Cellular mechanisms in perinatal hypoxic-ischemic brain injury

Current Pediatric Reviews

Volumn 2, Issue 2, 2006, Pages 131-141

  Hilario, Enrique ^a   Alvarez, Antonia ^a   Alvarez, Francisco J ^b   Gastiasoro, Elena ^b   Valls i Soler, Adolf ^b  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b HOSPITAL DE CRUCES   (Spain)

Author keywords

Brain damage; Excitotoxicity; Hipoxia ischemia; Perinatal asphyxia

Indexed keywords

ADENOSINE TRIPHOSPHATE; AUTACOID; GLUTAMATE RECEPTOR;

BRAIN DAMAGE; BRAIN HYPOXIA; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN MATURATION; BRAIN REGION; CELL ENERGY; CYTOPATHOLOGY; EXCITOTOXICITY; GENETIC TRANSCRIPTION; HUMAN; INFLAMMATION; MORBIDITY; MORTALITY; NONHUMAN; PERINATAL ASPHYXIA; PERINATAL PERIOD; PRIORITY JOURNAL; REVIEW; SURVIVAL TIME; TRANSCRIPTION INITIATION;

EID: 33745852776     PISSN: 15733963     EISSN: None     Source Type: Journal    
DOI: 10.2174/157339606776894667     Document Type: Review

References (94)

1. Vannucci RC, Perlman JM. Interventions for perinatal hypoxic ischemic encephalopathy. Pediatrics 1977; 100: 1004-14.
2. Edwards AD, Azzopardi DV. Perinatal hypoxia-ischemia and brain injury. Pediatric Res 2000; 47: 431-2.
3. Volpe JJ. Hypoxic-ischemic encephalopathy: Clinical aspects. In: Volpe JJ Ed, Neurology of the newborn. Philadelphia, WB Saunders Co. 1995; 314-69.
4. Aboul-Enein F, Rauschka H, Kornek B, et al. Preferential loss of myelin-associated glycoprotein reflects hypoxia-like white matter damage in stroke and inflammatory brain diseases. J Neuropathol Exp Neurol 2003; 62: 25-33.
5. Walton M, Connor B, Lawlor P, et al. Neuronal death and survival in two models of hypoxic-ischemic brain damage. Brain Res Rev 1999; 29: 137-68.
6. McGee JO'D, Isaacson PG, Wright NA. Oxford textbook of pathology. New York, Oxford University Press. 1992.
7. Alvarez A, Goñi de Cerio F, Alvarez FJ, et al. Early cerebral cell damage induced by hypoxic-ischemic injury. In: Antsaklis A Ed, Perinatal medicine. Bologna, Medimond Editore. 2004; 381-5.
8. Hilario E, Rey MC, Goñi de Cerio F, et al. Cerebral blood flow and morphological changes after hypoxic-ischemic injury in preterm lambs. Acta Paediatrica 2005; 94: 903-11.
9. Kinney HC, Armstrong DD. Perinatal neuropathology. In: Graham DI, Lantos PL Eds, Greenfields Neuropathology 6nd edit. London, Arnold. 1997; 537-600.
10. Mandai K, Matsumoto M, Kitagawa K, et al. Ischemic damage and subsequent proliferation of oligodendrocytes in focal cerebral ischemia. Neuroscience 1997; 77: 849-61.
11. Rezaie P, Dean A. Periventricular leukomalacia, inflammation and white matter lesions within the developing nervous system. Neuropathology 2002; 22: 106-32.
12. Pourcyrous M. Cerebral hemodynamic measurements in acute versus chronic asphyxia. Clin Perinatol 1999; 26: 811-28.
13. Grow J, Barks JD. Pathogenesis of hypoxic-ischemic cerebral injury in the term infant: current concepts. Clin Perinatol 2002; 29: 585-602.
14. Johnston MV, Trescher WH, Ishida A, Nakajima W. Neurobiology of hypoxic-ischemic injury in the developing brain. Pediatric Res 2001; 49: 735-41.
15. Farooqui AA, Horrocks LA. Excitatory amino acid receptors, neural membrane phospholipid metabolism and neurological disorders. Brain Res Brain Res Rev 1991; 16: 171-91.
16. Hack N, Balazs R. Selective stimulation of excitatory amino acid receptor subtypes and the survival of granule cells in culture: effect of quisqualate and AMPA. Neurochem Int 1994; 25: 235-41.
17. Chong ZZ, kang JQ, Maiese K. Metabotropic glutamate receptors promote neuronal and vascular plasticity through novel intracellular pathways. Histol Histopathol 2003; 18: 173-89.
18. Olney JW. New mechanisms of excitatory transmitter neurotoxicity. J Neural Transm Suppl 1994; 43: 47-51.
19. Lynch DR, Guttmann RP. Excitotoxicity: perspectives based on N-methyl-D-aspartate receptor subtypes. J Pharmacol Exp Ther 2002; 300: 717-23.
20. Auer RN. Excitotoxic mechanisms, and age-related susceptibility to brain damage in ischemia, hypoglycemia and toxic mussel poisoning. Neurotoxicology 1991; 12: 541-6.
21. Takai H, Katayama K, Yasoshima A, Uetsuka K, Nakayama H, Doi K. NMDA-induced apoptosis in the developing rat brain. Exp Toxicol Pathol 2003; 55: 33-7.
22. Sugawara T, Fujimura M, Noshita N, et al. Neuronal death/survival signaling pathways in cerebral ischemia. NeuroRx 2004; 1: 17-25.
23. + transport. J Neurosci 1992; 12: 840-53.
24. Ballesteros JR, Mishra OP, McGowan JE. Alterations in cerebral mitochondria during acute hypoglycemia. Biol Neonate 2003; 84: 159-63.
25. Davis M, Whitely T, Turnbull DM, Mendelow AD. Selective impairments of mitochondrial respiratory chain activity during aging and ischemic brain damage. Acta Neurochir 1997; 70: 56-8.
26. Eguchi Y, Shimizu S, Tsujimoto Y. Intracellular ATP levels determine cell death fate by apoptosis or necrosis. Cancer Res 1997; 57: 1835-40.
27. Almeida A, Bolaños JP. A transient inhibition of mitochondrial ATP synthesis by nitric oxide synthase activation triggered apoptosis in primary cortical neurons. J Neurochem 2001; 77: 676-90.
28. Delgado-Esteban M, Almeida A, Bolaños JP. D-glucose prevents glutathione oxidation and mitochondrial damage after glutamate receptor stimulation in rat cortical primary neurons. J Neurochem 2000; 75: 1618-24.
29. Buonocore G, Perrone S, Bracci R. Free radicals and brain damage in the newborn. Biol Neonate 2001; 79: 180-6.
30. Suzuki M, Tabuchi M, Ikeda M, Tomita T. Concurrent formation of peroxynitrite with the expression of inducible nitric oxide synthase in the brain during middle cerebral artery occlusion and reperfusion in rats. Brain Res 2002; 951: 113-20.
31. Chan PH. Oxygen radicals in focal cerebral ischemia. Brain Res 1994; 4: 59-65.
32. Wei YH, Lu CY, Lee HC. Pang CY, Ma YS. Oxidative damage and mutation to mitochondrial DNA and age-dependent decline of mitochondrial respiratory function. Ann NY Acad Sci 1998; 854: 155-70.
33. 2) in neuronal injury induced by deprivation of oxygen and glucose in vitro. Acta Neurochir Suppl 1994; 60: 94-7.
34. Yamamoto Y, Henrich M, Snipes RL, Kummer W. Altered production of nitric oxide and reactive oxygen species in rat nodose ganglion neurons during acute hypoxia. Brain Res 2003; 961: 1-9.
35. Almeida A, Delgado-Esteban M, Bolaños JP, Medina JM. Oxygen and glucose deprivation induces mitochondrial dysfunction and oxidative stress in neurones but not in astrocytes in primary culture. J Neurochem 2002; 81: 207-17.
36. Wang JY, Shum AYC, Wang JY. Hypoxia/reoxygenation induces cell injury via different mechanisms in cultured rat cortical neurons and glial cells. Neurosci Lett 2002; 322: 187-91.
37. Garthwaite J, Charles SL, Chess-Williams R. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests a role as intercellular messenger in the brain. Nature 1988; 336: 385-7.
38. Fernández AP, Alonso D, Lisazoain I, et al. Postnatal changes in the nitric oxide system of the rat cerebral cortex after hypoxia during delivery. Brain Res Dev Brain Res 2003; 142: 177-92.
39. Knowles RG, Moncada S. Nitric oxide synthases in mammals. Biochem J 1994; 298: 249-58.
40. Ghafourifar P, Richter C. Nitric oxide synthase activity in mitochondria. FEBS Lett 1997; 418: 291-6.
41. Giulivi C, Poderoso JJ, Boveris A. Production of nitric oxide by mitochondria. J Biol Chem 1998; 273: 11038-43.
42. Giulivi C. Characterization and function of mitochondrial nitric-oxide synthase. Free Radic Biol Med 2003; 34: 397-408.
43. Elfering SL, Sarkela TM, Giulivi C. Biochemistry of mitochondrial nitric-oxide synthase. J Biol Chem 2002; 277: 38079-86.
44. Alvarez S, Valdez LB, Zaobornyj T, Boveris A. Oxygen dependence of mitochondrial nitric oxide synthase activity. Biochem Biophys Res Commun 2003; 305: 771-5.
45. Bolaños JP, Almeida A. Roles of nitric oxide in brain hypoxia-ischemia. Biochim Biophys Acta 1999; 1411: 415-36.
46. Kiedrowski L, Costa E, Wroblewski JT. Glutamate receptor agonists stimulate nitric oxide synthase in primary cultures of cerebellar granule cells. J Neurochem 1992; 58: 335-41.
47. Bolaños JP, Almeida A, Medina JM. Nitric oxide mediates brain mitochondrial damage during perinatal anoxia. Brain Res 1998; 787: 117-22.
48. Beckman JS, Viera L, Estévez AG, Teng R. Nitric oxide and peroxynitrite in the perinatal period. Semin Perinatol 2000; 24: 37-41.
49. Keynes RG, Garthwaite J. Nitric oxide and its role in ischaemic brain injury. Curr Mol Med 2004; 4: 179-91.
50. Lipton SA, Nicotera P. Calcium, free radicals and excitotoxins in neuronal apoptosis. Cell Calcium 1998; 23: 165-71.
51. Nakata M, Anno K, Sugino N, Matsumori LT, Nakamura Y, Kato H. Effect of intrauterine ischemia-hypoxia on endothelial nitric oxide synthase in fetal brain in rats. Biol Neonate 2002; 82: 117-21.
52. Melino G, Bernassola F, Catani MV, et al. Nitric oxide inhibits apoptosis via AP-1-dependent CD95L transactivation. Cancer Res 2000; 60; 2377-83.
53. Peeters-Scholte C, Koster J, Veldhuis W, et al. Neuroprotection by selective nitric oxide synthase inhibition at 24 hours after perinatal hypoxia-ischemia. Stroke 2002; 33: 2304-10.
54. Mills LR. The sodium-calcium exchanger and glutamate-induced calcium loads in aged hippocampal neurons in vitro. Ann NY Acad Sci 1996; 15; 379-90.
55. Siao CJ, Tsirka SE. Extracellular proteases and neuronal cell death. Cell Mol Biol 2002; 48: 151-61.
56. Paschen W, Doutheil J. Disturbance of endoplasmic reticulum functions: a key mechanism underlying cell damage?. Acta Neurochir Suppl 1999; 73: 1-5.
57. ++-influx in neuronal nuclei and cortical synaptosomes of normoxic and hypoxic newborn piglets. Neurosci Lett 2002; 318: 93-7.
58. Sugrue MM, Wang Y, Rideout HJ, Chalmers-Redman RM, Tanon WG. Reduced mitochondrial membranes potential and altered responsiveness of a mitochondrial membrane megachannel in p-53-induced senescence. Biochem Biophys Commun 1999; 261: 123-30.
59. Cassarino DS, Bennett JP Jr. An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration. Brain Res Brain Res Rev 1999; 29: 1-25.
60. Jacotot E, Costantini P, Laboureau E, Zamzami N, Susin SA, Kroemer G. Mitochondrial membrane permeabilization during the apoptotic process. Ann NY Acad Sci 1999; 887: 18-30.
61. Siesjö BK, Hu B, Kristian T. Is the cell death pathway triggered by the mitochondrion or the endoplasmic reticulum? J Cereb Blood Flow Metab 1999; 19: 19-26.
62. Maslinska D, Laure-Kamionowska M, Kaliszek A, Makarewicz D. Proinflammatory cytokines in injured rat brain following perinatal asphyxia. Folia Neuropathol 2002; 40: 177-82.
63. Chiesa C, Pellegrini G, Panero A, et al. Umbilical cord interleukin-6 levels are elevated in term neonates with perinatal asphyxia. Eur J Clin Invest 2003; 33: 352-8.
64. Veldhuis WB, Floris S, van der Meide PH, et al. Interferon-beta prevents cytokine-induced neutrophil infiltration and attenuates blood-brain barrier disruption. J Cereb Blood Flow Metab 2003; 23: 1060-9.
65. Love S. Oxidative stress in brain ischemia. Brain Pathol 1999; 9: 119-31.
66. Park SY, Lee H, Hur J, et al. Hypoxia induces nitric oxide production in mouse microglia via p38 mitogen-activated protein kinase pathway. Brain Res Mol Brain Res 2002; 107: 9-16.
67. Gehrmann J, Banati RB, Wiessner C, Hossmann KA, Kreutzberg GW. Reactive microglia in cerebral ischemia: an early mediator of tissue damage?. Neuropathol Appl Neurobiol 1995; 21: 277-89.
68. Kato H, Walz W. The initiation of the microglial response. Brain Pathol 2000; 10: 137-43.
69. Abbott NJ. Inflammatory mediators and modulation of blood-brain barrier permeability. Cell Mol Neurobiol 2000; 20: 131-47.
70. Stanimirovic D, Satoh K. Inflammatory mediators of cerebral endothelium: a role in ischemic brain inflammation. Brain Pathol 2000; 10: 113-26.
71. Stoll G, Jander S, Schroeter M. Inflammation and glial responses in ischemic brain lesions. Prog Neurobiol 1998; 56: 149-71.
72. Fedoroff S, Berezovskaya O, Maysinger D. Role of colony stimulating factor-1 in brain damage caused by ischemia. Neurosci Biobehav Rev 1997; 21: 187-91.
73. Vincent VAM, Robinson CC, Simsek D, Murphy GM. Macrophage colony stimulating factor prevents NMDA-induced neuronal death in hippocampal organotypic cultures. J Neurochem 2002; 82: 1388-97.
74. Flanders KC, Ren RF, Lippa CF. Transforming growth factor-beta in neurodegenerative disease. Prog Neurobiol 1998; 54: 71-85.
75. 2 tension. Proc Natl Acad Sci USA 1995; 92: 5510-4.
76. Jiang Y, Wu J, Keep RF, Hua Y, Hoff JT, Xi G. Hypoxia-inducible factor-1alpha accumulation in the brain after experimental intracerebral hemorrhage. J Cereb Blood Flow Metab 2002; 22: 689-96.
77. Kumral A, Ozer E, Yilmaz O, et al. Neuroprotective effect of erythropoietin on hypoxic-ischemic brain injury in neonatal rats. Biol Neonate 2003; 83: 224-8.
78. Fusco M, Vantini G, Schiavo N, et al. Gangliosides and neurotrophic factors in neurodegenerative diseases: from experimental findings to clinical perspectives. Ann NY Acad Sci 1993; 695: 314-7.
79. Puka-Sundvall M, Wallin C, Gilland E, et al. Impairment of mitochondrial respiration after cerebral hypoxia-ischemia in immature rats: relationship to activation of caspase-3 and neuronal injury. Dev Brain Res 2000; 125: 43-50.
80. Hu BR, Liu CL, Ouyang Y, Blomgren K, Siesjö BK. Involvement of caspase-3 in cell death after hypoxia-ischemia declines during brain maturation. J Cereb Blood Flow Metab 2000; 20: 1294-300.
81. Ankarcrona M. Glutamate induced cell death: apoptosis or necrosis?. Prog Brain Res 1998; 116: 265-72.
82. Green DR, Reed JC. Mitochondria and apoptosis. Science 1998; 281: 1309-12.
83. Halestrap AP, Doran E, Gillespie JP, O'Toole A. Mitochondria and cell death. Biochem Soc Trans 2000; 28; 170-7.
84. Shi Y. A structural view of mitochondria-mediated apoptosis. Nat Struct Biol 2001; 8: 394-401.
85. Lacza Z, Puskar M, Figueroa JP, Zhang J, Rajapakse N, Busija DW. Mitochondrial nitric oxide synthase is constitutively active and is functionally upregulated in hypoxia. Free Radic Biol Med 2001; 31: 1609-15.
86. L. Cell 1996; 87: 619-28.
87. Ghafourifar P, Schenk U, Klein SD, Richter C. Mitochondrial nitric-oxide synthase stimulation causes cytochrome C release from isolated mitochondria. Evidence for intramitochondrial peroxynitrite formation. J Biol Chem. 1999; 274: 31185-8.
88. Ghafourifar P, Bringold U, Klein SD, Richter C. Mitochondrial nitric oxide synthase, oxidative stress and apoptosis. Biol Signals Recept 2001; 10: 57-65.
89. Dennis J, Bennett JP Jr. Interactions among nitric oxide and Bcl-family proteins after MPP+ exposure of SH-SY5Y neural cells I: MPP+ increases mitochondrial NO and Bax protein. J Neurosci Res 2003; 72: 76-88.
90. Yin XM, Luo Y, Cao G, et al. Bid-mediated mitochondrial pathway is critical to ischemic neuronal apoptosis and focal cerebral ischemia. J Biol Chem 2002; 277: 42074-81.
91. Crompton M. The mitochondrial permeability transition pore and its role in cell death. Biochem J 1999; 341: 233-49.
92. Kluck RM, Martin SJ, Hoffman BM, Zhou JS, Green DR, 1Newmeyer DD. Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system. EMBO J 1997; 16: 4639-49.
93. Parikh NA, Katsetos CD, Ashraf QM, et al. Hypoxia-induced caspase-3 activation and DNA fragmentation in cortical neurons of newborn piglets: role of nitric oxide. Neurochem Res 2003; 28: 1351-7.
94. Ko HS, Uehara T, Nomura Y. Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death. J Biol Chem 2002; 277: 35386-92.