N-acetylcysteine attenuates TNF-α-induced p38 MAP kinase activation and p38 MAP kinase-mediated IL-8 production by human pulmonary vascular endothelial cells

British Journal of Pharmacology

Volumn 132, Issue 1, 2001, Pages 270-276

  Hashimoto, S ^a   Gon, Y ^a   Matsumoto, K ^a   Takeshita, I ^a   Horie, T ^a  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Acute lung injury; IL 8; NAC; p38 MAP kinase; Pulmonary vascular endothelial cells

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; CYTOKINE; GLUTATHIONE; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; CYTOKINE PRODUCTION; ENZYME ACTIVATION; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; LUNG INJURY; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 0035145860     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703787     Document Type: Article

References (36)

1. Determination of glutathione and glutathione disulfide in biological samples
2. Reactive oxygen species in acute lung injury
3. Stimulation of 'stress-regulated' mitogen-activated protein kinases (stress-activated protein kinases/c-jun N-terminal kinases and p38-mitogen-activated protein kinase) in perfused rat hearts by oxidative and other stresses
4. The metabolism of N-acetylcysteine by human endothelial cells
5. MAPKs: New JNK expand the group
6. HIV-induced cysteine deficiency and T-cell dysfunction - A rationale for treatment with N-acetylcysteine
7. Cooling and rewarming-induced IL-8 expression in human bronchial epithelial cells through p38 MAP kinase-dependent pathway
8. Reactive oxygen species- and dimerization-induced activation of apoptosis signal-regulating kinase I in tumor necrosis factor-α signal transduction
9. Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury
10. A Map kinase targeted by endotoxin and hyperosmolarity in mammalian cells
11. Adult respiratory distress syndrome and adhesion molecules
12. Thioredoxin negatively regulates p38 MAP kinase activation and IL-6 production by tumor necrosis factor-α
13. p38 mitogen-activated protein kinase regulate IL-8 expression in human pulmonary vascular endothelial cells
14. Hyperosmolarity-induced IL-8 expression in human bronchial epithelial cells through p38 MAP kinase-dependent pathway
15. p38 MAP kinase regulates TNF-α, IL-1 α- and PAF-induced RANTES and GM-CSF production by human bronchial epithelial cells
16. Regulation of transendothelial neutrophil migration by endogenous interleukin-8
17. Tumor necrosis factor levels in serum and bronchoalveolar lavage fluid of patients with the adult respiratory distress syndrome
18. Induction of apoptosis by ASKI, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathway
19. Hypoxia/reoxygenation stimulates Jun kinase activity through redox signaling in cardiac myocytes
20. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
21. Cytokines as communication signals between leukocytes and endothelial cells
22. Proinflammatory cytokine- and chemical mediator-induced IL-8 expression in human bronchial epithelial cells through p38 MAP kinase-dependent pathway
23. N-acetylcysteine inhibits IL-1α-induced IL-8 secretion by human bronchial epithelial cells
24. The adult respiratory distress syndrome, definition and prognosis
25. Human fibroblasts release reactive oxygen species in response to interleukin-1 and tumor necrosis factor-α
26. Elevated levels of NAP-1/interleukin-8 are present in the airspace of patients with adult respiratory distress syndrome and are associated with increased mortality
27. Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-α and H2O2
28. Adult respiratory distress syndrome
29. Production of hydrogen peroxide transforming growth factorβ1 and its involvement in induction of erg-1 in mouse osteoblastic cells
30. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
31. Mammalian thioredoxin is a direct inhibitor of apoptosis signal regulating kinase (ASK) I
32. Nuclear factor κB: An oxidative stress-responsive transcriptional factor of eukaryotic cells
33. A role of oxygen radicals as second messengers
34. Tumor necrosis factor alpha-induced apoptosis in human neural cells: Protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA
35. Neutrophils and the adult respiratory distress syndrome
36. The levels of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents