The 1.8 Å crystal structure of the dimeric peroxisomal 3-ketoacyl-CoA thiolase of Saccharomyces cerevisiae: Implications for substrate binding and reaction mechanism

Journal of Molecular Biology

Volumn 273, Issue 3, 1997, Pages 714-728

  Mathieu, Magali ^a,f   Modis, Yorgo ^a   Zeelen, Johan Ph ^a   Engel, Christian K ^a   Abagyan, Ruben A ^b   Ahlberg, Anders ^c   Rasmussen, Bjarne ^c   Lamzin, Victor S ^d   Kunau, Wolf H ^e   Wierenga, Rik K ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (France)

^d EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^e RUHR UNIVERSITY BOCHUM   (Germany)

^f LABORATOIRE D ENZYMOLOGIE ET BIOCHIMIE STRUCTURALES   (France)

Author keywords

CoA; Crystal structure; Reaction mechanism; Thiolase; oxidation

Indexed keywords

ACETYL COENZYME A ACYLTRANSFERASE; ACYL COENZYME A; ARGININE; LYSINE; PHOSPHATE; ACETOACETYL COENZYME A;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; COVALENT BOND; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; GENETIC CONSERVATION; HYDROGEN BOND; MOLECULAR INTERACTION; NONHUMAN; PEROXISOME; PRIORITY JOURNAL; PROTEIN BINDING; SACCHAROMYCES CEREVISIAE; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; ENZYME SPECIFICITY; ENZYMOLOGY; METABOLISM; MICROBODY; MOLECULAR GENETICS; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

SACCHAROMYCES CEREVISIAE;

ACETYL-COA C-ACYLTRANSFERASE; ACYL COENZYME A; AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; MICROBODIES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SUBSTRATE SPECIFICITY;

EID: 0031592777     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1997.1331     Document Type: Article

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