Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation

Cancer Science

Volumn 97, Issue 8, 2006, Pages 729-736

  Fujii, Yo ^a,b   Yada, Masayoshi ^a,b   Nishiyama, Masaaki ^a,b   Kamura, Takumi ^a,b   Takahashi, Hidehisa ^a,b   Tsunematsu, Ryosuke ^a,b   Susaki, Etsuo ^a,b   Nakagawa, Tadashi ^a,b   Matsumoto, Akinobu ^a,b   Nakayama, Keiichi I ^a,b  

^a KYUSHU UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA A KINASE; CYCLIN E; F BOX PROTEIN; MYC PROTEIN; ONCOPROTEIN; PROTEIN FBXW7; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME SUBSTRATE; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; MUTANT; MUTATIONAL ANALYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; RNA INTERFERENCE; UBIQUITINATION;

BREAST NEOPLASMS; CELL CYCLE PROTEINS; CELL PROLIFERATION; CYCLIN E; F-BOX PROTEINS; HUMANS; MUTATION; NEOPLASM PROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-MYC; RNA INTERFERENCE; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 33745613510     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2006.00239.x     Document Type: Article

References (55)

1. Nakayama KI, Nakayama K. Ubiquitin ligases: Cell cycle control and cancer. Nat Rev Cancer 2006; 6: 369-81.
2. Hershko A, Ciechanover A. The ubiquitin system. Annu Rev Biochem 1998; 67: 425-79.
3. Bai C, Sen P, Hofmann K et al. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 1996; 86: 263-74.
4. Feldman RM, Correll CC, Kaplan KB, Deshaies RJ. A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 1997; 91: 221-30.
5. Skowyra D, Craig KL, Tyers M, Elledge SJ, Harper JW. F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 1997; 91: 209-19.
6. King RW, Peters JM, Tugendreich S, Rolfe M, Hieter P, Kirschner MW. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell 1995; 81: 279-88.
7. Sudakin V, Ganoth D, Dahan A et al. The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol Biol Cell 1995; 6: 185-97.
8. Harper JW, Burton JL, Solomon MJ. The anaphase-promoting complex: It's not just for mitosis any more. Genes Dev 2002; 16: 2179-206.
9. Nakayama KI, Nakayama K. Regulation of the cell cycle by SCF-type ubiquitin ligases. Semin Cell Dev Biol 2005; 16: 323-33.
10. 1Cip1 in S phase. J Biol Chem 2003; 278: 25 752-7.
11. Carrano AC, Eytan E, Hershko A, Pagano M. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol 1999; 1: 193-9.
12. Kip1 degradation and induces S phase in quiescent cells. Nat Cell Biol 1999; 1: 207-14.
13. Skp2 complex through phosphorylated Thr187 in p27. Curr Biol 1999; 9: 661-4.
14. Skp2-dependent ubiquitylation. Proc Natl Acad Sci USA 2003; 100: 10 231-6.
15. Fbw7 ubiquitin ligase. Science 2001; 294: 173-7.
16. Moberg KH, Bell DW, Wahrer DC, Haber DA, Hariharan IK. Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines. Nature 2001; 413: 311-16.
17. Strohmaier H, Spruck CH, Kaiser P, Won KA, Sangfelt O, Reed SI. Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Nature 2001; 413: 316-22.
18. Yada M, Hatakeyama S, Kamura T et al. Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J 2004; 23: 2116-25.
19. Welcker M, Orian A, Jin J et al. The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc Natl Acad Sci USA 2004; 101: 9085-90.
20. Mao JH, Perez-Losada J, Wu D et al. Fbxw7/Cdc4 is a p53-dependent, haploin sufficient tumour suppressor gene. Nature 2004; 432: 775-9.
21. Hubbard EJ, Wu G, Kitajewski J, Greenwald I. Sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins. Genes Dev 1997; 11: 3182-93.
22. Gupta-Rossi N, Le Bail O, Gonen H et al. Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor. J Biol Chem 2001; 276: 34 371-8.
23. Oberg C, Li J, Pauley A, Wolf E, Gurney M, Lendahl U. The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog. J Biol Chem 2001; 276: 35 847-53.
24. Wu G, Lyapina S, Das I et al. SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation. Mol Cell Biol 2001; 21: 7403-15.
25. Fbw7 antagonizes apoptotic JNK signaling. Science 2004; 303: 1374-8.
26. Kwak EL, Moberg KH, Wahrer DC et al. Infrequent mutations of Archipelago (hAGO, hCDC4, Fbw7) in primary ovarian cancer. Gynecol Oncol 2005; 98: 124-8.
27. Ekholm-Reed S, Spruck CH, Sangfelt O et al. Mutation of hCDC4 leads to cell cycle deregulation of cyclin E in cancer. Cancer Res 2004; 64: 795-800.
28. Cassia R, Moreno-Bueno G, Rodriguez-Perales S, Hardisson D, Cigudosa JC, Palacios J. Cyclin E gene (CCNE) amplification and hCDC4 mutations in endometrial carcinoma. J Pathol 2003; 201: 589-95.
29. Spruck CH, Strohmaier H, Sangfelt O et al. hCDC4 gene mutations in endometrial cancer. Cancer Res 2002; 62: 4535-9.
30. Rajagopalan H, Jallepalli PV, Rago C et al. Inactivation of hCDC4 can cause chromosomal instability. Nature 2004; 428: 77-81.
31. Spruck CH, Won KA, Reed SI. Deregulated cyclin E induces chromosome instability. Nature 1999; 401: 297-300.
32. Tsunematsu R, Nakayama K, Oike Y et al. Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J Biol Chem 2004; 279: 9417-23.
33. Kip1, polyploidy and centrosome overduplication. EMBO J 2000; 19: 2069-81.
34. Nakayama K, Nagahama H, Minamishima YA et al. Skp2-mediated degradation of p27 regulates progression into mitosis. Dev Cell 2004; 6: 661-72.
35. kip1 is essential for cell cycle progression. Genes Dev 2004; 18: 2602-7.
36. Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 1996; 85: 707-20.
37. Hatakeyama S, Kitagawa M, Nakayama K et al. Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/ Cul 1/F-box protein FWD1. Proc Natl Acad Sci USA 1999; 96: 3859-63.
38. Morita S, Kojima T, Kitamura T. Plat-E: An efficient and stable system for transient packaging of retroviruses. Gene Ther 2000; 7: 1063-6.
39. Kamura T, Maenaka K, Kotoshiba S et al. VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. Genes Dev 2004; 18: 3055-65.
40. Kip1 at G1 phase. Nat Cell Biol 2004; 6: 1229-35.
41. Hatakeyama S, Watanabe M, Fujii Y, Nakayama KI. Targeted destruction of c-Myc by an engineered ubiquitin ligase suppresses cell transformation and tumor formation. Cancer Res 2005; 65: 7874-9.
42. Tetzlaff MT, Yu W, Li M et al. Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc Natl Acad Sci USA 2004; 101: 3338-45.
43. Adhikary S, Eilers M. Transcriptional regulation and transformation by Myc proteins. Nature Rev Mol Cell Biol 2005; 6: 635-45.
44. Giet R, Petretti C, Prigent C. Aurora kinases, aneuploidy and cancer, a coincidence or a real link? Trends Cell Biol 2005; 15: 241-50.
45. Weng AP, Aster JC. Multiple niches for Notch in cancer: Context is everything. Curr Opin Genet Dev 2004; 14: 48-54.
46. Callahan R, Raafat A. Notch signaling in mammary gland tumorigenesis. J Mammary Gland Biol Neoplasia 2001; 6: 23-36.
47. Capobianco AJ, Zagouras P, Blaumueller CM, Artavanis-Tsakonas S, Bishop JM. Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2. Mol Cell Biol 1997; 17: 6265-73.
48. Hoemann CD, Beaulieu N, Girard L, Rebai N, Jolicoeur P. Two distinct Notch1 mutant alleles are involved in the induction of T-cell leukemia in c-myc transgenic mice. Mol Cell Biol 2000; 20: 3831-42.
49. Pear WS, Aster JC, Scott ML et al. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med 1996; 183: 2283-91.
50. Gallahan D, Callahan R. The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4). Oncogene 1997; 14: 1883-90.
51. Hartl M, Bader AG, Bister K. Molecular targets of the oncogenic transcription factor jun. Curr Cancer Drug Targets 2003; 3: 41-55.
52. Li K, Lin SY, Brunicardi FC, Seu P. Use of RNA interference to target cyclin E-overexpressing hepatocellular carcinoma. Cancer Res 2003; 63: 3593-7.
53. Williams NS, Gaynor RB, Scoggin S et al. Identification and validation of genes involved in the pathogenesis of colorectal cancer using cDNA microarrays and RNA interference. Clin Cancer Res 2003; 9: 931-46.
54. Du J, Hannon GJ. Suppression of p160ROCK bypasses cell cycle arrest after Aurora-A/STK15 depletion. Proc Natl Acad Sci USA 2004; 101: 8975-80.
55. Hata T, Furukawa T, Sunamura M et al. RNA interference targeting aurora kinase A suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells. Cancer Res 2005; 65: 2899-905.