Binding of factor VIIa to tissue factor on human fibroblasts leads to activation of phospholipase C and enhanced PDGF-BB-stimulated chemotaxis

Blood

Volumn 96, Issue 10, 2000, Pages 3452-3458

  Siegbahn, A ^a   Johnell, M ^a   Rorsman, C ^a   Ezban, M ^a   Heldin, C H ^a   Ronnstrand, L ^a  

^a Clinical Chemistry   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 7A; INOSITOL 1,4,5 TRISPHOSPHATE; PHOSPHOLIPASE C; PLATELET DERIVED GROWTH FACTOR BB; THROMBIN; THROMBOPLASTIN;

ARTICLE; BLOOD CLOTTING; CELL MIGRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; FIBROBLAST; HUMAN; HUMAN CELL; NEUTROPHIL CHEMOTAXIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

EID: 0034670040     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.10.3452     Document Type: Article

References (47)

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2. Structural design and molecular evolution of a cytokine receptor superfamily
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7. 2+ signals in J82 cells, transfected COS-1 cells, Madin-Darby canine kidney cells and in human endothelial cells induced to synthesize tissue factor
8. 2+ oscillations in Madin-Darby canine kidney cells only when proteolytically active
9. Signal transduction via the mitogen-activated protein kinase pathway induced by binding of coagulation factor VIIa to tissue factor
10. Coagulation factors VIIa and Xa induce cell signaling leading to up-regulation of the egr-1 gene
11. Binding of factor VIIa to tissue factor on keratinocytes induces gene expression
12. Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation
13. Role of tissue factor in metastasis: Functions of the cytoplasmic and extracellular domains of the molecule
14. A role for tissue factor in cell adhesion and migration mediated by interaction with actin-binding protein 280
15. Mechanism of action and in vivo role of platelet-derived growth factor
16. Signal transduction via platelet-derived growth factor receptors
17. Differential effects of the various isoforms of platelet-derived growth factor on chemotaxis of fibroblasts, monocytes, and granulocytes
18. Amino acid sequence and posttranslational modification of human factor VII from plasma and transfected baby hamster kidney cells
19. Incorporation of an active site inhibitor in factor FVIIa alters the affinity for tissue factor
20. Monoclonal antibody analysis of purified and cell-associated tissue factor
21. IL-10 inhibits LPS-induced human monocyte tissue factor expression in whole blood
22. A glioma-derived PDGF A chain homodimer has different functional activities from a PDGF AB heterodimer purified from human platelets
23. Demonstration of functionally different interactions between phospholipase C-γ and the two types of platelet-derived growth factor receptors
24. Binding of different dimeric forms of PDGF to human fibroblasts: Evidence for two separate receptor types
25. Elevated content of the tyrosine kinase substrate phospholipase C-γl in primary human breast carcinomas
26. A growth factor-responsive gene of murine Balb/c 3T3 cells encodes a protein homologous to human tissue factor
27. Tissue factor expression during human and mouse development
28. Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation
29. Role of tissue factor in embryonic blood vessel development
30. Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice
31. Regulation of vascular endothelial growth factor production and angiogenesis by the cytoplasmic tail of tissue factor
32. Effect of tissue factor deficiency on mouse and tumor development
33. Tissue factor is required for uterine hemostasis and maintenance of the placental labyrinth during gestation
34. Factor VIIa and thrombin induce the expression of Cyr61 and connective tissue growth factor, extracellular matrix signaling proteins that could act as possible downstream mediators in factor VIIa tissue factor-induced signal transduction
35. Requirement for binding of catalytically active factor VIIa in tissue factor-dependent experimental metastasis
36. Tissue factor induces migration of cultured aortic smooth muscle cells
37. Overexpression of tissue factor pathway inhibitor in aortic smooth muscle cells inhibits cell migration induced by tissue factor/factor VII complex
38. Mutation of a Src phosphorylation site in the PDGF β-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis
39. Overactivation of phospholipase C-YI renders PDGF β-receptor expressing cells independent of the PI3-kinase pathway for chemotaxis
40. Exclusion of known protease activated receptors in factor VIIa-induced signal transduction
41. Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa
42. Localisation of tissue factor in actin-filament-rich membrane areas of epithelial cells
43. Cell migration: A physically integrated molecular process
44. Membrane ruffling and chemotaxis transduced by the PDGF β-receptor require the binding site for phosphatidylinositol 3-kinase
45. Phosphatidylinositol 3-kinase-independent signal transduction pathway for platelet-derived growth factor-induced chemotaxis
46. Regulation of chemotaxis by the platelet-derived growth factor receptor-β
47. Influence of blockade at specific levels of the coagulation cascade on restenosis in a rabbit atherosclerotic femoral artery injury model