Domain swapping in the human histamine H1 receptor

Journal of Pharmacology and Experimental Therapeutics

Volumn 311, Issue 1, 2004, Pages 131-138

  Bakker, Remko A ^a   Dees, Guido ^a   Carrillo, Juan J ^b   Booth, Raymond G ^c   López Gimenez, Juan F ^b   Milligan, Graeme ^b   Strange, Philip G ^d   Leurs, Rob ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d UNIVERSITY OF READING   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 PHENYL 3 N,N DIMETHYLAMINO 1,2,3,4 TETRAHYDRONAPHTHALENE; ALANINE; ASPARTIC ACID; DIMER; G PROTEIN COUPLED RECEPTOR; HISTAMINE H1 D107 A RECEPTOR; HISTAMINE H1 F432 A RECEPTOR; HISTAMINE H1 RECEPTOR; MEPYRAMINE; MONOMER; NAPHTHALENE DERIVATIVE; PHENYLALANINE; POLYMER; RADIOLIGAND; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL STRAIN COS7; CONTROLLED STUDY; DIMERIZATION; DOMAIN SWAPPING; FLUORESCENCE RESONANCE ENERGY TRANSFER; IMMUNOPRECIPITATION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; TRANSMEMBRANE DOMAIN 3; TRANSMEMBRANE DOMAIN 6; TRANSMEMBRANE DOMAIN 7;

ANIMALS; BINDING SITES; CERCOPITHECUS AETHIOPS; COS CELLS; ENERGY METABOLISM; FLUORESCENCE; HISTAMINE H1 ANTAGONISTS; HUMANS; IMMUNOPRECIPITATION; PROTEIN STRUCTURE, TERTIARY; PYRILAMINE; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE H1; TIME FACTORS; TRITIUM;

EID: 4644263679     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.067041     Document Type: Article

References (59)

1. Agnati LF, Ferre S, Lluis C, Franco R, and Fuxe K (2003) Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons. Pharmacol Rev 55:509-550.
2. 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET). Proc Natl Acad Sci USA 97:3684-3689.
3. 2 receptor dimer formation: evidence from ligand binding. J Biol Chem 276:22621-22629.
4. Bai M, Trivedi S, and Brown EM (1998) Dimerization of the extracellular calcium-sensing receptor (CaR) on the cell surface of CaR-transfected HEK293 cells. J Biol Chem 273:23605-23610. .
5. 1-receptor antagonists. Eur J Pharmacol 387:R5-R7.
6. 1 receptors. J Pharmacol Exp Ther 302:328-336.
7. 3H]-(-)-trans-1- phenyl-3-aminotetralin. Brain Res 837:95-105.
8. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
9. 1 receptors. J Med Chem 42: 3041-3054.
10. Carrillo JJ, Pediani J, and Milligan G (2003) Dimers of class A G protein-coupled receptors function via agonist-mediated trans-activation. J Biol Chem 278:42578-42387.
11. 1 receptors and stimulates dopamine synthesis in vivo in rat brain. Brain Res 852:151-160.
12. Cvejic S and Devi LA (1997) Dimerization of the delta opioid receptor: implication for a role in receptor internalization. J Biol Chem 272:26959-26964.
13. Dean MK, Higgs C, Smith RE, Bywater RP, Snell CR, Scott PD, Upton GJ, Howe TJ, and Reynolds CA (2001) Dimerization of G-protein-coupled receptors. J Med Chem 44:4595-4614.
14. Devi LA (2001) Heterodimerization of G-protein-coupled receptors: pharmacology, signaling and trafficking. Trends Pharmacol Sci 22:532-537.
15. 2 receptor subtypes. J Pharmacol Exp Ther 238:554-563.
16. Filizola M, Olmea O, and Weinstein H (2002) Prediction of heterodimerization interfaces of G-protein coupled receptors with a new subtractive correlated mutation method. Protein Eng 15:881-885.
17. 1 receptor. Mol Pharmacol 55:735-742.
18. 2 dopamine receptors expressed in Spodoptera frugiperda 9 (Sf9) and in HEK293 cells: analysis using co-immunoprecipitation and time-resolved fluorescence resonance energy transfer. Eur J Biochem 270:3928-3938.
19. Gazi L, Lopez-Gimenez JF, and Strange PG (2002) Formation of oligomers by G protein-coupled receptors. Curr Opin Drug Discov Dev 5:756-763.
20. George SR, O'Dowd BF, and Lee SP (2002) G-protein-coupled receptor oligomerization and its potential for drug discovery. Nat Rev Drug Discov 1:808-820.
21. 1 receptors form functionally interacting heteromeric complexes. Proc Natl Acad Sci USA 97:8606-8611.
22. Goldman LA, Cutrone EC, Kotenko SV, Krause CD, and Langer JA (1996) Modifications of vectors pEF-BOS, pcDNA1 and pcDNA3 result in improved convenience and expression. Biotechniques 21:1013-1015.
23. Gomes I, Jordan BA, Gupta A, Trapaidze N, Nagy V, and Devi LA (2000) Heterodimerization of μ- and δ-opioid receptors: a role in opiate synergy. J Neurosci 20:110RC.
24. Gouldson PR, Higgs C, Smith RE, Dean MK, Gkoutos GV, and Reynolds CA (2000) Dimerization and domain swapping in G-protein-coupled receptors: a computational study. Neuropsychopharmacology 23:860-77.
25. Guo W, Shi L, and Javitch JA (2003) The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer. J Biol Chem 278:4385-4388.
26. 2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation. J Biol Chem 271:16384-16392.
27. 2-adrenergic receptors: a role in trafficking and mitogen-activated protein kinase activation. Proc Natl Acad Sci USA 98:343-348.
28. Lazareno S and Birdsall NJM (1993) Estimation of competitive antagonist affinity from functional inhibition curves using the Gaddum, Schild and Cheng-Prusoff equations. Br J Pharmacol 109:1110-1119.
29. Lee JH and el-Fakahany EE (1985) Heterogeneity of binding of muscarinic receptor antagonists in rat brain homogenates. J Pharmacol Exp Ther 233:707-714.
30. Liang Y, Fotiadis D, Filipek S, Saperstein DA, Palczewski K, and Engel A (2003) Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes. J Biol Chem 278:21655-21662.
31. 2 receptor ligand, N-methyl spiperone. J Neural Transm 108:279-286.
32. Maggio R, Barbier P, Colelli A, Salvadori F, Demontis G, and Corsini GU (1999) G protein-linked receptors: pharmacological evidence for the formation of heterodimers. J Pharmacol Exp Ther 291:251-257.
33. Maggio R, Vogel Z, and Wess J (1993a) Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular "cross-talk" between G-protein-linked receptors. Proc Natl Acad Sci USA 90:3103-3107.
34. Maggio R, Vogel Z, and Wess J (1993b) Reconstitution of functional muscarinic receptors by co-expression of amino- and carboxyl-terminal receptor fragments. FEBS Lett 319:195-200.
35. McVey M, Ramsay D, Kellett E, Rees S, Wilson S, Pope AJ, and Milligan G (2001) Monitoring receptor oligomerization using time-resolved fluorescence resonance energy transfer and bioluminescence resonance energy transfer: the human S opioid receptor displays constitutive oligomerization at the cell surface which is not regulated by receptor occupancy. J Biol Chem 276:14092-14099.
36. Milligan G (2001) Oligomerisation of G-protein-coupled receptors. J Cell Sci 114: 1265-1271.
37. 1 histaminic receptor, in Animal Cell Technology: Basic and Applied Aspects (Wachi M ed) pp 65-69, Kluwer Academic Publishers, Dordrecht, The Netherlands.
38. Monnot C, Bihoreau C, Conchon S, Curnow KM, Corvol P, and Clauser E (1996) Polar residues in the transmembrane domains of the type 1 angiotensin II receptor are required for binding and coupling: reconstitution of the binding site by co-expression of two deficient mutants. J Biol Chem 271:1507-1513.
39. 3 receptor dimers and tetramers in brain and in transfected cells. J Biol Chem 272:29229-29237.
40. 194. Biochem Biophys Res Commun 203:1096-1101.
41. Overton MC and Blumer KJ (2002) The extracellular N-terminal domain and trans-membrane domains 1 and 2 mediate oligomerization of a yeast G protein-coupled receptor. J Biol Chem 277:41463-41472.
42. 236. J Biol Chem 274:11629-11634.
43. Park PS, Sum CS, Pawagi AB, and Wells JW (2002) Cooperativity and oligomeric status of cardiac muscarinic cholinergic receptors. Biochemistry 41:5588-5604.
44. Pfeiffer M, Koch T, Schroder H, Laugsch M, Hollt V, and Schulz S (2002) Heterodimerization of somatostatin and opioid receptors cross-modulates phosphorylation, internalization and desensitization. J Biol Chem 277:19762-19772.
45. Ramsay D, Kellett E, McVey M, Rees S and Milligan G (2002) Homo- and hetero-oligomeric interactions between G-protein-coupled receptors in living cells monitored by two variants of bioluminescence resonance energy transfer (BRET): hetero-oligomers between receptor subtypes form more efficiently than between less closely related sequences. Biochem J 365:429-440.
46. Rios CD, Jordan BA, Gomes I, and Devi LA (2001) G-protein-coupled receptor dimerization: modulation of receptor function. Pharmacol Ther 92:71-87.
47. Robbins MJ, Ciruela F, Rhodes A, and McIlhinney RAJ (1999) Characterization of the dimerization of metabotropic glutamate receptors using an N-terminal truncation of mGluR1. J Neurochem 72:2539-2547.
48. Rocheville M, Lange DC, Kumar U, Sasi R, Patel RC, and Patel YC (2000) Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers. J Biol Chem 275:7862-7869.
49. Rockman HA, Koch WJ, and Lefkowitz RJ (2002) Seven-transmembrane-spanning receptors and heart function. Nature (Land) 415:206-212.
50. 3H]spiperone in isotonic medium: implications for human positron emission tomography. Synapse 48:209-215.
51. 3 receptor. J Pharmacol Exp Ther 301:451-458.
52. 1-receptor. J Biol Chem 274:29994-30000.
53. Woosley RL (1996) Cardiac actions of antihistamines. Annu Rev Pharmacol Toxicol 36:233-252.
54. Wreggett KA and Wells JW (1995) Cooperativity manifest in the binding properties of purified cardiac muscarinic receptors. J Biol Chem 270:22488-22499.
55. 2-PAT). J Labeled Compounds Radiopharmaceuticals 34:131-134.
56. 2 receptor dimers in human and rat brain. FEBS Lett 441:383-386.
57. Zeng F-Y and Wess J (1999) Identification and molecular characterization of m3 muscarinic receptor dimers. J Biol Chem 274:19487-19497.
58. Zhang Z, Sun S, Quinn SJ, Brown EM, and Bai M (2001) The extracellular calcium-sensing receptor dimerizes through multiple types of intermolecular interactions. J Biol Chem 276:5316-5322.
59. Zhu X and Wess J (1998) Truncated V2 vasopressin receptors as negative regulators of wild-type V2 receptor function. Biochemistry 37:15773-15784.