Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 16, 2006, Pages 6154-6159

  Gong, Yi ^a   Lee, Joon No ^a   Brown, Michael S ^a   Goldstein, Joseph L ^a   Ye, Jin ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

25 hydroxycholesterol; Ianosterol membrane proteins; Proteolytic activation; Scap

Indexed keywords

25 HYDROXYCHOLESTEROL; ALANINE; AMINO ACID; ASPARTIC ACID; CHAPERONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; INSIG 1 PROTEIN; INSIG 2 PROTEIN; LANOSTEROL; MEMBRANE PROTEIN; MUTANT PROTEIN; SCAP PROTEIN; STEROL; STEROL REGULATORY ELEMENT BINDING PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; CYTOSOL; ENDOPLASMIC RETICULUM; FEEDBACK SYSTEM; GENETIC CONSERVATION; MAMMAL CELL; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ASPARTIC ACID; CELL MEMBRANE; CELLS, CULTURED; CHOLESTEROL; HOMEOSTASIS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; POINT MUTATION;

ANIMALIA; MAMMALIA;

EID: 33646587074     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0601923103     Document Type: Article

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