Analysis of the CHK2 gene lymphoid malignancies

Leukemia and Lymphoma

Volumn 42, Issue 3, 2001, Pages 517-520

  Tavor, S ^a   Takeuchi, S ^a   Tsukasaki, K ^a   Miller, C W ^a   Hofmann, W K ^a   Ikezoe, T ^a   Said, J W ^a   Koeffler, H P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

ALL; ATL; CHK2; Genes; Lymphoid malignancy; NHL; SSCP

Indexed keywords

CDC25C PROTEIN; CHECKPOINT KINASE 2; DNA; GENE PRODUCT; PHENYLALANINE; PROTEIN KINASE; PROTEIN P53; SERINE; UNCLASSIFIED DRUG;

ACUTE LYMPHOCYTIC LEUKEMIA; ARTICLE; ATAXIA TELANGIECTASIA; CELL CYCLE; CELL CYCLE G2 PHASE; CHILD; CHILDHOOD CANCER; CODON; COLON CANCER; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA DAMAGE; DNA DETERMINATION; DNA SEQUENCE; EVOLUTION; EXON; FAMILIAL CANCER; GENE MUTATION; GENETIC ANALYSIS; GENETIC CODE; GENETIC CONSERVATION; GERM LINE; HETEROZYGOSITY; HUMAN; LEUKEMOGENESIS; LYMPHOMA; MAJOR CLINICAL STUDY; MISSENSE MUTATION; MODULATION; NONHODGKIN LYMPHOMA; PENETRANCE; PHENOTYPE; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SEQUENCE HOMOLOGY; SINGLE STRAND CONFORMATION POLYMORPHISM; T CELL LEUKEMIA; TUMOR SUPPRESSOR GENE;

EID: 0034909673     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428190109064610     Document Type: Article

References (15)

1. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
2. DNA damage-induced activation of p53 by the checkpoint kinase Chk2
3. A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage
4. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
5. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
6. Piecing together the p53 puzzle
7. Diagnostic criteria and classification of clinical subtypes of adult T-cell leukemia-lymphoma
8. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues
9. Screening hCHK2 for mutations
10. Mutations of the p53 gene in adult T-cell leukemia
11. p53 in hematologic malignancies
12. Altered expression of p53 and mdm-2 proteins at diagnosis is associated with early treatment failure in childhood acute lymphoblastic leukemia
13. DNA damage-induced activation of p53 by the checkpoint kinase Chk2
14. Mutations of the p53 gene as a prognostic factor in aggressive B-cell Lymphoma
15. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites