Is RNA interference involved in intrinsic antiviral immunity in mammals?

Nature Immunology

Volumn 7, Issue 6, 2006, Pages 563-567

  Cullen, Bryan R ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; MESSENGER RNA; MICRORNA; SMALL INTERFERING RNA; TRANSACTIVATOR PROTEIN;

ADENOVIRUS; BIOGENESIS; DATA ANALYSIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNITY; INNATE IMMUNITY; INVERTEBRATE; MAMMAL; MAMMAL CELL; NONHUMAN; POSTTRANSCRIPTIONAL GENE SILENCING; PRIORITY JOURNAL; REVIEW; RNA INTERFERENCE; RNA STRUCTURE; RNA TRANSCRIPTION; SOMATIC CELL; VACCINIA VIRUS; VIRAL PLANT DISEASE; VIRUS INFECTION;

ANIMALS; HUMANS; IMMUNITY; MICRORNAS; NUCLEIC ACID CONFORMATION; PLANTS; RNA INTERFERENCE; VIRUS DISEASES; VIRUSES;

EID: 33744476400     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1352     Document Type: Review

References (57)

1. Fire, A. et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811 (1998).
2. Gitlin, L. & Andino, R. Nucleic acid-based immune system: The antiviral potential of mammalian RNA silencing. J. Virol. 77, 7159-7165 (2003).
3. Bartel, D.P. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116, 281-297 (2004).
4. Cullen, B.R. Transcription and processing of human microRNA precursors. Mol. Cell 16, 861-865 (2004).
5. Zeng, Y., Yi, R. & Cullen, B.R. Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha. EMBO J. 24, 138-148 (2005).
6. Han, J. et al. The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev. 18, 3016-3027 (2004).
7. Yi, R., Qin, Y., Macara, I.G. & Cullen, B.R. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev. 17, 3011-3016 (2003).
8. Lund, E., Güttinger, S., Calado, A., Dahlberg, J.E. & Kutay, U. Nuclear export of microRNA precursors. Science 303, 95-98 (2004).
9. Zeng, Y. & Cullen, B.R. Structural requirements for pre-microRNA binding and nuclear export by Exportin 5. Nucleic Acids Res. 32, 4776-4785 (2004).
10. Chendrimada, T.P. et al. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 436, 740-744 (2005).
11. Hutvágner, G. et al. A cellular function for the RNA-interference enzyme dicer in the maturation of the let-7 small temporal RNA. Science 293, 834-838 (2001).
12. Macrae, I.J. et al. Structural basis for double-stranded RNA processing by Dicer. Science 311, 195-198 (2006).
13. Hammond, S.M., Bernstein, E., Beach, D. & Hannon, G.J. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature 404, 293-295 (2000).
14. Schwarz, D.S., Hutvágner, G., Haley, B. & Zamore, P.D. Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways. Mol. Cell 10, 537-548 (2002).
15. Elbashir, S.M. et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494-498 (2001).
16. Paddison, P.J., Caudy, A.A., Bernstein, E., Hannon, G.J. & Conklin, D.S. Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev. 16, 948-958 (2002).
17. Zeng, Y., Wagner, E.J. & Cullen, B.R. Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells. Mol. Cell 9, 1327-1333 (2002).
18. Yang, S., Tutton, S., Pierce, E. & Yoon, K. Specific double-stranded RNA interference in undifferentiated mouse embryonic stem cells. Mol. Cell. Biol. 21, 7807-7816 (2001).
19. Zhang, H., Kolb, F.A., Brondani, V., Billy, E. & Filipowicz, W. Human dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP. EMBO J. 21, 5875-5885 (2002).
20. Katze, M.G., He, Y. & Gale, M.G., Jr. Viruses and interferon: A fight for supremacy. Nat. Rev. Immunol. 2, 675-687 (2002).
21. Hamilton, A.J. & Baulcombe, D.C. A species of small antisense RNA in posttranscriptional gene silencing in plants. Science 286, 950-952 (1999).
22. Zamore, P.D., Tuschl, T., Sharp, P.A. & Bartel, D.P. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell 101, 25-33 (2000).
23. Mourrain, P. et al. Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance. Cell 101, 533-542 (2000).
24. Dalmay, T., Horsefield, R., Braunstein, T.H. & Baulcombe, D.C. SDE3 encodes an RNA helicase required for posttranscriptional gene silencing in Arabidopsis. EMBO J. 20, 2069-2077 (2001).
25. Voinnet, O., Pinto, Y.M. & Baulcombe, D.C. Suppression of gene silencing: A general strategy used by diverse DNA and RNA viruses of plants. Proc. Natl. Acad. Sci. USA 96, 14147-14152 (1999).
26. Roth, B.M., Pruss, G.J. & Vance, V.B. Plant viral suppressors of RNA silencing. Virus Res. 102, 97-108 (2004).
27. Li, H., Li, W.X. & Ding, S.W. Induction and suppression of RNA silencing by an animal virus. Science 296, 1319-1321 (2002).
28. Galiana-Arnoux, D., Dostert, C., Schneemann, A., Hoffmann, J.A. & Imler, J.-L. Essential function in vivo for Dicer-2 in host defense against RNA viruses in drosophila. Nat. Immunol. advance online publication, 23 March 2006 (doi:10.1038/ni1335).
29. Wang, X.H. et al. RNA interference directs innate immunity against viruses in adult Drosophila. Science 312, 452-454 (2006).
30. Keene, K.M. et al. RNA interference acts as a natural antiviral response to O'nyongnyong virus (Alphavirus; Togaviridae) infection of Anopheles gambiae. Proc. Natl. Acad. Sci. USA 101, 17240-17245 (2004).
31. Johnson, K.L., Price, B.D., Eckerle, L.D. & Ball, L.A. Nodamura virus nonstructural protein B2 can enhance viral RNA accumulation in both mammalian and insect cells. J. Virol. 78, 6698-6704 (2004).
32. Sullivan, C.S. & Ganem, D. A virus-encoded inhibitor that blocks RNA interference in mammalian cells. J. Virol. 79, 7371-7379 (2005).
33. Fenner, B.J., Thiagarajan, R., Chua, H.K. & Kwang, J. Betanodavirus B2 is an RNA interference antagonist that facilitates intracellular viral RNA accumulation. J. Virol. 80, 85-94 (2006).
34. Wilkins, C. et al. RNA interference is an antiviral defence mechanism in Caenorhabditis elegans. Nature 436, 1044-1047 (2005).
35. Schott, D.H., Cureton, D.K., Whelan, S.P. & Hunter, C.P. An antiviral role for the RNA interference machinery in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 102, 18420-18424 (2005).
36. Lu, R. et al. Animal virus replication and RNAi-mediated antiviral silencing in Caenorhabditis elegans. Nature 436, 1040-1043 (2005).
37. Pfeffer, S. et al. Identification of microRNAs of the herpesvirus family. Nat. Methods 2, 269-276 (2005).
38. Bennasser, Y., Le, S.-Y., Benkirane, M. & Jeang, K.-T. Evidence that HIV-1 encodes an siRNA and a suppressor of RNA silencing. Immunity 22, 607-619 (2005).
39. Malim, M.H., Hauber, J., Le, S.-Y., Maizel, J.V. & Cullen, B.R. The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA. Nature 338, 254-257 (1989).
40. Charpentier, B., Stutz, F. & Rosbash, M. A dynamic in vivo view of the HIV-1 Rev-RRE interaction. J. Mol. Biol. 266, 950-962 (1997).
41. Mann, D.A. et al. A molecular rheostat. Cooperative rev binding to stem I of the rev-response element modulates human immunodeficiency virus type-1 late gene expression. J. Mol. Biol. 241, 193-207 (1994).
42. Elbashir, S.M., Lendeckel, W. & Tuschl, T. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev. 15, 188-200 (2001).
43. Brown, K.M., Chu, C.-Y. & Rana, T.M. Target accessibility dictates the potency of human RISC. Nat. Struct. Mol. Biol. 12, 469-470 (2005).
44. Westerhout, E.M., Ooms, M., Vink, M., Das, A.T. & Berkhout, B. HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome. Nucleic Acids Res. 33, 796-804 (2005).
45. Lu, S. & Cullen, B.R. Adenovirus VA1 noncoding RNA can inhibit small interfering RNA and microRNA biogenesis. J. Virol. 78, 12868-12876 (2004).
46. Andersson, M.G. et al. Suppression of RNA interference by adenovirus virus-associated RNA. J. Virol. 79, 9556-9565 (2005).
47. Gwizdek, C. et al. Terminal minihelix, a novel RNA motif that directs polymerase III transcripts to the cell cytoplasm. J. Biol. Chem. 276, 25910-25918 (2001).
48. Li, W.-X. et al. Interferon antagonist proteins of influenza and vaccinia viruses are suppressors of RNA silencing. Proc. Natl. Acad. Sci. USA 101, 1350-1355 (2004).
49. Bucher, E., Hemmes, H., de Haan, P., Goldbach, R. & Prins, M. The influenza A virus NS1 protein binds small interfering RNAs and suppresses RNA silencing in plants. J. Gen. Virol. 85, 983-991 (2004).
50. Delgadillo, M.O., Sáenz, P., Salvador, B., García, J.A. & Simón-Mateo, C. Human influenza virus NS1 protein enhances viral pathogenicity and acts as an RNA silencing supresor in plants. J. Gen. Virol. 85, 993-999 (2004).
51. Lichner, Z., Silhavy, D. & Burgyan, J. Double-stranded RNA-binding proteins could suppress RNA interference-mediated antiviral defences. J. Gen. Virol. 84, 975-980 (2003).
52. Garcia-Sastre, A. et al. Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems. Virology 252, 324-330 (1998).
53. Lecellier, C.-H. et al. A cellular microRNA mediates antiviral defense in human cells. Science 308, 557-560 (2005).
54. Weeks, K.M., Ampe, C., Schultz, S.C., Steitz, T.A. & Crothers, D.M. Fragments of the HIV-1 Tat protein specifically bind TAR RNA. Science 249, 1281-1285 (1990).
55. Jopling, C.L., Yi, M., Lancaster, A.M., Lemon, S.M. & Sarnow, P. Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA. Science 309, 1577-1581 (2005).
56. Sullivan, C.S., Grundhoff, A.T., Tevethia, S., Pipas, J.M. & Ganem, D. SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells. Nature 435, 682-686 (2005).
57. Cullen, B.R. RNAi the natural way. Nat. Genet. 37, 1163-1165 (2005).