메뉴 건너뛰기




Volumn 2, Issue 1, 2006, Pages 83-89

FOXO factors: A matter of life and death

Author keywords

Akt; FOXO proteins; FOXO1; FOXO3a; FOXO4; Phosphorylation; Prostate cancer; Proteasome degradation; PTEN; Skp2; Ubiquitination

Indexed keywords

BORTEZOMIB; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; S PHASE KINASE ASSOCIATED PROTEIN 2; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR FOXO; TRANSCRIPTION FACTOR FOXO4; UNCLASSIFIED DRUG;

EID: 33646782964     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/14796694.2.1.83     Document Type: Review
Times cited : (82)

References (70)
  • 2
    • 0028364374 scopus 로고
    • Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma
    • Davis RJ, D'Cruz CM, Lovell MA, Biegel JA, Barr FG: Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma. Cancer Res. 54, 2869-7282 (1994).
    • (1994) Cancer Res , vol.54 , pp. 2869-7282
    • Davis, R.J.1    D'Cruz, C.M.2    Lovell, M.A.3    Biegel, J.A.4    Barr, F.G.5
  • 3
    • 0032518255 scopus 로고    scopus 로고
    • Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily
    • Anderson MJ, Viars CS, Czekay S, Cavenee WK, Arden KC: Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. Genomics 47, 187-199 (1998)
    • (1998) Genomics , vol.47 , pp. 187-199
    • Anderson, M.J.1    Viars, C.S.2    Czekay, S.3    Cavenee, W.K.4    Arden, K.C.5
  • 4
    • 0030869789 scopus 로고    scopus 로고
    • AF6q21, a novel partner of the MLL gene in t(6;11) (q21;q23), defines a forkhead transcriptional factor subfamily
    • Hillion J, Le Coniat M, Jonveaux P, Berger R, Bernard OA: AF6q21, a novel partner of the MLL gene in t(6;11) (q21;q23), defines a forkhead transcriptional factor subfamily. Blood 90, 3714-3719 (1997).
    • (1997) Blood , vol.90 , pp. 3714-3719
    • Hillion, J.1    Le Coniat, M.2    Jonveaux, P.3    Berger, R.4    Bernard, O.A.5
  • 5
    • 0027184681 scopus 로고
    • Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation
    • Corral J, Forster A, Thompson S et al.: Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation. Proc. Natl Acad. Sci. USA 90, 8538-8542 (1993).
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 8538-8542
    • Corral, J.1    Forster, A.2    Thompson, S.3
  • 6
    • 0027959091 scopus 로고
    • Cloning and characterization of the t(X;11) breakpoint from a leukemic cell line identify a new member of the forkhead gene family
    • Parry P, Wei Y, Evans G: Cloning and characterization of the t(X;11) breakpoint from a leukemic cell line identify a new member of the forkhead gene family. Genes Chromosomes Cancer 11, 79-84 (1994).
    • (1994) Genes Chromosomes Cancer , vol.11 , pp. 79-84
    • Parry, P.1    Wei, Y.2    Evans, G.3
  • 7
    • 0031031378 scopus 로고    scopus 로고
    • Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23)
    • Borkhardt A, Repp R, Haas OA et al.: Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23). Oncogene 14, 195-202 (1997).
    • (1997) Oncogene , vol.14 , pp. 195-202
    • Borkhardt, A.1    Repp, R.2    Haas, O.A.3
  • 8
    • 0342614209 scopus 로고    scopus 로고
    • Unified nomenclature for the winged helix/forkhead transcription factors
    • Kaestner KH, Knochel W, Martinez DE: Unified nomenclature for the winged helix/forkhead transcription factors. Genes Dev. 14, 142-146 (2000).
    • (2000) Genes Dev , vol.14 , pp. 142-146
    • Kaestner, K.H.1    Knochel, W.2    Martinez, D.E.3
  • 10
    • 0030659557 scopus 로고    scopus 로고
    • The fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
    • Ogg S, Paradis S, Gottlieb S, Patterson GI et al.: The fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389, 994-999 (1997).
    • (1997) Nature , vol.389 , pp. 994-999
    • Ogg, S.1    Paradis, S.2    Gottlieb, S.3    Patterson, G.I.4
  • 11
    • 0030657540 scopus 로고    scopus 로고
    • daf-16: An HNF-3/forkhead family member that can function to double the lifespan of Caenorhabditis elegans
    • Lin K, Dorman JB, Rodan A, Kenyon C: daf-16: An HNF-3/forkhead family member that can function to double the lifespan of Caenorhabditis elegans. Science 278, 1319-1322 (1997).
    • (1997) Science , vol.278 , pp. 1319-1322
    • Lin, K.1    Dorman, J.B.2    Rodan, A.3    Kenyon, C.4
  • 12
    • 0032782364 scopus 로고    scopus 로고
    • The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans
    • Honda Y, Honda S: The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans. FASEB J. 13, 1385-1393 (1999).
    • (1999) FASEB J. , vol.13 , pp. 1385-1393
    • Honda, Y.1    Honda, S.2
  • 13
    • 0035846604 scopus 로고    scopus 로고
    • Daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans
    • Henderson ST, Johnson TE: daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr. Biol. 11, 1975-1980 (2001).
    • (2001) Curr. Biol. , vol.11 , pp. 1975-1980
    • Henderson, S.T.1    Johnson, T.E.2
  • 14
    • 0033582929 scopus 로고    scopus 로고
    • Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
    • Brunet A, Bonni A, Zigmond MJ et al.: Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96, 857-868 (1999).
    • (1999) Cell , vol.96 , pp. 857-868
    • Brunet, A.1    Bonni, A.2    Zigmond, M.J.3
  • 16
    • 0033595011 scopus 로고    scopus 로고
    • Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
    • Biggs WH 3rd, Meisenhelder J, Hunter T, Cavenee WK, Arden KC: Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc. Natl. Acad. Sci. USA 96, 7421-7426 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 7421-7426
    • Biggs III, W.H.1    Meisenhelder, J.2    Hunter, T.3    Cavenee, W.K.4    Arden, K.C.5
  • 17
    • 0039425278 scopus 로고    scopus 로고
    • Negative regulation of the forkhead transcription factor FKHR by Akt
    • Tang ED, Nunez G, Barr FG, Guan KL: Negative regulation of the forkhead transcription factor FKHR by Akt. J. Biol. Chem. 274, 16741-16746 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 16741-16746
    • Tang, E.D.1    Nunez, G.2    Barr, F.G.3    Guan, K.L.4
  • 18
    • 0034643331 scopus 로고    scopus 로고
    • AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
    • Medema RH, Kops GJ, Bos JL, Burgering BM: AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature, 104, 782-787 (2000).
    • (2000) Nature , vol.404 , pp. 782-787
    • Medema, R.H.1    Kops, G.J.2    Bos, J.L.3    Burgering, B.M.4
  • 19
    • 0034462121 scopus 로고    scopus 로고
    • Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN
    • Nakamura N, Ramaswamy S, Vazquez F, Signoretti S, Loda M, Sellers WR: Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. Mol. Cell. Biol. 20, 8969-8982 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 8969-8982
    • Nakamura, N.1    Ramaswamy, S.2    Vazquez, F.3    Signoretti, S.4    Loda, M.5    Sellers, W.R.6
  • 20
    • 0036651790 scopus 로고    scopus 로고
    • A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR
    • Ramaswamy S, Nakamura N, Sansal I, Bergeron L, Sellers WR: A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. Cancer Cell 2, 81-91 (2002).
    • (2002) Cancer Cell , vol.2 , pp. 81-91
    • Ramaswamy, S.1    Nakamura, N.2    Sansal, I.3    Bergeron, L.4    Sellers, W.R.5
  • 22
    • 0035909313 scopus 로고    scopus 로고
    • Forkhead transcription factors contribute to execution of the mitotic programme in mammals
    • Alvarez B, Martinez AC, Burgering BM, Carrera AC: Forkhead transcription factors contribute to execution of the mitotic programme in mammals. Nature 413, 744-777 (2001).
    • (2001) Nature , vol.413 , pp. 744-777
    • Alvarez, B.1    Martinez, A.C.2    Burgering, B.M.3    Carrera, A.C.4
  • 23
    • 0037134040 scopus 로고    scopus 로고
    • DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein
    • Tran H, Brunet A, Grenier JM et al.: DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science 296, 530-534 (2002).
    • (2002) Science , vol.296 , pp. 530-534
    • Tran, H.1    Brunet, A.2    Grenier, J.M.3
  • 24
    • 0037178789 scopus 로고    scopus 로고
    • FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stress
    • Furukawa-Hibi Y, Yoshida-Araki K, Ohta T, Ikeda K, Motoyama N: FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stress. J. Biol. Chem. 277, 26729-26732 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 26729-26732
    • Furukawa-Hibi, Y.1    Yoshida-Araki, K.2    Ohta, T.3    Ikeda, K.4    Motoyama, N.5
  • 25
    • 0037192473 scopus 로고    scopus 로고
    • Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway
    • Nemoto S, Finkel T: Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science 295, 2450-2452 (2002).
    • (2002) Science , vol.295 , pp. 2450-2452
    • Nemoto, S.1    Finkel, T.2
  • 26
    • 0034609737 scopus 로고    scopus 로고
    • Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
    • Dijkers PF, Medema RH, Lammers JW, Koenderman L, Coffer PJ: Expression of the pro-apoptotic Bc1-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr. Biol. 10, 1201-1204 (2000).
    • (2000) Curr. Biol. , vol.10 , pp. 1201-1204
    • Dijkers, P.F.1    Medema, R.H.2    Lammers, J.W.3    Koenderman, L.4    Coffer, P.J.5
  • 27
    • 0037033005 scopus 로고    scopus 로고
    • FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer
    • Modur V, Nagarajan R. Evers BM, Milbrandt J: FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer. J. Biol. Chem. 277, 47928-47937 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 47928-47937
    • Modur, V.1    Nagarajan, R.2    Evers, B.M.3    Milbrandt, J.4
  • 28
    • 0042477712 scopus 로고    scopus 로고
    • FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons
    • Gilley J, Coffer PJ, Ham J: FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J. Cell Biol. 162, 613-622 (2003).
    • (2003) J. Cell Biol. , vol.162 , pp. 613-622
    • Gilley, J.1    Coffer, P.J.2    Ham, J.3
  • 29
    • 0038187621 scopus 로고    scopus 로고
    • Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
    • Puigserver P, Rhee J, Donovan J et al.: Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature 423, 550-555 (2003).
    • (2003) Nature , vol.423 , pp. 550-555
    • Puigserver, P.1    Rhee, J.2    Donovan, J.3
  • 30
    • 0037416153 scopus 로고    scopus 로고
    • FKHR (FOXO1a) is required for myotube fusion of primary mouse myoblasts
    • Bois PR, Grosveld GC: FKHR (FOXO1a) is required for myotube fusion of primary mouse myoblasts. EMBO J. 22, 1147-1157 (2003).
    • (2003) EMBO J. , vol.22 , pp. 1147-1157
    • Bois, P.R.1    Grosveld, G.C.2
  • 31
    • 22944451474 scopus 로고    scopus 로고
    • Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin
    • Liu ZP, Wang Z, Yanagisawa H, Olson EN: Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin. Dev. Cell 9, 261-270 (2005).
    • (2005) Dev. Cell , vol.9 , pp. 261-270
    • Liu, Z.P.1    Wang, Z.2    Yanagisawa, H.3    Olson, E.N.4
  • 32
    • 0141866848 scopus 로고    scopus 로고
    • Insulin affects vascular smooth muscle cell phenotype and migration via distinct signaling pathways
    • Wang CC, Gurevich I, Draznin B: Insulin affects vascular smooth muscle cell phenotype and migration via distinct signaling pathways. Diabetes 52, 2562-2569 (2003).
    • (2003) Diabetes , vol.52 , pp. 2562-2569
    • Wang, C.C.1    Gurevich, I.2    Draznin, B.3
  • 33
    • 2342496712 scopus 로고    scopus 로고
    • FoxOs at the crossroads of cellular metabolism, differentiation, and transformation
    • Accill D, Arden KC: FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 117, 421-426 (2004).
    • (2004) Cell , vol.117 , pp. 421-426
    • Accili, D.1    Arden, K.C.2
  • 34
    • 1542267804 scopus 로고    scopus 로고
    • Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification
    • Hosaka T, Biggs WH 3rd, Tieu D et al.: Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc. Natl Acad. Sci. USA 101, 2975-2980 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 2975-2980
    • Hosaka, T.1    Biggs III, W.H.2    Tieu, D.3
  • 35
    • 4544227785 scopus 로고    scopus 로고
    • Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice
    • Furuyama T, Kitayama K, Shimoda Y et al.: Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice. J. Biol. Chem. 279, 34741-34749 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 34741-34749
    • Furuyama, T.1    Kitayama, K.2    Shimoda, Y.3
  • 36
    • 2442608732 scopus 로고    scopus 로고
    • Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1)
    • Daly C, Wong V, Burova E et al.: Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1). Genes Dev. 18, 1060-1071 (2004).
    • (2004) Genes Dev , vol.18 , pp. 1060-1071
    • Daly, C.1    Wong, V.2    Burova, E.3
  • 37
    • 0038152845 scopus 로고    scopus 로고
    • Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a
    • Castrillon DH, Miao L, Kollipara R, Horner JW, DePinho RA: Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science 301, 215-218 (2003).
    • (2003) Science , vol.301 , pp. 215-218
    • Castrillon, D.H.1    Miao, L.2    Kollipara, R.3    Horner, J.W.4    DePinho, R.A.5
  • 38
    • 0033522897 scopus 로고    scopus 로고
    • Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway
    • Nakae J, Park BC, Accili D: Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway. J. Biol. Chem. 274, 15982-15985 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 15982-15985
    • Nakae, J.1    Park, B.C.2    Accili, D.3
  • 39
    • 0033546439 scopus 로고    scopus 로고
    • Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
    • Rena G, Guo S, Cichy SC, Unterman TG, Cohen P: Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. J. Biol. Chem. 274, 17179-17183 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 17179-17183
    • Rena, G.1    Guo, S.2    Cichy, S.C.3    Unterman, T.G.4    Cohen, P.5
  • 40
    • 0033546192 scopus 로고    scopus 로고
    • Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence
    • Guo S, Rena G, Cichy S, He X, Cohen P, Unterman T: Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence. J. Biol. Chem. 274, 17184-17192 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 17184-17192
    • Guo, S.1    Rena, G.2    Cichy, S.3    He, X.4    Cohen, P.5    Unterman, T.6
  • 41
    • 12144290563 scopus 로고    scopus 로고
    • Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    • Brunet A, Sweeney LB, Sturgill JF et al.: Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303, 2011-2015 (2004).
    • (2004) Science , vol.303 , pp. 2011-2015
    • Brunet, A.1    Sweeney, L.B.2    Sturgill, J.F.3
  • 42
    • 22944479314 scopus 로고    scopus 로고
    • JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3
    • Sunayama J, Tsuruta F, Masuyama N, Gotoh Y: JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3. J. Cell Biol. 170, 295-304 (2005).
    • (2005) J. Cell Biol. , vol.170 , pp. 295-304
    • Sunayama, J.1    Tsuruta, F.2    Masuyama, N.3    Gotoh, Y.4
  • 43
    • 0038362751 scopus 로고    scopus 로고
    • Akt activation promotes degradation of tuberin and FOXO3a via the proteasome
    • Plas DR, Thompson CB: Akt activation promotes degradation of tuberin and FOXO3a via the proteasome. J. Biol. Chem. 278, 12361-12366 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 12361-12366
    • Plas, D.R.1    Thompson, C.B.2
  • 44
    • 0141706357 scopus 로고    scopus 로고
    • Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation
    • Matsuzaki H, Daitoku H, Hatta M, Tanaka K, Fukamizu A: Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation. Proc. Natl Acad. Sci. USA 100, 11285-11290 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 11285-11290
    • Matsuzaki, H.1    Daitoku, H.2    Hatta, M.3    Tanaka, K.4    Fukamizu, A.5
  • 45
    • 13444252337 scopus 로고    scopus 로고
    • Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation
    • Huang H, Regan KM, Wang F et al.: Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation. Proc. Natl Acad. Sci. USA 102, 1649-1654 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 1649-1654
    • Huang, H.1    Regan, K.M.2    Wang, F.3
  • 46
    • 0035916325 scopus 로고    scopus 로고
    • PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2)
    • Mamillapalli R, Gavrilova N, Mihaylova VT et al.: PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2). Curr. Biol. 11, 263-267 (2001).
    • (2001) Curr. Biol. , vol.11 , pp. 263-267
    • Mamillapalli, R.1    Gavrilova, N.2    Mihaylova, V.T.3
  • 47
    • 0033564514 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells
    • Lin J, Adam RM, Santiestevan E, Freeman MR: The phosphatidylinositol 3-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells. Cancer Res. 59, 2891-2897 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 2891-2897
    • Lin, J.1    Adam, R.M.2    Santiestevan, E.3    Freeman, M.R.4
  • 48
    • 0034749615 scopus 로고    scopus 로고
    • Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state
    • Murillo H, Huang H, Schmidt LJ, Smith DI, Tindall DJ: Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state. Endocrinologv 142, 4795-4805 (2001).
    • (2001) Endocrinology , vol.142 , pp. 4795-4805
    • Murillo, H.1    Huang, H.2    Schmidt, L.J.3    Smith, D.I.4    Tindall, D.J.5
  • 49
    • 1842690558 scopus 로고    scopus 로고
    • Androgens negatively regulate forkhead transcription factor FKHR (FOXO1) through a proteolytic mechanism in prostate cancer cells
    • Huang H, Muddiman DC, Tindall DJ: Androgens negatively regulate forkhead transcription factor FKHR (FOXO1) through a proteolytic mechanism in prostate cancer cells. J. Biol. Chem. 279, 13866-13877 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 13866-13877
    • Huang, H.1    Muddiman, D.C.2    Tindall, D.J.3
  • 50
    • 12944335299 scopus 로고    scopus 로고
    • DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
    • Nasrin N, Ogg S, Cahill CM et al.: DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells. Proc. Natl Acad. Sci, USA 97, 10412-10417 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 10412-10417
    • Nasrin, N.1    Ogg, S.2    Cahill, C.M.3
  • 51
    • 2342445654 scopus 로고    scopus 로고
    • Negative regulation of forkhead transcription factor AFX (Foxo4) by CBP-induced acetylation
    • Fukuoka M, Daitoku H, Hatta M, Matsuzaki H, Umemura S, Fukamizu A: Negative regulation of forkhead transcription factor AFX (Foxo4) by CBP-induced acetylation. Int. J. Mol. Med. 12, 503-508 (2003).
    • (2003) Int. J. Mol. Med. , vol.12 , pp. 503-508
    • Fukuoka, M.1    Daitoku, H.2    Hatta, M.3    Matsuzaki, H.4    Umemura, S.5    Fukamizu, A.6
  • 52
    • 0035826271 scopus 로고    scopus 로고
    • Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
    • Tissenbaum HA, Guarente L: Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410, 227-230 (2001).
    • (2001) Nature , vol.410 , pp. 227-230
    • Tissenbaum, H.A.1    Guarente, L.2
  • 53
    • 1342264308 scopus 로고    scopus 로고
    • Mammalian SIRT1 represses forkhead transcription factors
    • Motta MC, Divecha N, Lemieux M et al.: Mammalian SIRT1 represses forkhead transcription factors. Cell 116, 551-563 (2004).
    • (2004) Cell , vol.116 , pp. 551-563
    • Motta, M.C.1    Divecha, N.2    Lemieux, M.3
  • 55
    • 3042750643 scopus 로고    scopus 로고
    • Silent Information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity
    • Daitoku H, Hatta M, Matsuzaki H et al.: Silent Information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc. Natl Acad. Sci. US4 101, 10042-10047 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 10042-10047
    • Daitoku, H.1    Hatta, M.2    Matsuzaki, H.3
  • 58
    • 0036787919 scopus 로고    scopus 로고
    • Pax3-FKHR knock-in mice show developmental aberrations but do not develop tumors
    • Lagutina I. Conway SJ, Sublett J, Grosveld GC: Pax3-FKHR knock-in mice show developmental aberrations but do not develop tumors. Mol. Cell. Biol. 22, 7204-7216 (2002).
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 7204-7216
    • Lagutina, I.1    Conway, S.J.2    Sublett, J.3    Grosveld, G.C.4
  • 59
    • 0035852715 scopus 로고    scopus 로고
    • Embryonic expression of the tumor-associated PAX3-FKHR fusion protein interferes with the developmental functions of Pax3
    • Anderson MJ, Shelton GD, Cavenee WK, Arden KC: Embryonic expression of the tumor-associated PAX3-FKHR fusion protein interferes with the developmental functions of Pax3. Proc. Natl Acad. Sci. USA 98, 1589-1594 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 1589-1594
    • Anderson, M.J.1    Shelton, G.D.2    Cavenee, W.K.3    Arden, K.C.4
  • 60
    • 0347384010 scopus 로고    scopus 로고
    • The transcriptional activator PAX3-FKHR rescues the defects of Pax3 mutant mice but induces a myogenic gain-of-function phenotype with ligand-independent activation of Met signaling in vivo
    • Relaix F, Polimeni M, Rocancourt D, Ponzetto C, Schafer BW, Buckingham M: The transcriptional activator PAX3-FKHR rescues the defects of Pax3 mutant mice but induces a myogenic gain-of-function phenotype with ligand-independent activation of Met signaling in vivo. Genes Dev. 17, 2950-2965 (2003).
    • (2003) Genes Dev. , vol.17 , pp. 2950-2965
    • Relaix, F.1    Polimeni, M.2    Rocancourt, D.3    Ponzetto, C.4    Schafer, B.W.5    Buckingham, M.6
  • 61
    • 0028881603 scopus 로고
    • The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3
    • Fredericks WJ, Galili N, Mukhopadhyay S et al.: The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3. Mol. Cell. Biol. 15, 1522-1535 (1995).
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 1522-1535
    • Fredericks, W.J.1    Galili, N.2    Mukhopadhyay, S.3
  • 62
    • 0037414791 scopus 로고    scopus 로고
    • PAX3-FKHR transformation increases 26 S proteasome-dependent degradation of p27Kip1, a potential role for elevated Skp2 expression
    • Zhang L, Wang C: PAX3-FKHR transformation increases 26 S proteasome-dependent degradation of p27Kip1, a potential role for elevated Skp2 expression. J. Biol. Chem. 278, 27-36 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 27-36
    • Zhang, L.1    Wang, C.2
  • 63
    • 7544243041 scopus 로고    scopus 로고
    • Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: Co-operativity of Ink4a/ARF and Trp53 loss of function
    • Keller C, Arenkiel BR, Coffin CM, E1-Bardeesy N, DePinho RA, Capecchi MR: Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: co-operativity of Ink4a/ARF and Trp53 loss of function. Genes Dev. 18, 2614-2626 (2004).
    • (2004) Genes Dev. , vol.18 , pp. 2614-2626
    • Keller, C.1    Arenkiel, B.R.2    Coffin, C.M.3    El-Bardeesy, N.4    DePinho, R.A.5    Capecchi, M.R.6
  • 65
    • 2942692143 scopus 로고    scopus 로고
    • Phase I trial of the proteasome inhibitor bortezomib in patients with advanced solid tumors with observations in androgen-independent prostate cancer
    • Papandreou CN, Daliani DD, Nix D et al.: Phase I trial of the proteasome inhibitor bortezomib in patients with advanced solid tumors with observations in androgen-independent prostate cancer. J. Clin. Oncol. 22, 2108-2121 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , pp. 2108-2121
    • Papandreou, C.N.1    Daliani, D.D.2    Nix, D.3
  • 66
    • 0036847690 scopus 로고    scopus 로고
    • Elevated Skp2 protein expression in human prostate cancer: Association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival
    • Yang G, Ayala G, De Marzo A, Tian W, Frolov A, Wheeler TM et al.: Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival. Clin. Cancer Res. 8, 3419-3426 (2002).
    • (2002) Clin. Cancer Res. , vol.8 , pp. 3419-3426
    • Yang, G.1    Ayala, G.2    De Marzo, A.3    Tian, W.4    Frolov, A.5    Wheeler, T.M.6
  • 67
    • 0038679293 scopus 로고    scopus 로고
    • Inverse relationship between Skp2 ubiquitin ligase and the cyclin dependent kinase inhibitor p27Kip1 in prostate cancer
    • Ben-Izhak O, Lahav-Baratz S, Meretyk S et al.: Inverse relationship between Skp2 ubiquitin ligase and the cyclin dependent kinase inhibitor p27Kip1 in prostate cancer. J. Biol. 170, 241-245 (2003).
    • (2003) J. Urol. , vol.170 , pp. 241-245
    • Ben-Izhak, O.1    Lahav-Baratz, S.2    Meretyk, S.3
  • 69
    • 0036733716 scopus 로고    scopus 로고
    • Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer
    • Signoretti S, Di Marcotullio, L, Richardson A et al.: Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer. J. Clin. Invest. 110, 633-641 (2002).
    • (2002) J. Clin. Invest. , vol.110 , pp. 633-641
    • Signoretti, S.1    Di Marcotullio, L.2    Richardson, A.3
  • 70
    • 0035942224 scopus 로고    scopus 로고
    • Skp2 is oncogenic and overexpressed in human cancers
    • Gstaiger M, Jordan R, Lim MJ et al.: Skp2 is oncogenic and overexpressed in human cancers. Proc. Natl Acad. Sci. USA 98, 5043-5048 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 5043-5048
    • Gstaiger, M.1    Jordan, R.2    Lim, M.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.