Oligomerization of recombinant and endogenously expressed human histamine H4 receptors

Molecular Pharmacology

Volumn 70, Issue 2, 2006, Pages 604-615

  Van Rijn, Richard M ^a   Chazot, Paul L ^b   Shenton, Fiona C ^b   Sansuk, Kamonchanok ^a   Bakker, Remko A ^a,c   Leurs, Rob ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b DURHAM UNIVERSITY   (United Kingdom)

^c BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; G PROTEIN COUPLED RECEPTOR; HISTAMINE; HISTAMINE H1 RECEPTOR; HISTAMINE H4 RECEPTOR; HYBRID PROTEIN; OLIGOMER; PHYTOHEMAGGLUTININ; POLYCLONAL ANTIBODY; TUNICAMYCIN;

AFFINITY CHROMATOGRAPHY; ANIMAL CELL; ARTICLE; CELL STRAIN COS7; CELL STRAIN HEK293; CELL SURFACE; CONTROLLED STUDY; FLUORESCENCE RESONANCE ENERGY TRANSFER; GLYCOSYLATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; WESTERN BLOTTING;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; DIMERIZATION; GLYCOSYLATION; HISTAMINE AGONISTS; HUMANS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; RECEPTORS, HISTAMINE H1; RECOMBINANT PROTEINS;

EID: 33746217413     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.105.020818     Document Type: Article

References (55)

1. Angers S, Salahpour A, and Bouvier M (2002) Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function. Annu Rev Pharmacol Toxicol 42:409-435.
2. 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET). Proc Natl Acad Sci USA 97:3684-3689.
3. 1 receptor. J Pharmacol Exp Ther 311:131-138.
4. Bakker RA, Lozada AF, van Marle A, Shenton FC, Drutel G, Karlstedt K, Hoffmann M, Lintunen M, Yamamoto Y, van Rijn RM, et al. (2006) Discovery of naturally occurring splice variants of the rat histamine h3 receptor that act as dominant-negative isoforms. Mol Pharmacol 69:1194-1206.
5. αq/11-subunits in constitutive and agonist-mediated signaling. Mol Pharmacol 60:1133-1142.
6. 4 receptor BLT1 and the G-protein. J Mol Biol 329:815-829.
7. Boute N, Jockers R, and Issad T (2002) The use of resonance energy transfer in high-throughput screening: BRET versus FRET. Trends Pharmacol Sci 23:351-354.
8. Bouvier M (2001) Oligomerization of G-protein-coupled transmitter receptors. Nat Rev Neurosci 2:274-286.
9. Bradford A, Barlow A, and Chazot PL (2005) Probing the differential effects of infrared light sources IR1072 and IR880 on human lymphocytes: evidence of selective cytoprotection by IR1072. J Photochem Photobiol B 81:9-14.
10. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
11. 4 receptor. Br J Pharmacol 140:1117-1127.
12. 1) receptor radioligand binding studies on normal T cell subsets, B cells and monocytes. J Immunol 136:2116-2120.
13. Carrillo JJ, Pediani J, and Milligan G (2003) Dimers of class A G protein-coupled receptors function via agonist-mediated trans-activation of associated G proteins. J Biol Chem 278:42578-42587.
14. Chazot PL, Cik M, and Stephenson FA (1992) Immunological detection of the NMDAR1 glutamate receptor subunit expressed in embryonic kidney 293 cells and in rat brain. J Neurochem 59:1176-1178.
15. Chazot PL, Cik M, and Stephenson FA (1995) An investigation into the role of N-glycosylation in the functional expression of a recombinant heteromeric NMDA receptor. Mol Membr Biol 12:331-337.
16. Chazot PL, Coleman SK, Cik M, and Stephenson FA (1994) Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule. J Biol Chem 269:24403-24409.
17. 3 histamine receptor in the mouse brain. Neuroreport 12:259-262.
18. Chazot PL, Pollard S, and Stephenson FA (1998) immunoprecipitation of receptors, in General Neurochemical Techniques: Techniques in Vitro, Molecular (Boulton A, Baker G, and Bateson A eds) pp 257-286, Humana Press Inc, Totowa.
19. 4 receptor as a new therapeutic target for inflammation. Trends Pharmacol Sci 26:462-469.
20. Devi LA (2001) Heterodimerization of G-protein-coupled receptors: pharmacology, signaling and trafficking. Trends Pharmacol Sci 22:532-537.
21. 5 receptors: implications for striatal neuronal function. Proc Natl Acad Sci USA 99:11940-11945.
22. Fotiadis D, Liang Y, Filipek S, Saperstein DA, Engel A, and Palczewski K (2003) Atomic-force microscopy: rhodopsin dimers in native disc membranes. Nature (Lond) 421:127-128.
23. Franco R, Canals M, Marcellino D, Ferre S, Agnati L, Mallol J, Casado V, Ciruela F, Fuxe K, Lluis C, et al. (2003) Regulation of heptaspanning-membrane- receptor function by dimerization and clustering. Trends Biochem Sci 28:238-243.
24. 2 receptors expressed in Sf9 and COS7 cells. FEBS Lett 409:283-286.
25. + T cells. J Pharmacol Exp Ther 303:300-307.
26. George SR, O'Dowd BF, and Lee SP (2002) G-protein-coupled receptor oligomerization and its potential for drug discovery. Nat Rev Drug Discov 1:808-820.
27. 1 histamine receptor mediates inflammatory responses in human keratinocytes. J Allergy Clin Immunol 114:1176-1182.
28. 3 result in improved convenience and expression. Biotechniques 21:1013-1015.
29. 4 receptor mediates chemotaxis and calcium mobilization of mast cells. J Pharmacol Exp Ther 305:1212-1221.
30. BR2. Nature (Lond) 396:674-679.
31. Kroeger KM, Hanyaloglu AC, Seeber RM, Miles LE, and Eidne KA (2001) Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer. J Biol Chem 276:12736-12743.
32. Lambright DG, Sondek J, Bohm A, Skiba NP, Hamm HE, and Sigler PB (1996) The 2.0 Å crystal structure of a heterotrimeric G protein. Nature (Lond) 379:311-319.
33. 4 receptor agonist. J Pharmacol Exp Ther 314:1310-1321.
34. 4) expressed in bone marrow. Mol Pharmacol 59:420-426.
35. 2+-dependent protein kinase C, Raf/MEK/ERK and IKK/IκB/NF-κB signal cascades. Biochem Pharmacol 69:433-449.
36. Michineau S, Alhenc-Gelas F, and Rajerison RM (2006) Human bradykinin B2 receptor sialylation and N-glycosylation participate with disulfide bonding in surface receptor dimerization. Biochemistry 45:2699-2707.
37. Morse KL, Behan J, Laz TM, West RE Jr, Greenfeder SA, Anthes JC, Umland S, Wan Y, Hipkin RW, Gonsiorek W, et al. (2001) Cloning and characterization of a novel human histamine receptor. J Pharmacol Exp Ther 296:1058-1066.
38. Nakamura T, Itadani H, Hidaka Y, Ohta M, and Tanaka K (2000) Molecular cloning and characterization of a new human histamine receptor, HH4R. Biochem Biophys Res Commun 279:615-620.
39. Nelson G, Chandrashekar J, Hoon MA, Feng L, Zhao G, Ryba NJ, and Zuker CS (2002) An amino-acid taste receptor. Nature (Lond) 416:199-202.
40. Nelson G, Hoon MA, Chandrashekar J, Zhang Y, Ryba NJ, and Zuker CS (2001) Mammalian sweet taste receptors. Cell 106:381-390.
41. Nguyen T, Shapiro DA, George SR, Setola V, Lee DK, Cheng R, Rauser L, Lee SP, Lynch KR, Roth BL, et al. (2001) Discovery of a novel member of the histamine receptor family. Mol Pharmacol 59:427-433.
42. Oda T, Morikawa N, Saito Y, Masuho Y, and Matsumoto S (2000) Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes. J Biol Chem 275:36781-36786.
43. 4 receptor on human eosinophils-role in eosinophil chemotaxis. J Recept Signal Transduct Res 22:431-448.
44. Patel RC, Lange DC, and Patel YC (2002) Photobleaching fluorescence resonance energy transfer reveals ligand-induced oligomer formation of human somatostatin receptor subtypes. Methods 27:340-348.
45. Pfleger KD and Eidne KA (2005) Monitoring the formation of dynamic G-protein-coupled receptor-protein complexes in living cells. Biochem J 385:625-637.
46. Salim K, Fenton T, Bacha J, Urien-Rodriguez H, Bonnert T, Skynner HA, Watts E, Kerby J, Heald A, Beer M, et al. (2002) Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation. J Biol Chem 277:15482-15485.
47. 3 histamine receptor higher oligomers. Inflamm Res 54 (Suppl 1):S48-S49.
48. Stanasila L, Perez JB, Vogel H, and Cotecchia S (2003) Oligomerization of the α1a- and α1b-adrenergic receptor subtypes. Potential implications in receptor internalization. J Biol Chem 278:40239-40251.
49. Suda K, Filipek S, Palczewski K, Engel A, and Fotiadis D (2004) The supramolecular structure of the GPCR rhodopsin in solution and native disc membranes. Mol Membr Biol 21:435-446.
50. 4 production and mast cell-dependent neutrophil recruitment induced by zymosan in vivo. J Pharmacol Exp Ther 307:1072-1078.
51. Terrillon S and Bouvier M (2004) Roles of G-protein-coupled receptor dimerization. EMBO (Eur Mol Biol Organ) Rep 5:30-34.
52. 4 receptor antagonist with anti-inflammatory properties. J Pharmacol Exp Ther 309:404-413.
53. Uberti MA, Hague C, Oller H, Minneman KP, and Hall RA (2005) Heterodimerization with beta2-adrenergic receptors promotes surface expression and functional activity of α1D-adrenergic receptors. J Pharmacol Exp Ther 313:16-23.
54. Waldhoer M, Fong J, Jones RM, Lunzer MM, Sharma SK, Kostenis E, Portoghese PS, and Whistler JL (2005) From the cover: a heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers. Proc Natl Acad Sci USA 102:9050-9055.
55. Zhu Y, Michalovich D, Wu H, Tan KB, Dytko GM, Mannan IJ, Boyce R, Alston J, Tierney LA, Li X, et al. (2001) Cloning, expression and pharmacological characterization of a novel human histamine receptor. Mol Pharmacol 59:434-441.