Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of 'effective charge balance'

Biochemistry

Volumn 39, Issue 5, 2000, Pages 1011-1020

  Morse, Richard J ^a   Kawase, Shido ^b   Santi, Daniel V ^a,b   Finer Moore, Janet ^a   Stroud, Robert M ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE DERIVATIVE; DEOXYURIDINE PHOSPHATE; LIGAND; OXYGEN; PHOSPHATE; THYMIDYLATE SYNTHASE;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ELECTRICITY; HYDROGEN BOND; KINETICS; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING;

ARGININE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DEOXYURACIL NUCLEOTIDES; ELECTROSTATICS; HYDROGEN BONDING; KINETICS; LACTOBACILLUS CASEI; MUTAGENESIS, SITE-DIRECTED; PHOSPHATES; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; THREONINE; THYMIDYLATE SYNTHASE;

EID: 0034620589     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9918590     Document Type: Article

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