Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo

Circulation Research

Volumn 95, Issue 1, 2004, Pages 34-41

  Uchiba, Mitsuhiro ^a   Okajima, Kenji ^a   Oike, Yuichi ^b   Ito, Yasuhiro ^b   Fukudome, Kenji ^c   Isobe, Hirotaka ^a   Suda, Toshio ^b  

^a KUMAMOTO UNIVERSITY   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c SAGA UNIVERSITY   (Japan)

Author keywords

Activated protein C; Angiogenesis; Endothelial protein C receptor; Mitogen activated protein kinase; Protease activated receptor 1

Indexed keywords

ACTIVATED PROTEIN C; CYCLIC GMP DEPENDENT PROTEIN KINASE; DNA; ENDOTHELIAL PROTEIN C RECEPTOR ANTIBODY; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN ANTIBODY; PROTEINASE ACTIVATED RECEPTOR 1; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANTICOAGULATION; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; MORPHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; RECEPTOR BINDING; UMBILICAL VEIN; VASCULAR ENDOTHELIUM; WILD TYPE;

ANIMALS; ANTIBODIES; BLOOD COAGULATION FACTORS; CELL PROLIFERATION; CELLS, CULTURED; CYCLIC GMP; DNA; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; NITRIC OXIDE; PROTEIN C; PROTEIN KINASE INHIBITORS; RECEPTOR, PAR-1; RECEPTORS, CELL SURFACE;

EID: 3142680906     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000133680.87668.FA     Document Type: Article

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