Impairment of mitochondrial respiration after cerebral hypoxia-ischemia in immature rats: Relationship to activation of caspase-3 and neuronal injury

Developmental Brain Research

Volumn 125, Issue 1-2, 2000, Pages 43-50

  Puka Sundvall, M ^a   Wallin, Camilla ^a   Gilland, E ^a   Hallin, U ^a   Wang, X ^a   Sandberg, Mats ^a   Karlsson, Jan Olof ^a   Blomgren, K ^a   Hagberg, H ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Brain damage; Caspase 3; Cerebral; Hypoxia ischemia; Mitochondria; Neonatal; Rat

Indexed keywords

CASPASE 3; MICROTUBULE ASSOCIATED PROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN MITOCHONDRION; CONTROLLED STUDY; ENZYME ACTIVATION; MITOCHONDRIAL RESPIRATION; NERVE CELL LESION; NEWBORN; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ANIMALS, NEWBORN; ANTIBODY SPECIFICITY; BLOTTING, WESTERN; CASPASE 3; CASPASES; CELL RESPIRATION; CEREBRAL CORTEX; ENZYME ACTIVATION; FEMALE; HYPOXIA-ISCHEMIA, BRAIN; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; NEURONS; RATS; RATS, INBRED WF;

EID: 0034731336     PISSN: 01653806     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-3806(00)00111-5     Document Type: Article

References (50)

1. Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain
2. Prognosis of newborn infants with hypoxic-ischemic brain injury assessed by phosphorus magnetic resonance spectroscopy
3. Excitatory amino acids contribute to the pathogenesis of perinatal hypoxic-ischemic brain injury
4. Light and electronmicroscopic studies of the distribution of microtubule-associated protein 2 in the rat brain: A difference between dendritic and axonal cytoskeletons
5. Relation between delayed impairment of cerebral energy metabolism and infarction following transient focal hypoxia-ischaemia in the developing rat brain
6. Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury
7. The mitochondrial permeability transition pore and its role in cell death
8. Apoptosis in perinatal hypoxic-ischaemic cerebral damage
9. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
10. Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family
11. Differences in the activation of the mitochondrial permeability transition among brain regions in the rat correlate with selective vulnerability
12. Temporal changes of regional glucose use, blood flow, and microtubule-associated protein 2 immunostaining after hypoxia-ischemia in the immature rat brain
13. NMDA Receptor-dependent increase of cerebral glucose utilization after hypoxia-ischemia in the immature rat
14. Mitochondrial function and energy metabolism after hypoxia-ischemia in the immature rat brain: Involvement of NMDA-receptors
15. Molecular characterization of microtubule-associated proteins tau and MAP2
16. Mitochondria and apoptosis
17. Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion
18. Hypoxia-ischemia in the neonatal rat brain: Histopathology after post-treatment with NMDA and non-NMDA receptor antagonists
19. Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage
20. Mitochondrial response to transient forebrain ischemia and recirculation in the rat
21. Perinatal brain damage, excitatory amino acids and oxygen derived free radicals
22. Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system
23. Regional alterations of ATP and heat-shock protein-72 mRNA following hypoxia-ischemia in neonatal rat brain
24. The mitochondrial death/life regulator in apoptosis and necrosis
25. Secondary bioenergetic failure after transient focal ischaemia is due to mitochondrial injury
26. Mitochondrial respiration during recirculation after prolonged ischemia in cat brain
27. An ICE inhibitor, z-VAD-DCB attenuates ischaemic brain damage in the rat
28. Delayed ('secondary') cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: Continuous 48-hour studies by phosphorus magnetic resonance spectroscopy
29. Protein measurement with the folin phenol reagent
30. Hypoxic-ischemic injury acutely disrupts microtubule-associated protein 2 immunostaining in neonatal rat brain
31. Microglia activation after neonatal hypoxic-ischemia
32. Acute disruption of cytochrome oxidase activity in brain in a perinatal rat stroke model
33. Carbohydrate and energy metabolism during the evolution of hypoxic-ischemic brain damage in the immature rat
34. Subcellular distribution of calcium and ultrastructural changes after hypoxia-ischemia in immature rats
35. Recovery of brain mitochondrial function in the rat after complete and incomplete cerebral ischemia
36. The influence of immaturity on hypoxic-ischemic brain damage in the rat
37. 2 metabolism after asphyxia in neonatal lambs
38. Mitochondrial function after asphyxia in newborn lambs
39. Selective impairment of respiration in mitochondria isolated from brain subregions following transient forebrain ischemia in the rat
40. Expression of classical mitochondrial respiratory responses in homogenates of rat forebrain
41. Altered mitochondrial respiration in selectively vulnerable brain subregions following transient forebrain ischemia in the rat
42. Brain damage due to cerebral hypoxia/ischemia in the neonate: Pathology and pharmacological modification
43. Delayed decreases in specific brain mitochondrial electron transfer complex activities and cytochrome concentrations following anoxia/ischemia
44. Columnar alterations of NADH fluorescence during hypoxia-ischemia in immature rat brain
45. An absolute method for protein determination based on difference in absorbance at 235 and 280 nm
46. Cerebral energy metabolism during hypoxia-ischemia and early recovery in immature rats
47. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
48. Selective reductions in the activity of the pyruvate dehydrogenase complex in mitochondria isolated from brain subregions following forebrain ischemia in rats
49. Correlation between caspase-3 activation and three different markers of DNA damage in neonatal cerebral hypoxia-ischemia
50. Involvement of caspase-3 in cell death after hypoxemia-ischemia declines during brain maturation