Inhibition of human mast cell activation with the novel selective adenosine A2B receptor antagonist 3-isobutyl-8-pyrrolidinoxanthine (IPDX)

Biochemical Pharmacology

Volumn 62, Issue 9, 2001, Pages 1163-1173

  Feoktistov, Igor ^a   Garland, Emily M ^a   Goldstein, Anna E ^a   Zeng, Dewan ^b   Belardinelli, Luiz ^b   Wells, Jack N ^a   Biaggioni, Italo ^a  

^a VANDERBILT UNIVERSITY   (United States)

^b CV THERAPEUTICS INC   (United States)

Author keywords

Adenosine; Asthma; Interleukin 8; Mast cells; P1; Receptors purinergic; Xanthines

Indexed keywords

3 ISOBUTYL 8 PYRROLIDINOXANTHINE; 4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; ADENOSINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; ANTIASTHMATIC AGENT; CYCLIC AMP; ENPROFYLLINE; INTERLEUKIN 8; TRITIUM; UNCLASSIFIED DRUG; XANTHINE DERIVATIVE;

ANIMAL CELL; ARTICLE; ASTHMA; BRONCHOSPASM; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG POTENCY; DRUG SELECTIVITY; ERYTHROLEUKEMIA CELL; HUMAN; HUMAN CELL; MAST CELL; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

NON-PROGRAMMATIC;

ADENOSINE; ADENOSINE-5'-(N-ETHYLCARBOXAMIDE); ANTI-ASTHMATIC AGENTS; CELLS, CULTURED; HUMANS; MAST CELLS; PYRROLIDINONES; RECEPTOR, ADENOSINE A2B; RECEPTORS, PURINERGIC P1; STRUCTURE-ACTIVITY RELATIONSHIP; VASODILATOR AGENTS; XANTHINE; XANTHINES;

EID: 0035504657     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00765-1     Document Type: Article

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