HIV infection: first battle decides the war

Trends in Immunology

Volumn 27, Issue 6, 2006, Pages 274-281

  Hel, Zdenek ^a,b   McGhee, Jerry R ^b   Mestecky, Jiri ^b,c  

^a University of Alabama at Birmingham   (United States)

^b University of Alabama at Birmingham   (United States)

^c University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CHEMOKINE RECEPTOR CXCR4; CYTOKINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; DENDRITIC CELL; DISEASE COURSE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOID TISSUE; MEMORY T LYMPHOCYTE; NONHUMAN; REGULATORY MECHANISM; REVIEW; SIMIAN IMMUNODEFICIENCY VIRUS; T CELL DEPLETION; TARGET CELL;

ANIMALS; ANTIBODY FORMATION; CD4-POSITIVE T-LYMPHOCYTES; HIV INFECTIONS; HIV-1; HUMANS; INTERFERON TYPE II;

EID: 33746892252     PISSN: 14714906     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.it.2006.04.007     Document Type: Review

References (75)

1. Zinkernagel R.M. On natural and artificial vaccinations. Annu. Rev. Immunol. 21 (2003) 515-546
2. Dalgleish A.G., et al. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature 312 (1984) 763-767
3. + T-cell response. Nat. Rev. Immunol. 4 (2004) 595-602
4. + T-cell memory: only the good ones last. Curr. Opin. Immunol. 16 (2004) 451-455
5. Mowat A.M., et al. Oral tolerance: physiologic basis and clinical applications. In: Mestecky J., et al. (Ed). Mucosal Immunology. 3rd edn (2005), Elsevier/Academic Press 487-537
6. Strober W., et al. IgA B cell development. In: Mestecky J., et al. (Ed). Mucosal Immunology. 3rd edn (2005), Elsevier/Academic Press 583-616
7. Douek D.C., et al. T cell dynamics in HIV-1 infection. Annu. Rev. Immunol. 21 (2003) 265-304
8. + T cell demographics and dynamics in lymphatic tissues. Annu. Rev. Immunol. 17 (1999) 625-656
9. Bishop P.E., et al. Immunological study of the rectal mucosa of men with and without human immunodeficiency virus infection. Gut 28 (1987) 1619-1624
10. Rodgers V.D., et al. Abnormalities in intestinal mucosal T cells in homosexual populations including those with the lymphadenopathy syndrome and acquired immunodeficiency syndrome. Gastroenterology 90 (1986) 552-558
11. Heise C., et al. Simian immunodeficiency virus infection of the gastrointestinal tract of rhesus macaques. Functional, pathological, and morphological changes. Am. J. Pathol. 142 (1993) 1759-1771
12. Veazey R.S., and Lackner A.A. Getting to the guts of HIV pathogenesis. J. Exp. Med. 200 (2004) 697-700
13. Clayton F., et al. Selective depletion of rectal lamina propria rather than lymphoid aggregate CD4 lymphocytes in HIV infection. Clin. Exp. Immunol. 107 (1997) 288-292
14. + T cells in multiple tissues during acute SIV infection. Nature 434 (2005) 1093-1097
15. + T lymphocytes from effector sites in the gastrointestinal tract. J. Exp. Med. 200 (2004) 761-770
16. + T cell depletion and viral replication in SIV infection. Science 280 (1998) 427-431
17. + T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J. Exp. Med. 200 (2004) 749-759
18. + memory T cells in rapidly progressive simian immunodeficiency virus infection. J. Exp. Med. 200 (2004) 1299-1314
19. + T cells in lymphoid tissues during simian immunodeficiency virus infection. J. Virol. 74 (2000) 11001-11007
20. + T cells express high levels of CCR5 and are rapidly depleted in simian immunodeficiency virus infection. J. Infect. Dis. 187 (2003) 769-776
21. + T cells. Nature 434 (2005) 1148-1152
22. De Maria R., et al. Functional expression of Fas and Fas ligand on human gut lamina propria T lymphocytes. A potential role for the acidic sphingomyelinase pathway in normal immunoregulation. J. Clin. Invest. 97 (1996) 316-322
23. Boirivant M., et al. HIV-1 gp120 accelerates Fas-mediated activation-induced human lamina propria T cell apoptosis. J. Clin. Immunol. 18 (1998) 39-47
24. + T cells by HIV-1: role of type I IFN-producing plasmacytoid dendritic cells. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 13974-13979
25. + T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosis. Blood 106 (2005) 3524-3531
26. Regoes R.R., and Bonhoeffer S. The HIV coreceptor switch: a population dynamical perspective. Trends Microbiol. 13 (2005) 269-277
27. Beq S., et al. Interleukin-7 (IL-7): immune function, involvement in the pathogenesis of HIV infection and therapeutic potential. Eur. Cytokine Netw. 15 (2004) 279-289
28. + T cells. Blood 101 (2003) 1024-1029
29. Parker R.A., et al. Variability of viral load in plasma of rhesus monkeys inoculated with simian immunodeficiency virus or simian-human immunodeficiency virus: implications for using nonhuman primate AIDS models to test vaccines and therapeutics. J. Virol. 75 (2001) 11234-11238
30. Hel Z., et al. Improved vaccine protection from simian AIDS by the addition of nonstructural simian immunodeficiency virus genes. J. Immunol. 176 (2006) 85-96
31. 251 infection of macaques. Nat. Med. 6 (2000) 1140-1146
32. Lifson J.D., et al. Containment of simian immunodeficiency virus infection: cellular immune responses and protection from rechallenge following transient postinoculation antiretroviral treatment. J. Virol. 74 (2000) 2584-2593
33. + T cells. Nature 417 (2002) 95-98
34. + T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression. Nat. Med. 5 (1999) 518-525
35. + T-cell responses associated with control of viremia. Science 278 (1997) 1447-1450
36. + T cells produce antiviral cytokines but are impaired in cytolytic function. J. Exp. Med. 192 (2000) 63-75
37. Goepfert P.A., et al. A significant number of human immunodeficiency virus epitope-specific cytotoxic T lymphocytes detected by tetramer binding do not produce gamma interferon. J. Virol. 74 (2000) 10249-10255
38. + T-cell function in mucosal and systemic compartments of simian immunodeficiency virus mac251- and simian-human immunodeficiency virus KU2-infected macaques. J. Virol. 75 (2001) 11483-11495
39. + T cell responses in chronic HIV infection are not restored by antiretroviral therapy. J. Immunol. 173 (2004) 2184-2189
40. Rosenberg E.S., et al. Immune control of HIV-1 after early treatment of acute infection. Nature 407 (2000) 523-526
41. Kaufmann G.R., et al. Rapid restoration of CD4 T cell subsets in subjects receiving antiretroviral therapy during primary HIV-1 infection. AIDS 14 (2000) 2643-2651
42. Tryniszewska E., et al. Vaccination of macaques with long-standing SIVmac251 infection lowers the viral set point after cessation of antiretroviral therapy. J. Immunol. 169 (2002) 5347-5357
43. + cells to macaques chronically infected with SIV is sufficient to induce long-term nonprogressor status. Blood 99 (2002) 590-599
44. Fujihashi K., and McGhee J.R. Th1/Th2/Th3 cells for regulation of mucosal immunity, tolerance, and inflammation. In: Mestecky J., et al. (Ed). Mucosal Immunology. 3rd edn (2005), Elsevier/Academic Press 539-558
45. McGhee J.R., et al. Regulation of IgA synthesis and immune response by T cells and interleukins. J. Clin. Immunol. 9 (1989) 175-199
46. Honjo T., et al. Molecular mechanism of class switch recombination: linkage with somatic hypermutation. Annu. Rev. Immunol. 20 (2002) 165-196
47. Kaetzel C.S., and Mostov K. Immunoglobulin transport and the polymeric immunoglobulin receptor. In: Mestecky J., et al. (Ed). Mucosal Immunology. 3rd edn (2005), Elsevier/Academic Press 211-250
48. Lehner T., and Bergmeier L.A. Mucosal infection and immune responses to simian immunodeficiency virus. In: Mestecky J., et al. (Ed). Mucosal Immunology. 3rd edn (2005), Elsevier/Academic Press 1179-1197
49. Alugupalli K.R., et al. B1b lymphocytes confer T cell-independent long-lasting immunity. Immunity 21 (2004) 379-390
50. Bos N.A., et al. B-1 cells and the mucosal immune system. In: Mestecky J., et al. (Ed). Mucosal Immunology. 3rd edn (2005), Elsevier/Academic Press 655-665
51. Macpherson A.J., et al. A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science 288 (2000) 2222-2226
52. Boursier L., et al. IgVH gene analysis suggests that peritoneal B cells do not contribute to the gut immune system in man. Eur. J. Immunol. 32 (2002) 2427-2436
53. Donze H.H., et al. Human peritoneal B-1 cells and the influence of continuous ambulatory peritoneal dialysis on peritoneal and peripheral blood mononuclear cell (PBMC) composition and immunoglobulin levels. Clin. Exp. Immunol. 109 (1997) 356-361
54. Boyaka P.N., et al. Mucosal vaccines: an overview. In: Mestecky J., et al. (Ed). Mucosal Immunology. 3rd edn (2005), Elsevier/Academic Press 855-874
55. Belec L., et al. Cervicovaginal overproduction of specific IgG to human immunodeficiency virus (HIV) contrasts with normal or impaired IgA local response in HIV infection. J. Infect. Dis. 172 (1995) 691-697
56. Lu F.X. Predominate HIV1-specific IgG activity in various mucosal compartments of HIV1-infected individuals. Clin. Immunol. 97 (2000) 59-68
57. Mestecky J., et al. Paucity of antigen-specific IgA responses in sera and external secretions of HIV-type 1-infected individuals. AIDS Res. Hum. Retroviruses 20 (2004) 972-988
58. Israel Z.R., and Marx P.A. Nonclassical mucosal antibodies predominate in genital secretions of HIV-1 infected chimpanzees. J. Med. Primatol. 24 (1995) 53-60
59. Schafer F., et al. Lack of simian immunodeficiency virus (SIV) specific IgA response in the intestine of SIV infected rhesus macaques. Gut 50 (2002) 608-614
60. Eriksson K., et al. Virus-specific antibody production and polyclonal B-cell activation in the intestinal mucosa of HIV-infected individuals. AIDS 9 (1995) 695-700
61. Lewis D.J., et al. Immune response following oral administration of cholera toxin B subunit to HIV-1-infected UK and Kenyan subjects. AIDS 8 (1994) 779-785
62. Pinching A.J. Antibody responses in HIV infection. Clin. Exp. Immunol. 84 (1991) 181-184
63. Wright P.F., et al. Detection of mucosal antibodies in HIV type 1-infected individuals. AIDS Res. Hum. Retroviruses 18 (2002) 1291-1300
64. + T cell responses. J. Immunol. 169 (2002) 4778-4787
65. Mooij P., et al. Qualitative T-helper responses to multiple viral antigens correlate with vaccine-induced immunity to simian/human immunodeficiency virus infection. J. Virol. 78 (2004) 3333-3342
66. Gloster S.E., et al. Association of strong virus-specific CD4 T cell responses with efficient natural control of primary HIV-1 infection. AIDS 18 (2004) 749-755
67. Collins K., et al. HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature 391 (1998) 397-401
68. van Baalen C.A., et al. The choice of antigen for therapeutic immunization against AIDS. Trends Immunol. 23 (2002) 478-479
69. Mestecky J., et al. Immune response versus mucosal tolerance to mucosally administered antigens. Vaccine 23 (2005) 1800-1803
70. Powrie F. Immune regulation in the intestine: a balancing act between effector and regulatory T cell responses. Ann. N. Y. Acad. Sci. 1029 (2004) 132-141
71. Brenchley J.M., et al. HIV disease: fallout from a mucosal catastrophe?. Nat. Immunol. 7 (2006) 235-239
72. Khanolkar A., et al. CD4 T cell-dependent CD8 T cell maturation. J. Immunol. 172 (2004) 2834-2844
73. + T cells after acute infection. Nat. Immunol. 5 (2004) 927-933
74. Shedlock D.J., and Shen H. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 300 (2003) 337-339
75. + T cell responses in vivo. J. Immunol. 171 (2003) 6339-6343