Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus

Journal of Virology

Volumn 80, Issue 12, 2006, Pages 6146-6154

  Le Pogam, Sophie ^a   Kang, Hyunsoon ^a   Harris, Seth F ^a   Leveque, Vincent ^a   Giannetti, Anthony M ^a   Ali, Samir ^a   Jiang, Wen Rong ^a   Rajyaguru, Sonal ^a   Tavares, Gisele ^a,b   Oshiro, Connie ^a   Hendricks, Than ^a   Klumpp, Klaus ^a   Symons, Julian ^a   Browner, Michelle F ^a   Cammack, Nick ^a   Nájera, Isabel ^a  

^a ROCHE BIOSCIENCE   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID; PALM BINDING POLYMERASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; THIOPHENE; THUMB BINDING POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; DRUG SELECTIVITY; ENZYME ACTIVE SITE; ENZYME INHIBITION; HEPATITIS C VIRUS; MOLECULAR CLONING; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; REPLICON; VIRUS CHARACTERIZATION; VIRUS IDENTIFICATION; VIRUS INFECTION; VIRUS RESISTANCE;

ANTIVIRAL AGENTS; DRUG RESISTANCE, VIRAL; DRUG THERAPY, COMBINATION; HEPACIVIRUS; MUTATION, MISSENSE; REPLICON; RNA REPLICASE; SELECTION (GENETICS); THIOPHENES; VARIATION (GENETICS); VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

HEPATITIS C VIRUS;

EID: 33744930847     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.02628-05     Document Type: Article

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