kato, I and Tanaka, H. (1998) Development of novel box-shaped shake flask with efficient gas exchange capacity J Ferment Bioeng, 85, pp. 404-409.
    • (1998) J Ferment Bioeng , vol.85 , pp. 404-409
    • Kato, I.1    Tanaka, H.2
  • 43
    • 0035108903 scopus 로고    scopus 로고
    • Scale-up of filamentous organisms from tubes and shake-flasks into stirred vessels
    • Katzer, W and Blackburn, M and Charman, K and Martin, S and Penn, J and Wrigley, S. (2001) Scale-up of filamentous organisms from tubes and shake-flasks into stirred vessels Biochem Eng J, 7, pp. 127-134.
    • (2001) Biochem Eng J , vol.7 , pp. 127-134
    • Katzer, W.1    Blackburn, M.2    Charman, K.3    Martin, S.4    Penn, J.5    Wrigley, S.6
  • 44
    • 16344367449 scopus 로고    scopus 로고
    • Oxygen transfer phenomena in 48-well microtiter plates: Determination by optical monitoring of sulfite oxidation and verification by real-time measurement during microbial growth
    • Kensy, F and Zimmermann, HF and Knabben, I and Anderlei, T and Trauthwein, H and Dingerdissen, U and, Büchs J. (2005) Oxygen transfer phenomena in 48-well microtiter plates: Determination by optical monitoring of sulfite oxidation and verification by real-time measurement during microbial growth Biotechnol Bioeng, 89, pp. 698-708.
    • (2005) Biotechnol Bioeng , vol.89 , pp. 698-708
    • Kensy, F.1    Zimmermann, H.F.2    Knabben, I.3    Anderlei, T.4    Trauthwein, H.5    Dingerdissen, U.6    Büchs, J.7
  • 45
    • 11944265432 scopus 로고
    • Oxygen-sensitive luminescent materials based on silicone-soluble ruthenium diimine complexes
    • Klimant, I and Wolfbeis, OS. (1995) Oxygen-sensitive luminescent materials based on silicone-soluble ruthenium diimine complexes Anal Chem, 67, pp. 3160-3166.
    • (1995) Anal Chem , vol.67 , pp. 3160-3166
    • Klimant, I.1    Wolfbeis, O.S.2
  • 46
    • 0345171515 scopus 로고    scopus 로고
    • Current status of modern analytical luminescence methods
    • Kulmala, S and Suomi, J. (2003) Current status of modern analytical luminescence methods Analytica Chimica Acta, 500, pp. 21-69.
    • (2003) Analytica Chimica Acta , vol.500 , pp. 21-69
    • Kulmala, S.1    Suomi, J.2
  • 48
    • 33747332361 scopus 로고    scopus 로고
    • GigaMatrix holding tray having through-hole wells
    • US Patent US2002080350
    • LaffertyM.2002. GigaMatrix holding tray having through-hole wells. US Patent US2002080350.
    • (2002)
    • Lafferty, M.1
  • 49
    • 0037294298 scopus 로고    scopus 로고
    • Design of a prototype miniature bioreactor for high throughput automated bioprocessing
    • Lamping, SR and Zhang, H and Allen, B and Shamlou, PA. (2003) Design of a prototype miniature bioreactor for high throughput automated bioprocessing Chem Eng Sci, 58, pp. 747-758.
    • (2003) Chem Eng Sci , vol.58 , pp. 747-758
    • Lamping, S.R.1    Zhang, H.2    Allen, B.3    Shamlou, P.A.4
  • 50
    • 0033458012 scopus 로고    scopus 로고
    • Control of pH in large-scale, free suspension animal cell bioreactors: Alkali addition and pH excursions
    • Langheinrich, C and Nienow, AW. (1999) Control of pH in large-scale, free suspension animal cell bioreactors: Alkali addition and pH excursions Biotechnol Bioeng, 66, pp. 171-179.
    • (1999) Biotechnol Bioeng , vol.66 , pp. 171-179
    • Langheinrich, C.1    Nienow, A.W.2
  • 51
    • 0030864056 scopus 로고    scopus 로고
    • Marvelous microplates
    • Leach, M. (1997) Marvelous microplates Drug Discov Today, 2, pp. 174-175.
    • (1997) Drug Discov Today , vol.2 , pp. 174-175
    • Leach, M.1
  • 52
    • 0035828738 scopus 로고    scopus 로고
    • Bioreactors: A chemical engineering perspective
    • Leib, TM and Pereira, CJ and Villadsen, J. (2001) Bioreactors: A chemical engineering perspective Chem Eng Sci, 56, pp. 5485-5497.
    • (2001) Chem Eng Sci , vol.56 , pp. 5485-5497
    • Leib, T.M.1    Pereira, C.J.2    Villadsen, J.3
  • 53
    • 4043119663 scopus 로고    scopus 로고
    • Effect of oxygen limitation and medium composition on Escherichia coli fermentation in shake-flask cultures
    • Losen, M and Frölich, B and Pohl, M and Büchs, J. (2004) Effect of oxygen limitation and medium composition on Escherichia coli fermentation in shake-flask cultures Biotechnol Prog, 20, pp. 1062-1068.
    • (2004) Biotechnol Prog , vol.20 , pp. 1062-1068
    • Losen, M.1    Frölich, B.2    Pohl, M.3    Büchs, J.4
  • 54
    • 1042264071 scopus 로고    scopus 로고
    • Utilization of specific power input measurements for optimization of culture conditions in shaking flasks
    • Lotter, S and Büchs, J. (2004) Utilization of specific power input measurements for optimization of culture conditions in shaking flasks Biochem Eng J, 17, pp. 195-203.
    • (2004) Biochem Eng J , vol.17 , pp. 195-203
    • Lotter, S.1    Büchs, J.2
  • 55
    • 0037212099 scopus 로고    scopus 로고
    • Accelerated design of bioconversion processes using automated microscale processing techniques
    • Lye, GJ and Ayazi-Shamlou, P and Baganz, F and Dalby, PA and Woodley, JM. (2003) Accelerated design of bioconversion processes using automated microscale processing techniques Trends Biotechnol, 21, pp. 29-37.
    • (2003) Trends Biotechnol , vol.21 , pp. 29-37
    • Lye, G.J.1    Ayazi-Shamlou, P.2    Baganz, F.3    Dalby, P.A.4    Woodley, J.M.5
  • 56
    • 0035101826 scopus 로고    scopus 로고
    • Characterisation of the gas-liquid mass transfer in shaking bioreactors
    • Maier, U and Büchs, J. (2001) Characterisation of the gas-liquid mass transfer in shaking bioreactors Biochem Eng J, 7, pp. 99-106.
    • (2001) Biochem Eng J , vol.7 , pp. 99-106
    • Maier, U.1    B̈chs, J.2
  • 57
    • 0034059496 scopus 로고    scopus 로고
    • Inverting enantioselectivity by directed evolution of hydantoinase for improved production of L-methionine
    • May, O and Nguyen, PT and Arnold, FH. (2000) Inverting enantioselectivity by directed evolution of hydantoinase for improved production of L-methionine Nat Biotechnol, 18, pp. 317-320.
    • (2000) Nat Biotechnol , vol.18 , pp. 317-320
    • May, O.1    Nguyen, P.T.2    Arnold, F.H.3
  • 58
    • 0001086765 scopus 로고
    • Effect of oxygen supply rates on growth of Escherichia coli. I. Studies in unbaffled and baffled shake flasks
    • McDaniel, LE and Bailey, EG and Zimmerli, A. (1965) Effect of oxygen supply rates on growth of Escherichia coli. I. Studies in unbaffled and baffled shake flasks Appl Microbiol, 13, pp. 100-114.
    • (1965) Appl Microbiol , vol.13 , pp. 100-114
    • McDaniel, L.E.1    Bailey, E.G.2    Zimmerli, A.3
  • 60
    • 0035105370 scopus 로고    scopus 로고
    • Mass transfer resistance of sterile plugs in shaking bioreactors
    • Mrotzek, C and Anderlei, T and Henzler, H-J and Büchs, J. (2001) Mass transfer resistance of sterile plugs in shaking bioreactors Biochem Eng J, 7, pp. 107-112.
    • (2001) Biochem Eng J , vol.7 , pp. 107-112
    • Mrotzek, C.1    Anderlei, T.2    Henzler H.-J. B̈chs, J.3
  • 61
    • 0008774595 scopus 로고    scopus 로고
    • Microplate assays for high-throughput screening
    • Nakayama, GRI. (1998) Microplate assays for high-throughput screening Curr Opin Drug Discov Develop, 1, pp. 85-91.
    • (1998) Curr Opin Drug Discov Develop , vol.1 , pp. 85-91
    • Nakayama, G.R.I.1
  • 63
    • 0031648103 scopus 로고    scopus 로고
    • Hydrodynamics of stirred bioreactors
    • Nienow, AW. (1998) Hydrodynamics of stirred bioreactors Appl Mech Rev, 51, pp. 3-32.
    • (1998) Appl Mech Rev , vol.51 , pp. 3-32
    • Nienow, A.W.1
  • 64
    • 0001799374 scopus 로고    scopus 로고
    • Assay miniaturization for ultra-high throughput screening of combinatorial and discrete compound libraries - A 9600-well (0.2 microliter) assay system
    • Oldenburg, KR and Zhang, JH and Chen, TM and Maffia, A and Blom, KF and Combs, AP and Chung, TDY. (1998) Assay miniaturization for ultra-high throughput screening of combinatorial and discrete compound libraries - A 9600-well (0.2 microliter) assay system J Biomol Screen, 3, pp. 55-62.
    • (1998) J Biomol Screen , vol.3 , pp. 55-62
    • Oldenburg, K.R.1    Zhang, J.H.2    Chen, T.M.3    Maffia, A.4    Blom, K.F.5    Combs, A.P.6    Chung, T.D.Y.7
  • 65
    • 12344291874 scopus 로고    scopus 로고
    • Adaptive dissolved oxygen control through the glycerol feeding in a recombinant Pichia pastoris cultivation in conditions of oxygen transfer limitation
    • Oliveira, R and Clemente, JJ and Cunha, AE and Carrondo, MJT. (2005) Adaptive dissolved oxygen control through the glycerol feeding in a recombinant Pichia pastoris cultivation in conditions of oxygen transfer limitation J Biotechnol, 116, pp. 35-50.
    • (2005) J Biotechnol , vol.116 , pp. 35-50
    • Oliveira, R.1    Clemente, J.J.2    Cunha, A.E.3    Carrondo, M.J.T.4
  • 66
    • 1042298858 scopus 로고    scopus 로고
    • Impact of out-of-phase conditions on screening results in shaking flask experiments
    • Peter, CP and Lotter, S and Maier, U and Büchs, J. (2004) Impact of out-of-phase conditions on screening results in shaking flask experiments Biochem Eng J, 17, pp. 205-215.
    • (2004) Biochem Eng J , vol.17 , pp. 205-215
    • Peter, C.P.1    Lotter, S.2    Maier, U.3    Büchs, J.4
  • 67
    • 0000422819 scopus 로고
    • Determination methods of the volumetric oxygen transfer coefficient kLa in bioreactors
    • Rainer, BW. (1990) Determination methods of the volumetric oxygen transfer coefficient kLa in bioreactors Chem Biochem Eng, 4, pp. 185-196.
    • (1990) Chem Biochem Eng , vol.4 , pp. 185-196
    • Rainer, B.W.1
  • 68
    • 4544297816 scopus 로고    scopus 로고
    • Engineering precursor flow for increased erythromycin production in Aeromicrobium erythreum
    • Reeves, AR. and Cernota, WH and Brikun, IA and Wesley, RK and Weber, JM. (2004) Engineering precursor flow for increased erythromycin production in Aeromicrobium erythreum Metabolic Eng, 6, pp. 300-312.
    • (2004) Metabolic Eng , vol.6 , pp. 300-312
    • Reeves, A.R.1    Cernota, W.H.2    Brikun, I.A.3    Wesley, R.K.4    Weber, J.M.5
  • 69
    • 0141429025 scopus 로고    scopus 로고
    • Reproducing shake flasks performance in stirred fermentors: Production of alginates by Azotobacter vinelandii
    • Reyes, C and Peña, C and Galindo, E. (2003) Reproducing shake flasks performance in stirred fermentors: Production of alginates by Azotobacter vinelandii J Biotechnol, 105, pp. 189-198.
    • (2003) J Biotechnol , vol.105 , pp. 189-198
    • Reyes, C.1    Peña, C.2    Galindo, E.3
  • 70
    • 1842531448 scopus 로고    scopus 로고
    • Recent progress in biocatalyst discovery and optimization
    • Robertson, DE and Steer, BA. (2004) Recent progress in biocatalyst discovery and optimization Curr Opin Chem Biol, 8, pp. 141-149.
    • (2004) Curr Opin Chem Biol , vol.8 , pp. 141-149
    • Robertson, D.E.1    Steer, B.A.2
  • 71
    • 0033941389 scopus 로고    scopus 로고
    • Molecular breeding of carotenoid biosynthetic pathways
    • Schmidt-Dannert, C and Umeno, D and Arnold, FH. (2000) Molecular breeding of carotenoid biosynthetic pathways Nat Biotechnol, 18, pp. 750-753.
    • (2000) Nat Biotechnol , vol.18 , pp. 750-753
    • Schmidt-Dannert, C.1    Umeno, D.2    Arnold, F.H.3
  • 72
    • 0038574329 scopus 로고    scopus 로고
    • Glucose oxidation by Gluconobacter oxydans: Characterization in shaking-flasks, scale-up and optimization of the pH profile
    • Silberbach, M and Maier, B and Zimmermann, M and Büchs, J. (2003) Glucose oxidation by Gluconobacter oxydans: Characterization in shaking-flasks, scale-up and optimization of the pH profile Appl Microbiol Biotechnol, 62, pp. 92-98.
    • (2003) Appl Microbiol Biotechnol , vol.62 , pp. 92-98
    • Silberbach, M.1    Maier, B.2    Zimmermann, M.3    Büchs, J.4
  • 73
    • 0024749967 scopus 로고
    • How suspension cultures of Catharantus roseus respond to oxygen limitation: Small-scale tests with applications to large-scale cultures
    • Snape, JB and Thomas, NH and Callow, JA. (1989) How suspension cultures of Catharantus roseus respond to oxygen limitation: Small-scale tests with applications to large-scale cultures Biotechnol Bioeng, 34, pp. 1058-1062.
    • (1989) Biotechnol Bioeng , vol.34 , pp. 1058-1062
    • Snape, J.B.1    Thomas, N.H.2    Callow, J.A.3
  • 74
    • 0034112476 scopus 로고    scopus 로고
    • Implementation of a rapid microbial screening procedure for biotransformation activities
    • Stahl, S and Greasham, R and Chartrain, M. (2000) Implementation of a rapid microbial screening procedure for biotransformation activities J Biosci Bioeng, 89, pp. 367-371.
    • (2000) J Biosci Bioeng , vol.89 , pp. 367-371
    • Stahl, S.1    Greasham, R.2    Chartrain, M.3
  • 75
    • 0242570666 scopus 로고    scopus 로고
    • Effect of oxygen supply on passaging, stabilising and screening of recombinant Hansenula polymorpha production strains in test tube cultures
    • Stöckmann, C and Losen, M and Dahlems, U and Knocke, C and Gellissen, G and Büchs, J. (2003a) Effect of oxygen supply on passaging, stabilising and screening of recombinant Hansenula polymorpha production strains in test tube cultures FEMS Yeast Res, 4, pp. 195-205.
    • (2003) FEMS Yeast Res , vol.4 , pp. 195-205
    • Stöckmann, C.1    Losen, M.2    Dahlems, U.3    Knocke, C.4    Gellissen, G.5    Büchs, J.6
  • 76
    • 0346249848 scopus 로고    scopus 로고
    • The oxygen transfer rate as key parameter for the characterization of Hansenula polymorpha screening cultures
    • Stöckmann, C and Maier, U and Anderlei, T and Knocke, C and Gellissen, G and Büchs, J. (2003b) The oxygen transfer rate as key parameter for the characterization of Hansenula polymorpha screening cultures J Ind Microbiol Biotechnol, 30, pp. 613-622.
    • (2003) J Ind Microbiol Biotechnol , vol.30 , pp. 613-622
    • Stöckmann, C.1    Maier, U.2    Anderlei, T.3    Knocke, C.4    Gellissen, G.5    Büchs, J.6
  • 77
    • 0000580056 scopus 로고
    • Performance of the shaking flask. Power consumption
    • Sumino, Y and Akiyama, S and Fukada, H. (1972) Performance of the shaking flask. I. Power consumption J Ferment Technol, 50, pp. 203-208.
    • (1972) J Ferment Technol , vol.50 , pp. 203-208
    • Sumino, Y.1    Akiyama, S.2    Fukada, H.3
  • 78
    • 0141888383 scopus 로고    scopus 로고
    • High-Throughput Screening for isolation of enhanced green fluorescent protein expressing transformants of filamentous fungus using an image analyzer
    • Suzuki, S and Taketani, H and Kusumoto, KI and Kashiwagy, Y. (2003) High-Throughput Screening for isolation of enhanced green fluorescent protein expressing transformants of filamentous fungus using an image analyzer J Biosci Bioeng, 96, pp. 313-316.
    • (2003) J Biosci Bioeng , vol.96 , pp. 313-316
    • Suzuki, S.1    Taketani, H.2    Kusumoto, K.I.3    Kashiwagy, Y.4
  • 79
    • 0036498616 scopus 로고    scopus 로고
    • Optimizing scale-up fermentation processes
    • Thiry, M and Cingolani, D. (2002) Optimizing scale-up fermentation processes Trends Biotechnol, 20, pp. 103-105.
    • (2002) Trends Biotechnol , vol.20 , pp. 103-105
    • Thiry, M.1    Cingolani, D.2
  • 80
    • 0037027824 scopus 로고    scopus 로고
    • Noninvasive measurement of dissolved oxygen in shake flasks
    • Tolosa, L and Kostov, Y and Harms, P and Rao, G. (2002) Noninvasive measurement of dissolved oxygen in shake flasks Biotechnol Bioeng, 80, pp. 594-597.
    • (2002) Biotechnol Bioeng , vol.80 , pp. 594-597
    • Tolosa, L.1    Kostov, Y.2    Harms, P.3    Rao, G.4
  • 81
    • 45249130725 scopus 로고
    • High aeration capacity shake-flask systems
    • Tunac, JB. (1989) High aeration capacity shake-flask systems J Ferment Bioeng, 68, pp. 157-159.
    • (1989) J Ferment Bioeng , vol.68 , pp. 157-159
    • Tunac, J.B.1
  • 82
    • 0018491753 scopus 로고
    • Review of measuring methods and results in nonviscous gas-liquid mass transfer in stirred vessels
    • Van't Riet, K. (1979) Review of measuring methods and results in nonviscous gas-liquid mass transfer in stirred vessels Ind Eng Chem Proc Design Develop, 18, pp. 357-364.
    • (1979) Ind Eng Chem Proc Design Develop , vol.18 , pp. 357-364
    • Van't Riet, K.1
  • 83
    • 0033933132 scopus 로고    scopus 로고
    • Location and limitation of cellulose production by Acetobacter xylinum established from oxygen profiles
    • Verschuren, PG and Cardona, TD and Nout, MJR and De Gooijer, KD and van den Heuvel, JC. (2000) Location and limitation of cellulose production by Acetobacter xylinum established from oxygen profiles J Biosci Bioeng, 89, pp. 414-419.
    • (2000) J Biosci Bioeng , vol.89 , pp. 414-419
    • Verschuren, P.G.1    Cardona, T.D.2    Nout, M.J.R.3    De Gooijer, K.D.4    van den Heuvel, J.C.5
  • 84
    • 0035313078 scopus 로고    scopus 로고
    • Novel methods for biocatalyst screening
    • Wahler, D and Reymond, J-L. (2001) Novel methods for biocatalyst screening Curr Opin Chem Biol, 5, pp. 152-158.
    • (2001) Curr Opin Chem Biol , vol.5 , pp. 152-158
    • Wahler, D.1    Reymond, J.-L.2
  • 86
    • 5444226007 scopus 로고    scopus 로고
    • Reliable high-throughput screening with Pichia pastoris by limiting yeast cell death phenomena
    • Weis, R and Luiten, R and Skranc, W and Schwab, H and Wubbolts, M and Glieder, A. (2004b) Reliable high-throughput screening with Pichia pastoris by limiting yeast cell death phenomena FEMS Yeast Res, 5, pp. 179-189.
    • (2004) FEMS Yeast Res , vol.5 , pp. 179-189
    • Weis, R.1    Luiten, R.2    Skranc, W.3    Schwab, H.4    Wubbolts, M.5    Glieder, A.6
  • 87
    • 0029657410 scopus 로고    scopus 로고
    • Estimation of gas solubilities in salt solutions at temperatures from 273 K to 363 K
    • Weisenberger, S and Schumpe, A. (1996) Estimation of gas solubilities in salt solutions at temperatures from 273 K to 363 K AIChE J, 42, pp. 298-300.
    • (1996) AIChE J , vol.42 , pp. 298-300
    • Weisenberger, S.1    Schumpe, A.2
  • 88
    • 0035104448 scopus 로고    scopus 로고
    • Parallel substrate feeding and pH-control in shaking flasks
    • Weuster-Botz, D and Altenbach-Rehm, J and Arnold, M. (2001) Parallel substrate feeding and pH-control in shaking flasks Biochem Eng J, 7, pp. 163-170.
    • (2001) Biochem Eng J , vol.7 , pp. 163-170
    • Weuster-Botz, D.1    Altenbach-Rehm, J.2    Arnold, M.3
  • 90
    • 0035369725 scopus 로고    scopus 로고
    • Miniaturized HTS technologies - uHTS
    • Wöcke, J and Ullmann, D. (2001) Miniaturized HTS technologies - uHTS Drug Discov Today, 6, pp. 637-646.
    • (2001) Drug Discov Today , vol.6 , pp. 637-646
    • Wölcke, J.1    Ullmann, D.2


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