Animal virus replication and RNAi-mediated antiviral silencing in Caenorhabditis elegans

Nature

Volumn 436, Issue 7053, 2005, Pages 1040-1043

  Lu, R ^a   Maduro, M ^a   Li, F ^a   Li, H W ^a   Broitman Maduro, G ^a   Li, W X ^a   Ding, S W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BIODIVERSITY; ENZYMES; IMMUNOLOGY; PROTEINS; RNA;

ANIMALS; IMMUNITY SYSTEM; PATHOGENS;

VIRUSES;

SMALL INTERFERING RNA; VIRUS RNA;

VIRUS;

ARTICLE; CAENORHABDITIS ELEGANS; GENE EXPRESSION; GENE SILENCING; MICROBIAL ACTIVITY; MUTATIONAL ANALYSIS; NONHUMAN; OPEN READING FRAME; POINT MUTATION; PRIORITY JOURNAL; RNA INTERFERENCE; TRANSCRIPTION INITIATION SITE; TRANSGENE; VIRUS CELL INTERACTION; VIRUS GENOME; VIRUS IMMUNITY; VIRUS REPLICATION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIVIRAL AGENTS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRIDAE; HOST-PARASITE RELATIONS; RIBONUCLEASE III; RNA INTERFERENCE; RNA, DOUBLE-STRANDED; RNA, SMALL INTERFERING; TRANSGENES; VIRAL PROTEINS; VIRUS REPLICATION;

ANIMALIA; CAENORHABDITIS ELEGANS; FLOCK HOUSE VIRUS; HEXAPODA; MAMMALIA; RNA VIRUSES;

EID: 23944506789     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03870     Document Type: Article

References (28)

1. Brenner, S. The genetics of Caenorhabditis elegans. Genetics 77, 71-94 (1974).
2. Mahajan-Miklos, S., Tan, M. W., Rahme, L. G. & Ausubel, F. M. Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model. Cell 96, 47-56 (1999).
3. Fire, A. et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811 (1998).
4. Xie, Z. et al. Genetic and functional diversification of small RNA pathways in plants. PLoS Biol. 2, 642-652 (2004).
5. Lee, Y. S. et al. Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/ miRNA silencing pathways. Cell 117, 69-81 (2004).
6. Tomari, Y. & Zamore, P. D. Perspective: machines for RNAi. Genes Dev. 19, 517-529 (2005).
7. Bernstein, E., Caudy, A. A., Hammond, S. M. & Hannon, G. J. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409, 363-366 (2001).
8. Hamilton, A. J. & Baulcombe, D. C. A species of small antisense RNA in posttranscriptional gene silencing in plants. Science 286, 950-952 (1999).
9. Li, H. W., Li, W. X. & Ding, S. W. Induction and suppression of RNA silencing by an animal virus. Science 296, 1319-1321 (2002).
10. Tabara, H. et al. The rde-1 gene, RNA interference, and transposon silencing in C. elegans. Cell 99, 123-132 (1999).
11. Hammond, S. M., Boettcher, S., Caudy, A. A., Kobayashi, R. & Hannon, G. J. Argonaute2, a link between genetic and biochemical analyses of RNAi. Science 293, 1146-1150 (2001).
12. Li, W. X. et al. Interferon antagonist proteins of influenza and vaccinia viruses are suppressors of RNA silencing. Proc. Natl Acad. Sci. USA 101, 1350-1355 (2004).
13. Ball, L. A. & Johnson, K. L. Reverse genetics of nodaviruses. Adv. Virus Res. 53, 229-244 (1999).
14. Grishok, A., Sinskey, J. L. & Sharp, P. A. Transcriptional silencing of a transgene by RNAi in the soma of C. elegans. Genes Dev. 19, 683-696 (2005).
15. Vastenhouw, N. L. & Plasterk, R. H. RNAi protects the Caenorhabditis elegans germline against transposition. Trends Genet. 20, 314-319 (2004).
16. Silhavy, D. & Burgyan, J. Effects and side-effects of viral RNA silencing suppressors on short RNAs. Trends Plant Sci. 9, 76-83 (2004).
17. Li, W. X. & Ding, S. W. Viral suppressors of RNA silencing. Curr. Opin. Biotechnol. 12, 150-154 (2001).
18. Voinnet, O. Induction and suppression of RNA silencing: insights from viral infections. Nature Rev. Genet. 6, 206-220 (2005).
19. Ding, S. W., Li, H., Lu, R., Li, F. & Li, W. X. RNA silencing: a conserved antiviral immunity of plants and animals. Virus Res. 102, 109-115 (2004).
20. Okamura, K., Ishizuka, A., Siomi, H. & Siomi, M. C. Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways. Genes Dev. 18, 1655-1666 (2004).
21. Pfeffer, S. et al. Identification of virus-encoded microRNAs. Science 304, 734-736 (2004).
22. Lecellier, C. H. et al. A cellular microRNA directs antiviral immunity in human cells. Science 308, 557-560 (2005).
23. Lee, W. M. & Ahlquist, P. Membrane synthesis, specific lipid requirements, and localized lipid composition changes associated with a positive-strand RNA virus RNA replication protein. J. Virol. 77, 12819-12828 (2003).
24. Stringham, E. G., Dixon, D. K., Jones, D. & Candido, E. P. Temporal and spatial expression patterns of the small heat shock (hsp16) genes in transgenic Caenorhabditis elegans. Mol. Biol. Cell 3, 221-233 (1992).
25. Mello, C. C., Kramer, J. M., Stinchcomb, D. & Ambros, V. Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J. 10, 3959-3970 (1991).
26. Maduro, M. F., Meneghini, M. D., Bowerman, B., Broitman-Maduro, G. & Rothman, J. H. Restriction of mesendoderm to a single blastomere by the combined action of SKN-1 and a GSK-3β homolog is mediated by MED-1 and -2 in C. elegans. Mol. Cell 7, 475-485 (2001).
27. Timmons, L., Court, D. L. & Fire, A. Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans. Gene 263, 103-112 (2001).
28. Silhavy, D. et al. A viral protein suppresses RNA silencing and binds silencing-generated, 21- to 25-nucleotide double-stranded RNAs. EMBO J. 21, 3070-3080 (2002).