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Volumn 32, Issue SUPPL. 1, 2006, Pages 61-68

Thrombin generation and the pathogenesis of cancer

Author keywords

Angiogenesis; Metastasis; Protease activated receptors; Protease signaling; Tissue factor

Indexed keywords

BLOOD CLOTTING FACTOR 7A; GROWTH FACTOR; INTEGRIN; MATRIX METALLOPROTEINASE; PROTEINASE ACTIVATED RECEPTOR; PROTEINASE ACTIVATED RECEPTOR 2; SERINE PROTEINASE; THROMBIN; THROMBOPLASTIN;

EID: 33646471394     PISSN: 00946176     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-939555     Document Type: Review
Times cited : (151)

References (77)
  • 2
    • 0034729786 scopus 로고    scopus 로고
    • Incidence of cancer after prophylaxis with warfarin against recurrent venous thromboembolism. Duration of Anticoagulation Trial
    • Schulman S, Lindmarker P. Incidence of cancer after prophylaxis with warfarin against recurrent venous thromboembolism. Duration of Anticoagulation Trial. N Engl J Med 2000;342:1953-1958
    • (2000) N Engl J Med , vol.342 , pp. 1953-1958
    • Schulman, S.1    Lindmarker, P.2
  • 3
    • 20244376337 scopus 로고    scopus 로고
    • The effect of low molecular weight heparin on survival in patients with advanced malignancy
    • Klerk CP, Smorenburg SM, Otten HM, et al. The effect of low molecular weight heparin on survival in patients with advanced malignancy. J Clin Oncol 2005;23:2130-2135
    • (2005) J Clin Oncol , vol.23 , pp. 2130-2135
    • Klerk, C.P.1    Smorenburg, S.M.2    Otten, H.M.3
  • 4
    • 0034648757 scopus 로고    scopus 로고
    • Thrombin signalling and protease-activated receptors
    • Coughlin SR. Thrombin signalling and protease-activated receptors. Nature 2000;407:258-264
    • (2000) Nature , vol.407 , pp. 258-264
    • Coughlin, S.R.1
  • 5
    • 0037783286 scopus 로고    scopus 로고
    • Human protease-activated receptor 1 expression in malignant epithelia: A role in invasiveness
    • Yin YJ, Salah Z, Grisaru-Granovsky S, et al. Human protease-activated receptor 1 expression in malignant epithelia: a role in invasiveness. Arterioscler Thromb Vasc Biol 2003;23:940-944
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 940-944
    • Yin, Y.J.1    Salah, Z.2    Grisaru-Granovsky, S.3
  • 6
    • 1342325343 scopus 로고    scopus 로고
    • Persistent signaling by dysregulated thrombin receptor trafficking promotes breast carcinoma cell invasion
    • Booden MA, Eckert LB, Der CJ, Trejo J. Persistent signaling by dysregulated thrombin receptor trafficking promotes breast carcinoma cell invasion. Mol Cell Biol 2004;24:1990-1999
    • (2004) Mol Cell Biol , vol.24 , pp. 1990-1999
    • Booden, M.A.1    Eckert, L.B.2    Der, C.J.3    Trejo, J.4
  • 7
    • 0028938978 scopus 로고
    • Tissue factor-initiated thrombin generation activates the signaling thrombin receptor on malignant melanoma cells
    • Fischer EG, Ruf W, Mueller BM. Tissue factor-initiated thrombin generation activates the signaling thrombin receptor on malignant melanoma cells. Cancer Res 1995;55:1629-1632
    • (1995) Cancer Res , vol.55 , pp. 1629-1632
    • Fischer, E.G.1    Ruf, W.2    Mueller, B.M.3
  • 8
    • 21544440159 scopus 로고    scopus 로고
    • Expression of protease-activated receptors 1 and 2 in melanocytic nevi and malignant melanoma
    • Massi D, Naldini A, Ardinghi C, et al. Expression of protease-activated receptors 1 and 2 in melanocytic nevi and malignant melanoma. Hum Pathol 2005;36:676-685
    • (2005) Hum Pathol , vol.36 , pp. 676-685
    • Massi, D.1    Naldini, A.2    Ardinghi, C.3
  • 9
    • 0036845746 scopus 로고    scopus 로고
    • A functional thrombin receptor (PAR1) is expressed on bone-derived prostate cancer cell lines
    • Chay CH, Cooper CR, Gendernalik JD, et al. A functional thrombin receptor (PAR1) is expressed on bone-derived prostate cancer cell lines. Urology 2002;60:760-765
    • (2002) Urology , vol.60 , pp. 760-765
    • Chay, C.H.1    Cooper, C.R.2    Gendernalik, J.D.3
  • 10
    • 0034681427 scopus 로고    scopus 로고
    • Trypsin stimulates integrin alpha(5)beta(1)-dependent adhesion to fibronectin and proliferation of human gastric carcinoma cells through activation of proteinase-activated receptor-2
    • Miyata S, Koshikawa N, Yasumitsu H, Miyazaki K. Trypsin stimulates integrin alpha(5)beta(1)-dependent adhesion to fibronectin and proliferation of human gastric carcinoma cells through activation of proteinase-activated receptor-2. J Biol Chem 2000;275:4592-4598
    • (2000) J Biol Chem , vol.275 , pp. 4592-4598
    • Miyata, S.1    Koshikawa, N.2    Yasumitsu, H.3    Miyazaki, K.4
  • 11
    • 11244255416 scopus 로고    scopus 로고
    • Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2
    • Ge L, Shenoy SK, Lefkowitz RJ, DeFea K. Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2. J Biol Chem 2004;279:55419-55424
    • (2004) J Biol Chem , vol.279 , pp. 55419-55424
    • Ge, L.1    Shenoy, S.K.2    Lefkowitz, R.J.3    Defea, K.4
  • 12
    • 1842474888 scopus 로고    scopus 로고
    • Tissue factor-factor VIIa-specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration
    • Hjortoe GM, Petersen LC, Albrektsen T, et al. Tissue factor-factor VIIa-specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration. Blood 2004;103:3029-3037
    • (2004) Blood , vol.103 , pp. 3029-3037
    • Hjortoe, G.M.1    Petersen, L.C.2    Albrektsen, T.3
  • 13
    • 0034969753 scopus 로고    scopus 로고
    • Differential expression of protease-activated receptors-1 and -2 in stromal fibroblasts of normal, benign, and malignant human tissues
    • D'Andrea MR, Derian CK, Santulli RJ, Andrade-Gordon P. Differential expression of protease-activated receptors-1 and -2 in stromal fibroblasts of normal, benign, and malignant human tissues. Am J Pathol 2001;158:2031-2041
    • (2001) Am J Pathol , vol.158 , pp. 2031-2041
    • D'Andrea, M.R.1    Derian, C.K.2    Santulli, R.J.3    Andrade-Gordon, P.4
  • 14
    • 21244502159 scopus 로고    scopus 로고
    • Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling
    • Riewald M, Ruf W. Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling. J Biol Chem 2005;280:19808-19814
    • (2005) J Biol Chem , vol.280 , pp. 19808-19814
    • Riewald, M.1    Ruf, W.2
  • 15
    • 13544255506 scopus 로고    scopus 로고
    • PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and rumorigenesis of breast cancer cells
    • Boire A, Covic L, Agarwal A, et al. PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and rumorigenesis of breast cancer cells. Cell 2005;120:303-313
    • (2005) Cell , vol.120 , pp. 303-313
    • Boire, A.1    Covic, L.2    Agarwal, A.3
  • 16
    • 0035421226 scopus 로고    scopus 로고
    • Signaling from protease-activated receptor-1 inhibits migration and invasion of breast cancer cells
    • Kamath L, Meydani A, Foss F, Kuliopulos A. Signaling from protease-activated receptor-1 inhibits migration and invasion of breast cancer cells. Cancer Res 2001;61:5933-5940
    • (2001) Cancer Res , vol.61 , pp. 5933-5940
    • Kamath, L.1    Meydani, A.2    Foss, F.3    Kuliopulos, A.4
  • 17
    • 0141498162 scopus 로고    scopus 로고
    • Specificity of coagulation factor signaling
    • Ruf W, Dorfleutner A, Riewald M. Specificity of coagulation factor signaling. J Thromb Haemost 2003;1:1495-1503
    • (2003) J Thromb Haemost , vol.1 , pp. 1495-1503
    • Ruf, W.1    Dorfleutner, A.2    Riewald, M.3
  • 18
    • 0034624973 scopus 로고    scopus 로고
    • Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa
    • Camerer E, Huang W, Coughlin SR. Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc Natl Acad Sci USA 2000;97:5255-5260
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 5255-5260
    • Camerer, E.1    Huang, W.2    Coughlin, S.R.3
  • 19
    • 0034933683 scopus 로고    scopus 로고
    • Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor
    • Riewald M, Ruf W. Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor. Proc Natl Acad Sci USA 2001;98:7742-7747
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 7742-7747
    • Riewald, M.1    Ruf, W.2
  • 20
    • 0035874536 scopus 로고    scopus 로고
    • Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1
    • Riewald M, Kravchenko W, Petrovan RJ, et al. Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1. Blood 2001;97:3109-3116
    • (2001) Blood , vol.97 , pp. 3109-3116
    • Riewald, M.1    Kravchenko, W.2    Petrovan, R.J.3
  • 21
    • 15244349532 scopus 로고    scopus 로고
    • Regulation of tissue factor-induced signaling by endogenous and recombinant tissue factor pathway inhibitor 1
    • Ahamed J, Belting M, Ruf W. Regulation of tissue factor-induced signaling by endogenous and recombinant tissue factor pathway inhibitor 1. Blood 2005;105:2384-2391
    • (2005) Blood , vol.105 , pp. 2384-2391
    • Ahamed, J.1    Belting, M.2    Ruf, W.3
  • 22
    • 0025938196 scopus 로고
    • Inhibition of murine melanoma experimental metastasis by recombinant desulfatohirudin, a highly specific thrombin inhibitor
    • Esumi N, Fan D, Fidler IJ. Inhibition of murine melanoma experimental metastasis by recombinant desulfatohirudin, a highly specific thrombin inhibitor. Cancer Res 1991;51:4549-4556
    • (1991) Cancer Res , vol.51 , pp. 4549-4556
    • Esumi, N.1    Fan, D.2    Fidler, I.J.3
  • 23
    • 0027071674 scopus 로고
    • Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis
    • Mueller BM, Reisfeld RA, Edgington TS, Ruf W. Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis. Proc Natl Acad Sci USA 1992;89:11832-11836
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 11832-11836
    • Mueller, B.M.1    Reisfeld, R.A.2    Edgington, T.S.3    Ruf, W.4
  • 24
    • 9244265563 scopus 로고    scopus 로고
    • Coagulation facilitates tumor cell spreading in the pulmonary vasculature during early metastatic colony formation
    • Im JH, Fu W, Wang H, et al. Coagulation facilitates tumor cell spreading in the pulmonary vasculature during early metastatic colony formation. Cancer Res 2004;64:8613-8619
    • (2004) Cancer Res , vol.64 , pp. 8613-8619
    • Im, J.H.1    Fu, W.2    Wang, H.3
  • 25
    • 0029806633 scopus 로고    scopus 로고
    • Tissue factor in cancer angiogenesis and metastasis
    • Ruf W, Mueller BM. Tissue factor in cancer angiogenesis and metastasis. Curr Opin Hematol 1996;3:379-384
    • (1996) Curr Opin Hematol , vol.3 , pp. 379-384
    • Ruf, W.1    Mueller, B.M.2
  • 26
    • 0347710160 scopus 로고    scopus 로고
    • Abrogation of thrombin-induced increase in pulmonary microvascular permeability in PAR-1 knockout mice
    • Vogel SM, Gao X, Mehta D, et al. Abrogation of thrombin-induced increase in pulmonary microvascular permeability in PAR-1 knockout mice. Physiol Genomics 2000;4:137-145
    • (2000) Physiol Genomics , vol.4 , pp. 137-145
    • Vogel, S.M.1    Gao, X.2    Mehta, D.3
  • 27
    • 4444259670 scopus 로고    scopus 로고
    • Tumor cell alpha3beta1 integrin and vascular laminin-5 mediate pulmonary arrest and metastasis
    • Wang H, Fu W, Im JH, et al. Tumor cell alpha3beta1 integrin and vascular laminin-5 mediate pulmonary arrest and metastasis. J Cell Biol 2004;164:935-941
    • (2004) J Cell Biol , vol.164 , pp. 935-941
    • Wang, H.1    Fu, W.2    Im, J.H.3
  • 28
    • 0000348593 scopus 로고    scopus 로고
    • Requirement for binding of catalytically active factor VIIa in tissue factor-dependent experimental metastasis
    • Mueller BM, Ruf W. Requirement for binding of catalytically active factor VIIa in tissue factor-dependent experimental metastasis. J Clin Invest 1998;101:1372-1378
    • (1998) J Clin Invest , vol.101 , pp. 1372-1378
    • Mueller, B.M.1    Ruf, W.2
  • 29
    • 0032795002 scopus 로고    scopus 로고
    • Role of tissue factor in metastasis: Functions of the cytoplasmic and extracellular domains of the molecule
    • Bromberg ME, Sundaram R, Homer RJ, Garen A, Konigsberg WH. Role of tissue factor in metastasis: functions of the cytoplasmic and extracellular domains of the molecule. Thromb Haemost 1999;82:88-92
    • (1999) Thromb Haemost , vol.82 , pp. 88-92
    • Bromberg, M.E.1    Sundaram, R.2    Homer, R.J.3    Garen, A.4    Konigsberg, W.H.5
  • 30
    • 4644312977 scopus 로고    scopus 로고
    • Cross-talk of integrin alpha3beta1 and tissue factor in cell migration
    • Dorfleutner A, Hintermann E, Tarui T, Takada Y, Ruf W. Cross-talk of integrin alpha3beta1 and tissue factor in cell migration. Mol Biol Cell 2004;15:4416-4425
    • (2004) Mol Biol Cell , vol.15 , pp. 4416-4425
    • Dorfleutner, A.1    Hintermann, E.2    Tarui, T.3    Takada, Y.4    Ruf, W.5
  • 31
    • 11144230059 scopus 로고    scopus 로고
    • Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells
    • Palumbo JS, Talmage KE, Massari JV, et al. Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells. Blood 2005;105:178-185
    • (2005) Blood , vol.105 , pp. 178-185
    • Palumbo, J.S.1    Talmage, K.E.2    Massari, J.V.3
  • 32
    • 3142592165 scopus 로고    scopus 로고
    • Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis
    • Camerer E, Qazi AA, Duong DN, et al. Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis. Blood 2004;104:397-401
    • (2004) Blood , vol.104 , pp. 397-401
    • Camerer, E.1    Qazi, A.A.2    Duong, D.N.3
  • 33
    • 15244343497 scopus 로고    scopus 로고
    • Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer
    • Boucharaba A, Serre CM, Gres S, et al. Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer. J Clin Invest 2004;114:1714-1725
    • (2004) J Clin Invest , vol.114 , pp. 1714-1725
    • Boucharaba, A.1    Serre, C.M.2    Gres, S.3
  • 34
    • 0032533268 scopus 로고    scopus 로고
    • Protease-activated receptor 1 (PAR-1) is required and rate-limiting for thrombin-enhanced experimental pulmonary metastasis
    • Nierodzik ML, Chen K, Takeshita K, et al. Protease-activated receptor 1 (PAR-1) is required and rate-limiting for thrombin-enhanced experimental pulmonary metastasis. Blood 1998;92:3694-3700
    • (1998) Blood , vol.92 , pp. 3694-3700
    • Nierodzik, M.L.1    Chen, K.2    Takeshita, K.3
  • 35
    • 0032699212 scopus 로고    scopus 로고
    • Tumor cell adhesion and migration supported by interaction of a receptor-protease complex with its inhibitor
    • Fischer EG, Riewald M, Huang HY, et al. Tumor cell adhesion and migration supported by interaction of a receptor-protease complex with its inhibitor. J Clin Invest 1999;104:1213-1221
    • (1999) J Clin Invest , vol.104 , pp. 1213-1221
    • Fischer, E.G.1    Riewald, M.2    Huang, H.Y.3
  • 36
    • 13244292386 scopus 로고    scopus 로고
    • Does hypercoagulability awaken dormant tumor cells in the host?
    • Karpatkin S. Does hypercoagulability awaken dormant tumor cells in the host? J Thromb Haemost 2004;2:2103-2106
    • (2004) J Thromb Haemost , vol.2 , pp. 2103-2106
    • Karpatkin, S.1
  • 37
    • 3543121913 scopus 로고    scopus 로고
    • Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis
    • Shi X, Gangadharan B, Brass LF, Ruf W, Mueller BM. Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis. Mol Cancer Res 2004;2:395-402
    • (2004) Mol Cancer Res , vol.2 , pp. 395-402
    • Shi, X.1    Gangadharan, B.2    Brass, L.F.3    Ruf, W.4    Mueller, B.M.5
  • 38
    • 0034608013 scopus 로고    scopus 로고
    • Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-deaved PAR1
    • O'Brien PJ, Prevost N, Molino M, et al. Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-deaved PAR1. J Biol Chem 2000;275:13502-13509
    • (2000) J Biol Chem , vol.275 , pp. 13502-13509
    • O'Brien, P.J.1    Prevost, N.2    Molino, M.3
  • 39
    • 7244231210 scopus 로고    scopus 로고
    • Role of endogenous thrombin in tumor implantation, seeding, and spontaneous metastasis
    • Hu L, Lee M, Campbell W, Perez-Soler R, Karpatkin S. Role of endogenous thrombin in tumor implantation, seeding, and spontaneous metastasis. Blood 2004;104:2746-2751
    • (2004) Blood , vol.104 , pp. 2746-2751
    • Hu, L.1    Lee, M.2    Campbell, W.3    Perez-Soler, R.4    Karpatkin, S.5
  • 40
    • 0031882775 scopus 로고    scopus 로고
    • Activation of coagulation and angiogenesis in cancer: Immunohistochemical localization in situ of clotting proteins and vascular endothelial growth factor in human cancer
    • Shoji M, Hancock WW, Abe K, et al. Activation of coagulation and angiogenesis in cancer: immunohistochemical localization in situ of clotting proteins and vascular endothelial growth factor in human cancer. Am J Pathol 1998;152:399-411
    • (1998) Am J Pathol , vol.152 , pp. 399-411
    • Shoji, M.1    Hancock, W.W.2    Abe, K.3
  • 41
    • 0036894405 scopus 로고    scopus 로고
    • Spontaneous hematogenous and lymphatic metastasis, but not primary tumor growth or angiogenesis, is diminished in fibrinogen-deficient mice
    • Palumbo JS, Potter JM, Kaplan LS, et al. Spontaneous hematogenous and lymphatic metastasis, but not primary tumor growth or angiogenesis, is diminished in fibrinogen-deficient mice. Cancer Res 2002;62:6966-6972
    • (2002) Cancer Res , vol.62 , pp. 6966-6972
    • Palumbo, J.S.1    Potter, J.M.2    Kaplan, L.S.3
  • 42
    • 0034669975 scopus 로고    scopus 로고
    • Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells
    • Palumbo JS, Kombrinck KW, Drew AF, et al. Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells. Blood 2000;96:3302-3309
    • (2000) Blood , vol.96 , pp. 3302-3309
    • Palumbo, J.S.1    Kombrinck, K.W.2    Drew, A.F.3
  • 43
    • 3042697202 scopus 로고    scopus 로고
    • Thrombin induces neoangiogenesis in the chick chorioallantoic membrane
    • Caunt M, Huang YQ, Brooks PC, Karpatkin S. Thrombin induces neoangiogenesis in the chick chorioallantoic membrane. J Thromb Haemost 2003;1:2097-2102
    • (2003) J Thromb Haemost , vol.1 , pp. 2097-2102
    • Caunt, M.1    Huang, Y.Q.2    Brooks, P.C.3    Karpatkin, S.4
  • 44
    • 0030817878 scopus 로고    scopus 로고
    • Thrombin promotes endothelial cell alignment in Matrigel in vitro and angiogenesis in vivo
    • Haralabopoulos GC, Grant DS, Kleinman HK, Maragoudakis ME. Thrombin promotes endothelial cell alignment in Matrigel in vitro and angiogenesis in vivo. Am J Physiol 1997;273:C239-C245
    • (1997) Am J Physiol , vol.273
    • Haralabopoulos, G.C.1    Grant, D.S.2    Kleinman, H.K.3    Maragoudakis, M.E.4
  • 45
    • 17444410423 scopus 로고    scopus 로고
    • Proteinase-activated receptor 1 (PAR1) and cell apoptosis
    • Flynn AN, Buret AG. Proteinase-activated receptor 1 (PAR1) and cell apoptosis. Apoptosis 2004;9:729-737
    • (2004) Apoptosis , vol.9 , pp. 729-737
    • Flynn, A.N.1    Buret, A.G.2
  • 48
    • 2442692682 scopus 로고    scopus 로고
    • Protease-activated receptor 2 in colon cancer: Trypsin-induced MAPK phosphorylation and cell proliferation are mediated by epidermal growth factor receptor transactivation
    • Darmoul D, Gratio V, Devaud H, Laburthe M. Protease-activated receptor 2 in colon cancer: trypsin-induced MAPK phosphorylation and cell proliferation are mediated by epidermal growth factor receptor transactivation. J Biol Chem 2004;279:20927-20934
    • (2004) J Biol Chem , vol.279 , pp. 20927-20934
    • Darmoul, D.1    Gratio, V.2    Devaud, H.3    Laburthe, M.4
  • 49
    • 0033599039 scopus 로고    scopus 로고
    • EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
    • Prenzel N, Zwick E, Daub H, et al. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 1999;402:884-888
    • (1999) Nature , vol.402 , pp. 884-888
    • Prenzel, N.1    Zwick, E.2    Daub, H.3
  • 50
    • 3543009588 scopus 로고    scopus 로고
    • The epidermal growth factor receptor (EGFR) and proline rich tyrosine kinase 2 (PYK2) are involved in tissue factor dependent factor VIIa signalling in HaCaT cells
    • Wiiger MT, Prydz H. The epidermal growth factor receptor (EGFR) and proline rich tyrosine kinase 2 (PYK2) are involved in tissue factor dependent factor VIIa signalling in HaCaT cells. Thromb Haemost 2004;92:13-22
    • (2004) Thromb Haemost , vol.92 , pp. 13-22
    • Wiiger, M.T.1    Prydz, H.2
  • 51
    • 0037189580 scopus 로고    scopus 로고
    • Factor VIIa induces tissue factor-dependent up-regulation of interleukin-8 in a human keratinocyte line
    • Wang X, Gjernes E, Prydz H. Factor VIIa induces tissue factor-dependent up-regulation of interleukin-8 in a human keratinocyte line. J Biol Chem 2002;277:23620-23626
    • (2002) J Biol Chem , vol.277 , pp. 23620-23626
    • Wang, X.1    Gjernes, E.2    Prydz, H.3
  • 52
    • 0027935431 scopus 로고
    • Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice
    • Zhang Y, Deng Y, Luther T, et al. Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice. J Clin Invest 1994;94:1320-1327
    • (1994) J Clin Invest , vol.94 , pp. 1320-1327
    • Zhang, Y.1    Deng, Y.2    Luther, T.3
  • 53
    • 13544256266 scopus 로고    scopus 로고
    • Oncogenic events regulate tissue factor expression in colorectal cancer cells: Implications for tumor progression and angiogenesis
    • Yu JL, May L, Lhotak V, et al. Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis. Blood 2005;105:1734-1741
    • (2005) Blood , vol.105 , pp. 1734-1741
    • Yu, J.L.1    May, L.2    Lhotak, V.3
  • 54
    • 0037567437 scopus 로고    scopus 로고
    • Tissue factor/factor VIIa inhibitors block angiogenesis and tumor growth through a nonhemostatic mechanism
    • Hembrough TA, Swartz GM, Papathanassiu A, et al. Tissue factor/factor VIIa inhibitors block angiogenesis and tumor growth through a nonhemostatic mechanism. Cancer Res 2003;63:2997-3000
    • (2003) Cancer Res , vol.63 , pp. 2997-3000
    • Hembrough, T.A.1    Swartz, G.M.2    Papathanassiu, A.3
  • 55
    • 2442700125 scopus 로고    scopus 로고
    • Regulation of angiogenesis by tissue factor cytoplasmic domain signaling
    • Belting M, Dorrell MI, Sandgren S, et al. Regulation of angiogenesis by tissue factor cytoplasmic domain signaling. Nat Med 2004;10:502-509
    • (2004) Nat Med , vol.10 , pp. 502-509
    • Belting, M.1    Dorrell, M.I.2    Sandgren, S.3
  • 56
    • 9544227474 scopus 로고    scopus 로고
    • Role of tissue factor in embryonic blood vessel development
    • Carmeliet P, Mackman N, Moons L, et al. Role of tissue factor in embryonic blood vessel development. Nature 1996;383:73-75
    • (1996) Nature , vol.383 , pp. 73-75
    • Carmeliet, P.1    Mackman, N.2    Moons, L.3
  • 57
    • 0035979691 scopus 로고    scopus 로고
    • A role for thrombin receptor signaling in endothelial cells during embryonic development
    • Griffin CT, Srinivasan Y, Zheng YW, Huang W, Coughlin SR. A role for thrombin receptor signaling in endothelial cells during embryonic development. Science 2001;293:1666-1670
    • (2001) Science , vol.293 , pp. 1666-1670
    • Griffin, C.T.1    Srinivasan, Y.2    Zheng, Y.W.3    Huang, W.4    Coughlin, S.R.5
  • 58
    • 0030020590 scopus 로고    scopus 로고
    • In situ detection of tissue factor in vascular endothelial cells: Correlation with the malignant phenotype of human breast disease
    • Contrino J, Hair G, Kreutzer DL, Rickles FR. In situ detection of tissue factor in vascular endothelial cells: correlation with the malignant phenotype of human breast disease. Nat Med 1996;2:209-215
    • (1996) Nat Med , vol.2 , pp. 209-215
    • Contrino, J.1    Hair, G.2    Kreutzer, D.L.3    Rickles, F.R.4
  • 59
    • 0042197340 scopus 로고    scopus 로고
    • TIMP-2 mediated inhibition of angiogenesis: An MMP-independent mechanism
    • Seo DW, Li H, Guedez L, et al. TIMP-2 mediated inhibition of angiogenesis: an MMP-independent mechanism. Cell 2003;114:171-180
    • (2003) Cell , vol.114 , pp. 171-180
    • Seo, D.W.1    Li, H.2    Guedez, L.3
  • 60
    • 0034670040 scopus 로고    scopus 로고
    • Binding of factor Vila to tissue factor on human fibroblasts leads to activation of phospholipase C and enhanced PDGF-BB-stimulated chemotaxis
    • Siegbahn A, Johnell M, Rorsman C, et al. Binding of factor Vila to tissue factor on human fibroblasts leads to activation of phospholipase C and enhanced PDGF-BB-stimulated chemotaxis. Blood 2000;96:3452-3458
    • (2000) Blood , vol.96 , pp. 3452-3458
    • Siegbahn, A.1    Johnell, M.2    Rorsman, C.3
  • 61
    • 0141483377 scopus 로고    scopus 로고
    • A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis
    • Ge L, Ly Y, Hollenberg M, DeFea K. A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis. J Biol Chem 2003;278:34418-34426
    • (2003) J Biol Chem , vol.278 , pp. 34418-34426
    • Ge, L.1    Ly, Y.2    Hollenberg, M.3    Defea, K.4
  • 62
    • 2442647329 scopus 로고    scopus 로고
    • Protease-activated receptor 2-dependent phosphorylation of the tissue factor cytoplasmic domain
    • Ahamed J, Ruf W. Protease-activated receptor 2-dependent phosphorylation of the tissue factor cytoplasmic domain. J Biol Chem 2004;279:23038-23044
    • (2004) J Biol Chem , vol.279 , pp. 23038-23044
    • Ahamed, J.1    Ruf, W.2
  • 63
    • 0344826105 scopus 로고    scopus 로고
    • Regulation of tissue factor cytoplasmic domain phosphorylation by palmitoylation
    • Dorfleutner A, Ruf W. Regulation of tissue factor cytoplasmic domain phosphorylation by palmitoylation. Blood 2003;102:3998-4005
    • (2003) Blood , vol.102 , pp. 3998-4005
    • Dorfleutner, A.1    Ruf, W.2
  • 64
    • 0031719897 scopus 로고    scopus 로고
    • Cancer invasion and tissue remodeling: Common themes in proteolytic matrix degradation
    • Johnsen M, Lund LR, Romer J, Almholt K, Dano K. Cancer invasion and tissue remodeling: common themes in proteolytic matrix degradation. Curr Opin Cell Biol 1998;10:667-671
    • (1998) Curr Opin Cell Biol , vol.10 , pp. 667-671
    • Johnsen, M.1    Lund, L.R.2    Romer, J.3    Almholt, K.4    Dano, K.5
  • 65
    • 0036739950 scopus 로고    scopus 로고
    • Plasmin induces Cyr61 gene expression in fibroblasts via protease-activated receptor-1 and p44/42 mitogen-activated protein kinase-dependent signaling pathway
    • Pendurthi UR, Ngyuen M, Andrade-Gordon P, Petersen LC, Rao LV. Plasmin induces Cyr61 gene expression in fibroblasts via protease-activated receptor-1 and p44/42 mitogen-activated protein kinase-dependent signaling pathway. Arterioscler Thromb Vasc Biol 2002;22:1421-1426
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 1421-1426
    • Pendurthi, U.R.1    Ngyuen, M.2    Andrade-Gordon, P.3    Petersen, L.C.4    Rao, L.V.5
  • 66
    • 4444229880 scopus 로고    scopus 로고
    • Plasmin-induced migration requires' signaling through protease-activated receptor 1 and integrin alpha(9)beta(1)
    • Majumdar M, Tarui T, Shi B, et al. Plasmin-induced migration requires' signaling through protease-activated receptor 1 and integrin alpha(9)beta(1). J Biol Chem 2004;279:37528-37534
    • (2004) J Biol Chem , vol.279 , pp. 37528-37534
    • Majumdar, M.1    Tarui, T.2    Shi, B.3
  • 67
    • 0037036069 scopus 로고    scopus 로고
    • Activation of endothelial cell protease activated receptor 1 by the protein C pathway
    • Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W. Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science 2002;296:1880-1882
    • (2002) Science , vol.296 , pp. 1880-1882
    • Riewald, M.1    Petrovan, R.J.2    Donner, A.3    Mueller, B.M.4    Ruf, W.5
  • 68
    • 3142680906 scopus 로고    scopus 로고
    • Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo
    • Uchiba M, Okajima K, Oike Y, et al. Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo. Circ Res 2004;95:34-41
    • (2004) Circ Res , vol.95 , pp. 34-41
    • Uchiba, M.1    Okajima, K.2    Oike, Y.3
  • 69
    • 0032508557 scopus 로고    scopus 로고
    • Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from Porphyromonas gingivalis
    • Lourbakos A, Chinni C, Thompson P, et al. Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from Porphyromonas gingivalis. FEBS Lett 1998;435:45-48
    • (1998) FEBS Lett , vol.435 , pp. 45-48
    • Lourbakos, A.1    Chinni, C.2    Thompson, P.3
  • 70
    • 0034634506 scopus 로고    scopus 로고
    • Evidence for the activation of PAR-2 by the sperm protease, acrosin: Expression of the receptor on oocytes
    • Smith R, Jenkins A, Lourbakos A, et al. Evidence for the activation of PAR-2 by the sperm protease, acrosin: expression of the receptor on oocytes. FEBS Lett 2000;484:285-290
    • (2000) FEBS Lett , vol.484 , pp. 285-290
    • Smith, R.1    Jenkins, A.2    Lourbakos, A.3
  • 71
    • 15444346942 scopus 로고    scopus 로고
    • Interactions of mast cell tryptase with thrombin receptors and PAR-2
    • Molino M, Barnathan ES, Numerof R, et al. Interactions of mast cell tryptase with thrombin receptors and PAR-2. J Biol Chem 1997;272:4043-4049
    • (1997) J Biol Chem , vol.272 , pp. 4043-4049
    • Molino, M.1    Barnathan, E.S.2    Numerof, R.3
  • 72
    • 21744437441 scopus 로고    scopus 로고
    • The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells
    • Wilson S, Greer B, Hooper J, et al. The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells. Biochem J 2005;388:967-972
    • (2005) Biochem J , vol.388 , pp. 967-972
    • Wilson, S.1    Greer, B.2    Hooper, J.3
  • 73
    • 0034714379 scopus 로고    scopus 로고
    • Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates
    • Takeuchi T, Harris JL, Huang W, et al. Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates. J Biol Chem 2000;275:26333-26342
    • (2000) J Biol Chem , vol.275 , pp. 26333-26342
    • Takeuchi, T.1    Harris, J.L.2    Huang, W.3
  • 74
    • 5344230112 scopus 로고    scopus 로고
    • CVS-3983, a selective matriptase inhibitor, suppresses the growth of androgen independent prostate tumor xenografts
    • Galkin AV, Mullen L, Fox WD, et al. CVS-3983, a selective matriptase inhibitor, suppresses the growth of androgen independent prostate tumor xenografts. Prostate 2004;61:228-235
    • (2004) Prostate , vol.61 , pp. 228-235
    • Galkin, A.V.1    Mullen, L.2    Fox, W.D.3
  • 75
    • 0037340473 scopus 로고    scopus 로고
    • Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis
    • Aimes RT, Zijlstra A, Hooper JD, et al. Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis. Thromb Haemost 2003;89:561-572
    • (2003) Thromb Haemost , vol.89 , pp. 561-572
    • Aimes, R.T.1    Zijlstra, A.2    Hooper, J.D.3
  • 76
    • 0037688169 scopus 로고    scopus 로고
    • Membrane anchored serine proteases: A rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer
    • Netzel-Arnett S, Hooper JD, Szabo R, et al. Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer. Cancer Metastasis Rev 2003;22:237-258
    • (2003) Cancer Metastasis Rev , vol.22 , pp. 237-258
    • Netzel-Arnett, S.1    Hooper, J.D.2    Szabo, R.3
  • 77
    • 0021243907 scopus 로고
    • Effect of warfarin anticoagulation on survival in carcinoma of the lung, colon, head and neck, and prostate. Final report of VA Cooperative Study #75
    • Zacharski LR, Henderson WG, Rickles FR, et al. Effect of warfarin anticoagulation on survival in carcinoma of the lung, colon, head and neck, and prostate. Final report of VA Cooperative Study #75. Cancer 1984;53:2046-2052
    • (1984) Cancer , vol.53 , pp. 2046-2052
    • Zacharski, L.R.1    Henderson, W.G.2    Rickles, F.R.3


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