Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni syndrome

Cancer Research

Volumn 61, Issue 22, 2001, Pages 8062-8067

  Lee, Sean Bong ^a   Kim, Sang Hyon ^a   Bell, Daphne W ^a   Wahrer, Doke C R ^a   Schiripo, Taryn A ^a   Jorczak, Melissa M ^a   Shannon, Kristen M ^a   Harlow, Ed ^a   Haber, Daniel A ^a   Sgroi, Dennis C ^b   Garber, Judy E ^c   Li, Frederick P ^c   Nichols, Kim E ^d   Varley, Jenny M ^e   Godwin, Andrew K ^f  

^a MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^e UNIVERSITY OF MANCHESTER   (United Kingdom)

^f FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHECKPOINT KINASE 2; GENE PRODUCT; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; FAMILIAL CANCER; GENE LOCUS; HUMAN; HUMAN TISSUE; MISSENSE MUTATION; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION;

ADULT; BASE SEQUENCE; COLONIC NEOPLASMS; DNA, COMPLEMENTARY; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENES, P53; HUMANS; LI-FRAUMENI SYNDROME; LOSS OF HETEROZYGOSITY; MALE; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; PEDIGREE; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; TUMOR CELLS, CULTURED;

EID: 0035890407     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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