Enhanced hippocampal F2-isoprostane formation following kainate-induced seizures

Journal of Neurochemistry

Volumn 79, Issue 5, 2001, Pages 1065-1069

  Patel, Manisha ^a   Liang, Li Ping ^a   Roberts II, L Jackson ^b  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Hippocampus; Isoprostane; Kainate; Lipid peroxidation; Oxidative stress; Seizures

Indexed keywords

ACONITATE HYDRATASE; EXCITOTOXIN; ISOPROSTANE; KAINIC ACID; PROSTAGLANDIN F2; AMINO ACID RECEPTOR STIMULATING AGENT; F2 ISOPROSTANES; FUMARATE HYDRATASE; ISOPROSTANE DERIVATIVE; SUPEROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVITY; ESTERIFICATION; LIPID PEROXIDATION; MALE; NERVE CELL DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SEIZURE; ANIMAL; BIOSYNTHESIS; CELL COUNT; CELL SURVIVAL; DRUG EFFECT; ENZYMOLOGY; HIPPOCAMPUS; IATROGENIC DISEASE; METABOLISM; MITOCHONDRION; PATHOLOGY; RAT STRAIN;

ANIMALIA;

ACONITATE HYDRATASE; ANIMAL; CELL COUNT; CELL DEATH; CELL SURVIVAL; EXCITATORY AMINO ACID AGONISTS; F2-ISOPROSTANES; FUMARATE HYDRATASE; HIPPOCAMPUS; KAINIC ACID; LIPID PEROXIDATION; MALE; MITOCHONDRIA; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES; SUPEROXIDES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0034747324     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00659.x     Document Type: Article

References (19)

1. Effect of mannitol treatment on brain neurotransmitter markers in kainic acid-induced epilepsy
2. Kainate, a double agent that generates seizures: Two decades of progress
3. Electrographic, clinical and pathological alterations following systemic administration of kainic acid, bicuculline or pentetrazole: Metabolic mapping using the deoxyglucose method with special reference to the pathology of epilepsy
4. Oxygen free radicals in rat limbic structures after kainate-induced seizures
5. Oxidative stress, glutamate, and neurodegenerative disorders
6. Mechanism of kainate toxicity to cerebellar neurons in vitro is analogous to reperfusion tissue injury
7. Detection of free radicals and other reactive species: Trapping and fingerprinting
8. Mitochondrial superoxide production in kainate-induced hippocampal damage
9. Acsorbate attenuates the systemic kainate-induced neurotoxicity in the rat hippocampus
10. Mass spectrometric quantification of F2-isoprostanes in biological fluids and tissues as measure of oxidant stress
11. 2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism
12. Kainic acid: Neurophysiology and neurotoxic actions
13. Inciting excitotoxic cytocide among central neurons
14. Requirement for superoxide in excitotoxic cell death
15. Kainic acid-induced lipid peroxidation: Protection with butylated hydroxytoluene and U78517F in primary cultures of cerebellar granule cells
16. Measurement of F (2)-isoprostanes as an index of oxidative stress in vivo
17. 'Epileptic' brain damage in rats induced by sustained electrical stimulation of the perforant path. I. Acute electrophysiological and light microscopic studies
18. The biochemical mechanisms of the excitotoxicity of kainic acid. Free radical formation
19. Melatonin protects hippocampal neurons in vivo against kainic acid-induced damage in mice