The oxygen transfer rate as key parameter for the characterization of Hansenula polymorpha screening cultures

Journal of Industrial Microbiology and Biotechnology

Volumn 30, Issue 10, 2003, Pages 613-622

  Stöckmann, Christoph ^a   Maier, Ulrike ^a   Anderlei, Tibor ^a   Knocke, Christof ^a   Gellissen, Gerd ^b   Büchs, Jochen ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b Rhein Biotech GmbH   (Germany)

Author keywords

Hansenula polymorpha; Material balance; Oxygen transfer rate; Screening condition; Shaking culture

Indexed keywords

ALPHA2A INTERFERON; AMMONIUM DERIVATIVE; ANTINEOPLASTIC AGENT; OXYGEN; URACIL;

ARTICLE; BIOLOGICAL MODEL; BIOMASS; BIOSYNTHESIS; BIOTECHNOLOGY; CULTURE MEDIUM; FERMENTATION; GENETIC SCREENING; GENETICS; GROWTH, DEVELOPMENT AND AGING; HANSENULA; HANSENULA POLYMORPHA; IONIC STRENGTH; METABOLISM; METHODOLOGY; MOLECULAR CLONING; NONHUMAN; OXYGEN TRANSPORT; PH; PICHIA; STOICHIOMETRY;

ANTINEOPLASTIC AGENTS; BIOTECHNOLOGY; CLONING, MOLECULAR; CULTURE MEDIA; FERMENTATION; GENETIC SCREENING; HYDROGEN-ION CONCENTRATION; INTERFERON ALFA-2A; MODELS, BIOLOGICAL; OXYGEN; PICHIA; QUATERNARY AMMONIUM COMPOUNDS; URACIL;

PICHIA; PICHIA ANGUSTA;

EID: 0346249848     PISSN: 13675435     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10295-003-0090-9     Document Type: Article

References (36)

1. Buckholz RG, Gleeson MAG (1991) Yeast systems for the commercial production of heterologous proteins. Bio/Technology 9:1067-1072
2. Hansen HG, Hollenberg CP (1996) Hansenula polymorpha. In: Wolf K (ed) Nonconventional yeasts in biotechnology. Springer, Berlin-Heidelberg New York, pp 293-311
3. Hollenberg CP, Gellissen G (1997) Production of recombinant proteins by methylotrophic yeasts. Curr Opin Biotech 8:554-560
4. Cereghino JL, Cregg JM (2000) Heterologous protein expression in the methylotrophic yeast Pichia pastoris. FEMS Microbiol Rev 24:45-66
5. Gellissen G (2002) Hansenula polymorpha biology and applications. Wiley-VCH, Weinheim, Germany
6. Parekh S, Vinci VI, Strobel RJ (2000) Improvement of microbial strains and fermentation processes. Appl Microbiol Biotechnol 54:287-301
7. Hilton MD (1999) Small-scale liquid fermentations. In: Demain AL (ed) Manual of industrial microbiology and biotechnology. American Society of Microbiology, Washington DC, pp 49-60
8. Büchs J, Maier U, Milbradt C, Zoels B (2000) Power consumption in shaking flasks on rotary shaking machines: II Nondimensional description of specific power consumption and flow regimes in unbaffled flasks at elevated liquid viscosity. Biotechnol Bioeng 68:594-601
9. Payne GF, Davison SW, Tate JL (1990) Experimental constraints to studying the effects of dissolved oxygen and dissolved carbon dioxide on plant cell growth. Dev Ind Microbiol 31:293-301
10. Anderlei T, Büchs J (2001) Device for sterile online measurement of the oxygen transfer rate in shaking flasks. Biochem Eng J 7:157-162
11. Schaefer S, Piontek M, Ahn S-J, Papendieck A, Janowicz ZA, Gellissen G (2001) Recombinant hepatitis B vaccines - characterisation of the viral disease and vaccine production in the methylotrophic yeast, Hansenula polymorpha. In: Dembowsky K, Stadler P (eds) Novel therapeutic proteins - selected case studies. Wiley-VCH, Weinheim, Germany, pp 245-274
12. Weydemann U, Keup P, Gellissen G, Janowicz ZA (1995) Ein industrielles Herstellungsverfahren von rekombinantem Hirudin in der methylotrophen Hefe Hansenula polymorpha. Bioscope 1/95:7-13
13. Zurek C, Kubis E, Keup P, Hörlein D, Beunink J, Thömmes J, Kula M-R, Hollenberg CP, Gellissen G (1996) Production of two aprotinin variants in Hansenula polymorpha. Process Biochem 31:679-689
14. Gellissen G, Melber K (1996) Methylotrophic yeast Hansenula polymorpha as production organism for recombinant pharmaceuticals. Drug Res 46:943-948
15. Gellissen G (2000) Heterologous protein production in methylotrophic yeasts. Appl Microbiol Biotechnol 54:741-750
16. Gellissen G, Hollenberg CP, Janowicz ZA (1994) Gene expression in methylotrophic yeasts. In: Smith A (ed) Gene expression in recombinant microorganisms. Marcel Dekker, New York, pp 195-239
17. Maier U, Büchs J (2001) Characterisation of the gas-liquid mass transfer in shaking bioreactors. Biochem Eng J 7:99-106
18. Maier U, Losen M, Büchs J (2003) Advances in understanding and modeling the gas liquid mass transfer in shaking flasks. Biochem Eng J (in press)
19. Espeso EA, Arst HN (2000) On the mechanism by which alkaline pH prevents expression of an acid-expressed gene. Mol Cell Biol 20:3355-3363
20. Denison SH (2000) pH regulation of gene expression in fungi. Fungal Genet Biol 29:61-71
21. Wubben JP, ten Have A, van Kan JAL, Visser J (2000) Regulation of endopolygalacturonase gene expression in Botrytis cinerea by galacturonic acid, ambient pH and carbon catabolite repression. Curr Genet 37:152-157
22. 34 endo-xylanase is subject to catabolite repression and pH control. World J Microb Biot 17:57-60
23. Roggenkamp R, Hansen H, Eckart M, Janowicz ZA, Hollenberg CP (1986) Transformation of the methylotrophic yeast Hansenula polymorpha by autonomous replication and integration vectors. Mol Gen Genet 202:302-308
24. Pronk JT (2002) Auxotrophic yeast strains in fundamental and applied research. Appl Environ Microbiol 68:2095-2100
25. Nielsen TL, Holmberg S, Petersen JGL (1990) Regulated overproduction and secretion of yeast carboxypeptidase Y. Appl Microbiol Biotechnol 33:307-312
26. Lopes TS, Hakkaart GAJ, Koerts BL, Raue HA, Planta RJ (1991) Mechanism of high-copy-number integration of pMI-RY-type vectors into the ribosomal DNA of Saccharomyces cerevisiae. Gene 105:83-90
27. Nieto A, Prieto JA, Sanz P (1999) Stable high-copy-number integration of Aspergillus oryzae a-amylase cDNA in an industrial baker's yeast strain. Biotechnol Prog 15:459-466
28. Atkinson B, Mavituna F (1983) Biochemical engineering and biotechnology handbook. Macmillan, Surrey, UK
29. Egli T, Quayle JR (1986) Influence of the carbon:nitrogen ratio of the growth medium on the cellular composition and the ability of the methylotrophic yeast Hansenula polymorpha to utilize mixed carbon sources. J Gen Microbiol 132:1779-1788
30. Guthke R, Schmidt-Heck W, Pfaff M (1998) Knowledge acquisition and knowledge based control in bioprocess engineering. J Biotechnol 65:37-46
31. Zigova J (2000) Effect of RQ and pre-seed conditions on biomass and galactosyl transferase production during fed-batch culture of S. cerevisiae BT150. J Biotechnol 80:55-62
32. Neves AA, Vieira LM, Menezes JC (2001) Effects of preculture variability on clavulanic acid fermentation. Biotechnol Bioeng 72:628-633
33. Cimander C, Bachinger T, Mandenius C-F (2002) Assessment of the performance of a fed-batch cultivation from the precultrue quality using an electronic nose. Biotechnol Prog 18:380-386
34. Calado CRC, Monteiro SMS, Cabral JMS, Fonseca LP (2002) Effect of pre-fermentation on the production of cutinase by a recombinant Saccharomyces cerevisiae. J Biosci Bioeng 93:354-359
35. Perrin DD (1982) Ionization of inorganic acids and bases in aqueous solution, 2nd edn. Pergamon, Oxford
36. Snoep JL, Yomano LP, Westerhoff HV, Ingram LO (1995) Protein burden in Zymomonas mobilis: negative flux and growth control due to overproducion of glycolytic enzymes. Microbiology 141:2329-2337