Effects of ageing on insulin secretion and action

Hormone Research

Volumn 60, Issue SUPPL. 1, 2003, Pages 102-104

  Møller, Niels ^a   Gormsen, Lars ^a   Fuglsang, Jens ^a   Gjedsted, Jakob ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

Ageing; Insulin; Insulin resistance; Insulin secretion; Type 2 diabetes mellitus

Indexed keywords

FATTY ACID; GLUCOSE; INSULIN;

AGING; BODY COMPOSITION; CARDIOVASCULAR RISK; CONFERENCE PAPER; DISEASE PREDISPOSITION; ENDOCRINE FUNCTION; FITNESS; HORMONE ACTION; HUMAN; INSULIN METABOLISM; INSULIN RELEASE; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS FUNCTION; PREVALENCE; PRIORITY JOURNAL;

AGING; ANIMALS; HUMANS; INSULIN;

EID: 0042413939     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000071233     Document Type: Conference Paper

References (23)

1. Wilson PW, Anderson KM, Kannel WB: Epidemiology of diabetes mellitus in the elderly. The Framingham Study. Am J Med 1986;80:3-9.
2. Despres JP, Lamarche B, Mauriege P, Cantin B, Dagenais GR, Moorjani S, Lupien PJ: Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med 1996;334:952-957.
3. Groop L, Orho-Melander M: The dysmetabolic syndrome. J Intern Med 2001;250:105-120.
4. Alberti KG, Zimmet P: Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabetic Med 1998;15:539-553.
5. Porksen N: The in vivo regulation of pulsatile insulin secretion. Diabetologia 2002;45:3-20.
6. Meneilly GS, Ryan AS, Veldhuis JD, Elahi D: Increased disorderliness of basal insulin release, attenuated insulin secretory burst mass and reduced ultradian rhythmicity of insulin secretion in older individuals. J Clin Endocrinol Metab 1997;82:4088-4093.
7. Iozzo P, Beck-Nielsen H, Laakso M, Smith U, Yki-Jarvinen H, Ferranninni E: Independent influence of age on basal insulin secretion in non-diabetic humans. J Clin Endocrinol Metab 1999;84:863-868.
8. Ginsberg HN: Insulin resistance and cardiovascular disease. J Clin Invest 2000;106:453-458.
9. DeFronzo RA, Tobin JD, Andres R: Glucose clamp technique: A method for quantifying insulin secretion and resistance. Am J Physiol 1979;237:E214-223.
10. Rowe JW, Minaker KL, Pallotta JA, Flier JS: Characterization of the insulin resistance of aging. J Clin Invest 1983;71:1581-1587.
11. Fink RI, Kolterman OG, Griffin J, Olefsky JM: Mechanisms of insulin resistance in aging. J Clin Invest 1983;71:1523-1535.
12. Jackson JA, Hawa MI, Roshania RD, Sim BM, DiSilvio L, Jaspan JB: Influence of aging on hepatic and peripheral glucose metabolism in humans. Diabetes 1988;36:119-129.
13. Ryan AS, Nicklas BJ, Elahi D: A cross-sectional study on body composition and energy expenditure in women athletes during aging. Am J Physiol 1996;271:E916-E921.
14. Balagopal P, Rooyackers OE, Adey DB, Ades PA, Nair KS: Effects of aging on in vivo synthesis of skeletal muscle myosin heavy-chain protein and sarcoplasmic protein in humans. Am J Physiol 1997;273:E790-E800.
15. Korht WM, Kirwan JP, Staten MA, Bourey RE, King DS, Holloszy JO: Insulin resistance in aging is related to abdominal obesity. Diabetes 1993;42:273-281.
16. Rooyackers OE, Adey DB, Ades PA, Nair KS: Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle. Proc Natl Acad Sci USA 1996;93:15364-15369.
17. Ferranninni E, Vichi S, Beck-Nielsen H, Laakso M, Paolisso G, Smith U: Insulin action and age. Diabetes 1996;45:947-953.
18. Toth MJ, Sites CK, Cefalu WT, Mathews DE, Poehlman ET: Determinants of insulin-stimulated glucose disposal in middle-aged, premenopausal women. Am J Physiol 2001;281:E113-E121.
19. Møller N, O'Brien P, Nair KS: Disruption of the relationship between fat content and leptin levels with aging in humans. J Clin Endocrinol Metab 1998;83:931-934.
20. Weir GC, Laybutt DR, Kaneto H, Bonner-Weir S, Sharma A: Beta-cell adaptation and decompensation during the progression of diabetes. Diabetes 2001;50:S154-S159.
21. Yki-Jarvinen H: Glucose toxicity. Endocr Rev 1992;13:415-431.
22. McGarry JD, Dobbins RL: Fatty acids, lipotoxicity and insulin secretion. Diabetologia 1999;42:128-138.
23. Randle PJ, Garland PB, Hales CN, Newsholme EA: The glucose-fatty acid cycle: Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963;i:785-789.