The sodium-calcium exchanger and glutamate-induced calcium loads in aged hippocampal neurons in vitro

Annals of the New York Academy of Sciences

Volumn 779, Issue , 1996, Pages 379-390

  Mills, L R ^a  

^a TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; SODIUM ION;

AGED; ANIMAL CELL; CALCIUM HOMEOSTASIS; CONFERENCE PAPER; HIPPOCAMPUS; NERVE CELL; NONHUMAN; RAT; SODIUM CALCIUM EXCHANGE;

ANIMALIA;

EID: 0029882302     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb44809.x     Document Type: Conference Paper

References (39)

1. KHACHATURIAN, Z. 1984. Towards theories of brain aging. In Handbook of Studies in Old Age. D. W. Kay & G. D. Burrows, Eds. 7-30. Elsevier. New York.
2. GIBSON, G. E. & C. PETERSON. 1987. Calcium and the aging nervous system. In Neurobiology of Aging. Vol. 8. Pergamon Press.
3. KHACHATURIAN, Z. S. 1994. The calcium hypothesis revisited. Ann. N. Y. Acad. Sci. 747: 1-13.
4. BADING, H., D. D. GINTY & M. E. GREENBERG. 1993. Regulation of gene expression in hippocampal neurons by distinct calcium signalling pathways. Science 260: 181-186.
5. LLINÁS, R. & M. SUGIMORI. 1979. Calcium conductances in Purkinje cell dendrites: their role in development and integration. Prog. Brain Res. 51: 323-334.
6. KATZ, B. 1969. The Release of Neural Transmitter Substances. Liverpool University Press. Liverpool, England.
7. 2+ signalling takes the local route. Curr. Opin. Neurobiol. 2: 302-307.
8. KOMURA, H. & P. RAKIC. 1992. Selective role of N-type calcium channels in neuronal migration. Science 257: 806-809.
9. KATER, S. B. & L. R. MILLS. 1991. Regulation of growth cone behaviour by calcium. J. Neurosci. 11(4): 891-899.
10. LANKFORD, K. & P. C. LETOURNEAU. 1987. Evidence that calcium may control neurite outgrowth by regulating the stability of actin filaments. J. Cell Biol. 109: 1229.
11. SCHANNE, F. A. X., A. B. KANE, E. E. YOUNG & J. L. FARBER. 1979. Calcium dependence of toxic cell death. Science 206: 700-702.
12. BONDY, S. C. & H. KOMULAINEN. 1988. Intracellular calcium as an index of neurotoxic damage. Toxicology 49: 35-49.
13. CHOI, D. W. 1988. Glutamate toxicity and diseases of the nervous system. Neuron 1: 623-634.
14. ROTH, G. S. 1989. Calcium homeostasis and aging: role in altered signal transduction. Ann. N. Y. Acad. Sci. 658: 68.
15. KATER, S. B., M. P. MATTSON & P. B. GUTHRIE. 1990. Calcium-induced neuronal degeneration: a normal growth cone regulating signal gone awry (?). Ann. N. Y. Acad. Sci. 568: 252-261.
16. MILLS, L. R. 1991. Neuron-specific and state-specific differences in calcium regulation: their role in the development of neuronal architecture. Ann. N. Y. Acad. Sci. 639: 312.
17. +-dependence after hyperpolarizations in hippocampal neurons of aged rat. Science 226: 1092.
18. MICHAELIS, M. L. 1989. Calcium handling systems and neuronal aging. Ann. N. Y. Acad. Sci. 658: 89-94.
19. MICHAELIS, M. L. 1994. Ion transport systems and calcium regulation in aging neurons. Ann. N. Y. Acad. Sci. 747: 407-418.
20. 2+ exchange activity in human brain: the effect of normal aging. Neurobiol. Aging 14: 373-381.
21. SHIGENAGA, M. K., T. M. HAGEN & B. N. AMES. 1994. Oxidative damage and mitochondrial decay in aging. Proc. Natl. Acad. Sci. USA 91: 10771-10778.
22. VITORICA, J. & J. SATRUSTEGUI. 1986. Involvement of mitochondria in the age-dependent decrease in calcium uptake of rat brain synaptosomes. Brain Res. 378: 36-48.
23. IACOPINO, A.M. & S. CHRISTAKOS. 1990. Specific reduction of calcium-binding protein gene expression in aging and neurodegenerative diseases. Proc. Natl. Acad. Sci. USA 87: 4078.
24. SMITH, D. O. 1987. Non-uniform changes in nerve-terminal calcium homeostasis during aging. Neurobiol. Aging 8: 366.
25. ZEE, C. E., VAN DER SCHURRMANN & W. H. GISPEN. 1990. Beneficial effects of nimodipine on peripheral nerve function in aged rats. Neurobiol. Aging 11: 541.
26. MILLS, L. R., F-H. MANG & C. TANG. 1995. Calcium regulation in cultured hippocampal neurons from aged rats. Neurobiol. Aging. Submitted.
27. MILLS, L. R. & M. FRANTSEVA. 1995. Neuronal and glial development in organotypic cultures of spinal cord and hippocampus from adult and aged rats. J. Neurosci. Res. Methods. Submitted.
28. CARAFOLI, E. 1987. Intracellular calcium homeostasis. Annu. Rev. Biochem. 56: 395-433.
29. BLAUSTEIN, M. P. 1977. Effects of internal and external cations and of ATP on sodium-calcium and calcium-calcium exchange in squid axons. Biophys. J. 20: 79-110.
30. BLAUSTEIN, M. P. & R. DIPOLO, Eds. 1991. Sodium-Calcium Exchange: Proceedings of the Second International Conference. Ann. N. Y. Acad. Sci. 639: 1-667.
31. MICHAELS, R. L. & S. M. ROTHMAN. 1990. Glutamate neurotoxicity in vitro: antagonist pharmacology and intracellular calcium concentrations. J. Neurosci. 10(1): 283-292.
32. MILLS, L. R. 1994. Confocal calcium imaging. In Three-Dimensional Confocal Microscopy. J. K. Stevens, L. R. Mills & J. Trogadis, Eds. Academic Press Inc. Orlando, FL.
33. KOCH, A. R. & M. E. BARISH. 1994. Perturbation of intracellular calcium and hydrogen ion regulation in cultured mouse hippocampal neurons by reduction of the sodium ion concentration gradient. J. Neurosci. 14: 2585-2593.
34. STOPPINI, L., P. A. BUCHS & D. MULLER. 1991. A simple method for organotypic cultures of nervous tissue. J. Neurosci. Methods 37: 173-182.
35. PEREZ-VALAZQUEZ, J. L., A. VELUMIAN, P. L. CARLEN, J. F. BECHBERGER, C. C. G. NAUS, M. FRANTSEVA & L. R. MILLS. 1996. The development of astrocytes and neurons in organotypic brain slices lacking connexin 43. NeuroReport.
36. 2+ exchange buffer glutamate induced calcium loads in cultured cortical neurons. J. Neurosci. 15: 1318-1326.
37. KIEDROWSKI, L., G. BROOKER, E. COSTA & J. T. WROBLEWSKI. 1994. Glutamate impairs neuronal calcium extrusion while reducing sodium gradient. Neuron 12: 295-300.
38. MILLS, L. R. & R. G. KERR. 1995. Chronic alcohol exposure reduces neuronal survival and potentiates glutamate toxicity in cultured rat fetal hippocampal neurons. Res. Soc. Alchol. Abstr.
39. BLAUSTEIN, M., W. F. GOLDMAN, G. FONTANA, B. KRUEGER & P. YAROWSKY. 1991. Physiological roles of the sodium-calcium exchanger in nerve and muscle. Ann. N. Y. Acad. Sci. 639: 254.