Rescue of folding defects in ABC transporters using pharmacological chaperones

Journal of Bioenergetics and Biomembranes

Volumn 37, Issue 6, 2005, Pages 501-507

  Loo, Tip W ^a   Bartlett, M Claire ^a   Clarke, David M ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

CFTR; Cystic fibrosis; Drug rescue; P glycoprotein; Pharmacological chaperones; Protein misfolding

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; ABC TRANSPORTER; BENZO[C]QUINOLIZINIUM DERIVATIVE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CAPSAICIN; CFCOR 325; CHAPERONE; CURCUMIN; CYCLOHEXIMIDE; CYCLOSPORIN; CYCLOSPORIN A; DIAZOXIDE; DOXORUBICIN; GLYCOPROTEIN P; LIXIVAPTAN; N TERT BUTYL 4 [5' ETHOXY 4 (2 MORPHOLINOETHOXY) 2' OXOSPIRO[CYCLOHEXANE 1,3' INDOLE] 1' SULFONYL] 3 METHOXYBENZAMIDE; NALTREXONE; NONYLPHENOL; NONYLPHENOL ETHOXYLATE; PHENYLALANINE; QUINAZOLINE DERIVATIVE; QUINOLIZINE DERIVATIVE; RETINOID; SILDENAFIL; SULFONYLUREA DERIVATIVE; THAPSIGARGIN; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERAPAMIL; VINBLASTINE;

CONFORMATIONAL TRANSITION; CYSTIC FIBROSIS; DRUG EFFECT; DRUG IDENTIFICATION; DRUG POTENCY; HIGH THROUGHPUT SCREENING; HUMAN; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN TRANSPORT; REVIEW;

ATP-BINDING CASSETTE TRANSPORTERS; CYSTIC FIBROSIS; HUMANS; LIGANDS; MUTATION; P-GLYCOPROTEIN; PROTEIN FOLDING; PROTEIN RENATURATION; QUINAZOLINES;

EID: 33646578825     PISSN: 0145479X     EISSN: 15736881     Source Type: Journal    
DOI: 10.1007/s10863-005-9499-3     Document Type: Review

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