메뉴 건너뛰기




Volumn 51, Issue 10, 2003, Pages 574-580

Insulin receptor and ageing

Author keywords

Ageing; Insulin receptor; Insulin receptor substrate; Insulin resistance; Signal transduction

Indexed keywords

GLUCOSE TRANSPORTER; INSULIN; INSULIN RECEPTOR;

EID: 0344413421     PISSN: 03698114     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.patbio.2003.09.007     Document Type: Article
Times cited : (63)

References (53)
  • 1
    • 0004810161 scopus 로고    scopus 로고
    • Diabetes mellitus
    • Hazzard WR, Blass JP, Ettinger WH, Halter JB, Ouslander JG, editors. New york: McGraw Hill
    • Halter JB. Diabetes mellitus. In: Hazzard WR, Blass JP, Ettinger WH, Halter JB, Ouslander JG, editors. Principles of geriatric medicine and gerontology. New york: McGraw Hill 1999; p. 991-1012.
    • (1999) Principles of Geriatric Medicine and Gerontology , pp. 991-1012
    • Halter, J.B.1
  • 2
    • 0037382455 scopus 로고    scopus 로고
    • Contributions of insulin-resistance and insulin secretory defects to the pathogenesis of type 2 diabetes mellitus
    • Gerich JE. Contributions of insulin-resistance and insulin secretory defects to the pathogenesis of type 2 diabetes mellitus. Mayo Clinic Proc 2003;78:447-56.
    • (2003) Mayo Clinic Proc , vol.78 , pp. 447-456
    • Gerich, J.E.1
  • 3
    • 0034616931 scopus 로고    scopus 로고
    • Biomedicine: New insights into type 2 diabetes
    • Alper J. Biomedicine: new insights into type 2 diabetes. Science 2000;289:37-9.
    • (2000) Science , vol.289 , pp. 37-39
    • Alper, J.1
  • 4
    • 0036434431 scopus 로고    scopus 로고
    • Insulin regulation of glucose uptake: A complex interplay of intracellular signalling pathways
    • Khan AH, Pessin JE. Insulin regulation of glucose uptake: a complex interplay of intracellular signalling pathways. Diabetologia 2002;45:1475-83.
    • (2002) Diabetologia , vol.45 , pp. 1475-1483
    • Khan, A.H.1    Pessin, J.E.2
  • 5
    • 0037773543 scopus 로고    scopus 로고
    • Molecular mechanisms of insulin receptor substrate protein-mediated modulation of insulin signalling
    • Jonsaton AM, Pirola L, Van Obberghen E. Molecular mechanisms of insulin receptor substrate protein-mediated modulation of insulin signalling. FEBS Lett 2003;546:32-6.
    • (2003) FEBS Lett , vol.546 , pp. 32-36
    • Jonsaton, A.M.1    Pirola, L.2    Van Obberghen, E.3
  • 6
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2000;103:211-25.
    • (2000) Cell , vol.103 , pp. 211-225
    • Schlessinger, J.1
  • 8
    • 0030669392 scopus 로고    scopus 로고
    • A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation
    • Paz K, Hemi R, LeRoith D, Karasik A, Elhanany E, Kanethy H, et al. A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation. J Biol Chem 1997;272:29911-8.
    • (1997) J Biol Chem , vol.272 , pp. 29911-29918
    • Paz, K.1    Hemi, R.2    LeRoith, D.3    Karasik, A.4    Elhanany, E.5    Kanethy, H.6
  • 9
    • 0037018924 scopus 로고    scopus 로고
    • Positive and negative regulatory role of insulin receptor substrate 1 and 2 (IRS-1 and IRS-2) serine/threonine phosphorylation
    • Greene MW, Carofalo RS. Positive and negative regulatory role of insulin receptor substrate 1 and 2 (IRS-1 and IRS-2) serine/threonine phosphorylation. Biochemistry 2002;41:7082-91.
    • (2002) Biochemistry , vol.41 , pp. 7082-7091
    • Greene, M.W.1    Carofalo, R.S.2
  • 10
    • 0036183603 scopus 로고    scopus 로고
    • Coordinated action of protein tyrosine phosphatases in insulin signal transduction
    • Cheng A, Dubé N, Gu F, Tremblay ML. Coordinated action of protein tyrosine phosphatases in insulin signal transduction. Eur J Biochem 2002;269:1050-9.
    • (2002) Eur J Biochem , vol.269 , pp. 1050-1059
    • Cheng, A.1    Dubé, N.2    Gu, F.3    Tremblay, M.L.4
  • 11
    • 0032987220 scopus 로고    scopus 로고
    • Insuilin signalling; Metabolic pathways and mechanisms for specificity
    • Nystrom FH, Quon MJ. Insuilin signalling; metabolic pathways and mechanisms for specificity. Cell Signal 1999;11:563-74.
    • (1999) Cell Signal , vol.11 , pp. 563-574
    • Nystrom, F.H.1    Quon, M.J.2
  • 12
    • 0030734345 scopus 로고    scopus 로고
    • Physiological role of Akt in insulin stimulated translocation of GLUT4 in transfected rat adipose cells
    • Cong LN, Chen H, Li Y, Zhu L, McGibbon MA, Taylor SI, et al. Physiological role of Akt in insulin stimulated translocation of GLUT4 in transfected rat adipose cells. Mol Endocrinol 1997;11:1881-90.
    • (1997) Mol Endocrinol , vol.11 , pp. 1881-1890
    • Cong, L.N.1    Chen, H.2    Li, Y.3    Zhu, L.4    McGibbon, M.A.5    Taylor, S.I.6
  • 13
    • 0034603858 scopus 로고    scopus 로고
    • Roles of insulin receptor, PI3Kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells
    • Zeng G, Nystrom FH, Ravichandran RV, Cong LN, Kirby M, Mostowski H, et al. Roles of insulin receptor, PI3Kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells. Circulation 2000;101:1539-45.
    • (2000) Circulation , vol.101 , pp. 1539-1545
    • Zeng, G.1    Nystrom, F.H.2    Ravichandran, R.V.3    Cong, L.N.4    Kirby, M.5    Mostowski, H.6
  • 14
    • 0036120714 scopus 로고    scopus 로고
    • Insulin inhibits apoptosis of macrophage cell line, THP-1 cells, via phosphatidylinositol-3-kinase dependent pathway
    • Iida KT, Suzuki H, Sone H, Shimano H, Toyoshima H, Yatoh S, et al. Insulin inhibits apoptosis of macrophage cell line, THP-1 cells, via phosphatidylinositol-3-kinase dependent pathway. Arterioscler Thromb Vasc Biol 2002;22:380-6.
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 380-386
    • Iida, K.T.1    Suzuki, H.2    Sone, H.3    Shimano, H.4    Toyoshima, H.5    Yatoh, S.6
  • 16
    • 0034648794 scopus 로고    scopus 로고
    • CAP defines a second signalling pathway required for insulin stimulated glucose transport
    • Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, Shigematsu S, et al. CAP defines a second signalling pathway required for insulin stimulated glucose transport. Nature 2000;407:202-7.
    • (2000) Nature , vol.407 , pp. 202-207
    • Baumann, C.A.1    Ribon, V.2    Kanzaki, M.3    Thurmond, D.C.4    Mora, S.5    Shigematsu, S.6
  • 17
    • 0030949124 scopus 로고    scopus 로고
    • Functional rafts in cell membranes
    • Simons K, Ikonen E. Functional rafts in cell membranes. Nature 1997;387:569-75.
    • (1997) Nature , vol.387 , pp. 569-575
    • Simons, K.1    Ikonen, E.2
  • 18
    • 0037429735 scopus 로고    scopus 로고
    • Role of cholesterol in lipid raft formation: Lessons from lipid model systems
    • Silvius JR. Role of cholesterol in lipid raft formation: lessons from lipid model systems. Biochim Biophys Acta 2003;1610:174-83.
    • (2003) Biochim Biophys Acta , vol.1610 , pp. 174-183
    • Silvius, J.R.1
  • 19
    • 0036166283 scopus 로고    scopus 로고
    • Dynamic association of human insulin receptor with lipid rafts in cells lacking caveolae
    • Vaino S, Heino S, Mansson JE, Fredman P, Kuismanen E, Vaarala O, et al. Dynamic association of human insulin receptor with lipid rafts in cells lacking caveolae. EMBO Rep 2002;3:95-100.
    • (2002) EMBO Rep , vol.3 , pp. 95-100
    • Vaino, S.1    Heino, S.2    Mansson, J.E.3    Fredman, P.4    Kuismanen, E.5    Vaarala, O.6
  • 20
    • 0027466915 scopus 로고
    • Age-related changes in hepatic and splenic insulin receptors and serum insulin and glucose levels in inbred mice
    • Murray TM, Deesay KS, Cinader B. Age-related changes in hepatic and splenic insulin receptors and serum insulin and glucose levels in inbred mice. Metabolism 1993;42:140-4.
    • (1993) Metabolism , vol.42 , pp. 140-144
    • Murray, T.M.1    Deesay, K.S.2    Cinader, B.3
  • 21
    • 0030659608 scopus 로고    scopus 로고
    • Effect of age and caloric restriction on insulin receptor binding and glucose transporter levels in aging rat
    • Wang ZQ, Bell-Farrow AD, Sonntag W, Cefalu WT. Effect of age and caloric restriction on insulin receptor binding and glucose transporter levels in aging rat. Exp Ger 1997;32:671-84.
    • (1997) Exp Ger , vol.32 , pp. 671-684
    • Wang, Z.Q.1    Bell-Farrow, A.D.2    Sonntag, W.3    Cefalu, W.T.4
  • 23
    • 0023180249 scopus 로고
    • Glucose intolerance and insulin resistance with aging. Studies on insulin receptors and post-receptor events
    • Fulop Jr T, Nagy J, Worum I, Foris G, Mudri K, Udvardy M. Glucose intolerance and insulin resistance with aging. Studies on insulin receptors and post-receptor events. Arch Gerontol Geriatr 1987;6:107-15.
    • (1987) Arch Gerontol Geriatr , vol.6 , pp. 107-115
    • Fulop Jr., T.1    Nagy, J.2    Worum, I.3    Foris, G.4    Mudri, K.5    Udvardy, M.6
  • 24
    • 0033956417 scopus 로고    scopus 로고
    • Insulin receptors in the brain cortex of aging mice
    • Zaia A, Piantanelli L. Insulin receptors in the brain cortex of aging mice. Mech Age Dev 2000;113:227-32.
    • (2000) Mech Age Dev , vol.113 , pp. 227-232
    • Zaia, A.1    Piantanelli, L.2
  • 25
    • 0033555575 scopus 로고    scopus 로고
    • Age associated alterations in cardiac and skeletal muscle glucose transporters, insulin and IGF-1 receptors and PI3-kinase protein contents in the C57BL/6 mouse
    • Martineau LC, Chadan SG, Parkhouse WS. Age associated alterations in cardiac and skeletal muscle glucose transporters, insulin and IGF-1 receptors and PI3-kinase protein contents in the C57BL/6 mouse. Mech Age Dev 1999;106:217-32.
    • (1999) Mech Age Dev , vol.106 , pp. 217-232
    • Martineau, L.C.1    Chadan, S.G.2    Parkhouse, W.S.3
  • 26
    • 0025331303 scopus 로고
    • Changes in insulin receptor kinase with aging in rat skeletal muscle and liver
    • Kono S, Kuzuya H, Okamoto M, Nishimura H, Kosaki A, Kakahi T, et al. Changes in insulin receptor kinase with aging in rat skeletal muscle and liver. Am J Physiol 1990;259:27-35.
    • (1990) Am J Physiol , vol.259 , pp. 27-35
    • Kono, S.1    Kuzuya, H.2    Okamoto, M.3    Nishimura, H.4    Kosaki, A.5    Kakahi, T.6
  • 27
    • 0030066985 scopus 로고    scopus 로고
    • Effect of aging on insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle rats
    • Carvalho CR, Brenelli SL, Silva AC, Nunez AI, Velloso LA, Staad MJ. Effect of aging on insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle rats. Endocrinology 1996;137:151-9.
    • (1996) Endocrinology , vol.137 , pp. 151-159
    • Carvalho, C.R.1    Brenelli, S.L.2    Silva, A.C.3    Nunez, A.I.4    Velloso, L.A.5    Staad, M.J.6
  • 28
    • 0027280608 scopus 로고
    • Why does insulin resistance develop during maturation
    • Reed MJ, Reaven GM, Mondoe CE, Azhar S. Why does insulin resistance develop during maturation. J Gerontol 1993;48:139-44.
    • (1993) J Gerontol , vol.48 , pp. 139-144
    • Reed, M.J.1    Reaven, G.M.2    Mondoe, C.E.3    Azhar, S.4
  • 29
  • 30
    • 0033968126 scopus 로고    scopus 로고
    • Insulin resistance differentially affects the PI3-kinase and MAPK mediated signalling in human muscle
    • Cusi K, Maezono K, Osman A, Pendergrass M, Patti ME, Patipanawatr T, et al. Insulin resistance differentially affects the PI3-kinase and MAPK mediated signalling in human muscle. J Clin Invest 2000;105:597-611.
    • (2000) J Clin Invest , vol.105 , pp. 597-611
    • Cusi, K.1    Maezono, K.2    Osman, A.3    Pendergrass, M.4    Patti, M.E.5    Patipanawatr, T.6
  • 32
    • 0036311771 scopus 로고    scopus 로고
    • The aging brain. Changes in the neuronal insulin/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review
    • Hoyer S. The aging brain. Changes in the neuronal insulin/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review. J Neurol Transm 2002;109:991-1002.
    • (2002) J Neurol Transm , vol.109 , pp. 991-1002
    • Hoyer, S.1
  • 34
    • 0037155553 scopus 로고    scopus 로고
    • Insulin induced expression of the activity regulated cytoskeleton associated gene (ARC) in human neuroblastoma cells requires p21ras mitogen activated protein kinase/extracellular regulated kinase and src tyrosine kinases but is protein kinase C-independent
    • Kremerskothen J, Wendholt D, Teber I, Barnekow A. Insulin induced expression of the activity regulated cytoskeleton associated gene (ARC) in human neuroblastoma cells requires p21ras mitogen activated protein kinase/extracellular regulated kinase and src tyrosine kinases but is protein kinase C-independent. Neurosci Lett 2002;321:153-6.
    • (2002) Neurosci Lett , vol.321 , pp. 153-156
    • Kremerskothen, J.1    Wendholt, D.2    Teber, I.3    Barnekow, A.4
  • 35
    • 0035123649 scopus 로고    scopus 로고
    • Insulin signalling leading to proliferation, survival and membrane ruffling in C2C12 myoblasts
    • Conejo R, Lorenzo M. Insulin signalling leading to proliferation, survival and membrane ruffling in C2C12 myoblasts. J Cell Physiol 2001;187:96-108.
    • (2001) J Cell Physiol , vol.187 , pp. 96-108
    • Conejo, R.1    Lorenzo, M.2
  • 36
    • 0034672599 scopus 로고    scopus 로고
    • Hyperinsulinemia: The missing link among oxidative stress and age-related diseases?
    • Facchini FS, Hua NW, Reaven GM, Stoohs RA. Hyperinsulinemia: the missing link among oxidative stress and age-related diseases? Free Radic Biol Med 2000;29:1302-6.
    • (2000) Free Radic Biol Med , vol.29 , pp. 1302-1306
    • Facchini, F.S.1    Hua, N.W.2    Reaven, G.M.3    Stoohs, R.A.4
  • 37
    • 0033972493 scopus 로고    scopus 로고
    • Negative consequences of glycation
    • Brownlee M. Negative consequences of glycation. Metabolism 2000;49:9-13.
    • (2000) Metabolism , vol.49 , pp. 9-13
    • Brownlee, M.1
  • 38
    • 0029919185 scopus 로고    scopus 로고
    • Accumulation of advanced glycation end products of the Maillard reaction with age in human hippocampal neurons
    • Kimura T, Takamatsu J, Ikeda K, Kondo A, Miyakawa T, Horiuchi S. Accumulation of advanced glycation end products of the Maillard reaction with age in human hippocampal neurons. Neurosci Lett 1996;208:53-6.
    • (1996) Neurosci Lett , vol.208 , pp. 53-56
    • Kimura, T.1    Takamatsu, J.2    Ikeda, K.3    Kondo, A.4    Miyakawa, T.5    Horiuchi, S.6
  • 39
    • 0028102075 scopus 로고
    • Advanced glycation end products (AGEs) on the surface of diabetic erythrocytes bind to the vessel wall via a specific receptor inducing oxidant stress in the vasculature: A link between surface associated AGEs and diabetic complications
    • Wautier JL, Wautier MP, Schmidt AM, Anderson GM, Hori O, Zoukourian C, et al. Advanced glycation end products (AGEs) on the surface of diabetic erythrocytes bind to the vessel wall via a specific receptor inducing oxidant stress in the vasculature: a link between surface associated AGEs and diabetic complications. Proc Natl Acad Sci USA 1994;91:7742-6.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 7742-7746
    • Wautier, J.L.1    Wautier, M.P.2    Schmidt, A.M.3    Anderson, G.M.4    Hori, O.5    Zoukourian, C.6
  • 40
    • 0025853670 scopus 로고
    • Protein glycation and oxidative stress in diabetes mellitus and aging
    • Wolff SP, Jianng ZY, Hunt JV. Protein glycation and oxidative stress in diabetes mellitus and aging. Free Radic Biol Med 1991;10:339-52.
    • (1991) Free Radic Biol Med , vol.10 , pp. 339-352
    • Wolff, S.P.1    Jianng, Z.Y.2    Hunt, J.V.3
  • 41
    • 77049308856 scopus 로고
    • Ageing: A theory based on free radical and radiation chemistry
    • Harman D. Ageing: a theory based on free radical and radiation chemistry. J Gerontol 1956;11:145-7.
    • (1956) J Gerontol , vol.11 , pp. 145-147
    • Harman, D.1
  • 42
    • 0033394934 scopus 로고    scopus 로고
    • Effect of oral glucose challenge on free radicals/antioxidant balance in an older population with non insulin dependent diabetes mellitus (NIDDM)
    • Tessier D, Khalil A, Fülöp Jr T. Effect of oral glucose challenge on free radicals/antioxidant balance in an older population with non insulin dependent diabetes mellitus (NIDDM). J Gerontol 1999;54A: M541-5.
    • (1999) J Gerontol , vol.54 A
    • Tessier, D.1    Khalil, A.2    Fülöp Jr., T.3
  • 43
    • 0017366211 scopus 로고
    • Longevity and lifetime body weight in mice selected for rapid growth
    • Eklund J, Bradford GE. Longevity and lifetime body weight in mice selected for rapid growth. Nature 1977;265:48-9.
    • (1977) Nature , vol.265 , pp. 48-49
    • Eklund, J.1    Bradford, G.E.2
  • 44
    • 0037238644 scopus 로고    scopus 로고
    • Body size, insulin/IGF signalling and aging in the nematode Caenorhabditis elegans
    • McCulloch D, Gems D. Body size, insulin/IGF signalling and aging in the nematode Caenorhabditis elegans. Exp Ger 2003;38:129-36.
    • (2003) Exp Ger , vol.38 , pp. 129-136
    • McCulloch, D.1    Gems, D.2
  • 45
    • 0030014296 scopus 로고    scopus 로고
    • A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans
    • Murakami S, Johnson TE. A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans. Genetics 1996;143:1207-18.
    • (1996) Genetics , vol.143 , pp. 1207-1218
    • Murakami, S.1    Johnson, T.E.2
  • 47
    • 0029862973 scopus 로고    scopus 로고
    • Hyperinsulinemia is an independent risk factor for ischemic heart disease
    • Deprès JP, Lamarche B, Marioge B. Hyperinsulinemia is an independent risk factor for ischemic heart disease. New Engl J Med 1996;334:952-7.
    • (1996) New Engl J Med , vol.334 , pp. 952-957
    • Deprès, J.P.1    Lamarche, B.2    Marioge, B.3
  • 48
    • 0030029119 scopus 로고    scopus 로고
    • Insulin resistance; a multifaceted metabolic syndrome. Insights gained using low-dose insulin infusion technique
    • Krentz AJ, Nattrass M. Insulin resistance; a multifaceted metabolic syndrome. Insights gained using low-dose insulin infusion technique. Diabetes Med 1996;13:30-9.
    • (1996) Diabetes Med , vol.13 , pp. 30-39
    • Krentz, A.J.1    Nattrass, M.2
  • 49
    • 0029898677 scopus 로고    scopus 로고
    • Glucose tolerance and insulin action in healthy centenarians
    • Paolisso G, Garnbardella A, Ammendola S. Glucose tolerance and insulin action in healthy centenarians. Am J Physiol 1996;270:E890-4.
    • (1996) Am J Physiol , vol.270
    • Paolisso, G.1    Garnbardella, A.2    Ammendola, S.3
  • 50
    • 0026398216 scopus 로고
    • Retardation of the aging processes in rats by food restriction
    • Masoro EJ, Shimokawa I, Yu BP. Retardation of the aging processes in rats by food restriction. Ann NY Acad Sci 1991;621:337-52.
    • (1991) Ann NY Acad Sci , vol.621 , pp. 337-352
    • Masoro, E.J.1    Shimokawa, I.2    Yu, B.P.3
  • 52
    • 0022483238 scopus 로고
    • Age-dependent decrease of the lateral diffusion constant of proteins in the plasma membrane of hepatocytes as revealed by fluorescent recovery after photobleaching in tissue smears
    • Zs-Nagy I, Kitani K, Ohta M, Zs-Nagy V, Imahori K. Age-dependent decrease of the lateral diffusion constant of proteins in the plasma membrane of hepatocytes as revealed by fluorescent recovery after photobleaching in tissue smears. Arch Gerontol Geriatr 1986;5:131-41.
    • (1986) Arch Gerontol Geriatr , vol.5 , pp. 131-141
    • Zs-Nagy, I.1    Kitani, K.2    Ohta, M.3    Zs-Nagy, V.4    Imahori, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.