Modified HMG-CoA reductase and LDLr regulation is deeply involved in age-related hypercholesterolemia

Journal of Cellular Biochemistry

Volumn 98, Issue 5, 2006, Pages 1044-1053

  Pallottini, Valentina ^a   Martini, Chiara ^a   Cavallini, Gabriella ^b   Donati, Alessio ^b   Bergamini, Ettore ^b   Notarnicola, Maria ^c   Caruso, Maria Gabriella ^c   Trentalance, Anna ^a  

^a ROMA TRE UNIVERSITY   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c NATIONAL INSTITUTE FOR DIGESTIVE DISEASES   (Italy)

Author keywords

Ageing; Cholesterol; HMG CoA reductase; Insig; LDLr; Rat liver; SCAP; SREBPs

Indexed keywords

CAVEOLIN 1; CHOLESTEROL; GENE PRODUCT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; INSULIN; INSULIN INDUCED GENE PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN CLEAVAGE ACTIVATING PROTEIN; UNCLASSIFIED DRUG;

AGE; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME REGULATION; GENETIC TRANSCRIPTION; HYPERCHOLESTEROLEMIA; INSULIN SENSITIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RNA TRANSCRIPTION;

AGING; ANIMALS; CAVEOLIN 1; CELL NUCLEUS; CHOLESTEROL; GENE EXPRESSION REGULATION; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYPERCHOLESTEROLEMIA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER; MALE; MEMBRANE PROTEINS; PHOSPHOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, LDL; STEROL REGULATORY ELEMENT BINDING PROTEINS;

ANIMALIA;

EID: 33746401044     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.20951     Document Type: Article

References (36)

1. Anderson RG. 1998. The caveolae membrane system. Annu Rev Biochem 67:199-225.
2. Bist A, Fielding PE, Fielding CJ. 1997. Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol. Proc Natl Acad Sci USA 94: 10693-10698.
3. Bruscalupi G, Leoni S, Mangiantini MT, Spagnolo S, Trentalance A. 1985. True uncoupling between cholesterol synthesis and 3-hydroxy-3-methylglutaryl coenzyme A reductase in early stage of liver regeneration. Cell Mol Biol 31:365-368.
4. Cao S, Fernandez-Zapico ME, Jin D, Puri V, Cook TA, Lerman LO, Zhu XY, Urrutia R, Shah V. 2005. KLF11-mediated repression antagonizes Sp1/sterol-responsive element-binding protein-induced transcriptional activation of Caveolin 1 in response to cholesterol signaling. J Biol Chem 280:1901-1910.
5. Ching YP, Davies SP, Hardie DG. 1996. Analysis of the specificity of the AMP-activated protein kinase by site-directed mutagenesis of bacterially expressed 3-hydrox 3-methylglutaryl-CoA reductase, using a single primer variant of the unique-site-elimination method. Eur J Biochem 237:800-808.
6. Crott JW, Choi SW, Ordovas JM, Ditelberg JS, Mason JB. 2004. Effects of dietary folate and aging on gene expression in the colonie mucosa of rats: Implications for carcinogenesis. Carcinogenesis 25:69-76.
7. Devaux PF. 1993. Phospholipid translocation in the endoplasmic reticulum. Subcell Biochem 21:273-285.
8. Dietschy JM, Turley SD, Spady DK. 1993. Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans. J Lipid Res 34:1637-1659.
9. Fulop T, Larbi A, Douziech N. 2003. Insulin receptor and ageing. Pathol Biol (Paris) 51:574-580.
10. Gaussin V, Skarlas P, Ching YP, Hardie DG, Hue L. 1997. Distinct type-2A protein phosphatases activate HMGCoA reductase and acetyl-CoAcarboxylase in liver. FEBS Lett 4131:115-118.
11. Geelen MJ, Gibson DM, Rodwell VW. 1986. Hydroxymethylglutaryl-CoA reductase-the rate-limiting enzyme of cholesterol biosynthesis. A report of a meeting held at Nijenrode Castle, Breukelen, The Netherlands, August 24, 1985. FEBS Lett 201:183-186.
12. Goldstein JL, Brown MS. 1990. Regulation of the mevalonate pathway. Nature 343:425-430.
13. Horton JD, Goldstein JL, Brown MS. 2002. SREBPs activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109:1125-1131.
14. Hua X, Yokoyama C, Wu J, Briggs MR, Brown MS, Goldstein JL, Wang X. 1993. SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc Natl Acad Sci USA 90:11603-11607.
15. Kast-Woelbern HR, Dana SL, Cesario RM, Sun L, de Grandpre LY, Brooks ME, Osburn DL, Reifel-Miller A, Klausing K, Leibowitz MD. 2004. Rosiglitazone induction of Insig-1 in white adipose tissue reveals a novel interplay of peroxisome proliferator-activated receptor gamma and sterol regulatory element-binding protein in the regulation of adipogenesis. J Biol Chem 279: 23908-23915.
16. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
17. Marino M, Dolfi C, Paradiso C, Cavallini G, Masini M, Gori Z, Pollera M, Trentalance A, Bergamini E. 1998. Age-dependent accumulation of dolichol in rat liver: Is tissue dolichol a biomarker of aging? J Gerontol A Biol Sci Med Sci 53:B87-B93.
18. Marino M, Pallottini V, D'Eramo C, Cavallini G, Bergamini E, Trentalance A. 2002. Age-related changes of cholesterol and dolichol biosynthesis in rat liver. Mech Ageing Develop 123:1183-1189.
19. Masoro EJ. 2005. Overview of caloric restriction and ageing. Mech Ageing Dev 126:913-922.
20. McPherson R, Gauthier A. 2004. Molecular regulation of SREBP function: The Insig-SCAP connection and isoform-specific modulation of lipid synthesis. Biochem Cell Biol 82:201-211.
21. Moller N, Gormsen L, Fuglsang J, Gjedsted J. 2003. Effects of ageing on insulin secretion and action. Horm Res 60:102-104.
22. Mulas MF, Demuro G, Mulas C, Putzolu M, Cavallini G, Donati A, Bergamini E, Dessi S. 2005. Dietary restriction counteracts age-related changes in cholesterol metabolism in the rat. Mech Ageing Dev 126:648-654.
23. Ness GC, Kohlruss N, Gertz KR. 2003. Association of the low-density lipoprotein receptor with caveolae in hamster and rat liver. Biochem Biophys Res Commun 303: 177-181.
24. Pallottini V, Marino M, Cavallini G, Bergamini E, Trentalance A. 2003. Age-related changes of isoprenoid biosynthesis in rat liver and brain. Biogerontology 4:371-378.
25. Pallottini V, Montanari L, Cavallini G, Bergamini E, Gori Z, Trentalance A. 2004. Mechanisms underlying the impaired regulation of 3-hydroxy-3- methylglutaryl coenzyme A reductase in aged rat liver. Mech Ageing Develop 125:633-639.
26. Sakai J, Nohturfft A, Cheng D, Ho YK, Brown MS, Goldstein JL. 1997. Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein. J Biol Chem 272:20213-20221.
27. Sato R, Yang J, Wang X, Evans MJ, Ho YK, Goldstein JL, Brown MS. 1994. Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1). J Biol Chem 269:17267-17273.
28. Sever N, Song BL, Yabe D, Goldstein JL, Brown MS, DeBose-Boyd RA. 2003a. Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3- methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol. J Biol Chem 278:52479-52490.
29. Sever N, Yang T, Brown MS, Goldstein JL, DeBose-Boyd RA. 2003b. Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain. Mol Cell 11:25-33.
30. Simons K, Ikonen E. 1997. Functional rafts in cell membranes. Nature 387:569-572.
31. Small DM, Shipley GG. 1974. Physical-chemical basis of lipid deposition in atherosclerosis. Science 185:222-229.
32. Tollet-Egnell P, Parini P, Stahlberg N, Lonnstedt I, Lee NH, Rudling M, Flores-Morales A, Norstedt G. 2004. Growth hormone-mediated alteration of fuel metabolism in the aged rat as determined from transcript profiles. Physiol Genomics 16:261-267.
33. Weber LW, Boll M, Stampfl A. 2004. Maintaining cholesterol homeostasis: Sterol regulatory element-binding proteins. World J Gastroenterol 10:3081-3087.
34. Yabe D, Komuro R, Liang G, Goldstein JL, Brown MS. 2003. Liver-specific mRNA for Insig-2 down-regulated by insulin: Implications for fatty acid synthesis. Proc Natl Acad Sci USA 100:3155-3160.
35. Yang T, Espenshade PJ, Wright ME, Yabe D, Gong Y, Aebersold R, Goldstein JL, Brown MS. 2002. Crucial step in cholesterol homeostasis: Sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell 110:489-500.
36. Yokoyama C, Wang X, Briggs MR, Admon A, Wu J, Hua X, Goldstein JL, Brown MS. 1993. SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell 75:187-197.