Impact of out-of-phase conditions on screening results in shaking flask experiments

Biochemical Engineering Journal

Volumn 17, Issue 3, 2004, Pages 205-215

  Peter, Cyril P ^a   Lotter, Stefan ^a   Maier, Ulrike ^a   Buchs J ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Bioprocess design; Filamentous fungi; Mass transfer; Mixing; Out of phase conditions; Viscosity

Indexed keywords

CELL CULTURE; FERMENTATION; MASS TRANSFER; MICROORGANISMS; PLASTIC FLOW; VISCOSITY;

FERMENTATION BROTH; OUT-OF-PHASE CONDITIONS; SHAKING FLASKS;

BIOCHEMICAL ENGINEERING;

BIOPROCESS; BIOTECHNOLOGICAL PROCEDURES; CHEMICAL ENGINEERING; CONFERENCE PAPER; CONTROLLED STUDY; FERMENTATION TECHNIQUE; FUNGUS; NONHUMAN; OXYGEN TRANSPORT; PRIORITY JOURNAL; SHEAR RATE; VISCOSITY;

FUNGI;

EID: 1042298858     PISSN: 1369703X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1369-703X(03)00179-7     Document Type: Conference Paper

References (10)

1. Büchs J., Maier U., Milbradt C., Zoels B. Power consumption in shaking flasks on rotary shaking machines. II. Nondimensional description of specific power consumption and flow regimes in unbaffled flasks at elevated liquid viscosity. Biotechnol. Bioeng. 68:2000;594-601.
2. Büchs J., Lotter S., Milbradt C. Out-of-phase operating conditions, a hitherto unknown phenomenon in shaking bioreactors. Biochem. Eng. J. 7(2):2001;135-141.
3. S. Lotter, J. Büchs, Utilization of power input measurements for optimisation of culture conditions in shaking flasks, Biochem. Eng. J., this issue.
4. Metzner A.B., Otto R.E. Agitation of non-Newtonian fluids. AIChE J. 3(1):1957;3-10.
5. Büchs J., Maier U., Milbradt C., Zoels B. Power consumption in shaking flasks on rotary shaking machines. I. Power consumption measurements in unbaffled flasks at low liquid viscosity. Biotechnol. Bioeng. 68:2000;589-593.
6. Maier U., Büchs J. Characterisation of the gas-liquid mass transfer in shaking bioreactors. Biochem. Eng. J. 7(2):2001;99-107.
7. Anderlei T., Büchs J. Device for sterile on-line measurement of the respiration rates in shaking flasks. Biochem. Eng. J. 7(2):2001;157-162.
8. T. Anderlei, W. Zang, J. Büchs, Online respiration activity measurement (OTR, CTR, RQ) in shake flasks, Biochem. Eng. J., this issue.
9. Prof. Dr. Fleck, Hans-Knöll-Institut, Jena, Germany, personal communication.
10. Prof. Bushell, University of Surrey, Great Britain, personal communication.