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Volumn 10, Issue 1-2, 2001, Pages 57-65

Mitochondrial nitric oxide synthase, oxidative stress and apoptosis

Author keywords

Apoptosis; Ca2 plus; ; Cytochrome c; Mitochondria; Mitochondrial; Nitric oxide; Nitric oxide synthase; Peroxynitrite; Respiration

Indexed keywords

CALCIUM ION; CYTOCHROME C; NITRIC OXIDE SYNTHASE; PEROXYNITRITE; SUPEROXIDE;

EID: 0035108910     PISSN: 1424862X     EISSN: 14248638     Source Type: Journal    
DOI: 10.1159/000046875     Document Type: Article
Times cited : (90)

References (83)
  • 2
    • 0018832418 scopus 로고
    • Injury of neoplastic cells by murine macrophages leads to inhibition of mitochondrial respiration
    • Granger DL, Taintor RR, Cook JL, Hibbs JB Jr: Injury of neoplastic cells by murine macrophages leads to inhibition of mitochondrial respiration. J Clin Invest 1980;65:357-370.
    • (1980) J Clin Invest , vol.65 , pp. 357-370
    • Granger, D.L.1    Taintor, R.R.2    Cook, J.L.3    Hibbs, J.B.4
  • 3
    • 0020460870 scopus 로고
    • Sites of inhibition of mitochondrial electron transport in macrophage-injured neoplastic cells
    • Granger DL, Lehninger AL: Sites of inhibition of mitochondrial electron transport in macrophage-injured neoplastic cells. J Cell Biol 1982;95: 527-535.
    • (1982) J Cell Biol , vol.95 , pp. 527-535
    • Granger, D.L.1    Lehninger, A.L.2
  • 4
    • 0023505509 scopus 로고
    • Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide
    • Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G: Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 1987;84:9265-9269.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 9265-9269
    • Ignarro, L.J.1    Buga, G.M.2    Wood, K.S.3    Byrns, R.E.4    Chaudhuri, G.5
  • 5
    • 0023198721 scopus 로고
    • Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
    • Palmer RMJ, Ferrige AG, Moncada S: Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987;327:524-526.
    • (1987) Nature , vol.327 , pp. 524-526
    • Palmer, R.1    Ferrige, A.G.2    Moncada, S.3
  • 7
    • 0024584020 scopus 로고
    • Nitric oxide: A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells
    • Stuehr DJ, Nathan CF: Nitric oxide: A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J Exp Med 1989;169:1543-1555.
    • (1989) J Exp Med , vol.169 , pp. 1543-1555
    • Stuehr, D.J.1    Nathan, C.F.2
  • 8
    • 0025248146 scopus 로고
    • Nitric oxide formed by nitrite reductase of Para-coccus denitrificans is sufficiently stable to inhibit cytochrome oxidase activity and is reduced by its reductase under aerobic conditions
    • Carr GJ, Ferguson SJ: Nitric oxide formed by nitrite reductase of Para-coccus denitrificans is sufficiently stable to inhibit cytochrome oxidase activity and is reduced by its reductase under aerobic conditions. Bio-chim Biophys Acta 1990; 1017:5762.
    • (1990) Bio-Chim Biophys Acta , vol.1017 , pp. 5762
    • Carr, G.J.1    Ferguson, S.J.2
  • 9
    • 0025731384 scopus 로고
    • Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes
    • Stadler J, Billiar TR, Curran RD, Stuehr DJ, Ochoa JB, Simmons RL: Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes. Am J Physiol 1991;260:C910-C916.
    • (1991) Am J Physiol , vol.260 , pp. C910-C916
    • Stadler, J.1    Billiar, T.R.2    Curran, R.D.3    Stuehr, D.J.4    Ochoa, J.B.5    Simmons, R.L.6
  • 10
    • 0028134892 scopus 로고
    • Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase
    • Brown GC, Cooper CE: Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Lett 1994;356:295-298.
    • (1994) FEBS Lett , vol.356 , pp. 295-298
    • Brown, G.C.1    Cooper, C.E.2
  • 11
    • 0027945838 scopus 로고
    • Nitric oxide potently and reversibly deenergizes mitochondria at low oxygen tension
    • Schweizer M, Richter C: Nitric oxide potently and reversibly deenergizes mitochondria at low oxygen tension. Biochem Biophys Res Commun 1994;204:169-175.
    • (1994) Biochem Biophys Res Commun , vol.204 , pp. 169-175
    • Schweizer, M.1    Richter, C.2
  • 12
    • 0029998238 scopus 로고    scopus 로고
    • Differential inhibitory action of nitric oxide and peroxynitrite on mitochondrial electron transport
    • Cassina A, Radi R: Differential inhibitory action of nitric oxide and peroxynitrite on mitochondrial electron transport. Arch Biochem Biophys 1996;328:309-316.
    • (1996) Arch Biochem Biophys , vol.328 , pp. 309-316
    • Cassina, A.1    Radi, R.2
  • 13
    • 28044464985 scopus 로고
    • Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases
    • Cleeter MWJ, Cooper JM, Darley-Usmar VM, Moncada S, Schapira AHV: Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases. FEBS Lett 1994;345:50-54.
    • (1994) FEBS Lett , vol.345 , pp. 50-54
    • Cleeter, M.1    Cooper, J.M.2    Darley-Usmar, V.M.3    Moncada, S.4    Schapira, A.5
  • 14
    • 0033573981 scopus 로고    scopus 로고
    • On the mechanism by which vascular endothelial cells regulate their oxygen consumption
    • Clementi E, Brown GC, Foxwell N, Moncada S: On the mechanism by which vascular endothelial cells regulate their oxygen consumption. Proc Natl Acad Sci USA 1999;96: 1559-1562.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 1559-1562
    • Clementi, E.1    Brown, G.C.2    Foxwell, N.3    Moncada, S.4
  • 16
    • 0031730661 scopus 로고    scopus 로고
    • Transcellular regulation of cell respiration by nitric oxide generated by activated macrophages
    • Brown GC, Foxwell N, Moncada S: Transcellular regulation of cell respiration by nitric oxide generated by activated macrophages. FEBS Lett 1998;439:321-324.
    • (1998) FEBS Lett , vol.439 , pp. 321-324
    • Brown, G.C.1    Foxwell, N.2    Moncada, S.3
  • 17
    • 0029986691 scopus 로고    scopus 로고
    • Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles
    • Poderoso JJ, Carreras MC, Lisdero C, Riobo N, Schopfer F, Boveris A: Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles. Arch Biochem Biophys 1996;328: 85-92.
    • (1996) Arch Biochem Biophys , vol.328 , pp. 85-92
    • Poderoso, J.J.1    Carreras, M.C.2    Lisdero, C.3    Riobo, N.4    Schopfer, F.5    Boveris, A.6
  • 18
    • 0030200037 scopus 로고    scopus 로고
    • The effects of nitric oxide on electron transport complexes
    • Welter R, Yu L, Yu CA: The effects of nitric oxide on electron transport complexes. Arch Biochem Biophys 1996;331:9-14.
    • (1996) Arch Biochem Biophys , vol.331 , pp. 9-14
    • Welter, R.1    Yu, L.2    Yu, C.A.3
  • 19
    • 0026655617 scopus 로고
    • Interferon-gamma and tumor necrosis factor synergize to induce nitric oxide production and inhibit mitochondrial respiration in vascular smooth muscle cells
    • Geng Y, Hansson GK, Holme E: Interferon-gamma and tumor necrosis factor synergize to induce nitric oxide production and inhibit mitochondrial respiration in vascular smooth muscle cells. Circ Res 1992; 71:1268-1276.
    • (1992) Circ Res , vol.71 , pp. 1268-1276
    • Geng, Y.1    Hansson, G.K.2    Holme, E.3
  • 20
    • 0032560572 scopus 로고    scopus 로고
    • Persistent inhibition of cell respiration by nitric oxide: Crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione
    • Clementi E, Brown GC, Feelisch M, Moncada S: Persistent inhibition of cell respiration by nitric oxide: Crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione. Proc Natl Acad Sci USA 1998;95:7631-7636.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7631-7636
    • Clementi, E.1    Brown, G.C.2    Feelisch, M.3    Moncada, S.4
  • 21
    • 0028145462 scopus 로고
    • Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes
    • Bolanos JP, Peuchen S, Heales SJ, Land JM, Clark JB: Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes. J Neurochem 1994;63:910-916.
    • (1994) J Neurochem , vol.63 , pp. 910-916
    • Bolanos, J.P.1    Peuchen, S.2    Heales, S.J.3    Land, J.M.4    Clark, J.B.5
  • 22
  • 23
    • 0030781227 scopus 로고    scopus 로고
    • Formation and properties of peroxynitrite as studied by laser flash photolysis, high-pressure stopped-flow technique, and pulse radiolysis
    • Kissner R, Nauser T, Bugnon P, Lye PG, Koppenol WH: Formation and properties of peroxynitrite as studied by laser flash photolysis, high-pressure stopped-flow technique, and pulse radiolysis. Chem Res Toxicol 1997;10:1285-1292.
    • (1997) Chem Res Toxicol , vol.10 , pp. 1285-1292
    • Kissner, R.1    Nauser, T.2    Bugnon, P.3    Lye, P.G.4    Koppenol, W.H.5
  • 24
    • 0032044020 scopus 로고    scopus 로고
    • Living and dying with reactive species. Focus on ‘peroxynitrite induces apoptosis of HL-60 cells by activation of a cas-pase-3 family protease’
    • Ischiropoulos H: Living and dying with reactive species. Focus on ‘peroxynitrite induces apoptosis of HL-60 cells by activation of a cas-pase-3 family protease’. Am J Physiol 1998;274:C853-C854.
    • (1998) Am J Physiol , vol.274 , pp. C853-C854
    • Ischiropoulos, H.1
  • 25
    • 0033120926 scopus 로고    scopus 로고
    • Peroxynitrite: Reactive, invasive and enigmatic
    • Groves JT: Peroxynitrite: Reactive, invasive and enigmatic. Curr Opin Chem Biol 1999;3:226-235.
    • (1999) Curr Opin Chem Biol , vol.3 , pp. 226-235
    • Groves, J.T.1
  • 26
  • 27
    • 0029981670 scopus 로고    scopus 로고
    • Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose
    • Lizasoain I, Moro MA, Knowles RG, Darley-Usmar V, Moncada S: Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose. Biochem J 1996;314:877-880.
    • (1996) Biochem J , vol.314 , pp. 877-880
    • Lizasoain, I.1    Moro, M.A.2    Knowles, R.G.3    Darley-Usmar, V.4    Moncada, S.5
  • 28
    • 0028952832 scopus 로고
    • Effect of peroxynitrite on the mitochondrial respiratory chain: Differential susceptibility of neurons and astrocytes in primary culture
    • Bolanos JP, Heales SJ, Land JM, Clark JB: Effect of peroxynitrite on the mitochondrial respiratory chain: Differential susceptibility of neurons and astrocytes in primary culture. J Neurochem 1995;64:1965-1972.
    • (1995) J Neurochem , vol.64 , pp. 1965-1972
    • Bolanos, J.P.1    Heales, S.J.2    Land, J.M.3    Clark, J.B.4
  • 29
    • 0032553302 scopus 로고    scopus 로고
    • Interaction of peroxynitrite with mitochondrial cytochrome oxidase. Catalytic production of nitric oxide and irreversible inhibition of enzyme activity
    • Sharpe MA, Cooper CE: Interaction of peroxynitrite with mitochondrial cytochrome oxidase. Catalytic production of nitric oxide and irreversible inhibition of enzyme activity. J Biol Chem 1998;273:30961-30972.
    • (1998) J Biol Chem , vol.273 , pp. 30961-30972
    • Sharpe, M.A.1    Cooper, C.E.2
  • 30
    • 0021229861 scopus 로고
    • Decreased defence against free radicals in rat heart during normal reperfusion after hypoxic, ischemic and calcium-free perfusion
    • Julicher RH, Tijburg LB, Sterren-berg L, Bast A, Koomen JM, Noord-hoek J: Decreased defence against free radicals in rat heart during normal reperfusion after hypoxic, ischemic and calcium-free perfusion. Life Sci 1984;35:1281-1288.
    • (1984) Life Sci , vol.35 , pp. 1281-1288
    • Julicher, R.H.1    Tijburg, L.B.2    Sterren-Berg, L.3    Bast, A.4    Koomen, J.M.5    Noord-Hoek, J.6
  • 31
    • 0029806383 scopus 로고    scopus 로고
    • Role of nitric oxide and its interaction with superoxide in the suppression of cardiac muscle mitochondrial respiration. Involvement in response to hypoxia/ reoxygenation
    • Xie YW, Wolin MS: Role of nitric oxide and its interaction with superoxide in the suppression of cardiac muscle mitochondrial respiration. Involvement in response to hypoxia/ reoxygenation. Circulation 1996;94: 2580-2586
    • (1996) Circulation , vol.94 , pp. 2580-2586
    • Xie, Y.W.1    Wolin, M.S.2
  • 32
    • 0032482126 scopus 로고    scopus 로고
    • Inhibition of rat cardiac muscle contraction and mitochondrial respiration by endogenous peroxynitrite formation during posthypoxic reoxygenation
    • Xie YW, Kaminski PM, Wolin MS: Inhibition of rat cardiac muscle contraction and mitochondrial respiration by endogenous peroxynitrite formation during posthypoxic reoxygenation. Circ Res 1998;82:891-897.
    • (1998) Circ Res , vol.82 , pp. 891-897
    • Xie, Y.W.1    Kaminski, P.M.2    Wolin, M.S.3
  • 33
    • 0029962693 scopus 로고    scopus 로고
    • Glutathione protects astrocytes from peroxyni-trite-mediated mitochondrial damage: Implications for neuronal/astro-cytic trafficking and neurodegeneration
    • Barker JE, Bolanos JP, Land JM, Clark JB, Heales SJ: Glutathione protects astrocytes from peroxyni-trite-mediated mitochondrial damage: Implications for neuronal/astro-cytic trafficking and neurodegeneration. Dev Neurosci 1996; 18:391-396.
    • (1996) Dev Neurosci , vol.18 , pp. 391-396
    • Barker, J.E.1    Bolanos, J.P.2    Land, J.M.3    Clark, J.B.4    Heales, S.J.5
  • 34
    • 0023069451 scopus 로고
    • Intracellular calcium homeostasis
    • Carafoli E: Intracellular calcium homeostasis. Annu Rev Biochem 1987;56:395-433.
    • (1987) Annu Rev Biochem , vol.56 , pp. 395-433
    • Carafoli, E.1
  • 35
    • 0002647379 scopus 로고
    • The regulation of mitochondrial calcium transport in heart
    • Crompton M: The regulation of mitochondrial calcium transport in heart. Curr Top Membr Transport 1985;25:231-276.
    • (1985) Curr Top Membr Transport , vol.25 , pp. 231-276
    • Crompton, M.1
  • 36
    • 0029977549 scopus 로고    scopus 로고
    • Peroxyni-trite stimulates the pyridine nucleotide-linked Ca2+ release from intact rat liver mitochondria
    • 2+ release from intact rat liver mitochondria. Biochemistry 1996;35:4524-4528.
    • (1996) Biochemistry , vol.35 , pp. 4524-4528
    • Schweizer, M.1    Richter, C.2
  • 37
    • 0029862502 scopus 로고    scopus 로고
    • Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts
    • MacMillan-Crow LA, Crow JP, Ker-by JD, Beckman JS, Thompson JA: Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts. Proc Natl Acad Sci USA 1996;93:11853-11858.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 11853-11858
    • Macmillan-Crow, L.A.1    Crow, J.P.2    Ker-By, J.D.3    Beckman, J.S.4    Thompson, J.A.5
  • 38
    • 0028800903 scopus 로고
    • Historic apoptosis
    • Clarke PG, Clarke S: Historic apoptosis. Nature 1995;378:230.
    • (1995) Nature , vol.378 , pp. 230
    • Clarke, P.G.1    Clarke, S.2
  • 39
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr JF, Wyllie AH, Currie AR: Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972;26:239-257.
    • (1972) Br J Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 40
    • 0027186493 scopus 로고
    • Nitric oxide synthase induces macrophage death by apoptosis
    • Sarih M, Souvannavong V, Adam A: Nitric oxide synthase induces macrophage death by apoptosis. Bio-chem Biophys Res Commun 1993; 191:503-508.
    • (1993) Bio-Chem Biophys Res Commun , vol.191 , pp. 503-508
    • Sarih, M.1    Souvannavong, V.2    Adam, A.3
  • 41
    • 0033004242 scopus 로고    scopus 로고
    • Mechanisms of nitric oxide-dependent apoptosis: Involvement of mitochondrial mediators
    • Bosca L, Hortelano S: Mechanisms of nitric oxide-dependent apoptosis: Involvement of mitochondrial mediators. Cell Signal 1999; 11:239-244.
    • (1999) Cell Signal , vol.11 , pp. 239-244
    • Bosca, L.1    Hortelano, S.2
  • 44
    • 0033608739 scopus 로고    scopus 로고
    • Increased nitrotyrosine immunoreactivity in substantia nigra neurons in MPTP treated baboons is blocked by inhibition of neuronal nitric oxide synthase
    • Ferrante RJ, Hantraye P, Brouillet E, Beal MF: Increased nitrotyrosine immunoreactivity in substantia nigra neurons in MPTP treated baboons is blocked by inhibition of neuronal nitric oxide synthase. Brain Res 1999;823:177-182.
    • (1999) Brain Res , vol.823 , pp. 177-182
    • Ferrante, R.J.1    Hantraye, P.2    Brouillet, E.3    Beal, M.F.4
  • 45
    • 0033615544 scopus 로고    scopus 로고
    • Mitochondrial nitric oxide synthase stimulation causes cytochrome c release from isolated mitochondria. Evidence for intramitochondrial peroxynitrite formation
    • Ghafourifar P, Schenk U, Klein SD, Richter C: Mitochondrial nitric oxide synthase stimulation causes cytochrome c release from isolated mitochondria. Evidence for intramitochondrial peroxynitrite formation. J Biol Chem 1999;274:31185-31188.
    • (1999) J Biol Chem , vol.274 , pp. 31185-31188
    • Ghafourifar, P.1    Schenk, U.2    Klein, S.D.3    Richter, C.4
  • 46
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green DR, Reed JC: Mitochondria and apoptosis. Science 1998;281: 1309-1312.
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 47
    • 0032504574 scopus 로고    scopus 로고
    • Mitochondrial control of apoptosis: The role of cytochrome c
    • Cai J, Yang J, Jones DP: Mitochondrial control of apoptosis: The role of cytochrome c. Biochim Biophys Acta 1998;1366:139-149.
    • (1998) Biochim Biophys Acta , vol.1366 , pp. 139-149
    • Cai, J.1    Yang, J.2    Jones, D.P.3
  • 48
    • 0033542810 scopus 로고    scopus 로고
    • Reduction in mitochondrial membrane potential is an early event in Fas-independent CTL-mediated apoptosis
    • Hu D, Kipps TJ: Reduction in mitochondrial membrane potential is an early event in Fas-independent CTL-mediated apoptosis. Cell Immunol 1999;195:43-52.
    • (1999) Cell Immunol , vol.195 , pp. 43-52
    • Hu, D.1    Kipps, T.J.2
  • 49
    • 0033525685 scopus 로고    scopus 로고
    • Ceramide induces cytochrome c release from isolated mitochondria. Importance of mitochondrial redox state
    • Ghafourifar P, Klein SD, Schucht O, Schenk U, Rocha S, Pruschy M, Richter C: Ceramide induces cytochrome c release from isolated mitochondria. Importance of mitochondrial redox state. J Biol Chem 1999; 274:6080-6084.
    • (1999) J Biol Chem , vol.274 , pp. 6080-6084
    • Ghafourifar, P.1    Klein, S.D.2    Schucht, O.3    Schenk, U.4    Rocha, S.5    Pruschy, M.6    Richter, C.7
  • 51
    • 0031754499 scopus 로고    scopus 로고
    • Glutathione depletion is associated with decreased Bcl-2 expression and increased apoptosis in cholangiocytes
    • Celli A, Que FG, Gores GJ, LaRus-so NF: Glutathione depletion is associated with decreased Bcl-2 expression and increased apoptosis in cholangiocytes. Am J Physiol 1998; 275:749-757.
    • (1998) Am J Physiol , vol.275 , pp. 749-757
    • Celli, A.1    Que, F.G.2    Gores, G.J.3    Larus-So, N.F.4
  • 52
    • 0033120803 scopus 로고    scopus 로고
    • Nitric-oxide-induced apoptosis in human leukemic lines requires mitochondrial lipid degradation and cytochrome c release
    • Ushmorov A, Ratter F, Lehmann V, Droge W, Schirrmacher V, Umans-ky V: Nitric-oxide-induced apoptosis in human leukemic lines requires mitochondrial lipid degradation and cytochrome c release. Blood 1999; 93:2342-2352.
    • (1999) Blood , vol.93 , pp. 2342-2352
    • Ushmorov, A.1    Ratter, F.2    Lehmann, V.3    Droge, W.4    Schirrmacher, V.5    Umans-Ky, V.6
  • 53
    • 0032955601 scopus 로고    scopus 로고
    • Caspase activation accompanying cytochrome c release from mitochondria is possibly involved in nitric oxide-induced neuronal apoptosis in SH-SY5Y cells
    • Uehara T, Kikuchi Y, Nomura Y: Caspase activation accompanying cytochrome c release from mitochondria is possibly involved in nitric oxide-induced neuronal apoptosis in SH-SY5Y cells. J Neurochem 1999;72:196-205.
    • (1999) J Neurochem , vol.72 , pp. 196-205
    • Uehara, T.1    Kikuchi, Y.2    Nomura, Y.3
  • 54
    • 0033627736 scopus 로고    scopus 로고
    • Nitric oxide-mediated apoptosis in human breast cancer cells requires changes in mitochondrial functions and is independent of CD95 (APO-1/Fas)
    • Umansky V, Ushmorov A, Ratter F, Chlichlia K, Bucur M, Lichtenauer A, Rocha M: Nitric oxide-mediated apoptosis in human breast cancer cells requires changes in mitochondrial functions and is independent of CD95 (APO-1/Fas). Int J Oncol 2000;16:109-117.
    • (2000) Int J Oncol , vol.16 , pp. 109-117
    • Umansky, V.1    Ushmorov, A.2    Ratter, F.3    Chlichlia, K.4    Bucur, M.5    Lichtenauer, A.6    Rocha, M.7
  • 55
    • 17344371804 scopus 로고    scopus 로고
    • Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: Suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction
    • Keller JN, Kindy MS, Holtsberg FW, St Clair DK, Yen HC, Ger-meyer A, Steiner SM, Bruce-Keller AJ, Hutchins JB, Mattson MP: Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: Suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. J Neurosci 1998;18:687-697.
    • (1998) J Neurosci , vol.18 , pp. 687-697
    • Keller, J.N.1    Kindy, M.S.2    Holtsberg, F.W.3    St Clair, D.K.4    Yen, H.C.5    Ger-Meyer, A.6    Steiner, S.M.7    Bruce-Keller, A.J.8    Hutchins, J.B.9    Mattson, M.P.10
  • 56
    • 0030662226 scopus 로고    scopus 로고
    • Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms
    • Kim YM, Talanian RV, Billiar TR: Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms. J Biol Chem 1997;272: 31138-31148.
    • (1997) J Biol Chem , vol.272 , pp. 31138-31148
    • Kim, Y.M.1    Talanian, R.V.2    Billiar, T.R.3
  • 57
    • 0030827880 scopus 로고    scopus 로고
    • Nitric oxide inhibits Fas-induced apoptosis
    • Mannick JB, Miao XQ, Stamler JS: Nitric oxide inhibits Fas-induced apoptosis. J Biol Chem 1997;272: 24125-24128.
    • (1997) J Biol Chem , vol.272 , pp. 24125-24128
    • Mannick, J.B.1    Miao, X.Q.2    Stamler, J.S.3
  • 59
    • 0033563776 scopus 로고    scopus 로고
    • Inhibition of mitochondrial ATP generation by nitric oxide switches apoptosis to necrosis
    • Leist M, Single B, Naumann H, Fava E, Simon B, Kuhnle S, Nico-tera P: Inhibition of mitochondrial ATP generation by nitric oxide switches apoptosis to necrosis. Exp Cell Res 1999;249:396-403.
    • (1999) Exp Cell Res , vol.249 , pp. 396-403
    • Leist, M.1    Single, B.2    Naumann, H.3    Fava, E.4    Simon, B.5    Kuhnle, S.6    Nico-Tera, P.7
  • 60
    • 0032553447 scopus 로고    scopus 로고
    • Nitric oxide suppression of apoptosis occurs in association with an inhibition of Bcl-2 cleavage and cytochrome c release
    • Kim YM, Kim TH, Seol DW, Tal-anian RV, Billiar TR: Nitric oxide suppression of apoptosis occurs in association with an inhibition of Bcl-2 cleavage and cytochrome c release. J Biol Chem 1998;273:31437-31441.
    • (1998) J Biol Chem , vol.273 , pp. 31437-31441
    • Kim, Y.M.1    Kim, T.H.2    Seol, D.W.3    Tal-Anian, R.V.4    Billiar, T.R.5
  • 61
    • 0029086659 scopus 로고
    • Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver
    • Bates TE, Loesch A, Burnstock G, Clark JB: Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochem Biophys Res Com-mun 1995;213:896-900.
    • (1995) Biochem Biophys Res Com-Mun , vol.213 , pp. 896-900
    • Bates, T.E.1    Loesch, A.2    Burnstock, G.3    Clark, J.B.4
  • 62
    • 0030029056 scopus 로고    scopus 로고
    • Mitochondrial nitric oxide synthase: A ubiquitous regulator of oxidative phosphorylation?
    • Bates TE, Loesch A, Burnstock G, Clark JB: Mitochondrial nitric oxide synthase: A ubiquitous regulator of oxidative phosphorylation? Bio-chem Biophys Res Commun 1996; 218:40-44.
    • (1996) Bio-Chem Biophys Res Commun , vol.218 , pp. 40-44
    • Bates, T.E.1    Loesch, A.2    Burnstock, G.3    Clark, J.B.4
  • 65
    • 0030697859 scopus 로고    scopus 로고
    • Nitric oxide synthase activity in mitochondria
    • Ghafourifar P, Richter C: Nitric oxide synthase activity in mitochondria. FEBS Lett 1997;418:291-296.
    • (1997) FEBS Lett , vol.418 , pp. 291-296
    • Ghafourifar, P.1    Richter, C.2
  • 66
    • 0032079478 scopus 로고    scopus 로고
    • Production of nitric oxide by mitochondria
    • Giulivi C, Poderoso JJ, Boveris A: Production of nitric oxide by mitochondria. J Biol Chem 1998;273: 11038-11043.
    • (1998) J Biol Chem , vol.273 , pp. 11038-11043
    • Giulivi, C.1    Poderoso, J.J.2    Boveris, A.3
  • 67
    • 0032079851 scopus 로고    scopus 로고
    • Purification and characterization of a nitric-oxide synthase from rat liver mitochondria
    • Tatoyan A, Giulivi C: Purification and characterization of a nitric-oxide synthase from rat liver mitochondria. J Biol Chem 1998;273: 11044-11048.
    • (1998) J Biol Chem , vol.273 , pp. 11044-11048
    • Tatoyan, A.1    Giulivi, C.2
  • 68
    • 0032777013 scopus 로고    scopus 로고
    • Nitric oxide, superoxide, and hydrogen peroxide production in brain mitochondria after haloperidol treatment
    • Arnaiz SL, Coronel MF, Boveris A: Nitric oxide, superoxide, and hydrogen peroxide production in brain mitochondria after haloperidol treatment. Nitric Oxide 1999;3: 235-243.
    • (1999) Nitric Oxide , vol.3 , pp. 235-243
    • Arnaiz, S.L.1    Coronel, M.F.2    Boveris, A.3
  • 69
    • 0032882857 scopus 로고    scopus 로고
    • Ultrastructural localization of neuronal nitric oxide synthase in the latero-dorsal tegmental nucleus of wild-type and knockout mice
    • Rothe F, Huang PL, Wolf G: Ultrastructural localization of neuronal nitric oxide synthase in the latero-dorsal tegmental nucleus of wild-type and knockout mice. Neuroscience 1999;94:193-201.
    • (1999) Neuroscience , vol.94 , pp. 193-201
    • Rothe, F.1    Huang, P.L.2    Wolf, G.3
  • 70
    • 0032526039 scopus 로고    scopus 로고
    • Functional implications of nitric oxide produced by mitochondria in mitochondrial metabolism
    • Giulivi C: Functional implications of nitric oxide produced by mitochondria in mitochondrial metabolism. Biochem J 1998;332:673-679.
    • (1998) Biochem J , vol.332 , pp. 673-679
    • Giulivi, C.1
  • 71
    • 0032883191 scopus 로고    scopus 로고
    • Mitochondrial nitric oxide synthase regulates mitochondrial matrix pH
    • Ghafourifar P, Richter C: Mitochondrial nitric oxide synthase regulates mitochondrial matrix pH. Biol Chem 1999;380:1025-1028.
    • (1999) Biol Chem , vol.380 , pp. 1025-1028
    • Ghafourifar, P.1    Richter, C.2
  • 72
    • 0032550199 scopus 로고    scopus 로고
    • Glutamate neurotoxicity is associated with nitric oxide-mediated mitochondrial dysfunction and glutathione depletion
    • Almeida A, Heales SJR, Bolanos JP, Medina JM: Glutamate neurotoxicity is associated with nitric oxide-mediated mitochondrial dysfunction and glutathione depletion. Brain Res 1998;790:209-216.
    • (1998) Brain Res , vol.790 , pp. 209-216
    • Almeida, A.1    Heales, S.2    Bolanos, J.P.3    Medina, J.M.4
  • 73
  • 74
    • 0032902145 scopus 로고    scopus 로고
    • Pivotal role of mitochondrial calcium uptake in neural cell apoptosis and necrosis
    • Kruman II, Mattson MP: Pivotal role of mitochondrial calcium uptake in neural cell apoptosis and necrosis. J Neurochem 1999;72:529-540.
    • (1999) J Neurochem , vol.72 , pp. 529-540
    • Kruman, I.I.1    Mattson, M.P.2
  • 75
    • 0032006868 scopus 로고    scopus 로고
    • Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells
    • Kruman I, Guo Q, Mattson MP: Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells. J Neurosci Res 1998;51:293-308.
    • (1998) J Neurosci Res , vol.51 , pp. 293-308
    • Kruman, I.1    Guo, Q.2    Mattson, M.P.3
  • 76
    • 0033570890 scopus 로고    scopus 로고
    • Apoptosis driven by IP(3)-linked mitochondrial calcium signals
    • Szalai G, Krishnamurthy R, Haj-noczky G: Apoptosis driven by IP(3)-linked mitochondrial calcium signals. EMBO J 1999;18:6349-6361.
    • (1999) EMBO J , vol.18 , pp. 6349-6361
    • Szalai, G.1    Krishnamurthy, R.2    Haj-Noczky, G.3
  • 77
    • 0033199019 scopus 로고    scopus 로고
    • Glutamate-induced mitochondrial depolarisation and perturbation of calcium homeostasis in cultured rat hippocampal neurones
    • Vergun O, Keelan J, Khodorov BI, Duchen MR: Glutamate-induced mitochondrial depolarisation and perturbation of calcium homeostasis in cultured rat hippocampal neurones. J Physiol (Lond) 1999;519: 451-466.
    • (1999) J Physiol (Lond) , vol.519 , pp. 451-466
    • Vergun, O.1    Keelan, J.2    Khodorov, B.I.3    Duchen, M.R.4
  • 78
    • 0028855352 scopus 로고
    • Fas antigen-mediated DNA fragmentation and apoptotic morphologic changes are regulated by elevated cytosolic Ca2+ level
    • 2+ level. J Immunol 1995; 154:599-609.
    • (1995) J Immunol , vol.154 , pp. 599-609
    • Oshimi, Y.1    Miyazaki, S.2
  • 79
    • 0032929052 scopus 로고    scopus 로고
    • Release of cytochrome c from heart mitochondria is induced by high Ca2+ and peroxynitrite and is responsible for Ca2+-induced inhibition of substrate oxidation
    • 2+-induced inhibition of substrate oxidation. Biochim Biophys Acta 1999;1453:41-48.
    • (1999) Biochim Biophys Acta , vol.1453 , pp. 41-48
    • Borutaite, V.1    Morkuniene, R.2    Brown, G.C.3
  • 81
    • 0001062667 scopus 로고    scopus 로고
    • Control of the prooxidant-dependent calcium release from intact liver mitochondria
    • Richter C: Control of the prooxidant-dependent calcium release from intact liver mitochondria. Redox Rep 1996;2:217-221.
    • (1996) Redox Rep , vol.2 , pp. 217-221
    • Richter, C.1


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