Cerebral blood flow and morphological changes after hypoxic-ischaemic injury in preterm lambs

Acta Paediatrica, International Journal of Paediatrics

Volumn 94, Issue 7, 2005, Pages 903-911

  Hilario, Enrique ^a   Rey Santano, Mari Carmen ^b   Goñi De Cerio, Felipe ^a   Alvarez, Francisco Jose ^b   Gastiasoro, Elena ^b   Mielgo, Victoria Eugenia ^b   Caballero, Amale ^a   Valls I Soler, Adolfo ^a   Gómez Urquijo, Sonia ^a   Alvarez, Antonia ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b HOSPITAL DE CRUCES   (Spain)

Author keywords

Apoptosis; Brain damage; Cell death; Cellular lesion; Perinatal asphyxia

Indexed keywords

MICROSPHERE;

ACIDOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN INJURY; CEREBELLUM; CEREBELLUM NUCLEUS; CONTROLLED STUDY; ELECTRON MICROSCOPY; FETUS; GAS EXCHANGE; HYPOXIA; ISCHEMIA; LAMB; MESENCEPHALON; MICROSCOPY; NERVE CELL NECROSIS; NICK END LABELING; NONHUMAN; OLIGODENDROGLIA; OLIVARY NUCLEUS; PERINATAL ASPHYXIA; PH; PONS; PREMATURITY; PRIORITY JOURNAL; UMBILICAL CORD;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CEREBROVASCULAR CIRCULATION; DNA FRAGMENTATION; HYPOXIA-ISCHEMIA, BRAIN; IN SITU NICK-END LABELING; PULMONARY GAS EXCHANGE; SHEEP;

EID: 22944442937     PISSN: 08035253     EISSN: None     Source Type: Journal    
DOI: 10.1080/08035250510031151     Document Type: Article

References (28)

1. Johnston MV, Trescher WH, Ishida A, Nakajima W. Neurobiology of hypoxic ischemic injury in the developing brain. Pedriatr Res 2001;49:735-41.
2. Vannucci RC, Perlman JM. Interventions for perinatal hypoxic ischemic encephalopathy. Pediatrics 1977;100:1004-14.
3. Terzidou V, Bennett P. Maternal risk factors for the fetal and neonatal brain damage. Biol Neonate 2001;79:157-62.
4. Walton M, Connor B, Lawlor P, Young D, Sirimanne E, Gluckman P, et al. Neuronal death and survival in two models of hypoxic-ischemic brain damage. Brain Res Rev 1999;29:137-68.
5. Almeida A, Bolaños JP. A transient inhibition of mitochondrial ATP synthesis by nitric oxide synthase activation triggered apoptosis in primary cortical neurons. J Neurochem 2001;77:676-90.
6. Jassem W, Fuggle SV, Rela M, Koo DDH, Heaton ND. The role of mitochondria in ischemia/reperfusion injury. Transplantation 2002;73:493-9.
7. Szymonowicz W, Walker AM, Cussen L, Cannata J, Yu VY. Developmental changes in regional cerebral blood flow in fetal and newborn lambs. Am J Physiol 1988;254:H52-8.
8. Ikeda T, Murata Y, Quilligan EJ, Choi BH, Parer JT, Doi S, et al. Physiologic and histologic changes in near-term fetal lambs exposed to asphyxia by partial umbilical cord occlusion. Am J Obstet Gynecol 1998;178:24-32.
9. de Haan HH, Van Reempts JLH, Vles JSH, de Haan J, Hasaart THM. Effects of asphyxia on the fetal lamb brain. Am J Obstet Gynecol 1993;169:1493-501.
10. Mallard EC, Williams CE, Johnston BM, Gluckman PD. Increased vulnerability to neuronal damage after umbilical cord occlusion in fetal sheep with advancing gestation. Am J Obstet Gynecol 1994;170:206-14.
11. de Haan HH, Gunn AJ, Williams CE, Gluckman PD. Brief repeated umbilical cord occlusions cause sustained cytotoxic cerebral edema and focal infarcts in near-term fetal lambs. Pediatr Res 1997;41:96-104.
12. Marumo G, Kozuma S, Ohyu J, Hamai Y, Machida Y, Kobayashi K, et al. Generation of periventricular leukomalacia by repeated umbilical cord occlusion in near-term fetal sheep and its possible pathogenetical mechanisms. Biol Neonate 2001;79:39-45.
13. Raju TNK. Some animal models for the study of perinatal asphyxia. Biol Neonate 1992;62:202-14.
14. 2 uptake. In: Cabero L, Carrera JM, editors. The perinatal medicine in the new milenium. Bologna: Monduzzi Editore; 2002.
15. Heymann MA, Payne BD, Hoffman JI, Rudolf AM. Blood flow measurements with radionuclide-labeled particles. Progr Cardiovasc Dis 1977;20:55-78.
16. Van Reempts JLH. The hypoxic brain: histological and ultrastructural aspects. Behav Brain Res 1984;14:99-108.
17. Gravieli Y, Sherman Y, Ben S. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992;119:493-501.
18. Wyllie H, Duvall E. Cell injury and death. In: McGee JOD, Isaacson PG, Wright NA, editors. Oxford textbook of pathology. New York: Oxford University Press; 1992.
19. Rezaie P, Dean A. Periventricular leukomalacia, inflammation and white matter lesions within the developing nervous system. Neuropathology 2002;22:106-32.
20. Back SA, Luo NL, Borenstein N-S, Levine JM, Volpe JJ, Kinney HC. Late oligodendrocyte progenitors coincide with the developmental window of vulnerability for human perinatal white matter injury. J Neurosci 2001;21:1302-12.
21. Eguchi Y, Shimizu S, Tsujimoto Y. Intracellular ATP levels determine cell death fate by apoptosis or necrosis. Cancer Res 1997;57:1835-40.
22. Delgado-Esteban M, Almeida A, Bolaños JP. D-glucose prevents glutathione oxidation and mitochondrial damage after glutamate receptor stimulation in rat cortical primary neurons. J Neurochem 2000;75:1618-24.
23. 2 metabolism after asphyxia in neonatal lambs. Pediatr Res 1986;20:778-82.
24. Szymonowicz W, Walker AM, Yu VYH, Stewart ML, Cannata J, Cussen L. Regional cerebral blood flow after hemorrhagic hypotension in the preterm, near-term, and newborn lamb. Pediatr Res 1990;28:361-6.
25. Kjellmer I, Karlsson K, Olsson T, Rosen KG. Cerebral reactions during intrauterine asphyxia in the sheep. I. Circulation and oxygen consumption in the fetal brain. Pediatr Res 1974;8:50-7.
26. Whittelaw A, Karlson BR, Haaland K, Dahlin I, Steen PA, Thoresen M. Hypocapnia and cerebral ischaemia in hypotensive newborn piglets. Arch Dis Child 1991;66:1110-4.
27. Lou HC, Lassen NA, Tweed WA, Johnson G, Jones M, Palahniuk F. Pressure passive cerebral blood flow and breakdown of the blood-brain barrier in experimental fetal asphyxia. Acta Paediatr Scand 1979;68:57-63.
28. Palmer C, Brucklacher RM, Christensen MA, Vannucci RC. Carbohydrate and energy metabolism during the evolution of hypoxic-ischemic brain damage in the immature rat. J Cereb Blood Flow Metab 1990;10:227-35.