메뉴 건너뛰기




Volumn 347, Issue 3, 2006, Pages 781-790

p38 MAPK downregulates phosphorylation of Bad in doxorubicin-induced endothelial apoptosis

Author keywords

Akt; Bad; Doxorubicin; Endothelial cells; p38 MAPK

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CASPASE 3; DOXORUBICIN; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAD; PROTEIN BCL XL; PROTEIN KINASE B;

EID: 33746214638     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.06.159     Document Type: Article
Times cited : (23)

References (55)
  • 1
    • 0026714331 scopus 로고
    • The anthracyclines: will we ever find a better doxorubicin?
    • Weiss R.B. The anthracyclines: will we ever find a better doxorubicin?. Semin. Oncol. 19 (1992) 670-686
    • (1992) Semin. Oncol. , vol.19 , pp. 670-686
    • Weiss, R.B.1
  • 2
    • 0021878134 scopus 로고
    • Early and delayed clinical cardiotoxicity of doxorubicin
    • Buzdar A.U., Marcus C., Smith T.L., and Blumenschein G.R. Early and delayed clinical cardiotoxicity of doxorubicin. Cancer 55 (1985) 2761-2765
    • (1985) Cancer , vol.55 , pp. 2761-2765
    • Buzdar, A.U.1    Marcus, C.2    Smith, T.L.3    Blumenschein, G.R.4
  • 3
    • 0034721770 scopus 로고    scopus 로고
    • Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen. Role of reactive oxygen and nitrogen species
    • Kotamraju S., Konorev E.A., Joseph J., and Kalyanaraman B. Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen. Role of reactive oxygen and nitrogen species. J. Biol. Chem. 275 (2000) 33585-33592
    • (2000) J. Biol. Chem. , vol.275 , pp. 33585-33592
    • Kotamraju, S.1    Konorev, E.A.2    Joseph, J.3    Kalyanaraman, B.4
  • 5
    • 19544371393 scopus 로고    scopus 로고
    • Coenzyme Q10 for prevention of anthracycline-induced cardiotoxicity
    • Conklin K.A. Coenzyme Q10 for prevention of anthracycline-induced cardiotoxicity. Integr. Cancer Ther. 4 (2005) 110-130
    • (2005) Integr. Cancer Ther. , vol.4 , pp. 110-130
    • Conklin, K.A.1
  • 6
    • 0036897097 scopus 로고    scopus 로고
    • Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs
    • Bocci G., Nicolaou K.C., and Kerbel R.S. Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs. Cancer Res. 62 (2002) 6938-6943
    • (2002) Cancer Res. , vol.62 , pp. 6938-6943
    • Bocci, G.1    Nicolaou, K.C.2    Kerbel, R.S.3
  • 12
    • 29044443481 scopus 로고    scopus 로고
    • p38 MAPK mediates inhibition of Bad via PP2A-dependent suppression of the MEK1/2-ERK1/2 survival pathway in TNF-α-induced endothelial apoptosis
    • Grethe S., and Pörn-Ares M.I. p38 MAPK mediates inhibition of Bad via PP2A-dependent suppression of the MEK1/2-ERK1/2 survival pathway in TNF-α-induced endothelial apoptosis. Cell. Signal. 18 (2006) 531-540
    • (2006) Cell. Signal. , vol.18 , pp. 531-540
    • Grethe, S.1    Pörn-Ares, M.I.2
  • 13
    • 0347997608 scopus 로고    scopus 로고
    • MAPK signal pathways in the regulation of cell proliferation in mammalian cells
    • Zhang W., and Liu H.T. MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res. 12 (2002) 9-18
    • (2002) Cell Res. , vol.12 , pp. 9-18
    • Zhang, W.1    Liu, H.T.2
  • 14
    • 0035253794 scopus 로고    scopus 로고
    • Hyperphosphorylation of tau is mediated by ERK activation during anticancer drug-induced apoptosis in neuroblastoma cells
    • Guise S., Braguer D., Carles G., Delacourte A., and Briand C. Hyperphosphorylation of tau is mediated by ERK activation during anticancer drug-induced apoptosis in neuroblastoma cells. J. Neurosci. Res. 63 (2001) 257-267
    • (2001) J. Neurosci. Res. , vol.63 , pp. 257-267
    • Guise, S.1    Braguer, D.2    Carles, G.3    Delacourte, A.4    Briand, C.5
  • 15
  • 16
    • 2442639165 scopus 로고    scopus 로고
    • Phosphorylation of p53 on Thr55 by ERK2 is necessary for doxorubicin-induced p53 activation and cell death
    • Yeh P.Y., Chuang S.E., Yeh K.H., Song Y.C., Chang L.L., and Cheng A.L. Phosphorylation of p53 on Thr55 by ERK2 is necessary for doxorubicin-induced p53 activation and cell death. Oncogene 23 (2004) 3580-3588
    • (2004) Oncogene , vol.23 , pp. 3580-3588
    • Yeh, P.Y.1    Chuang, S.E.2    Yeh, K.H.3    Song, Y.C.4    Chang, L.L.5    Cheng, A.L.6
  • 18
    • 0034708482 scopus 로고    scopus 로고
    • Akt/Protein Kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site
    • Toker A., and Newton A.C. Akt/Protein Kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site. J. Biol. Chem. 275 (2000) 8271-8274
    • (2000) J. Biol. Chem. , vol.275 , pp. 8271-8274
    • Toker, A.1    Newton, A.C.2
  • 21
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta S.R., Dudek H., Tao X., Masters S., Fu H., Gotoh Y., and Greenberg M.E. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91 (1997) 231-241
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6    Greenberg, M.E.7
  • 23
    • 0032493729 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway
    • Pap M., and Cooper G.M. Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway. J. Biol. Chem. 273 (1998) 19929-19932
    • (1998) J. Biol. Chem. , vol.273 , pp. 19929-19932
    • Pap, M.1    Cooper, G.M.2
  • 25
    • 0038414629 scopus 로고    scopus 로고
    • TRAIL promotes the survival and proliferation of primary human vascular endothelial cells by activating the Akt and ERK pathways
    • Secchiero P., Gorelli A., Carnevale E., Milani D., Pandolfi A., Zella D., and Zauli G. TRAIL promotes the survival and proliferation of primary human vascular endothelial cells by activating the Akt and ERK pathways. Circulation 107 (2003) 2250-2256
    • (2003) Circulation , vol.107 , pp. 2250-2256
    • Secchiero, P.1    Gorelli, A.2    Carnevale, E.3    Milani, D.4    Pandolfi, A.5    Zella, D.6    Zauli, G.7
  • 26
    • 0347093421 scopus 로고    scopus 로고
    • Suppression of adriamycin-induced apoptosis by sustained activation of the phosphatidylinositol-3′-OH kinase-Akt pathway
    • Takeuchi K., and Ito F. Suppression of adriamycin-induced apoptosis by sustained activation of the phosphatidylinositol-3′-OH kinase-Akt pathway. J. Biol. Chem. 279 (2004) 892-900
    • (2004) J. Biol. Chem. , vol.279 , pp. 892-900
    • Takeuchi, K.1    Ito, F.2
  • 27
    • 0033143385 scopus 로고    scopus 로고
    • How BAD phosphorylation is good for survival
    • Downward J. How BAD phosphorylation is good for survival. Nat. Cell Biol. 1 (1999) E33-E35
    • (1999) Nat. Cell Biol. , vol.1
    • Downward, J.1
  • 28
    • 0028809209 scopus 로고
    • Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death
    • Yang E., Zha J., Jockel J., Boise L.H., Thompson C.B., and Korsmeyer S.J. Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80 (1995) 285-291
    • (1995) Cell , vol.80 , pp. 285-291
    • Yang, E.1    Zha, J.2    Jockel, J.3    Boise, L.H.4    Thompson, C.B.5    Korsmeyer, S.J.6
  • 33
    • 0035859956 scopus 로고    scopus 로고
    • p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD
    • Harada H., Andersen J.S., Mann M., Terada N., and Korsmeyer S.J. p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Proc. Natl. Acad. Sci. USA 98 (2001) 9666-9670
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 9666-9670
    • Harada, H.1    Andersen, J.S.2    Mann, M.3    Terada, N.4    Korsmeyer, S.J.5
  • 34
    • 0001637870 scopus 로고
    • Permanent cell line expressing human factor VIII-related antigen established by hybridization
    • Edgell C.J., McDonald C.C., and Graham J.B. Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc. Natl. Acad. Sci. USA 80 (1983) 3734-3737
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 3734-3737
    • Edgell, C.J.1    McDonald, C.C.2    Graham, J.B.3
  • 35
    • 0037192824 scopus 로고    scopus 로고
    • Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism
    • Lorenzo E., Ruiz-Ruiz C., Quesada A.J., Hernandez G., Rodriguez A., Lopez-Rivas A., and Redondo J.M. Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism. J. Biol. Chem. 277 (2002) 10883-10892
    • (2002) J. Biol. Chem. , vol.277 , pp. 10883-10892
    • Lorenzo, E.1    Ruiz-Ruiz, C.2    Quesada, A.J.3    Hernandez, G.4    Rodriguez, A.5    Lopez-Rivas, A.6    Redondo, J.M.7
  • 36
    • 0034040751 scopus 로고    scopus 로고
    • Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences
    • Follenzi A., Ailles L.E., Bakovic S., Geuna M., and Naldini L. Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences. Nat. Genet. 25 (2000) 217-222
    • (2000) Nat. Genet. , vol.25 , pp. 217-222
    • Follenzi, A.1    Ailles, L.E.2    Bakovic, S.3    Geuna, M.4    Naldini, L.5
  • 37
    • 0027936755 scopus 로고
    • A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
    • Han J., Lee J.D., Bibbs L., and Ulevitch R.J. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265 (1994) 808-811
    • (1994) Science , vol.265 , pp. 808-811
    • Han, J.1    Lee, J.D.2    Bibbs, L.3    Ulevitch, R.J.4
  • 38
    • 3442901352 scopus 로고    scopus 로고
    • Truncated RON tyrosine kinase drives tumor cell progression and abrogates cell-cell adhesion through E-cadherin transcriptional repression
    • Bardella C., Costa B., Maggiora P., Patane S., Olivero M., Ranzani G.N., De Bortoli M., Comoglio P.M., and Di Renzo M.F. Truncated RON tyrosine kinase drives tumor cell progression and abrogates cell-cell adhesion through E-cadherin transcriptional repression. Cancer Res. 64 (2004) 5154-5161
    • (2004) Cancer Res. , vol.64 , pp. 5154-5161
    • Bardella, C.1    Costa, B.2    Maggiora, P.3    Patane, S.4    Olivero, M.5    Ranzani, G.N.6    De Bortoli, M.7    Comoglio, P.M.8    Di Renzo, M.F.9
  • 39
    • 0022263591 scopus 로고
    • Characterization of the cycle of iron-mediated electron transfer from Adriamycin to molecular oxygen
    • Gianni L., Zweier J.L., Levy A., and Myers C.E. Characterization of the cycle of iron-mediated electron transfer from Adriamycin to molecular oxygen. J. Biol. Chem. 260 (1985) 6820-6826
    • (1985) J. Biol. Chem. , vol.260 , pp. 6820-6826
    • Gianni, L.1    Zweier, J.L.2    Levy, A.3    Myers, C.E.4
  • 41
    • 0035145860 scopus 로고    scopus 로고
    • N-acetylcysteine attenuates TNF-alpha-induced p38 MAP kinase activation and p38 MAP kinase-mediated IL-8 production by human pulmonary vascular endothelial cells
    • Hashimoto S., Gon Y., Matsumoto K., Takeshita I., and Horie T. N-acetylcysteine attenuates TNF-alpha-induced p38 MAP kinase activation and p38 MAP kinase-mediated IL-8 production by human pulmonary vascular endothelial cells. Br. J. Pharmacol. 132 (2001) 270-276
    • (2001) Br. J. Pharmacol. , vol.132 , pp. 270-276
    • Hashimoto, S.1    Gon, Y.2    Matsumoto, K.3    Takeshita, I.4    Horie, T.5
  • 42
    • 10744227768 scopus 로고    scopus 로고
    • Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB203580, by alteration of one or more amino acids within the ATP binding pocket
    • Gum R.J., McLaughlin M.M., Kumar S., Wang Z., Bower M.J., Lee J.C., Adams J.L., Livi G.P., Goldsmith E.J., and Young P.R. Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB203580, by alteration of one or more amino acids within the ATP binding pocket. J. Biol. Chem. 273 (1998) 15605-15610
    • (1998) J. Biol. Chem. , vol.273 , pp. 15605-15610
    • Gum, R.J.1    McLaughlin, M.M.2    Kumar, S.3    Wang, Z.4    Bower, M.J.5    Lee, J.C.6    Adams, J.L.7    Livi, G.P.8    Goldsmith, E.J.9    Young, P.R.10
  • 44
    • 0033974063 scopus 로고    scopus 로고
    • Posttranslational modification of Bcl-2 facilitates its proteasome-dependent degradation: molecular characterization of the involved signaling pathway
    • Breitschopf K., Haendeler J., Malchow P., Zeiher A.M., and Dimmeler S. Posttranslational modification of Bcl-2 facilitates its proteasome-dependent degradation: molecular characterization of the involved signaling pathway. Mol. Cell. Biol. 20 (2000) 1886-1896
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 1886-1896
    • Breitschopf, K.1    Haendeler, J.2    Malchow, P.3    Zeiher, A.M.4    Dimmeler, S.5
  • 45
    • 0034193343 scopus 로고    scopus 로고
    • A role for the p38 mitogen-activated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents
    • Sanchez-Prieto R., Rojas J.M., Taya Y., and Gutkind J.S. A role for the p38 mitogen-activated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents. Cancer Res. 60 (2000) 2464-2472
    • (2000) Cancer Res. , vol.60 , pp. 2464-2472
    • Sanchez-Prieto, R.1    Rojas, J.M.2    Taya, Y.3    Gutkind, J.S.4
  • 46
    • 0034608083 scopus 로고    scopus 로고
    • Suppression by metallothionein of doxorubicin-induced cardiomyocyte apoptosis through inhibition of p38 mitogen-activated protein kinases
    • Kang Y.J., Zhou Z.X., Wang G.W., Buridi A., and Klein J.B. Suppression by metallothionein of doxorubicin-induced cardiomyocyte apoptosis through inhibition of p38 mitogen-activated protein kinases. J. Biol. Chem. 275 (2000) 13690-13698
    • (2000) J. Biol. Chem. , vol.275 , pp. 13690-13698
    • Kang, Y.J.1    Zhou, Z.X.2    Wang, G.W.3    Buridi, A.4    Klein, J.B.5
  • 47
    • 15044342095 scopus 로고    scopus 로고
    • Phosphorylation-dependent degradation of p300 by doxorubicin-activated p38 mitogen-activated protein kinase in cardiac cells
    • Poizat C., Puri P.L., Bai Y., and Kedes L. Phosphorylation-dependent degradation of p300 by doxorubicin-activated p38 mitogen-activated protein kinase in cardiac cells. Mol. Cell. Biol. 25 (2005) 2673-2687
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 2673-2687
    • Poizat, C.1    Puri, P.L.2    Bai, Y.3    Kedes, L.4
  • 48
    • 0038823730 scopus 로고    scopus 로고
    • Doxorubicin and vinorelbine act independently via p53 expression and p38 activation respectively in breast cancer cell lines
    • Liem A.A., Appleyard M.V., O'Neill M.A., Hupp T.R., Chamberlain M.P., and Thompson A.M. Doxorubicin and vinorelbine act independently via p53 expression and p38 activation respectively in breast cancer cell lines. Br. J. Cancer 88 (2003) 1281-1284
    • (2003) Br. J. Cancer , vol.88 , pp. 1281-1284
    • Liem, A.A.1    Appleyard, M.V.2    O'Neill, M.A.3    Hupp, T.R.4    Chamberlain, M.P.5    Thompson, A.M.6
  • 49
    • 3843074548 scopus 로고    scopus 로고
    • Distinctive regulation and function of PI 3K/Akt and MAPKs in doxorubicin-induced apoptosis of human lung adenocarcinoma cells
    • Zhao Y., You H., Yang Y., Wei L., Zhang X., Yao L., Fan D., and Yu Q. Distinctive regulation and function of PI 3K/Akt and MAPKs in doxorubicin-induced apoptosis of human lung adenocarcinoma cells. J. Cell. Biochem. 91 (2004) 621-632
    • (2004) J. Cell. Biochem. , vol.91 , pp. 621-632
    • Zhao, Y.1    You, H.2    Yang, Y.3    Wei, L.4    Zhang, X.5    Yao, L.6    Fan, D.7    Yu, Q.8
  • 50
    • 0035970041 scopus 로고    scopus 로고
    • Glycoprotein 130 regulates cardiac myocyte survival in doxorubicin-induced apoptosis through phosphatidylinositol 3-kinase/Akt phosphorylation and Bcl-xL/caspase-3 interaction
    • Negoro S., Oh H., Tone E., Kunisada K., Fujio Y., Walsh K., Kishimoto T., and Yamauchi-Takihara K. Glycoprotein 130 regulates cardiac myocyte survival in doxorubicin-induced apoptosis through phosphatidylinositol 3-kinase/Akt phosphorylation and Bcl-xL/caspase-3 interaction. Circulation 103 (2001) 555-561
    • (2001) Circulation , vol.103 , pp. 555-561
    • Negoro, S.1    Oh, H.2    Tone, E.3    Kunisada, K.4    Fujio, Y.5    Walsh, K.6    Kishimoto, T.7    Yamauchi-Takihara, K.8
  • 52
    • 0036830417 scopus 로고    scopus 로고
    • Bcl-2/bcl-xL bispecific antisense treatment sensitizes breast carcinoma cells to doxorubicin, paclitaxel and cyclophosphamide
    • Simoes-Wüst A.P., Schürpf T., Hall J., Stahel R.A., and Zangemeister-Wittke U. Bcl-2/bcl-xL bispecific antisense treatment sensitizes breast carcinoma cells to doxorubicin, paclitaxel and cyclophosphamide. Breast Cancer Res. Treat. 76 (2002) 157-166
    • (2002) Breast Cancer Res. Treat. , vol.76 , pp. 157-166
    • Simoes-Wüst, A.P.1    Schürpf, T.2    Hall, J.3    Stahel, R.A.4    Zangemeister-Wittke, U.5
  • 53
    • 0035839556 scopus 로고    scopus 로고
    • Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells
    • Gratton J.P., Morales-Ruiz M., Kureishi Y., Fulton D., Walsh K., and Sessa W.C. Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells. J. Biol. Chem. 276 (2001) 30359-30365
    • (2001) J. Biol. Chem. , vol.276 , pp. 30359-30365
    • Gratton, J.P.1    Morales-Ruiz, M.2    Kureishi, Y.3    Fulton, D.4    Walsh, K.5    Sessa, W.C.6
  • 54
    • 0038342509 scopus 로고    scopus 로고
    • AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance
    • Yuan Z., Feldman R.I., Sussman G.E., Coppola D., Nicosia S.V., and Cheng J.Q. AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance. J. Biol. Chem. 278 (2003) 23432-23440
    • (2003) J. Biol. Chem. , vol.278 , pp. 23432-23440
    • Yuan, Z.1    Feldman, R.I.2    Sussman, G.E.3    Coppola, D.4    Nicosia, S.V.5    Cheng, J.Q.6
  • 55
    • 0043193866 scopus 로고    scopus 로고
    • Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis
    • Chiang C.W., Kanies C., Kim K.W., Fang W.B., Parkhurst C., Xie M., Henry T., and Yang E. Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis. Mol. Cell. Biol. 23 (2003) 6350-6362
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 6350-6362
    • Chiang, C.W.1    Kanies, C.2    Kim, K.W.3    Fang, W.B.4    Parkhurst, C.5    Xie, M.6    Henry, T.7    Yang, E.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.