The role of protein dynamics in thymidylate synthase catalysis: Variants of conserved 2′-deoxyuridine 5′-monophosphate (dUMP)-binding Tyr-261

Biochemistry

Volumn 45, Issue 24, 2006, Pages 7415-7428

  Newby, Zachary ^c   Lee, Tom T ^a   Morse, Richard J ^a   Liu, Yaoquan ^b   Liu, Lu ^b   Venkatraman, Prasanna ^b   Santi, Daniel V ^a,b   Finer Moore, Janet S ^a   Stroud, Robert M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Graduate Group in Chemistry and Chemical Biology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; COFACTORS; ENZYMATIC ACTIVITY; MUTANTS;

BIOPOLYMERS; CATALYSIS; CRYSTALS; ESCHERICHIA COLI; HYDROGEN BONDS; SUBSTRATES; X RAY CRYSTALLOGRAPHY;

ENZYMES;

ARGININE; DEOXYURIDINE PHOSPHATE; MUTANT PROTEIN; PROTEIN; SOLVENT; THYMIDINE PHOSPHATE; THYMIDYLATE SYNTHASE; TRYPTOPHAN; TYROSINE;

AMINO ACID SUBSTITUTION; ARTICLE; ATOMIC VIBRATION; CATALYSIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; GENETIC CONSERVATION; HYDROGEN BOND; METHYLATION; MOLECULAR DYNAMICS; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN VARIANT; REDUCTION; VIBRATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DEOXYURACIL NUCLEOTIDES; ESCHERICHIA COLI; HYDROGEN BONDING; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; THYMIDYLATE SYNTHASE; TYROSINE;

ESCHERICHIA COLI;

EID: 33745159979     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi060152s     Document Type: Article

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