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Volumn 6, Issue 7, 2006, Pages 671-684

The tumour microenvironment and implications for cancer immunotherapy

Author keywords

Cancer; Immunotherapy; Microenvironment; Vaccine

Indexed keywords

ANTINEOPLASTIC AGENT; INTERLEUKIN 2;

EID: 33746087681     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.6.7.671     Document Type: Review
Times cited : (34)

References (131)
  • 1
    • 0030051051 scopus 로고    scopus 로고
    • Cellular changes involved in conversion of normal to malignant breast: Importance of the stromal reaction
    • RONNOV-JESSEN L, PETERSEN OW, BISSELL MJ: Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction. Physiol. Rev. (1996) 76(1):69-125. (Pubitemid 26048279)
    • (1996) Physiological Reviews , vol.76 , Issue.1 , pp. 69-125
    • Ronnov-Jessen, L.1    Petersen, O.W.2    Bissell, M.J.3
  • 2
    • 0035253742 scopus 로고    scopus 로고
    • Know thy neighbor: Stromal cells can contribute oncogenic signals
    • DOI 10.1016/S0959-437X(00)00156-8
    • TLSTY TD, HEIN PW: Know thy neighbor: stromal cells can contribute oncogenic signals. Curr. Opin. Genet. Dev. (2001) 11(1):54-59. (Pubitemid 32119278)
    • (2001) Current Opinion in Genetics and Development , vol.11 , Issue.1 , pp. 54-59
    • Tlsty, T.D.1    Hein, P.W.2
  • 3
    • 0020570569 scopus 로고
    • Immunoperoxidase localization of lymphocyte subsets in the host responses to melanoma and nevi
    • KORNSTEIN MJ, BROOKS JS, ELDER DE: Immunoperoxidase localization of lymphocyte subsets in the host responses to melanoma and nevi. Cancer Res. (1983) 43:1268-1272.
    • (1983) Cancer Res. , vol.43 , pp. 1268-1272
    • Kornstein, M.J.1    Brooks, J.S.2    Elder, D.E.3
  • 4
    • 0023176124 scopus 로고
    • Immunohistological analysis of lymphocyte subpopulations infiltrating breast carcinomas and benign lesions
    • DOI 10.1002/ijc.2910400105
    • VON KLEIST S, BERLING J, BOHLE W, WITTEKIND C: Immunohiostochemical analysis of lymphocyte subpopulations infiltrating breast carcinomas and benign lesions. Int. J. Cancer (1987) 40:18-23. (Pubitemid 17099964)
    • (1987) International Journal of Cancer , vol.40 , Issue.1 , pp. 18-23
    • Von Kleist, S.1    Berling, J.2    Bohle, W.3    Wittekind, C.4
  • 5
    • 33244472107 scopus 로고    scopus 로고
    • Tumor-infiltrating T lymphocytes: Friends or foes?
    • DOI 10.1038/labinvest.3700389, PII 3700389
    • YU P, FU YX: Tumor-infiltrating T lymphocytes: friends or foes? Lab. Invest. (2006) 86(3):231-245. (Pubitemid 43276955)
    • (2006) Laboratory Investigation , vol.86 , Issue.3 , pp. 231-245
    • Yu, P.1    Fu, Y.-X.2
  • 8
    • 0031747564 scopus 로고    scopus 로고
    • The role of Fas/FasL in immunosuppression induced by human tumors
    • DOI 10.1007/s002620050476
    • WHITESIDE TL, RABINOWICH H: The role of Fas/FasL in immunosuppression induced by human tumors. Cancer Immunol. Immunother. (1998) 46:175-184. (Pubitemid 28293817)
    • (1998) Cancer Immunology Immunotherapy , vol.46 , Issue.4 , pp. 175-184
    • Whiteside, T.L.1    Rabinowich, H.2
  • 10
    • 0038193533 scopus 로고    scopus 로고
    • 2-microglobulin inactivation in MSI-positive tumors and LMP7/TAP2 downregulation in MSI-negative tumors
    • DOI 10.1034/j.1399-0039.2003.00020.x
    • CABRERA CM, JIMENEZ P, CABRERA T, ESPARZA C, RUIZ-CABELLO F, GARRIDO F: Total loss of MHC class I in colorectoal tumors can be explained by two molecular pathways: beta2-microglobulin inactivation in MSI-positive tumors and LMP7/TAP2 downregulation in MSI-negative tumors. Tissue Antigens (2003) 61(3):211-219. (Pubitemid 36605543)
    • (2003) Tissue Antigens , vol.61 , Issue.3 , pp. 211-219
    • Cabrera, C.M.1    Jimenez, P.2    Cabrera, T.3    Esparza, C.4    Ruiz-Cabello, F.5    Garrido, F.6
  • 11
    • 0038069515 scopus 로고    scopus 로고
    • MHC class I antigens, immune surveillance, and tumor immune escape
    • DOI 10.1002/jcp.10290
    • GARCIA-LORA A, ALGARA I, GARRIDO F: MHC Class I antigens, immune surveillance, and tumor immune escape. J. Cell. Phys. (2003) 195:345-355. (Pubitemid 36529863)
    • (2003) Journal of Cellular Physiology , vol.195 , Issue.3 , pp. 346-355
    • Garcia-Lora, A.1    Algarra, I.2    Garrido, F.3
  • 14
    • 0034034187 scopus 로고    scopus 로고
    • Poor clinical outcome of patients with Hodgkin's Disease and elevated interleukin-18 serum levels. Clinical significance of interleukin-10 serum levels for Hodgkin's disease
    • BOHLEN H, KESSLER M, SEXTRO M, DIEHL V, TESCH H: Poor clinical outcome of patients with Hodgkin's disease and elevated interleukin-10 serum levels. Clinical significance of interleukin-10 serum levels for Hodgkin's disease. Ann. Hematol. (2000) 79:110-113. (Pubitemid 30195606)
    • (2000) Annals of Hematology , vol.79 , Issue.3 , pp. 110-113
    • Bohlen, H.1    Kessler, M.2    Sextro, M.3    Diehl, V.4    Tesch, H.5
  • 15
    • 0006335227 scopus 로고    scopus 로고
    • Elevated serum levels of transforming growth factor-β1 in patients with colorectal carcinoma: Its association with tumor progression and its significant decrease after curative surgical resection
    • DOI 10.1002/(SICI)1097-0142(19990201)85:3<554::AID-CNCR6>3.0.CO;2-X
    • SHIM KS, KIM KH, HAN WS, PARK EB: Elevated serum levels of transforming growth factor-beta1 in patients with colorectal carcinoma: its association with tumor progression and its significant decrease after curative surgical resection. Cancer (1999) 85:554-561. (Pubitemid 29075277)
    • (1999) Cancer , vol.85 , Issue.3 , pp. 554-561
    • Shim, K.S.1    Kim, K.H.2    Han, W.S.3    Park, E.B.4
  • 18
    • 0032167547 scopus 로고    scopus 로고
    • Constitutive IL-10 production accounts for the high NK sensitivity, low MHC class I expression, and poor transporter associated with antigen processing (TAP)-1/2 function in the prototype NK target YAC-1
    • PETERSSON M, CHARO J, SALAZAR-ONFRAY F et al.: Constitutive IL-10 production accounts for the high NK sensitivity, low MHC class I expression, and poor transporter associated with antigen processing (TAP)-1/2 function in the prototype NK target YAC-1. J. Immunol. (1998) 161:2099-2105 (Pubitemid 28397018)
    • (1998) Journal of Immunology , vol.161 , Issue.5 , pp. 2099-2105
    • Petersson, M.1    Charo, J.2    Salazar-Onfray, F.3    Noffz, G.4    Mohaupt, M.5    Qin, Z.6    Klein, G.7    Blankenstein, T.8    Kiessling, R.9
  • 19
    • 0028833639 scopus 로고
    • IL-10 inhibits tumor antigen presentation by epidermal antigen presenting cells
    • BEISSERT S, HOSOI J, GRABBE S, ASAHINA A, GRANSTEIN RD: IL-10 inhibits tumor antigen presentation by epidermal antigen presenting cells. J. Immunol. (1995) 154:1280-1286.
    • (1995) J. Immunol. , vol.154 , pp. 1280-1286
    • Beissert, S.1    Hosoi, J.2    Grabbe, S.3    Asahina, A.4    Granstein, R.D.5
  • 20
    • 0028846845 scopus 로고
    • CD8 T cell clones inhibit antitumor T cell function by secreting IL-10
    • ROHRER JW, COGGIN JH JR: CD8 T cell clones inhibit antitumor T cell function by secreting IL-10. J. Immunol. (1995) 155:5719-5727.
    • (1995) J. Immunol. , vol.155 , pp. 5719-5727
    • Rohrer, J.W.1    Coggin Jr., J.H.2
  • 21
    • 0034034187 scopus 로고    scopus 로고
    • Poor clinical outcome of patients with Hodgkin's Disease and elevated interleukin-18 serum levels. Clinical significance of interleukin-10 serum levels for Hodgkin's disease
    • BOHLEN H, KESSLER M, SEXTRO M, DIEHL V, TESCH H: Poor clinical outcome of patients with Hodgkin's disease and elevated interleukin-10 serum levels. Clinical significance of interleukin-10 serum levels for Hodgkin's disease. Ann. Hematol. (2000) 79:110-113. (Pubitemid 30195606)
    • (2000) Annals of Hematology , vol.79 , Issue.3 , pp. 110-113
    • Bohlen, H.1    Kessler, M.2    Sextro, M.3    Diehl, V.4    Tesch, H.5
  • 22
    • 0029121415 scopus 로고
    • IL-10 production in cutaneous basal and squamous cell carcinomas. A mechanism for evading the local T cell immune response
    • KIM J, MODLIN RL, MOY RL et al.: IL-10 production in cutaneous basal and squamous cell carcinomas. A mechanism for evading the local T cell immune response. J. Immunol. (1995) 155:2240-2247.
    • (1995) J. Immunol. , vol.155 , pp. 2240-2247
    • Kim, J.1    Modlin, R.L.2    Moy, R.L.3
  • 23
    • 0029054684 scopus 로고
    • IL-10 converts mouse lymphoma cells to a CTL-resistant, NK-sensitive phenotype with low but peptide-inducible MHC class I expression
    • SALAZAR-ONFRAY F, PETERSSON M, FRANKSSON L et al.: IL-10 converts mouse lymphoma cells to a CTL-resistant, NK-sensitive phenotype with low but peptide-inducible MHC class I expression. J. Immunol. (1995) 154:6291-6298.
    • (1995) J. Immunol. , vol.154 , pp. 6291-6298
    • Salazar-Onfray, F.1    Petersson, M.2    Franksson, L.3
  • 24
    • 0029079866 scopus 로고
    • Local release of IL-10 by transfected mouse mammary adenocarcinoma cells does not suppress but enhances antitumor reaction and elicits a strong cytotoxic lymphocyte and antibody-dependent immune memory
    • GIOVARELLI M, MUSIANI P, MODESTI A et al.: Local release of IL-10 by transfected mouse mammary adenocarcinoma cells does not suppress but enhances antitumor reaction and elicits a strong cytotoxic lymphocyte and antibody-dependent immune memory. J. Immunol. (1995) 155:3112-3123.
    • (1995) J. Immunol. , vol.155 , pp. 3112-3123
    • Giovarelli, M.1    Musiani, P.2    Modesti, A.3
  • 25
    • 0032822627 scopus 로고    scopus 로고
    • IL-10 expression by CT26 colon carcinoma cells inhibits their malignant phenotype and induces a T cell-mediated tumor rejection in the context of a systemic Th2 response
    • DOI 10.1038/sj.gt.3301012
    • ADRIS S, KLEIN S, JASNIS M et al.: IL-10 expression by CT26 colon carcinoma cells inhibits their malignant phenotype and induces a T cell-mediated tumor rejection in the context of a systemic Th2 response. Gene Ther. (1999) 6:1705-1712. (Pubitemid 29485945)
    • (1999) Gene Therapy , vol.6 , Issue.10 , pp. 1705-1712
    • Adris, S.K.1    Klein, S.2    Jasnis, M.A.3    Chuluyan, E.4    Ledda, M.F.5    Bravo, A.I.6    Carbone, C.7    Chernajovsky, Y.8    Podhajcer, O.L.9
  • 26
    • 0032743867 scopus 로고    scopus 로고
    • Interleukin-10 enhances the therapeutic effectiveness of a recombinant poxvirus-based vaccine in an experimental murine tumor model
    • DOI 10.1097/00002371-199911000-00003
    • KAUFMAN HL, RAO JB, IRVINE KR, BRONTE V, ROSENBERG SA, RESTIFO NP: Interleukin-10 enhances the therapeutic effectiveness of a recombinant poxvirus-based vaccine in an experimental murine tumor model. J. Immunother. (1999) 22(6):489-496. (Pubitemid 29526344)
    • (1999) Journal of Immunotherapy , vol.22 , Issue.6 , pp. 489-496
    • Kaufman, H.L.1    Rao, J.B.2    Irivine, K.R.3    Bronte, V.4    Rosenberg, S.A.5    Restifo, N.P.6
  • 27
    • 0025778621 scopus 로고
    • Microscope-based multiparameter laser scanning cytometer yielding data comparable to flow cytometry data
    • KAMENTSKY LA, KAMENTSKY LD: Microscope-based multiparameter laser scanning cytometer yielding data comparable to flow cytometry data. Cytometry (1991) 12:381-387.
    • (1991) Cytometry , vol.12 , pp. 381-387
    • Kamentsky, L.A.1    Kamentsky, L.D.2
  • 28
    • 33746763680 scopus 로고    scopus 로고
    • TGF-β in cancer and as a therapeutic target
    • DOI 10.1016/j.bcp.2006.03.004, PII S0006295206001572
    • PINKAS J, TEICHER BA: TGF-β in cancer and as a therapeutic target. Biochem. Pharmacol. (2006) (In Press). (Pubitemid 44163293)
    • (2006) Biochemical Pharmacology , vol.72 , Issue.5 , pp. 523-529
    • Pinkas, J.1    Teicher, B.A.2
  • 29
    • 0028670939 scopus 로고
    • Paracrine and autocrine regulation of human melanocyte and melanoma cell growth by transforming growth factor beta in vitro
    • KRASAGAKIS K, GARBE C, SCHRIER PI, ORFANOS CE: Paracrine and autocrine regulation of human melanocyte and melanoma cell growth by transforming growth factor beta in vitro. Anticancer Res. (1994) 14:2565-2571.
    • (1994) Anticancer Res. , vol.14 , pp. 2565-2571
    • Krasagakis, K.1    Garbe, C.2    Schrier, P.I.3    Orfanos, C.E.4
  • 30
    • 0028674508 scopus 로고
    • Mechanisms of transforming growth factor-beta 1-induced cell cycle arrest
    • SATTERWHITE DJ, MOSES HL: Mechanisms of transforming growth factor-beta 1-induced cell cycle arrest. Invasion Metastasis (1994) 14:309-318.
    • (1994) Invasion Metastasis , vol.14 , pp. 309-318
    • Satterwhite, D.J.1    Moses, H.L.2
  • 32
    • 0033559577 scopus 로고    scopus 로고
    • Tumorigenicity of mouse thymoma is suppressed by soluble type II transforming growth factor β receptor therapy
    • WON J, KIM H, PARK EJ, HONG Y, KIM SJ, YUN Y: Tumorigenicity of mouse thymoma is suppressed by soluble Type II transforming growth factor beta receptor therapy. Cancer Res. (1999) 59:1273-1277. (Pubitemid 29136258)
    • (1999) Cancer Research , vol.59 , Issue.6 , pp. 1273-1277
    • Won, J.1    Kim, H.2    Park, E.J.3    Hong, Y.4    Kim, S.-J.5    Yun, Y.6
  • 36
    • 0033570029 scopus 로고    scopus 로고
    • The expression of transforming growth factor-β1 is significantly correlated with the expression of vascular endothelial growth factor and poor prognosis of patients with advanced gastric carcinoma
    • DOI 10.1002/(SICI)1097-0142(19991015)86:8<1455::AID-CNCR11>3.0. CO;2-L
    • SAITO H, TSUJITANI S, OKA S et al.: The expression of transforming growth factor-beta1 is significantly correlated with the expression of vascular endothelial growth factor and poor prognosis of patients with advanced gastric carcinoma. Cancer (1999) 86:1455-1462. (Pubitemid 29489778)
    • (1999) Cancer , vol.86 , Issue.8 , pp. 1455-1462
    • Saito, H.1    Tsujitani, S.2    Oka, S.3    Kondo, A.4    Ikeguchi, M.5    Maeta, M.6    Kaibara, N.7
  • 37
    • 0034018521 scopus 로고    scopus 로고
    • Regression of engineered tumor cells secreting cytokines is related to a shift in host cytokine profile from type 2 to type 1
    • DOI 10.1089/107999000312270
    • XIANG J, MOYANA T: Regression of engineered tumor cells secreting cytokines is related to a shift in host cytokine profile from Type 2 to Type 1. J. Interferon Cytokine Res. (2000) 20:349-354. (Pubitemid 30249561)
    • (2000) Journal of Interferon and Cytokine Research , vol.20 , Issue.4 , pp. 349-354
    • Xiang, J.1    Moyana, T.2
  • 39
    • 0034114552 scopus 로고    scopus 로고
    • IL-12- And IL-2-induced tumor regression in a new murine model of oral squamous-cell carcinoma is promoted by expression of the CD80 co-stimulatory molecule and interferon-γ
    • THOMAS GR, CHEN Z, ENAMORADO I, BANCROFT C, VAN WAES C: IL-12- and IL-2-induced tumor regression in a new murine model of oral squamous-cell carcinoma is promoted by expression of the CD80 co-stimulatory molecule and interferon-gamma. Int. J. Cancer (2000) 86:368-374. (Pubitemid 30187498)
    • (2000) International Journal of Cancer , vol.89 , Issue.2 , pp. 368-374
    • Thomas, G.R.1    Chen, Z.2    Enamorado, I.3    Bancroft, C.4    Van Waes, C.5
  • 42
    • 0027459260 scopus 로고
    • Specific release of cytokines by lymphocytes infiltrating human melanomas in response to shared melanoma antigens
    • HOM SS, SCHWARTZENTRUBER DJ, ROSENBERG SA, TOPALIAN SL: Specific release of cytokines by lymphocytes infiltrating human melanomas in response to shared melanoma antigens. J. Immunother. (1993) 13:18-30. (Pubitemid 23011931)
    • (1993) Journal of Immunotherapy , vol.13 , Issue.1 , pp. 18-30
    • Hom, S.S.1    Schwartzentruber, D.J.2    Rosenberg, S.A.3    Topalian, S.L.4
  • 43
  • 44
    • 0030070734 scopus 로고    scopus 로고
    • Eastern Cooperative Group trial of interferon gamma in metastatic melanoma: An innovative study design
    • SCHILLER JH, PUGH M, KIRKWOOD JM, KARP D, LARSON M, BORDEN E: Eastern Cooperative Group trial of interferon gamma in metastatic melanoma: an innovative study design. Clin. Cancer Res. (1996) 2:29-36. (Pubitemid 26042175)
    • (1996) Clinical Cancer Research , vol.2 , Issue.1 , pp. 29-36
    • Schiller, J.H.1    Pugh, M.2    Kirkwood, J.M.3    Karp, D.4    Larson, M.5    Borden, E.6
  • 45
    • 2542497114 scopus 로고    scopus 로고
    • The interleukin (IL)-2 family cytokines: Survival and proliferation signaling pathways in T lymphocytes
    • BENCZIK M, GAFFEN SL: The interleukin (IL)-2 family cytokines: survival and proliferation signaling pathways in T lymphocytes. Immunol. Invest. (2004) 33(2):109-142. (Pubitemid 38685927)
    • (2004) Immunological Investigations , vol.33 , Issue.2 , pp. 109-142
    • Benczik, M.1    Gaffen, S.L.2
  • 46
    • 0028843725 scopus 로고
    • Lack of interleukin-2 (IL-2) expression and selective expression of IL-10 mRNA in human renal cell carcinoma
    • NAKAGOMI H, PISA P, PISA EK et al.: Lack of interleukin-2 (IL-2) expression and selective expression of IL-10 mRNA in human renal cell carcinoma. Int. J. Cancer (1995) 63:366-371.
    • (1995) Int. J. Cancer , vol.63 , pp. 366-371
    • Nakagomi, H.1    Pisa, P.2    Pisa, E.K.3
  • 47
    • 0033814460 scopus 로고    scopus 로고
    • Characterization of intracellular cytokine profile of CD4(+) T cells in peripheral blood and tumor-draining lymph nodes of patients with gastrointestinal cancer
    • NAKAYAMA H, KITAYAMA J, MUTO T, NAGAWA H: Characterization of intracellular cytokine profile of CD4(+) T cells in peripheral blood and tumor-draining lymph nodes of patients with gastrointestinal cancer. Jpn. J. Clin. Oncol. (2000) 30:301-305. (Pubitemid 30752762)
    • (2000) Japanese Journal of Clinical Oncology , vol.30 , Issue.7 , pp. 301-305
    • Nakayama, H.1    Kitayama, J.2    Muto, T.3    Nagawa, H.4
  • 48
    • 0032534768 scopus 로고    scopus 로고
    • Repression of interleukin-2 mRNA translation in primary human breast carcinoma tumor-infiltrating lymphocytes
    • DOI 10.1006/cimm.1998.1390
    • LOPEZ CB, RAO TD, FEINER H, SHAPIRO R, MARKS JR, FREY AB: Repression of interleukin-2 mRNA translation in primary human breast carcinoma tumor-infiltrating lymphocytes. Cell. Immunol. (1998) 190:141-155. (Pubitemid 29011102)
    • (1998) Cellular Immunology , vol.190 , Issue.2 , pp. 141-155
    • Lopez, C.B.1    Rao, T.D.2    Feiner, H.3    Shapiro, R.4    Marks, J.R.5    Frey, A.B.6
  • 49
    • 0033024863 scopus 로고    scopus 로고
    • High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993
    • ATKINS, MB, LOTZE MT, DUTCHER JP et al.: High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993. J. Clin. Oncol. (1999) 17:2105-2116.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 2105-2116
    • Atkins, M.B.1    Lotze, M.T.2    Dutcher, J.P.3
  • 50
    • 0033847587 scopus 로고    scopus 로고
    • Long-term survival update for high-dose recombinant interleukin-2 in patients with renal cell carcinoma
    • FISHER RI, ROSENBERG SA, FYFE G: Long-term survival update for high-dose recombinant interleukin-2 in patients with renal cell carcinoma. Cancer J. Sci. Am. (2000) 6(Suppl. 1):S55-S57. (Pubitemid 30117639)
    • (2000) Cancer Journal from Scientific American , vol.6 , Issue.SUPPL. 1
    • Fisher, R.I.1    Rosenberg, S.A.2    Fyfe, G.3
  • 51
    • 0036669298 scopus 로고    scopus 로고
    • CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rβ-deficient mice: Implications for the nonredundant function of IL-2
    • DOI 10.1016/S1074-7613(02)00367-9
    • MALEK TR, YU A, VINCEK V, SCIBELLI P, KONG L: CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Immunity (2002) 17(2):167-178. (Pubitemid 35245959)
    • (2002) Immunity , vol.17 , Issue.2 , pp. 167-178
    • Malek, T.R.1    Yu, A.2    Vincek, V.3    Scibelli, P.4    Kong, L.5
  • 53
    • 33644784733 scopus 로고    scopus 로고
    • IL-2 administration increases CD4+CD25(hi) Foxp3+ regulatory T cells in cancer patients
    • AHMADZADEH M, ROSENBERG SA: IL-2 administration increases CD4+CD25(hi) Foxp3+ regulatory T cells in cancer patients. Blood (2006) 107(6):2408-2414.
    • (2006) Blood , vol.107 , Issue.6 , pp. 2408-2414
    • Ahmadzadeh, M.1    Rosenberg, S.A.2
  • 54
    • 85031382675 scopus 로고    scopus 로고
    • Characterization of CD4+CD25+ regulatory T cells in patients treated with high-dose interleukin-2 for metastatic melanoma or renal cell carcinoma
    • CESANA GC, DERAFFELE G, COHEN S et al.: Characterization of CD4+CD25+ regulatory T cells in patients treated with high-dose interleukin-2 for metastatic melanoma or renal cell carcinoma. Immunity (2002) 17(2):167-178.
    • (2002) Immunity , vol.17 , Issue.2 , pp. 167-178
    • Cesana, G.C.1    Deraffele, G.2    Cohen, S.3
  • 56
    • 17144376810 scopus 로고    scopus 로고
    • High-mobility group box 1 protein (HMGB1): Nuclear weapon in the immune arsenal
    • A thorough review of HMGB-1
    • LOTZE MT, TRACEY KJ: High-mobility group box 1 protein (HMGB1): Nuclear weapon in the immune arsenal. Nat. Rev. Immunol. (2005) 5:331-642. • A thorough review of HMGB-1.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 331-642
    • Lotze, M.T.1    Tracey, K.J.2
  • 60
    • 3042685214 scopus 로고    scopus 로고
    • S100 proteins as cancer biomarkers with focus on S100B in malignant melanoma
    • DOI 10.1016/j.clinbiochem.2004.05.012, PII S0009912004001353
    • HARPIO R, EINARSSON R: S100 proteins as cancer biomarkers with focus on S100B in malignant melanoma. Clin. Biochem. (2004) 37:512-518. (Pubitemid 38845014)
    • (2004) Clinical Biochemistry , vol.37 , Issue.7 , pp. 512-518
    • Harpio, R.1    Einarsson, R.2
  • 61
    • 27544490285 scopus 로고    scopus 로고
    • Indoleamine 2,3 dioxygenase and regulation of T cell immunity
    • DOI 10.1016/j.bbrc.2005.08.232, PII S0006291X05019649
    • MELLOR A: Indoleamine 2,3 dioxygenase and regulation of T cell immunity. Biochem. Biophys. Res. Commun. (2005) 338(1):20-24. (Pubitemid 41540532)
    • (2005) Biochemical and Biophysical Research Communications , vol.338 , Issue.1 , pp. 20-24
    • Mellor, A.1
  • 63
    • 19344377474 scopus 로고    scopus 로고
    • GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase
    • DOI 10.1016/j.immuni.2005.03.013, PII S1074761305001081
    • MUNN DH, SHARMA MD, BABAN B et al.: GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. Immunity (2005) 22(5):633-642. (Pubitemid 40719198)
    • (2005) Immunity , vol.22 , Issue.5 , pp. 633-642
    • Munn, D.H.1    Sharma, M.D.2    Baban, B.3    Harding, H.P.4    Zhang, Y.5    Ron, D.6    Mellor, A.L.7
  • 66
    • 0034658924 scopus 로고    scopus 로고
    • Activity in human breast cancer cell lines: N(ω)-hydroxy-L-arginine selectively inhibits cell proliferation and induces apoptosis in MDA-MB-468 cells
    • SINGH R, PERVIN S, KARIMI A, CEDERBAUM S, CHAUDHURI G: Arginase activity in human breast cancer cell lines: N(omega)-hydroxy-L- arginine selectively inhibits cell proliferation and induces apoptosis in MDA-MB-468 cells. Cancer Res. (2000) 60:3305-3312. (Pubitemid 30407931)
    • (2000) Cancer Research , vol.60 , Issue.12 , pp. 3305-3312
    • Singh, R.1    Pervin, S.2    Karimi, A.3    Cederbaum, S.4    Chaudhuri, G.5
  • 69
    • 0021952756 scopus 로고
    • Depression of natural killer cytotoxic activity in lymphocytes infiltrating human pulmonary tumors
    • MOY PM, HOLMES EC, GOLUB SH: Depression of natural killer cytotoxic activity in lymphocytes infiltrating human pulmonary tumors. Cancer Res. (1985) 45:54-60. (Pubitemid 15196930)
    • (1985) Cancer Research , vol.45 , Issue.1 , pp. 57-60
    • Moy, P.M.1    Holmes, E.C.2    Golub, S.H.3
  • 71
    • 0024246624 scopus 로고
    • Preferential clonogenic deficit of CD8-positive T-lymphocytes infiltrating human solid tumors
    • MIESCHER S, STOECK M, QIAO L, BARRAS C, BARRELET L, VON FLIEDNER V: preferential clonogenic deficit of CD8+ T lymphocytes infiltrating human solid tumors. Cancer Res. (1988) 48:6992-6998. (Pubitemid 19013970)
    • (1988) Cancer Research , vol.48 , Issue.24 I , pp. 6992-6998
    • Miescher, S.1    Stoeck, M.2    Qiao, L.3    Barras, C.4    Barrelet, L.5    Von Fliedner, V.6
  • 72
    • 0027056895 scopus 로고
    • Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice
    • MIZOGUCHI H, O'SHEA JJ, LONGO DL, LOEFFLER CM, MCVICAR DW, OCHOA AC: Alterations in signal transduction molecules in T lymphocytes from tumor bearing mice. Science (1992) 258:1795-1798. (Pubitemid 23087347)
    • (1992) Science , vol.258 , Issue.5089 , pp. 1795-1798
    • Mizoguchi, H.1    O'Shea, J.J.2    Longo, D.L.3    Loeffler, C.M.4    McVicar, D.W.5    Ochoa, A.C.6
  • 73
    • 0032102258 scopus 로고    scopus 로고
    • Lymphocyte apoptosis induced by Fas ligand-expressing ovarian carcinoma cells: Implications for altered expression of T cell receptor in tumor- Associated lymphocytes
    • RABINOWICH H, REICHERT TE, KASHII Y, GASTMAN BR, BELL MC, WHITESIDE TL: Lymphocyte apoptosis induced by Fas ligand-expressing ovarian carcinoma cells. Implications for altered expression of T cell receptor in tumor-associated lymphocytes. J. Clin. Invest. (1998) 101(11):2579-2588. (Pubitemid 28270452)
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.11 , pp. 2579-2588
    • Rabinowich, H.1    Reichert, T.E.2    Kashii, Y.3    Gastman, B.R.4    Bell, M.C.5    Whiteside, T.L.6
  • 75
    • 0035664885 scopus 로고    scopus 로고
    • Immunoglobulin genes expressed by B-lymphocytes infiltrating cervical carcinomas show evidence of antigen-driven selection
    • DOI 10.1007/s00262-001-0234-6
    • O'BRIEN PM, TSIRIMONAKI E, COOMBER DW, MILLAN DW, DAVIS JA, CAMPO MS: Immunoglobin genes expressed by B-lymphocytes infiltrating cervical carcinomas show evidence of antigen-driven selection. Cancer Immunol. Immunother. (2001) 50:523-532. (Pubitemid 34028285)
    • (2001) Cancer Immunology, Immunotherapy , vol.50 , Issue.10 , pp. 523-532
    • O'Brien, P.M.1    Tsirimonaki, E.2    Coomber, D.W.3    Millan, D.W.4    Davis, J.A.5    Campo, S.M.6
  • 76
    • 0035504918 scopus 로고    scopus 로고
    • Evidence for an antigen-driven humoral immune response in medullary ductal breast cancer
    • CORONELLA JA, TELLEMAN P, KINGSBURY GA, TRUONG TD, HAYS S, JUNGHANS RP: Evidence for an antigen-driven humoral immune response in medullary ductal breast cancer. Cancer Res. (2001) 61:7889-7899. (Pubitemid 33050986)
    • (2001) Cancer Research , vol.61 , Issue.21 , pp. 7889-7899
    • Coronella, J.A.1    Telleman, P.2    Kingsbury, G.A.3    Truong, T.D.4    Hays, S.5    Junghans, R.P.6
  • 79
    • 23044451429 scopus 로고    scopus 로고
    • Maturation requirements for dendritic cells in T cell stimulation leading to tolerance versus immunity
    • DOI 10.1189/jlb.1104664
    • TAN JK, O'NEILL HC: Maturation requirements for dendritic cells in T cell stimulation leading to tolerance versus immunity. J. Leukoc. Biol. (2005) 78(2):319-324. (Pubitemid 41061304)
    • (2005) Journal of Leukocyte Biology , vol.78 , Issue.2 , pp. 319-324
    • Tan, J.K.H.1    O'Neill, H.C.2
  • 80
    • 0035370880 scopus 로고    scopus 로고
    • The number of intratumoral dendritic cells and ζ-chain expression in T cells as prognostic and survival biomarkers in patients with oral carcinoma
    • DOI 10.1002/1097-0142(20010601)91:11<2136::AID-CNCR1242>3.0.CO;2-Q
    • REICHERT TE, SCHEUER C, DAY R, WAGNER W, WHITESIDE TL: The number of intratumoral dendritic cells and ζ-chain expression in T cells as prognostic and survival biomarkers in patients with oral carcinoma. Cancer (2001) 91:2136-2147. (Pubitemid 32476379)
    • (2001) Cancer , vol.91 , Issue.11 , pp. 2136-2147
    • Reichert, T.E.1    Scheuer, C.2    Day, R.3    Wagner, W.4    Whiteside, T.L.5
  • 81
    • 0027529478 scopus 로고
    • Autologous melanoma vaccine induces inflammatory responses in melanoma metastases: Relevance to immunologic regression and immunotherapy
    • MURPHY GF, RADU A, KAMINER M, BERG D: Autologous melanoma vaccine induces inflammatory responses in melanoma metastases: relevance to immunologic regression and immunotherapy. J. Invest. Dermatol. (1993) 100:335S-341S. (Pubitemid 23083194)
    • (1993) Journal of Investigative Dermatology , vol.100 , Issue.3
    • Murphy, G.F.1    Radu, A.2    Kaminer, M.3    Berd, D.4
  • 86
    • 20444475397 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibition: A potential mechanism for increasing the efficacy of bacillus Calmette-Guerin immunotherapy for bladder cancer
    • DOI 10.1097/01.ju.0000161589.85869.ae
    • DOVEDI SJ, KIRBY JA, ATKINS H, DAVIES BR, KELLY JD: Cyclooxygenase-2 inhibition: a potential mechanism for increasing the efficacy of bacillus calmette-guerin immunotherapy for bladder cancer. J. Urol. (2005) 174(1):332-337; discussion 337. (Pubitemid 40825752)
    • (2005) Journal of Urology , vol.174 , Issue.1 , pp. 332-337
    • Dovedi, S.J.1    Kirby, J.A.2    Atkins, H.3    Davies, B.R.4    Kelly, J.D.5
  • 87
    • 16244408626 scopus 로고    scopus 로고
    • Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy
    • DOI 10.1038/nm1196
    • MULLER AJ, DUHADAWAY JB, DONOVER PS et al.: Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy. Nat. Med. (2005) 11:312-319. (Pubitemid 40460560)
    • (2005) Nature Medicine , vol.11 , Issue.3 , pp. 312-319
    • Muller, A.J.1    Duhadaway, J.B.2    Donover, P.S.3    Sutanto-Ward, E.4    Prendergast, G.C.5
  • 88
    • 0034143110 scopus 로고    scopus 로고
    • Tumour-associated macrophages (TAMS): Disordered function, immune suppression and progressive tumour growth
    • AL-SARIREH B, EREMIN O: Tumour-associated macrophages (TAMS): disordered function, immune suppression and progressive tumour growth. J. R. Coll. Surg. Edinb. (2000) 45:1-16. (Pubitemid 35385843)
    • (2000) Journal of the Royal College of Surgeons of Edinburgh , vol.45 , Issue.1 , pp. 1-16
    • Al-Sarireh, B.1    Eremin, O.2
  • 89
    • 0029816609 scopus 로고    scopus 로고
    • Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma
    • LEEK RD, LEWIS CE, WHITEHOUSE R et al.: Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Res. (1996) 56:4625-4629. (Pubitemid 26338061)
    • (1996) Cancer Research , vol.56 , Issue.20 , pp. 4625-4629
    • Leek, R.D.1    Lewis, C.E.2    Whitehouse, R.3    Greenall, M.4    Clarke, J.5    Harris, A.L.6
  • 90
    • 0029811971 scopus 로고    scopus 로고
    • Immunosuppression in human tumor-host interaction: Role of cytokines and alterations in signal-transducing molecules
    • DOI 10.1007/BF00820668
    • KIESSLING R, KONO K, PETERSSON M,WASSERMAN K: Immunosuppression in human tumor-host interaction: role of cytokines and alterations in signaltransducing molecules. Springer Semin. Immunopathol. (1996) 18:227-242. (Pubitemid 26335408)
    • (1996) Springer Seminars in Immunopathology , vol.18 , Issue.2 , pp. 227-242
    • Kiessling, R.1    Kono, K.2    Petersson, M.3    Wasserman, K.4
  • 91
    • 0030039450 scopus 로고    scopus 로고
    • Induction of apoptosis in NK cells by monocyte-derived reactive oxygen metabolites
    • HANSSON M, ASEA A, ERICSSON U, HERMODSSON S, HELLSTRAND K: Induction of apoptosis in NK cells by monocyte-derived reactive oxygen metabolites. J. Immunol. (1996) 156:42-47. (Pubitemid 26006946)
    • (1996) Journal of Immunology , vol.156 , Issue.1 , pp. 42-47
    • Hansson, M.1    Asea, A.2    Ersson, U.3    Hermodsson, S.4    Hellstrand, K.5
  • 93
    • 24044461733 scopus 로고    scopus 로고
    • Macrophage responses to hypoxia: Implications for tumor progression and anti-cancer therapies
    • LEWIS C, MURDOCH C: Macrophage responses to hypoxia, implications for tumor progression and anti-cancer therapies. Am. J. Pathol. (2005) 167(3):627-635. (Pubitemid 41216349)
    • (2005) American Journal of Pathology , vol.167 , Issue.3 , pp. 627-635
    • Lewis, C.1    Murdoch, C.2
  • 94
    • 33748749463 scopus 로고    scopus 로고
    • Tumor-derived CD4(+)CD25 (+) regulatory T cell suppression of dendritic cell function involves TGF-beta and IL-10
    • In Press
    • LARMONIER N, MARRON M, ZENG Y et al.: Tumor-derived CD4(+)CD25 (+) regulatory T cell suppression of dendritic cell function involves TGF-beta and IL-10. Cancer Immunol. Immunother. (2006) (In Press).
    • (2006) Cancer Immunol. Immunother.
    • Larmonier, N.1    Marron, M.2    Zeng, Y.3
  • 95
    • 31344476704 scopus 로고    scopus 로고
    • Immune response to p53 in patients with cancer: Enrichment in tetramer +p53 peptide-specific T cells and regulatory T cells at tumor sites
    • ALBERS AE, FERRIS RL, KIM GG, CHIKAMATSU K, DELEO AB, WHITESIDE TL: Immune response to p53 in patients with cancer: enrichment in tetramer +p53 peptide-specific T cells and regulatory T cells at tumor sites. Cancer Immunol. Immunother. (2005) 62:670-679.
    • (2005) Cancer Immunol. Immunother. , vol.62 , pp. 670-679
    • Albers, A.E.1    Ferris, R.L.2    Kim, G.G.3    Chikamatsu, K.4    Deleo, A.B.5    Whiteside, T.L.6
  • 99
    • 28544452409 scopus 로고    scopus 로고
    • Combination B7-Fc fusion protein treatment and treg cell depletion therapy
    • DOI 10.1158/1078-0432.CCR-05-1411
    • LIU A, HU P, KHAWLI LA, EPSTEIN AL: Combination B7-Fc fusion protein treatment and Treg cell depletion therapy. Clin. Cancer Res. (2005) 11(23):8492-8502. (Pubitemid 41746965)
    • (2005) Clinical Cancer Research , vol.11 , Issue.23 , pp. 8492-8502
    • Liu, A.1    Hu, P.2    Khawli, L.A.3    Epstein, A.L.4
  • 103
    • 0036984640 scopus 로고    scopus 로고
    • Role of angiogenesis in tumor growth and metastasis
    • FOLKMAN J: Role of angiogenesis in tumor growth and metastasis. Semin. Oncol. (2002) 6(Suppl. 16):15-18.
    • (2002) Semin. Oncol. , vol.6 , Issue.SUPPL. 16 , pp. 15-18
    • Folkman, J.1
  • 104
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • DOI 10.1038/nm0603-653
    • CARMELIET P: Angiogenesis in health and disease. Nat. Med. (2003) 9(6):653-660. (Pubitemid 36749213)
    • (2003) Nature Medicine , vol.9 , Issue.6 , pp. 653-660
    • Carmeliet, P.1
  • 105
    • 9244227134 scopus 로고    scopus 로고
    • Stromal fibroblasts in cancer initiation and progression
    • An excellent review of how tumours manipulate the extracellular matrix to support their growth and metastasis, focusing particularly on the role of fibroblasts
    • BHOWMICK NA, NEILSON EG, MOSES HL: Stromal fibroblasts in cancer initiation and progression. Nature (2004) 432(7015):332-337. •• An excellent review of how tumours manipulate the extracellular matrix to support their growth and metastasis, focusing particularly on the role of fibroblasts.
    • (2004) Nature , vol.432 , Issue.7015 , pp. 332-337
    • Bhowmick, N.A.1    Neilson, E.G.2    Moses, H.L.3
  • 106
    • 16844379943 scopus 로고    scopus 로고
    • Hypoxia and anemia: Effects on tumor biology and treatment resistance
    • DOI 10.1016/j.tracli.2004.11.005
    • VAUPEL P, MAYER A: Hypoxia and anemia: effects on tumor biology and treatment resistance. Transfusion Clinique et Biologique (2005) 12(1):5-10. (Pubitemid 40487494)
    • (2005) Transfusion Clinique et Biologique , vol.12 , Issue.1 , pp. 5-10
    • Vaupel, P.1    Mayer, A.2
  • 107
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
    • DOI 10.1038/379088a0
    • GRAEBER TG, OSMANIAN C, JACKS T et al.: Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors. Nature (1996) 379:88-91. • An excellent review of hypoxia and tumour survival. (Pubitemid 26008141)
    • (1996) Nature , vol.379 , Issue.6560 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3    Housman, D.E.4    Koch, C.J.5    Lowe, S.W.6    Giaccia, A.J.7
  • 110
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
    • DOI 10.1038/nm0901-987
    • JAIN RK: Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat. Med. (2001) 7:987-989. (Pubitemid 32937367)
    • (2001) Nature Medicine , vol.7 , Issue.9 , pp. 987-989
    • Jain, R.K.1
  • 111
  • 112
    • 18444398046 scopus 로고    scopus 로고
    • Targeted therapies in the treatment of colorectal cancers
    • ALEKSHUN T, GARRETT C: Targeted therapies in the treatment of colorectal cancers. Cancer Control (2005) 12(2):105-110. (Pubitemid 40647053)
    • (2005) Cancer Control , vol.12 , Issue.2 , pp. 105-110
    • Alekshun, T.1    Garrett, C.2
  • 113
    • 4344643796 scopus 로고    scopus 로고
    • Relevance of tumor microenvironment for progression, therapy and drug development
    • DOI 10.1097/00001813-200401000-00002
    • HENNING T, KRAUS M, BRISCHWEIN M, OTTO AM, WOLF B: Relevance of tumor microenvironment for progression, therapy and drug development. Anticancer Drugs (2004) 15:7-14. (Pubitemid 39140166)
    • (2004) Anti-Cancer Drugs , vol.15 , Issue.1 , pp. 7-14
    • Henning, T.1    Kraus, M.2    Brischwein, M.3    Otto, A.M.4    Wolf, B.5
  • 114
    • 8844224030 scopus 로고    scopus 로고
    • Microenvironmental and cellular consequences of altered blood flow in tumours
    • DOI 10.1259/bjr/12913493, Angiogenesis Imaging
    • RAGHUNAND N, GATENBY RA, GILLIES RJ: Microenvironmental and cellular consequences of altered blood flow in tumours. Br. J. Radiol. (2003) 76:S11-S22. (Pubitemid 39530312)
    • (2003) British Journal of Radiology , vol.76 , Issue.SPEC. ISS. 1
    • Raghunand, N.1    Gatenby, R.A.2    Gillies, R.J.3
  • 115
    • 0033380522 scopus 로고    scopus 로고
    • Alterations in proteolytic activity at low pH and its association with invasion: A theoretical model
    • DOI 10.1023/A:1006667303583
    • WEBB SD, SHERRATT JA, FISH RG: Alterations in proteolytic activity at low pH and its association with invasion: a theoretical model. Clin. Exp. Metas. (1999) 17:397-407. (Pubitemid 30019997)
    • (1999) Clinical and Experimental Metastasis , vol.17 , Issue.5 , pp. 397-407
    • Webb, S.D.1    Sherratt, J.A.2    Fish, R.G.3
  • 116
    • 33745501867 scopus 로고    scopus 로고
    • Manipulating the local tumor microenvironment with poxviruses expressing costimulatory molecules
    • KAUFMAN HL: Manipulating the local tumor microenvironment with poxviruses expressing costimulatory molecules. Ann. NY Acad. Sci. (2005) 1062:41-50.
    • (2005) Ann. NY Acad. Sci. , vol.1062 , pp. 41-50
    • Kaufman, H.L.1
  • 122
    • 1442299843 scopus 로고    scopus 로고
    • Chemokine gene modification of human dendritic cell-based vaccines using a recombinant adenoviral vector
    • TERANDO A, ROESSLER B, MULE JJ: Chemokine gene modification of human dendritic cell-based vaccines using a recombinant adenoviral vector. Cancer Gene Ther. (2001) 11:165-173.
    • (2001) Cancer Gene Ther. , vol.11 , pp. 165-173
    • Terando, A.1    Roessler, B.2    Mule, J.J.3
  • 126
    • 31544455868 scopus 로고    scopus 로고
    • Maximal COX-2 immunostaining and clinical response to celecoxib and interferon alpha therapy in metastatic renal cell carcinoma
    • DOI 10.1002/cncr.21661
    • RINI BI, WEINBERG V, DUNLAP S et al.: Maximal COX-2 immunostaining and clinical response to celecoxib and interferon alpha therapy in metastatic renal cell carcinoma. Cancer (2006) 106(3):566-1375 (Pubitemid 43157619)
    • (2006) Cancer , vol.106 , Issue.3 , pp. 566-575
    • Rini, B.I.1    Weinberg, V.2    Dunlap, S.3    Elchinoff, A.4    Yu, N.5    Bok, R.6    Simko, J.7    Small, E.J.8
  • 130
    • 27444435581 scopus 로고    scopus 로고
    • 389IL-2, ONTAK) to eliminate regulatory T lymphocytes in patients with melanoma
    • ATTIA P, MAKER AV, HAWORTH LR, ROGERS-FREEZER L, ROSENBERG SA: Inability of a fusion protein of IL-2 and diphtheria toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to eliminate regulatory T lymphocytes in patients with melanoma. J. Immunother. (2005) 28(6):582-592. (Pubitemid 41533092)
    • (2005) Journal of Immunotherapy , vol.28 , Issue.6 , pp. 582-592
    • Attia, P.1    Maker, A.V.2    Haworth, L.R.3    Rogers-Freezer, L.4    Rosenberg, S.A.5


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