-
1
-
-
0035947776
-
Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor
-
Foghsgaard L, Wissing D, Mauch D, et al (2001) Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor. J Cell Biol 153:999-1010
-
(2001)
J Cell Biol
, vol.153
, pp. 999-1010
-
-
Foghsgaard, L.1
Wissing, D.2
Mauch, D.3
-
3
-
-
0242609099
-
Cathepsin D mediates cytochrome c release and caspase activation in human fibroblast apoptosis induced by staurosporine
-
Johansson AC, Steen H, Öllinger K, Roberg K (2003) Cathepsin D mediates cytochrome c release and caspase activation in human fibroblast apoptosis induced by staurosporine. Cell Death Differ 10:1253-1259
-
(2003)
Cell Death Differ
, vol.10
, pp. 1253-1259
-
-
Johansson, A.C.1
Steen, H.2
Öllinger, K.3
Roberg, K.4
-
4
-
-
0031897739
-
Oxidative stress causes relocation of the lysosomal enzyme cathepsin D with ensuing apoptosis in neonatal rat cardiomyocytes
-
Roberg K, Öllinger K (1998) Oxidative stress causes relocation of the lysosomal enzyme cathepsin D with ensuing apoptosis in neonatal rat cardiomyocytes. Am J Pathol 152:1151-1156
-
(1998)
Am J Pathol
, vol.152
, pp. 1151-1156
-
-
Roberg, K.1
Öllinger, K.2
-
5
-
-
0030862412
-
Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocytes
-
Roberts LR, Kurosawa H, Bronk SF, et al (1997) Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocytes. Gastroenterology 113:1714-1726
-
(1997)
Gastroenterology
, vol.113
, pp. 1714-1726
-
-
Roberts, L.R.1
Kurosawa, H.2
Bronk, S.F.3
-
6
-
-
0030048987
-
Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification
-
USA
-
Gottlieb RA, Nordberg J, Skowronski E, Babior BM (1996) Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification. Proc Natl Acad Sci USA 93:654-658
-
(1996)
Proc Natl Acad Sci
, vol.93
, pp. 654-658
-
-
Gottlieb, R.A.1
Nordberg, J.2
Skowronski, E.3
Babior, B.M.4
-
7
-
-
0028813378
-
Apoptosis in an interleukin-2-dependent cytotoxic T lymphocyte cell line is associated with intracellular acidification. Role of the Na+/H+-antiport
-
Li J, Eastman A (1995) Apoptosis in an interleukin-2-dependent cytotoxic T lymphocyte cell line is associated with intracellular acidification. Role of the Na+/H+-antiport. J Biol Chem 270:3203-3211
-
(1995)
J Biol Chem
, vol.270
, pp. 3203-3211
-
-
Li, J.1
Eastman, A.2
-
8
-
-
0033776271
-
Changes in intramitochondrial and cytosolic pH: Early events that modulate caspase activation during apoptosis
-
Matsuyama S, Llopis J, Deveraux QL , Tsien RY, Reed JC (2000) Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis. Nat Cellbiol 2:318-325
-
(2000)
Nat Cellbiol
, vol.2
, pp. 318-325
-
-
Matsuyama, S.1
Llopis, J.2
Deveraux, Q.L.3
Tsien, R.Y.4
Reed, J.C.5
-
9
-
-
0034523187
-
Mitochondria-dependent apoptosis and cellular pH regulation
-
Matsuyama S, Reed JC (2000) Mitochondria-dependent apoptosis and cellular pH regulation. Cell Death Differ 7:1155-1165
-
(2000)
Cell Death Differ
, vol.7
, pp. 1155-1165
-
-
Matsuyama, S.1
Reed, J.C.2
-
10
-
-
0032856998
-
Regulation of acidification and apoptosis by SHP-1 and Bcl-2
-
Thangaraju M, Sharma K, Leber B, Andrews DW, Shen SH, Srikant CB (1999) Regulation of acidification and apoptosis by SHP-1 and Bcl-2. J Biol Chem 274:29549-29557
-
(1999)
J Biol Chem
, vol.274
, pp. 29549-29557
-
-
Thangaraju, M.1
Sharma, K.2
Leber, B.3
Andrews, D.W.4
Shen, S.H.5
Srikant, C.B.6
-
11
-
-
4143093635
-
The 1.4-MDa apoptosome is a critical intermediate in apoptosome maturation
-
Beem E, Holliday LS, Segal MS (2004) The 1.4-MDa apoptosome is a critical intermediate in apoptosome maturation. Am J Physiol - Cell Physiol 287:C664-672
-
(2004)
Am J Physiol - Cell Physiol
, vol.287
-
-
Beem, E.1
Holliday, L.S.2
Segal, M.S.3
-
12
-
-
0034796446
-
Effect of pH, ionic charge, and osmolality on cytochrome c-mediated caspase-3 activity
-
Segal MS, Beem E (2001) Effect of pH, ionic charge, and osmolality on cytochrome c-mediated caspase-3 activity. Am J Physiol - Cell Physiol 281:C1196-1204
-
(2001)
Am J Physiol - Cell Physiol
, vol.281
-
-
Segal, M.S.1
Beem, E.2
-
13
-
-
14344272939
-
Maintenance of caspase-3 proenzyme dormancy by an intrinsic "safety catch" regulatory tripeptide
-
USA
-
Roy S, Bayly CI, Gareau Y, et al (2001) Maintenance of caspase-3 proenzyme dormancy by an intrinsic "safety catch" regulatory tripeptide. Proc Natl Acad Sci USA 98:6132-6137
-
(2001)
Proc Natl Acad Sci
, vol.98
, pp. 6132-6137
-
-
Roy, S.1
Bayly, C.I.2
Gareau, Y.3
-
14
-
-
0032553541
-
Cytoprotection by Bcl-2 requires the pore-forming alpha5 and alpha6 helices
-
Matsuyama S, Schendel SL, Xie Z, Reed JC (1998) Cytoprotection by Bcl-2 requires the pore-forming alpha5 and alpha6 helices. J Biol Chem 273:30995-31001
-
(1998)
J Biol Chem
, vol.273
, pp. 30995-31001
-
-
Matsuyama, S.1
Schendel, S.L.2
Xie, Z.3
Reed, J.C.4
-
15
-
-
0033618409
-
Ion channel activity of the BH3 only Bcl-2 family member, BID
-
Schendel SL, Azimov R, Pawlowski K, Godzik A, Kagan BL, Reed JC (1999) Ion channel activity of the BH3 only Bcl-2 family member, BID. J Biol Chem 274:21932-21936
-
(1999)
J Biol Chem
, vol.274
, pp. 21932-21936
-
-
Schendel, S.L.1
Azimov, R.2
Pawlowski, K.3
Godzik, A.4
Kagan, B.L.5
Reed, J.C.6
-
16
-
-
0031008397
-
Channel formation by antiapoptotic protein Bcl-2
-
USA
-
Schendel SL, Xie Z, Montal MO, Matsuyama S, Montal M, Reed JC (1997) Channel formation by antiapoptotic protein Bcl-2. Proc Natl Acad Sci USA 94:5113-5118
-
(1997)
Proc Natl Acad Sci
, vol.94
, pp. 5113-5118
-
-
Schendel, S.L.1
Xie, Z.2
Montal, M.O.3
Matsuyama, S.4
Montal, M.5
Reed, J.C.6
-
17
-
-
0030779846
-
Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2
-
USA
-
Schlesinger PH, Gross A, Yin XM, et al (1997) Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2. Proc Natl Acad Sci USA 94:11357-11362
-
(1997)
Proc Natl Acad Sci
, vol.94
, pp. 11357-11362
-
-
Schlesinger, P.H.1
Gross, A.2
Yin, X.M.3
-
18
-
-
0032485845
-
Acidic pH promotes dimerization of Bcl-2 family proteins
-
Xie Z, Schendel S, Matsuyama S, Reed JC (1998) Acidic pH promotes dimerization of Bcl-2 family proteins. Biochemistry 37:6410-6418
-
(1998)
Biochemistry
, vol.37
, pp. 6410-6418
-
-
Xie, Z.1
Schendel, S.2
Matsuyama, S.3
Reed, J.C.4
-
19
-
-
0035808388
-
Intracellular acidification triggered by mitochondrial-derived hydrogen peroxide is an effector mechanism for drug-induced apoptosis in tumor cells
-
Hirpara JL, Clement MV, Pervaiz S (2001) Intracellular acidification triggered by mitochondrial-derived hydrogen peroxide is an effector mechanism for drug-induced apoptosis in tumor cells. J Biol Chem 276:514-521
-
(2001)
J Biol Chem
, vol.276
, pp. 514-521
-
-
Hirpara, J.L.1
Clement, M.V.2
Pervaiz, S.3
-
20
-
-
0030057436
-
Events in apoptosis. Acidification is downstream of protease activation and BCL-2 protection
-
Meisenholder GW, Martin SJ, Green DR, Nordberg J, Babior BM, Gottlieb RA (1996) Events in apoptosis. Acidification is downstream of protease activation and BCL-2 protection. J Biol Chem 271:16260-16262
-
(1996)
J Biol Chem
, vol.271
, pp. 16260-16262
-
-
Meisenholder, G.W.1
Martin, S.J.2
Green, D.R.3
Nordberg, J.4
Babior, B.M.5
Gottlieb, R.A.6
-
21
-
-
0034737646
-
Caspase-8-mediated intracellular acidification precedes mitochondrial dysfunction in somatostatin-induced apoptosis
-
Liu D, Martino G, Thangaraju M, et al (2000) Caspase-8-mediated intracellular acidification precedes mitochondrial dysfunction in somatostatin-induced apoptosis. J Biol Chem 275:9244-9250
-
(2000)
J Biol Chem
, vol.275
, pp. 9244-9250
-
-
Liu, D.1
Martino, G.2
Thangaraju, M.3
-
22
-
-
0032988381
-
Oxidative stress, growth factor starvation and Fas activation may all cause apoptosis through lysosomal leak
-
Brunk UT, Svensson I (1999) Oxidative stress, growth factor starvation and Fas activation may all cause apoptosis through lysosomal leak. Redox Report 4:3-11
-
(1999)
Redox Report
, vol.4
, pp. 3-11
-
-
Brunk, U.T.1
Svensson, I.2
-
23
-
-
0034711474
-
Protection against oxidant-mediated lysosomal rupture: A new anti-apoptotic activity of Bcl-2?
-
Zhao M, Eaton JW, Brunk UT (2000) Protection against oxidant-mediated lysosomal rupture: a new anti-apoptotic activity of Bcl-2? FEBS Lett 485:104-108
-
(2000)
FEBS Lett
, vol.485
, pp. 104-108
-
-
Zhao, M.1
Eaton, J.W.2
Brunk, U.T.3
-
24
-
-
0033756474
-
Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c
-
Guicciardi ME, Deussing J, Miyoshi H, et al (2000) Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c. J Clin Invest 106:1127-1137
-
(2000)
J Clin Invest
, vol.106
, pp. 1127-1137
-
-
Guicciardi, M.E.1
Deussing, J.2
Miyoshi, H.3
-
25
-
-
17144421250
-
Analysis of cytosolic and lysosomal pH in apoptotic cells by flow cytometry
-
Nilsson C, Kågedal K, Johansson U, Öllinger K (2003) Analysis of cytosolic and lysosomal pH in apoptotic cells by flow cytometry. Methods Cell Sci 25:185-194
-
(2003)
Methods Cell Sci
, vol.25
, pp. 185-194
-
-
Nilsson, C.1
Kågedal, K.2
Johansson, U.3
Öllinger, K.4
-
26
-
-
0030757986
-
Photooxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts
-
Brunk UT, Dalen H, Roberg K, Hellquist HB (1997) Photooxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts. Free Radic Biol Med 23:616-626
-
(1997)
Free Radic Biol Med
, vol.23
, pp. 616-626
-
-
Brunk, U.T.1
Dalen, H.2
Roberg, K.3
Hellquist, H.B.4
-
27
-
-
0025830873
-
J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential
-
Reers M, Smith TW, Chen LB (1991) J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential. Biochemistry 30:4480-4486
-
(1991)
Biochemistry
, vol.30
, pp. 4480-4486
-
-
Reers, M.1
Smith, T.W.2
Chen, L.B.3
-
28
-
-
0025806764
-
Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1
-
USA
-
Smiley ST, Reers M, Mottola-Hartshorn C, et al (1991) Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1. Proc Natl Acad Sci USA 88:3671-3675
-
(1991)
Proc Natl Acad Sci
, vol.88
, pp. 3671-3675
-
-
Smiley, S.T.1
Reers, M.2
Mottola-Hartshorn, C.3
-
29
-
-
0035300531
-
Caspase-3 activation by lysosomal enzymes in cytochrome c-independent apoptosis in myelodysplastic syndrome-derived cell line P39
-
Hishita T, Tada-Oikawa S, Tohyama K, et al (2001) Caspase-3 activation by lysosomal enzymes in cytochrome c-independent apoptosis in myelodysplastic syndrome-derived cell line P39. Cancer Res 61:2878-2884
-
(2001)
Cancer Res
, vol.61
, pp. 2878-2884
-
-
Hishita, T.1
Tada-Oikawa, S.2
Tohyama, K.3
-
30
-
-
0033950037
-
Lysosomal destabilization during macrophage damage induced by cholesterol oxidation products
-
Yuan XM, Li W, Brunk UT, Dalen H, Chang YH, Sevanian A (2000) Lysosomal destabilization during macrophage damage induced by cholesterol oxidation products. Free Radic Biol Med 28:208-218
-
(2000)
Free Radic Biol Med
, vol.28
, pp. 208-218
-
-
Yuan, X.M.1
Li, W.2
Brunk, U.T.3
Dalen, H.4
Chang, Y.H.5
Sevanian, A.6
-
31
-
-
0038641715
-
3-Ammopropanal, formed during cerebral ischaemia, is a potent lysosomotropic neurotoxin
-
Li W, Yuan XM, Ivanova S, Tracey KJ, Eaton JW, Brunk UT (2003) 3-Ammopropanal, formed during cerebral ischaemia, is a potent lysosomotropic neurotoxin. Biochem J 371:429-436
-
(2003)
Biochem J
, vol.371
, pp. 429-436
-
-
Li, W.1
Yuan, X.M.2
Ivanova, S.3
Tracey, K.J.4
Eaton, J.W.5
Brunk, U.T.6
-
32
-
-
0034677741
-
Induction of cell death by the lysosomotropic detergent MSDH
-
Li W, Yuan X, Nordgren G, et al (2000) Induction of cell death by the lysosomotropic detergent MSDH. FEBS Lett 470:35-39
-
(2000)
FEBS Lett
, vol.470
, pp. 35-39
-
-
Li, W.1
Yuan, X.2
Nordgren, G.3
-
33
-
-
0021846763
-
Identification of two lysosomal membrane glycoproteins
-
Chen JW, Murphy TL, Willingham MC, Pastan I, August JT (1985) Identification of two lysosomal membrane glycoproteins. J Cell Biol 101:85-95
-
(1985)
J Cell Biol
, vol.101
, pp. 85-95
-
-
Chen, J.W.1
Murphy, T.L.2
Willingham, M.C.3
Pastan, I.4
August, J.T.5
-
34
-
-
0028957421
-
The in vitro effect of three lysosomotropic detergents against three human tumor cell lines
-
Dubowchik GM, Gawlak SL, Firestone RA (1995) The in vitro effect of three lysosomotropic detergents against three human tumor cell lines. Bioorg Med Chem Lett 5:893-898
-
(1995)
Bioorg Med Chem Lett
, vol.5
, pp. 893-898
-
-
Dubowchik, G.M.1
Gawlak, S.L.2
Firestone, R.A.3
-
35
-
-
0035887215
-
Sphingosine-induced apoptosis is dependent on lysosomal proteases
-
Kågedal K, Zhao M, Svensson I, Brunk UT (2001) Sphingosine-induced apoptosis is dependent on lysosomal proteases. Biochem J 359:335-343
-
(2001)
Biochem J
, vol.359
, pp. 335-343
-
-
Kågedal, K.1
Zhao, M.2
Svensson, I.3
Brunk, U.T.4
-
36
-
-
0030881603
-
Biochemical characteristics of caspases-3,-6,-7, and -8
-
Stennicke HR, Salvesen GS (1997) Biochemical characteristics of caspases-3,-6,-7, and -8. J Biol Chem 272:25719-25723
-
(1997)
J Biol Chem
, vol.272
, pp. 25719-25723
-
-
Stennicke, H.R.1
Salvesen, G.S.2
-
37
-
-
0033436344
-
Lysosomal release of cathepsin D precedes relocation of cytochrome c and loss of mitochondrial transmembrane potential during apoptosis induced by oxidative stress
-
Roberg K, Johansson U, Öllinger K (1999)Lysosomal release of cathepsin D precedes relocation of cytochrome c and loss of mitochondrial transmembrane potential during apoptosis induced by oxidative stress. Free Radic Biol Med 27:1228-1237
-
(1999)
Free Radic Biol Med
, vol.27
, pp. 1228-1237
-
-
Roberg, K.1
Johansson, U.2
Öllinger, K.3
-
38
-
-
0027459566
-
Kinetics of the pH-induced inactivation of human cathepsin L
-
Turk B, Dolenc I, Turk V, Bieth JG (1993) Kinetics of the pH-induced inactivation of human cathepsin L. Biochemistry 32:375-380
-
(1993)
Biochemistry
, vol.32
, pp. 375-380
-
-
Turk, B.1
Dolenc, I.2
Turk, V.3
Bieth, J.G.4
-
39
-
-
0034705826
-
The active-site residue Cys-29 is responsible for the neutral-pH inactivation and the refolding barrier of human cathepsin B
-
Song J, Xu P, Xiang H, Su Z, Storer AC, Ni F (2000) The active-site residue Cys-29 is responsible for the neutral-pH inactivation and the refolding barrier of human cathepsin B FEBS Lett 475:157-162
-
(2000)
FEBS Lett
, vol.475
, pp. 157-162
-
-
Song, J.1
Xu, P.2
Xiang, H.3
Su, Z.4
Storer, A.C.5
Ni, F.6
-
40
-
-
0036732169
-
Release of cytochrome c and activation of pro-caspase-9 following lysosomal photodamage involves Bid cleavage
-
Reiners JJ, Jr., Caruso JA, Mathieu P, Chelladurai B, Yin XM, Kessel D (2002) Release of cytochrome c and activation of pro-caspase-9 following lysosomal photodamage involves Bid cleavage. Cell Death Differ 9:934-944
-
(2002)
Cell Death Differ
, vol.9
, pp. 934-944
-
-
Reiners Jr., J.J.1
Caruso, J.A.2
Mathieu, P.3
Chelladurai, B.4
Yin, X.M.5
Kessel, D.6
-
41
-
-
0035793580
-
Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route
-
Stoka V, Turk B, Schendel SL, et al (2001) Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route. J Biol Chem 276:3149-3157
-
(2001)
J Biol Chem
, vol.276
, pp. 3149-3157
-
-
Stoka, V.1
Turk, B.2
Schendel, S.L.3
-
42
-
-
2442661614
-
Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation
-
Heinrich M, Neumeyer J, Jakob M, et al (2004) Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation. Cell Death Differ 11:550-563
-
(2004)
Cell Death Differ
, vol.11
, pp. 550-563
-
-
Heinrich, M.1
Neumeyer, J.2
Jakob, M.3
-
43
-
-
0942265544
-
Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins
-
Cirman T, Oresic K, Mazovec GD, et al (2004) Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins. J Biol Chem 279:3578-3587
-
(2004)
J Biol Chem
, vol.279
, pp. 3578-3587
-
-
Cirman, T.1
Oresic, K.2
Mazovec, G.D.3
|