Mechanism of Action and Antiviral Activity of Benzimidazole-Based Allosteric Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase

Journal of Virology

Volumn 77, Issue 24, 2003, Pages 13225-13231

  Tomei, Licia ^a   Altamura, Sergio ^a   Bartholomew, Linda ^a   Biroccio, Antonino ^a,b   Ceccacci, Alessandra ^a   Pacini, Laura ^a   Narjes, Frank ^a   Gennari, Nadia ^a   Bisbocci, Monica ^a   Incitti, Ilario ^a   Orsatti, Laura ^a   Harper, Steven ^a   Stansfield, Ian ^a   Rowley, Michael ^a   De Francesco, Raffaele ^a   Migliaccio, Giovanni ^a  

^a IRBM   (Italy)

^b BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; RNA DIRECTED RNA POLYMERASE; VIRUS RNA;

ALLOSTERISM; AMINO ACID SUBSTITUTION; ANTIVIRAL ACTIVITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHRONIC LIVER DISEASE; CONFORMATIONAL TRANSITION; DRUG ACTIVITY; DRUG MECHANISM; ENZYME ACTIVE SITE; ENZYME INHIBITION; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; REPLICON; VIRUS REPLICATION;

ALLOSTERIC SITE; ANTIVIRAL AGENTS; BENZIMIDAZOLES; CELL LINE; ENZYME INHIBITORS; HEPACIVIRUS; HUMANS; KINETICS; RNA REPLICASE; RNA, VIRAL; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 10744221995     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.77.24.13225-13231.2003     Document Type: Article

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