Up-regulation of IL-4 production by the activated cAMP/cAMP-dependent protein kinase (protein kinase A) pathway in CD3/CD28-stimulated naive T cells

International Immunology

Volumn 16, Issue 5, 2004, Pages 643-653

  Tokoyoda, Koji ^a   Tsujikawa, Kazutake ^a   Matsushita, Hiroaki ^a   Ono, Yuichi ^a   Hayashi, Tamon ^a   Harada, Yohsuke ^b   Abe, Ryo ^b   Kubo, Masato ^b   Yamamoto, Hiroshi ^a  

^a OSAKA UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Calcitonin gene related peptide; NF AT; Th1; Th2

Indexed keywords

BUCLADESINE; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CD28 ANTIGEN; CD3 ANTIGEN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DERIVATIVE; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; MESSENGER RNA; MONOCLONAL ANTIBODY; TRANSCRIPTION FACTOR NFAT;

ANIMAL CELL; ARTICLE; CELL POLARITY; CELLULAR IMMUNITY; CONTROLLED STUDY; DNA FLANKING REGION; DOWN REGULATION; ENZYME ACTIVATION; IMMUNOSTIMULATION; INTERFERON PRODUCTION; LYMPHOCYTE DIFFERENTIATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPRODUCIBILITY; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TH2 CELL; TRANSCRIPTION INITIATION; UPREGULATION;

ANIMALS; ANTIGENS, CD28; ANTIGENS, CD3; BUCLADESINE; CALCITONIN GENE-RELATED PEPTIDE; CELL DIFFERENTIATION; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA-BINDING PROTEINS; DOWN-REGULATION; HUMANS; INTERFERON TYPE II; INTERLEUKIN-2; INTERLEUKIN-4; ISOQUINOLINES; JURKAT CELLS; MALE; MICE; MICE, INBRED BALB C; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; SULFONAMIDES; TH1 CELLS; TH2 CELLS; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 2442506952     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/dxh072     Document Type: Article

References (54)

1. Schwartz, R. H. 1990. A cell culture model for T lymphocyte clonal anergy. Science 248:1349.
2. June, C. H., Bluestone, J. A., Nadler, L. M. and Thompson, C. B. 1994. The B7 and CD28 receptor families. Immunol. Today 15:321.
3. Linsley, P. S. and Ledbetter, J. A. 1993. The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 11:191.
4. Schwartz, R. H. 1992. Co-stimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 71:1065.
5. Gimmi, C. D., Freeman, G. J., Gribben, J. G., Gray, G. and Nadler, L. M. 1993. Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 co-stimulation. Proc. Natl Acad. Sci. USA 90:6586.
6. Tan, P., Anasetti, C., Hansen, J. A., Melrose, J., Brunvand, M., Bradshaw, J., Ledbetter, J. A. and Linsley, P. S. 1993. Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1. J. Exp. Med. 177:165.
7. Webb, S., Morris, C. and Sprent, J. 1990. Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity. Cell 63:1249.
8. Harding, F. A., McArthur, J. G., Gross, J. A., Raulet, D. H. and Allison, J. P. 1992. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 356:607.
9. Thompson, C. B., Lindsten, T., Ledbetter, J. A., Kunkel, S. L., Young, H. A., Emerson, S. G., Leiden, J. M. and June, C. H. 1989. CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proc. Natl Acad. Sci. USA 86:1333.
10. Shahinian, A., Pfeffer, K., Lee, K. P., Kundig, T. M., Kishihara, K., Wakeham, A., Kawai, K., Ohashi, P. S., Thompson, C. B. and Mak, T. W. 1993. Differential T cell co-stimulatory requirements in CD28-deficient mice. Science 261:609.
11. Reif, K. and Cantrell, D. A. 1998. Networking Rho family GTPases in lymphocytes. Immunity 8:395.
12. Jung, S., Yaron, A., Alkalay, I., Hatzubai, A., Avraham, A. and Ben-Neriah, Y. 1995. Co-stimulation requirement for AP-1 and NF-kappa B transcription factor activation in T cells. Ann. NY Acad. Sci. 766:245.
13. Maggirwar, S. B., Harhaj, E. W. and Sun, S. C. 1997. Regulation of the interleukin-2 CD28-responsive element by NF-ATp and various NF-kappaB/Rel transcription factors. Mol. Cell. Biol. 17:2605.
14. 2-terminal kinase pathway. Science 280:1945.
15. h2 effector cells. J. Immunol. 162:7110.
16. Kawamura, M., Tamura, H., Obana, S., Wenner, M., Ishikawa, T., Nakata, A. and Yamamoto, H. 1998. Differential effects of neuropeptides on cytokine production by mouse helper T cell subsets. Neuroimmunomodulation 5:9.
17. Rosenfeld, M. G., Mermod, J. J., Amara, S. G., Swanson, L. W., Sawchenko, P. E., Rivier, J., Vale, W. W. and Evans, R. M. 1983. Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature 304:129.
18. Disa, J., Parameswaran, N., Nambi, P. and Aiyar, N. 2000. Involvement of cAMP-dependent protein kinase and pertussis toxin-sensitive G-proteins in CGRP mediated JNK activation in human neuroblastoma cell line. Neuropeptides 34:229.
19. McLatchie, L. M., Fraser, N. J., Main, M. J., Wise, A., Brown, J., Thompson, N., Solari, R., Lee, M. G. and Foord, S. M. 1998. Protein RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature 393:333.
20. Bulloch, K., McEwen, B. S., Nordberg, J., Diwa, A. and Baird, S. 1998. Selective regulation of T-cell development and function by calcitonin gene-related peptide in thymus and spleen. An example of differential regional regulation of immunity by the neuroendocrine system. Ann. NY Acad. Sci. 840:551.
21. Rosenfeld, M. G., Emeson, R. B., Yeakley, J. M., Merillat, N., Hedjran, F., Lenz, J. and Delsert, C. 1992. Calcitonin gene-related peptide: a neuropeptide generated as a consequence of tissue-specific, developmentally regulated alternative RNA processing events. Ann. NY Acad. Sci. 657:1.
22. Miyauchi, K., Tadotsu, N., Hayashi, T., Ono, Y., Tokoyoda, K., Tsujikawa, K. and Yamamoto, H. 2002. Molecular cloning and characterization of mouse calcitonin gene-related peptide receptor. Neuropeptides 36:22.
23. Chatterjee, T. K., Moy, J. A., Cai, J. J., Lee, H. C. and Fisher, R. A. 1993. Solubilization and characterization of a guanine nucleotide-sensitive form of the calcitonin gene-related peptide receptor. Mol. Pharmacol. 43:167.
24. Goldstein, M. D., Cochrane, A. and Watts, T. H. 1997. Cyclic-AMP modulates downstream events in CD40-mediated signal transduction, but inhibition of protein kinase A has no direct effect on CD40 signaling. J. Immunol. 159:5871.
25. Kubo, M., Yamashita, M., Abe, R., Tada, T., Okumura, K., Ransom, J. T. and Nakayama, T. 1999. CD28 co-stimulation accelerates IL-4 receptor sensitivity and IL-4-mediated Th2 differentiation. J. Immunol. 163:2432.
26. Harada, Y., Tanabe, E., Watanabe, R., Weiss, B. D., Matsumoto, A., Ariga, H., Koiwai, O., Fukui, Y., Kubo, M., June, C. H. and Abe, R. 2001. Novel role of phosphatidylinositol 3-kinase in CD28-mediated co-stimulation. J. Biol. Chem. 276:9003.
27. + splenic T cells after CD28 receptor ligation. J. Immunol. 154:985.
28. h2 response to Schistosoma mansoni infection. Eur. J. Immunol. 26:2448.
29. h2 cytokine-producing cells. Blood 86:3479.
30. h2 cytokines. J. Immunol. 158:658.
31. Sakuta, H., Inaba, K. and Muramasu, S. 1996. Calcitonin generelated peptide enhances apoptosis of thymocytes. J. Neuroimmunol. 67:103.
32. Boudard, F. and Bastide, M. 1991. Inhibition of mouse T-cell proliferation by CGRP and VIP: effects of these neuropeptides; on IL-2 production and cAMP synthesis. J. Neurosci. Res. 29:29.
33. Wang, F., Millet, I., Bottomly, K. and Vignery, A. 1992. Calcitonin gene-related peptide inhibits interleukin 2 production by murine T lymphocytes. J. Biol. Chem. 267:21052.
34. June, C. H., Fletcher, M. C., Ledbetter, J. A. and Samelson, L. E. 1990. Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation. J. Immunol. 144:1591.
35. Nunes, J., Klasen, S., Franco, M. D., Lipcey, C., Mawas, C., Bagnasco, M. and Olive, D. 1993. Signalling through CD28 T-cell activation pathway involves an inositol phospholipid-specific phospholipase C activity. Biochem. J. 293:835.
36. Kvanta, A., Gerwins, P., Jondal, M. and Fredholm, B. B. 1990. Stimulation of T-cells with OKT3 antibodies increases forskolin binding and cyclic AMP accumulation. Cell Signal. 2:461.
37. Bihoreau, C., Heurtier, A., Enjalbert, A., Corvaia, N., Bensussan, A., Degos, L. and Kordon, C. 1991. Activation of the CD3/T cell receptor (TcR) complex or of protein kinase C potentiate adenylyl cyclase stimulation in a tumoral T cell line: involvement of two distinct intracellular pathways. Eur. J. Immunol. 21:2877.
38. s-stimulated adenylyl cyclases. FASEB J. 7:768.
39. Munoz, E., Zubiaga, A. M., Merrow, M., Sauter, N. P. and Huber, B. T. 1990. Cholera toxin discriminates between T helper 1 and 2 cells in T cell receptor-mediated activation: role of cAMP in T cell proliferation. J. Exp. Med. 172:95.
40. Novak, T. J. and Rothenberg, E. V. 1990. cAMP inhibits induction of interleukin 2 but not of interleukin 4 in T cells. Proc. Natl Acad. Sci. USA 87:9353.
41. Borger, P., Kauffman, H. F., Postma, D. S. and Vellenga, E. 1996. Interleukin-4 gene expression in activated human T lymphocytes is regulated by the cyclic adenosine monophosphate-dependent signaling pathway. Blood 87:691.
42. + T cells while decreasing IL-2 release and NF-AT induction. Int. Immunol. 6:1333.
43. Tokoyoda, K., Takemoto, Y., Nakayama, T., Arai, T. and Kubo, M. 2000. Synergism between the calmodulin-binding and autoinhibitory domains on calcineurin is essential for the induction of their phosphatase activity. J. Biol. Chem. 275:11728.
44. 2+ signals and immunosuppression. Nature 383:837.
45. Loh, C., Shaw, K. T., Carew, J., Viola, J. P., Luo, C., Perrino, B. A. and Rao, A. 1996. Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity. J. Biol. Chem. 271:10884.
46. Tsuruta, L., Lee, H. J., Masuda, E. S., Koyano-Nakagawa, N., Arai, N., Arai, K. and Yokota, T. 1995. Cyclic AMP inhibits expression of the IL-2 gene through the nuclear factor of activated T cells (NF-AT) site, and transfection of NF-AT cDNAs abrogates the sensitivity of EL-4 cells to cyclic AMP. J. Immunol. 154:5255.
47. Beals, C. R., Sheridan, C. M., Turck, C. W., Gardner, P. and Crabtree, G. R. 1997. Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science 275:1930.
48. Neilson, J., Stankunas, K. and Crabtree, G. R. 2001. Monitoring the duration of antigen-receptor occupancy by calcineurin/glycogen-synthase-kinase-3 control of NF-AT nuclear shuttling. Curr. Opin. Immunol. 13:346.
49. Fang, X., Yu, S. X., Lu, Y., Bast, R. C., Jr, Woodgett, J. R. and Mills, G. B. 2000. Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc. Natl Acad. Sci. USA 97:11960.
50. Zhang, J., Salojin, K. V., Gao, J. X., Cameron, M. J., Bergerot, I. and Delovitch, T. L. 1999. p38 mitogen-activated protein kinase mediates signal integration of TCR-CD28 co-stimulation in primary murine T cells. J. Immunol. 162:3819.
51. Pomerance, M., Abdullah, H. B., Kamerji, S., Correze, C. and Blondeau, J. P. 2000. Thyroid-stimulating hormone and cyclic AMP activate p38 mitogen-activated protein kinase cascade. Involvement of protein kinase A, rac1, and reactive oxygen species. J. Biol. Chem. 275:40539.
52. h2 cytokine gene expression. J. Immunol. 165:5597.
53. Lee, G. R., Fields, P. E. and Flavell, R. A. 2001. Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level. Immunity 14:447.
54. 2+/calmodulin-dependent protein kinase IV. Mol. Cell. Biol. 2:23.