Immunoglobulin genes expressed by B-lymphocytes infiltrating cervical carcinomas show evidence of antigen-driven selection

Cancer Immunology, Immunotherapy

Volumn 50, Issue 10, 2001, Pages 523-532

  O'Brien, Philippa M ^a,b   Tsirimonaki, Emmanouella ^a,b   Coomber, David W ^b,c   Millan, David W ^b,d   Davis, Jonathon A ^b,e   Campo, Saveria M ^a,b  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^c NINEWELLS HOSPITAL   (United Kingdom)

^d WESTERN INFIRMARY   (United Kingdom)

^e NHS GREATER GLASGOW AND CLYDE   (United Kingdom)

Author keywords

Antibody response; Cervical carcinoma; HPV

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN RECEPTOR;

ANTIBODY DETECTION; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN CELL; LYMPHOCYTIC INFILTRATION; MUTATION RATE; PHAGE DISPLAY; PRIORITY JOURNAL; UTERINE CERVIX CARCINOMA;

ANTIGEN PRESENTATION; ANTIGENS, NEOPLASM; B-LYMPHOCYTES; CARCINOMA, SQUAMOUS CELL; FEMALE; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOCYTES, TUMOR-INFILTRATING; UTERINE CERVICAL NEOPLASMS;

EID: 0035664885     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00262-001-0234-6     Document Type: Article

References (49)

1. Ig gene sequences in the study of clonality
2. Assembly of combinatorial antibody libraries on phage surfaces: The gene III site
3. Monoclonal antibodies from combinatorial libraries
4. + T lymphocytes are recruited to neoplastic cervix
5. Infiltration by immunocompetent cells in early stage invasive carcinoma of the uterine cervix: A prognostic study
6. Human papillomavirus type 16 E6/E7-specific cytotoxic T lymphocytes in women with cervical neoplasia
7. Tumor antigens recognised by T cells
8. Humoral immune response to human papillomavirus infection
9. The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement
10. Lymphocyte-infiltrated FIGO Stage IIB squamous cell carcinoma of the cervix is a prominent factor for disease-free survival
11. Cervical cancer cells induce apoptosis of cytotoxic T lymphocytes
12. The human immunoglobulin VH repertoire
13. Generation of anti-p53 Fab fragments from individuals with colorectal cancer using phage display
14. Normal uterine cervix: Characterization of isolated lymphocyte phenotypes and immunoglobulin secretion
15. The serological response to papillomaviruses
16. T lymphocytes infiltrating advanced grades of cervical neoplasia: CD8-positive cells are recruited to invasion
17. Immunoglobulin-containing plasma cells recruited to cervical neoplasia
18. Infiltration of cervical cancer tissue with human papillomavirus-specific cytotoxic T-lymphocytes
19. Immunology of papillomavirus infection
20. Potential strategies utilized by papilloma-virus to evade host immunity
21. Human immunoglobulin VH and VK repertoire revealed by in situ hybridization
22. Oligoclonal T cells in human cancer
23. + tumor-infiltrating lymphocytes in cervical cancer recognize HLA-DR-restricted peptides provided by human papillomavirus E7
24. The first dose of a Haemophilus influenzae type b conjugate vaccine reactivates memory B cells: Evidence for extensive clonal selection, intraclonal affinity maturation, and multiple isotype switches to IgA2
25. Tumor-infiltrating-B-cell-derived IgG recognizes tumor components in human lung cancer
26. Smoking, diet, pregnancy and oral contraceptive use as risk factors for cervical intra-epithelial neoplasia in relation to human papillomavirus infection
27. Immunoglobulin variable regions usage by B-lymphocytes infiltrating a human breast medullary carcinoma
28. HLA and susceptibility to cervical neoplasia
29. Natural and induced human antibody response to cancer
30. T-cell clonality in immune responses
31. Tumor-bound immunoglobulin in human gynecologic cancers
32. Variable region genes of anti-HIV human monoclonal antibodies: Non-restricted use of the V gene repertoire and extensive somatic mutation
33. Molecular analysis of human immunoglobulin heavy chain variable genes (IgVH) in normal and malignant B cells
34. Human papillomavirus and cancer: The epidemiological evidence
35. Characteristics of human antibody repertoires following active immune responses in vivo
36. Anti-tumor antibody produced by human tumor-infiltrating and peripheral blood B lymphocytes
37. Occasional memory cytotoxic T-cell responses of patients with human papillomavirus type 16-positive cervical lesions against a human leukocyte antigen-A*0201-restricted E7-encoded epitope
38. A recombinant vaccinia virus containing the papilloma E2 protein promotes tumor regression by stimulating macrophage antibody dependent cytotoxicity
39. Analysis of TCR usage in human tumors: A new tool for assessing tumor-specific immune responses
40. Cervical and vulva cancer: Changes in FIGO definitions of staging
41. The relation between the type of immunoreactive cells found in human papillomavirus (HPV) lesions of the uterine cervix and subsequent behaviour of these lesions
42. Fidelity of DNA synthesis by the Thermus aquaticus DNA polymerase
43. Exploitation of the antibody repertoire of cancer patients for the identification of human tumor antigens
44. Immunophenotypes of lymphocytes in prospectively followed up human papillomavirus lesions of the cervix
45. Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities
46. A human monoclonal antimelanoma single-chain Fv antibody derived from tumor-infiltrating lymphocytes
47. Simultaneous detection by consensus multiplex PCR of high- and low-risk and other types of human papilloma virus in clinical samples
48. Molecular pathogenesis of cancer of the cervix and its causation by specific human papillomavirus types
49. PCR amplification of murine immunoglobulin V genes: Strategies for minimization of recombination artefacts