Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors

Biochemical Pharmacology

Volumn 70, Issue 11, 2005, Pages 1601-1612

  Varani, Katia ^a   Gessi, Stefania ^a   Merighi, Stefania ^a   Vincenzi, Fabrizio ^a   Cattabriga, Elena ^a   Benini, Annalisa ^a   Klotz, Karl Norbert ^b   Baraldi, Pier Giovanni ^a   Tabrizi, Mojgan Aghazadeh ^a   Mac Lennan, Stephen ^c   Leung, Edward ^c   Borea, Pier Andrea ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c King Pharmaceuticals   (United States)

Author keywords

A2B adenosine receptors; Cyclic AMP assays; hA2BCHO cells; HEK 293 cells; HMC 1 cells; Inverse agonists

Indexed keywords

1,3 DIALLYL 8 [2 METHYL 5 [2 OXO 2 (4 PHENYLPIPERAZIN 1 YL)ETHOXY] 2H PYRAZOL 3 YL] 1,3 DIPROPYL 3,7 DIHYDROPURINE 2,6 DIONE; 2 (2 FURYL) 5 [3 (4 METHOXYPHENYL)UREIDO] 8 PROPYLPYRAZOLO[4,3 E] 1,2,4 TRIAZOLO[1,5 C]PYRIMIDINE; 2 (4 BENZYLOXYPHENYL) N [5 (2,6 DIOXO 1,3 DIPROPYL 2,3,6,7 TETRAHYDRO 1H PURIN 8 YL) 1 METHYL 1H PYRAZOL 3 YL]ACETAMIDE; 2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 2 HEXYNYL 5' N ETHYLCARBOXAMIDOADENOSINE; 5 (METHOXYPHENYLCARBAMOYL)AMINO 8 PROPYL 2 (2 FURYL)PYRAZOLO[4,3 E] 1,2,4 TRIAZOLO[1,5 C]PYRIMIDINE; 5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 8 [2 METHYL 5 [2 OXO 2 (4 PHENYLPIPERAZIN 1 YL)ETHOXY] 2H PYRAZOL 3 YL] 1,3 DIPROPYL 3,7 DIHYDROPURINE 2,6 DIONE; ACETAMIDE DERIVATIVE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2B RECEPTOR; ADENOSINE DERIVATIVE; ADENOSINE RECEPTOR AFFECTING AGENT; AMMONIUM TRICHLORO(DIOXYETHYLENE O,O')TELLURATE; AS 100; AS 16; AS 70; AS 74; AS 94; AS 95; AS 96; AS 99; CYCLIC AMP; FORSKOLIN; MRE 2029F20; N (3,4 DIMETHOXYPHENYL) 2 [5 (2,6 DIOXO 1,3 DIPROPYL 2,3,6,7 TETRAHYDRO 1H PURIN 8 YL) 1 METHYL 1H PYRAZOL 3 YLOXY]ACETAMIDE; N (4 CARBOXYPHENYL) 2 [5 (2,6 DIOXO 1,3 DIPROPYL 2,3,6,7 TETRAHYDRO 1H PURIN 8 YL) 1 METHYL 1H PYRAZOL 3 YLOXY]ACETAMIDE; N 6 (2 PHENYLISOPROPYL)ADENOSINE; N [4 (ETHOXYCARBONYL)PHENYL] 2 [5 (2,6 DIOXO 1,3 DIPROPYL 2,3,6,7 TETRAHYDRO 1H PURIN 8 YL) 1 METHYL 1H PYRAZOL 3 YLOXY]ACETAMIDE; N BENZO[1,3]DIOXOL 5 YL 2 [5 (2,6 DIOXO 1,3 DIPROPYL 2,3,6,7 TETRAHYDRO 1H PURIN 8 YL) 1 METHYL 1H PYRAZOL 3 YLOXYL]ACETAMIDE; N BENZO[1,3]DIOXOL 5 YL 2 [5 (2,6 DIOXO 1,3 DIPROPYL 2,3,6,7 TETRAHYDRO 1H PURIN 8 YL)ISOXAZOL 3 YLOXY]ACETAMIDE; PYRIMIDINE DERIVATIVE; RADIOLIGAND; RECOMBINANT RECEPTOR; THEOPHYLLINE; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL STIMULATION; CHO CELL; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; HUMAN; HUMAN CELL; IC 50; KIDNEY CELL; MAST CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOSINE; ANIMALS; BINDING, COMPETITIVE; CELL LINE; CYCLIC AMP; HUMANS; MOLECULAR STRUCTURE; PROTEIN BINDING; RECEPTOR, ADENOSINE A2B; RECOMBINANT PROTEINS;

EID: 27544446871     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.08.018     Document Type: Article

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