Multidrug Resistance to HIV-1 Protease Inhibition Requires Cooperative Coupling between Distal Mutations

Biochemistry

Volumn 42, Issue 46, 2003, Pages 13659-13666

  Ohtaka, Hiroyasu ^a   Schön, Arne ^a   Freire, Ernesto ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTATION;

AMINO ACIDS; DIMERIZATION; DIMERS; DRUG THERAPY; ENZYME KINETICS; ENZYMES; IMMUNOLOGY; SUBSTRATES; VIRUSES;

CHEMOTHERAPY;

AMPRENAVIR; ANTIRETROVIRUS AGENT; INDINAVIR; KNI 764; KYNOSTATIN 272; LOPINAVIR; MUTANT PROTEIN; NELFINAVIR; PROTEINASE; RITONAVIR; SAQUINAVIR; UNCLASSIFIED DRUG; VIRUS ENZYME;

AMINO ACID COMPOSITION; ARTICLE; BINDING AFFINITY; DIMERIZATION; DRUG PROTEIN BINDING; ENERGY TRANSFER; ENTHALPY; ENTROPY; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE; GENE MUTATION; HUMAN IMMUNODEFICIENCY VIRUS 1; MICROCALORIMETRY; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; VIRUS MUTANT;

AMINO ACID SUBSTITUTION; BINDING SITES; CATALYSIS; DIMERIZATION; DRUG RESISTANCE, MULTIPLE, VIRAL; HIV PROTEASE; HIV PROTEASE INHIBITORS; KINETICS; MODELS, MOLECULAR; PROTEIN BINDING; RECOMBINANT PROTEINS; THERMODYNAMICS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0344823654     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0350405     Document Type: Article

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