Genomic structure and refined chromosomal localization of the mouse Ptch2 gene

Cytogenetic and Genome Research

Volumn 97, Issue 1-2, 2002, Pages 106-110

  Frohlich L ^a,c   Liu, Z ^b   Beier, D R ^b   Lanske, B ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; MEMBRANE PROTEIN; MESSENGER RNA; PROTEIN PATCHED; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; DNA; MICROSATELLITE DNA; PATCHED RECEPTORS;

ANIMAL CELL; ARTICLE; CHROMOSOMAL LOCALIZATION; CONTROLLED STUDY; CPG ISLAND; DNA FLANKING REGION; EMBRYO; EXON; GENE MAPPING; GENE STRUCTURE; GENOME ANALYSIS; HUMAN; HUMAN VERSUS ANIMAL COMPARISON; INTRON; MICROSATELLITE MARKER; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYADENYLATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN MOTIF; RNA STABILITY; SINGLE STRAND CONFORMATION POLYMORPHISM; TRANSCRIPTION INITIATION SITE; ANIMAL; CHROMOSOME MAP; COMPARATIVE STUDY; GENETICS; GENOME; MOLECULAR GENETICS;

ERINACEIDAE; VERTEBRATA;

ANIMALS; BASE SEQUENCE; CHROMOSOME MAPPING; CPG ISLANDS; DNA; EXONS; GENOME; HUMANS; INTRONS; MEMBRANE PROTEINS; MICE; MICROSATELLITE REPEATS; MOLECULAR SEQUENCE DATA; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; RECEPTORS, CELL SURFACE;

EID: 0036048904     PISSN: 14248581     EISSN: None     Source Type: Journal    
DOI: 10.1159/000064064     Document Type: Article

References (26)

1. Alcedo J, Noll M: Hedgehog and its Patched-Smoothened receptor complex: a novel signalling mechanism at the cell surface. Biol Chem 378:583-590 (1997).
2. Brady KP, Rowe LB, Her H, Stevens TJ, Eppig J, Sussman DJ, Sikela J, Beier DR: Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism (SSCP) analysis. Genome Res 7:1085-1093 (1997).
3. Carpenter D, Stone DM, Brush J, Ryan A, Armanini M, Frantz G, Rosenthal A, de Sauvage FJ: Characterization of two patched receptors for the vertebrate hedgehog protein family. Proc natl Acad Sci, USA 95:13630-13634 (1998).
4. Chen Y, Struhl G: Dual roles for Patched in sequestering and transducing Hedgehog. Cell 87:553-563 (1996).
5. Chen Y, Struhl G: In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex. Development 125:4943-4948 (1998).
6. Gardiner-Garden M, Frommer M: CpG Islands in Vertebrate Genomes. J molec Biol 196:261-282 (1987).
7. Goodrich L, Milenkovic L, Higgins KM, Scott MP: Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277:1109-1113 (1997).
8. Hahn H, Christiansen J, Wicking C, Zaphiropoulos PG, Chidambaram A, Gerrard B, Vorechovsky I, Bale AE, Toftgard R, Dean M, Wainwright B: A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities. J biol Chem 271:12125-12128 (1996a).
9. Hahn H, Wicking C, Zaphiropoulos PG, Gailani MR, Shanley S, Chidambaram A, Vorechovsky I, Holmberg E, Unden AB, Gilies S, Negus K, Smyth I, Pressman C, Leffell DJ, Gerrard B, Goldstein AM, Dean M, Toftgard R, Chenevix-Trench G, Wainwright B, Bale AE: Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 85:841-851 (1996b).
10. Hubbard T, Barker D, Birney E, Cameron G, Chen Y, Clark L, Cox T, Cuff J, Curwen V, Down T, Durbin R, Eyras E, Gilbert J, Hammond M, Huminiecki L, Kasprzyk A, Lehvaslaiho H, Lijnzaad P, Melsopp C, Mongin E, Pettett R, Pocock M, Potter S, Rust A, Schidt E, Searle S, Slater G, Smith J, Spooner W, Stabenau A, Stalker J, Stupka E, Ureta-Vidal A, Vastrik I, Clamp M: The Ensembl genome database project. Nucl Acids Res 30:38-41 (2002).
11. Ingham PW: The patched gene in development and cancer. Curr Opin Genet Dev 8:88-94 (1998).
12. Johnson RL, Scott MP: Control of cell growth and fate by patched genes. Cold Spring Harb Symp Quant Biol 62:205-215 (1997).
13. Lewis KE, Concordet JP, Ingham PW: Characterisation of a second patched gene in the zebrafish Danio rerio and the differential response of patched genes to hedgehog signalling. Dev Biol 208:14-29 (1999)
14. Manly K: A Macintosh program for storage and analysis of experimental genetic mapping data. Mammal Genome 4:303-313 (1993).
15. Motoyama J, Takabatake T, Takeshima K, Hui C-C: Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog. Nature Genet 18:104-106 (1998a).
16. Motoyama J, Heng H, Crackower MA, Takabatake T, Takeshima K, Tsui L-C, Hui C-C: Overlapping and non-overlapping Ptch2 expression with Shh during mouse embryogenesis. Mech Dev 78:81-84 (1998b).
17. Mount S: A catalogue of splice junction sequences. Nucleic Acids Res 10:459-470 (1981).
18. Murone M, Rosenthal A, de Sauvage FJ: Sonic hedgehog signaling by the Patched-Smoothened receptor complex. Curr Biol 9:76-84 (1999).
19. Ponger L, Duret L, Mouchiroud D: Determinants of CpG islands: expression in early embryo and isochore structure. Genome Res 11:1854-1860 (2001).
20. Rowe LB, Nadeau JH, Turner R, Frankel WN, Letts VA, Eppig JT, Ko MSH, Thurston SJ, Birkenmeier EH: Maps from two interspecific backcross DNA panels available as a community genetic mapping resource. Mammal Genome 5:253-274 (1994).
21. Sambrook J, Fritsch EF, Maniatis T: Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Laboratory Press, Cold Spring Harbor 1989).
22. Scherf M, Klingenhoff A, Werner T: Highly specific localization of promoter regions in large genomic sequences by PromoterInspector: a novel context analysis approach. J molec Biol 297:599-606 (2000).
23. Smyth I, Narang MA, Evans T, Heimann C, Nakamura Y, Chenevix-Trench G, Pietsch T, Wicking C, Wainwright BJ: Isolation and characterization of human Patched 2 (PTCH2), a putative tumour suppressor gene in basal cell carcinoma and medulloblastoma on chromosome 1p32. Hum molec Genet 8:291-297 (1999).
24. Takabatake T, Ogawa M, Takahashi TC, Mizuno M, Okamoto M, Takeshima K: Hedgehog and patched gene expression in adult ocular tissues. FEBS Lett 410:485-489 (1997).
25. Takabatake T, Takahashi TC, Takabatake Y, Yamada K, Ogawa M, Takeshima K: Distinct expression of two types of Xenopus Patched genes during early embryogenesis and hindlimb development. Mech Dev 98:99-104 (2000).
26. Zaphiropoulos PG, Unden AB, Rahnama F, Hollingsworth RE, Toftgard R: PTCH2, a novel human patched gene, undergoing alternative splicing and up-regulated in basal cell carcinomas. Cancer Res 59:787-792 (1999).