Grb2 and Gads exhibit different interactions with CD28 and play distinct roles in CD28-mediated costimulation

Journal of Immunology

Volumn 177, Issue 2, 2006, Pages 1085-1091

  Watanabe, Ryosuke ^a   Harada, Yohsuke ^a   Takeda, Kei ^a   Takahashi, Jun ^a   Ohnuki, Kazunobu ^a   Ogawa, Shuhei ^a   Ohgai, Daisuke ^a   Kaibara, Nanako ^a   Koiwai, Osamu ^a   Tanabe, Kazunari ^b   Toma, Hiroshi ^b   Sugamura, Kazuo ^c   Abe, Ryo ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^c TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD28 ANTIGEN; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; ICOS ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; PROTEIN GADS; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; GENE EXPRESSION REGULATION; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; KNOCKOUT GENE; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

EID: 33745827029     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.177.2.1085     Document Type: Article

References (46)

1. Jenkins, M. K., J. D. Ashwell, and R. H. Schwartz. 1988. Allogeneic non-T spleen cells restore the responsiveness of normal T cell clones stimulated with antigen and chemically modified antigen- presenting cells. J. Immunol. 140: 3324-3330.
2. Rudd, C. E., and H. Schneider. 2003. Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling. Nat. Rev. Immunol. 3: 544-556.
3. Schneider, H., Y. C. Cai, K. V. Prasad, S. E. Shoelson, and C. E. Rudd. 1995. T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras. Eur. J. Immunol. 25: 1044-1050.
4. Ellis, J. H., C. Ashman, M. N. Burden, K. E. Kilpatrick, M. A. Morse, and P. A. Hamblin. 2000. GRID: a novel grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28. J. Immunol. 164: 5805-5814.
5. Harada, Y., M. Tokushima, Y. Matsumoto, S. Ogawa, M. Otsuka, K. Hayashi, B. D. Weiss, C. H. June, and R. Abe. 2001. Critical requirement for the membrane-proximal cytosolic tyrosine residue for CD28-mediated costimulation in vivo. J. Immunol. 166: 3797-3803.
6. Okkenhaug, K., L. Wu, K. M. Garza, J. La Rose, W. Khoo, B. Odermatt, T. W. Mak, P. S. Ohashi, and R. Rottapel. 2001. A point mutation in CD28 distinguishes proliferative signals from survival signals. Nat. Immunol. 1: 325-332.
7. L. J. Immunol. 166: 5331-5335.
8. Andres, P. G., K. C. Rowland, A. Nirula, L. P. Kane, L. Barron, D. Dresnek, A. Sadra, J. Imboden, A. Weiss, and A. K. Abbas. 2004. Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation. Nat. Immunol. 5: 435-442.
9. Hutloff, A., A. M. Dittrich, K. C. Beier, B. Eljaschewitsch, R. Kraft, I. Anagnostopoulos, and R. A. Kroczek. 1999. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature 397: 263-266.
10. Yoshinaga, S. K., J. S. Whoriskey, S. D. Khare, U. Sarmiento, J. Guo, T. Horan, G. Shih, M. Zhang, M. A. Coccia, T. Kohno, et al. 1999. T-cell co-stimulation through B7RP-1 and ICOS. Nature 402: 827-832.
11. Harada, Y., D. Ohgai, R. Watanabe, K. Okano, O. Koiwai, K. Tanabe, H. Toma, A. Altman, and R. Abe. 2003. A single amino acid alteration in cytoplasmic domain determines IL-2 promoter activation by ligation of CD28 but not inducible costimulator (ICOS). J. Exp. Med. 197: 257-262.
12. Coyle, A. J., S. Lehar, C. Lloyd, J. Tian, T. Delaney, S. Manning, T. Nguyen, T. Burwell, H. Schneider, J. A. Gonzalo, et al. 2000. The CD28-related molecule ICOS is required for effective T cell-dependent immune responses. Immunity 13: 95-105.
13. Harada, Y., E. Tanabe, R. Watanabe, B. D. Weiss, A. Matsumoto, H. Ariga, O. Koiwai, Y. Fukui, M. Kubo, C. H. June, and R. Abe. 2001. Novel role of PI3K in CD28-mediated costimulation. J. Biol Chem. 276: 9003-9008.
14. Lowenstein, E. J., R. J. Daly, A. G. Batzer, W. Li, B. Margolis, R. Lammers, A. Ullrich, E. Y. Skolnik, D. Bar-Sagi, and J. Schlessinger. 1992. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell 70: 431-442.
15. Buday, L., S. E. Egan, P. Rodriguez Viciana, D. A. Cantrell, and J. Downward. 1994. A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells. J. Biol. Chem. 269: 9019-9023.
16. Liu, S. K., and C. J. McGlade. 1998. Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated She. Oncogene 17: 3073-3082.
17. Law, C. L., M. K. Ewings, P. M. Chaudhary, S. A. Solow, T. J. Yun, A. J. Marshall, L. Hood, and E. A. Clark. 1999. GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation. J. Exp. Med. 189: 1243-1253.
18. Asada, H., N. Ishii, Y. Sasaki, K. Endo, H. Kasai, N. Tanaka, T. Takeshita, S. Tsuchiya, T. Konno, and K. Sugamura. 1999. Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT. J. Exp. Med. 189: 1383-1390.
19. Liu, S. K., N. Fang, G. A. Koretzky, and C. J. McGlade. 1999. The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors. Curr. Biol. 9: 67-75.
20. Boerth, N. J., J. J. Sadler, D. E. Bauer, J. L. Clements, S. M. Gheith, and G. A. Koretzky. 2000. Recruitment of SLP-76 to the membrane and glycolipid-enriched membrane microdomains replaces the requirement for linker for activation of T cells in T cell receptor signaling. J. Exp. Med. 192: 1047-1058.
21. Yoder, J., C. Pham, Y. M. Iizuka, O. Kanagawa, S. K. Liu, J. McGlade, and A. M. Cheng. 2001. Requirement for the SLP-76 adaptor GADS in T cell development. Science 291: 1987-1991.
22. Crooks, M. E., D. R. Littman, R. H. Carter, D. T. Fearon, A. Weiss, and P. H. Stein. 1995. CD28-mediated costimulation in the absence of phosphatidylinositol 3-kinase association and activation. Mol. Cell. Biol. 15: 6820-6828.
23. Kim, H. H., M. Tharayil, and C. E. Rudd. 1998. Growth factor receptor-bound protein 2 SH2/SH3 domain, binding to CD28 and its role in co-signaling. J. Biol. Chem. 273: 296-301.
24. Misawa, K., T. Nonaka, S. Morita, A. Kaneko, T. Nakahata, S. Asano, and T. Kitamura. 2000. A method to identify cDNAs based on localization of green fluorescent protein fusion products. Proc. Natl. Acad. Sci. USA 97: 3062-3066.
25. Morita, S., T. Kojima, and T. Kitamura. 2000. Plat-E: an efficient and stable system for transient packaging of retroviruses. Gene Ther. 7: 1063-1066.
26. Yamasaki, S., K. Nishida, M. Hibi, M. Sakuma, R. Shiina, A. Takeuchi, H. Ohnishi, T. Hirano, and T. Saito. 2001. Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules. J. Biol. Chem. 276: 45175-45183.
27. Garrity, P. A., D. Chen, E. V. Rothenberg, and B. J. Wold. 1994. Interleukin-2 transcription is regulated in vivo at the level of coordinated binding of both constitutive and regulated factors. Mol. Cell. Biol. 14: 2159-2169.
28. Rothenberg, E. V., and S. B. Ward. 1996. A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin 2 gene regulation. Proc. Natl. Acad. Sci. USA 93: 9358-9365.
29. McGuire, K. L., and M. Iacobelli. 1997. Involvement of Rel, Fos, and Jun proteins in binding activity to the IL-2 promoter CD28 response element/AP-1 sequence in human T cells. J. Immunol. 159: 1319-1327.
30. Michel, F., G. Mangino, G. Attal-Bonnefoy, L. Tuosto, A. Alcover, A. Roumier, D. Olive, and O. Acuto. 2000. CD28 utilizes Vav-1 to enhance TCR-proximal signaling and NF-AT activation. J. Immunol. 165: 3820-3829.
31. Raab, M., S. Pfister, and C. E. Rudd. 2001. CD28 signaling via VAV/SLP-76 adaptors: regulation of cytokine transcription independent of TCR ligation. Immunity 15: 921-933.
32. Ghosh, P., T. H. Tan, N. R. Rice, A. Sica, and H. A. Young. 1993. The interleukin 2 CD28-responsive complex contains at least three members of the NF-κB family: c-Rel, p50, and p65. Proc. Natl. Acad. Sci. USA 90: 1696-1700.
33. Okkenhaug, K., and R. Rottapel. 1998. Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction. J. Biol. Chem. 273: 21194-21202,
34. Holdorf, A. D., J. M. Green, S. D. Levin, M. F. Denny, D. B. Straus, V. Link, P. S. Changelian, P. M. Allen, and A. S. Shaw. 1999. Proline residues in CD28 and the Src homology (SH)3 domain of Lck are required for T cell costimulation. J. Exp. Med. 190: 375-384.
35. Isakov, N., and A. Altman. 2002. Protein kinase C6 in T cell activation. Annu. Rev. Immunol. 20: 761-794.
36. Lin, X., A. O'Mahony, Y. Mu, R. Geleziunas, and W. C. Greene. 2000. Protein kinase C-θ participates in NF-κB activation induced by CD3-CD28 costimulation through selective activation of IκB kinase β. Mol. Cell. Biol. 20: 2933-2940.
37. Ruland, J., G. S. Duncan, A. Elia, I. del Barco Barrantes, L. Nguyen, S. Plyte, D. G. Millar, D. Bouchard, A. Wakeham, P. S. Ohashi, and T. W. Mak. 2001. Bc110 is a positive regulator of antigen receptor-induced activation of NF-κB and neural tube closure. Cell 104: 33-42.
38. Sun, Z., C. W. Arendt, W. Ellmeier, E. M. Schaeffer, M. J. Sunshine, L. Gandhi, J. Annes, D. Petizilka, A. Kupfer, P. L. Schwartzberg, and D. R. Littman. 2000. PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes. Nature 404: 402-407.
39. Gaide, O., B. Favier, D. F. Legler, D. Bonnet, B. Brissoni, S. Valitutti, C. Bron, J. Tschopp, and M. Thome. 2002. CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-κB activation. Nat. Immunol. 3: 836-843.
40. Wang, D., Y. You, S. M. Case, L. M. McAllister-Lucas, L. Wang, P. S. DiStefano, G. Nunez, J. Bertin, and X. Lin. 2002. A requirement for CARMA1 in TCR-induced NF-κB activation. Nat. Immunol. 3: 830-835.
41. Pomerantz, J. L., E. M. Denny, and D. Baltimore. 2002. CARDI1 mediates factor-specific activation of NF-κB by the T cell receptor complex. EMBO J. 21: 5184-5194.
42. Lucas, P. C., M. Yonezumi, N. Inohara, L. M. McAllister-Lucas, M. E. Abazeed, F. F. Chen, S. Yamaoka, M. Seto, and G. Nunez. 2001. Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-κ signaling pathway. J. Biol. Chem. 276: 19012-19019.
43. Villalba, M., N. Coudronniere, M. Deckert, E. Teixeiro, P. Mas, and A. Altman. 2000. A novel functional interaction between Vav and PKCθ is required for TCR-induced T cell activation. Immunity 12: 151-160.
44. Ogawa, S., G. Nagamatsu, M. Watanabe, S. Watanabe, T. Hayashi, S. Horita, K. Nitta, H. Nihei, K. Tezuka, and R. Abe. 2001. Opposing effects of anti-activation-inducible lymphocyte-immunomodulatory molecule/inducible co-stimulator antibody on the development of acute versus chronic graft-versus-host disease. J. Immunol. 167: 5741-5748.
45. + T cells. J. Immunol. 165: 5035-5040.
46. L, and IL-2 expression in primary human CD4 T lymphocytes. J. Immunol. 171: 166-174.